HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/json
Vary: Accept
{
"count": 221292,
"next": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1053",
"previous": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1051",
"results": [
{
"created": "2022-01-13T15:08:58.155825+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10609",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: MAMLD1 was changed from Unknown to X-LINKED: hemizygous mutation in males, biallelic mutations in females",
"entity_name": "MAMLD1",
"entity_type": "gene"
},
{
"created": "2022-01-13T15:08:18.181641+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10608",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: MAMLD1: Rating: GREEN; Mode of pathogenicity: None; Publications: 26815876, 31555317, 32690052; Phenotypes: Hypospadias 2 (MIM#300758); Mode of inheritance: X-LINKED: hemizygous mutation in males, biallelic mutations in females",
"entity_name": "MAMLD1",
"entity_type": "gene"
},
{
"created": "2022-01-13T15:06:58.856204+11:00",
"panel_name": "Differences of Sex Development",
"panel_id": 99,
"panel_version": "0.237",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: MAMLD1 as ready",
"entity_name": "MAMLD1",
"entity_type": "gene"
},
{
"created": "2022-01-13T15:06:58.846233+11:00",
"panel_name": "Differences of Sex Development",
"panel_id": 99,
"panel_version": "0.237",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: mamld1 has been classified as Green List (High Evidence).",
"entity_name": "MAMLD1",
"entity_type": "gene"
},
{
"created": "2022-01-13T15:06:55.746522+11:00",
"panel_name": "Differences of Sex Development",
"panel_id": 99,
"panel_version": "0.237",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: MAMLD1 were changed from to Hypospadias 2 (MIM#300758)",
"entity_name": "MAMLD1",
"entity_type": "gene"
},
{
"created": "2022-01-13T15:05:01.720547+11:00",
"panel_name": "Differences of Sex Development",
"panel_id": 99,
"panel_version": "0.236",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: MAMLD1 were set to ",
"entity_name": "MAMLD1",
"entity_type": "gene"
},
{
"created": "2022-01-13T15:04:27.087937+11:00",
"panel_name": "Differences of Sex Development",
"panel_id": 99,
"panel_version": "0.235",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: MAMLD1 was changed from Unknown to X-LINKED: hemizygous mutation in males, biallelic mutations in females",
"entity_name": "MAMLD1",
"entity_type": "gene"
},
{
"created": "2022-01-13T15:02:58.618750+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1985",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: ITGA8 as ready",
"entity_name": "ITGA8",
"entity_type": "gene"
},
{
"created": "2022-01-13T15:02:58.607647+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1985",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: itga8 has been classified as Green List (High Evidence).",
"entity_name": "ITGA8",
"entity_type": "gene"
},
{
"created": "2022-01-13T15:02:53.458077+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1985",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: ITGA8 were set to 24439109",
"entity_name": "ITGA8",
"entity_type": "gene"
},
{
"created": "2022-01-13T15:02:30.178147+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1984",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: ITGA8 as Green List (high evidence)",
"entity_name": "ITGA8",
"entity_type": "gene"
},
{
"created": "2022-01-13T15:02:30.163131+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1984",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: itga8 has been classified as Green List (High Evidence).",
"entity_name": "ITGA8",
"entity_type": "gene"
},
{
"created": "2022-01-13T15:01:35.375776+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1983",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: INPP5K as ready",
"entity_name": "INPP5K",
"entity_type": "gene"
},
{
"created": "2022-01-13T15:01:35.364973+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1983",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: inpp5k has been classified as Amber List (Moderate Evidence).",
"entity_name": "INPP5K",
"entity_type": "gene"
},
{
"created": "2022-01-13T15:01:31.244966+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1983",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: INPP5K were changed from Muscular dystrophy, congenital, with cataracts and intellectual disability to Muscular dystrophy, congenital, with cataracts and intellectual disability MIM#617404",
"entity_name": "INPP5K",
"entity_type": "gene"
},
{
"created": "2022-01-13T15:01:10.796283+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1982",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: INPP5K were set to ",
"entity_name": "INPP5K",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:59:55.826185+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1981",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: LAMP2 as ready",
"entity_name": "LAMP2",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:59:55.813230+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1981",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: lamp2 has been classified as Red List (Low Evidence).",
"entity_name": "LAMP2",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:59:47.482369+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1981",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: LAMP2 were changed from DANON DISEASE to Danon disease (MIM#300257)",
"entity_name": "LAMP2",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:59:36.038228+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1980",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: LAMP2 were set to ",
"entity_name": "LAMP2",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:58:30.078325+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10608",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: INPP5K as ready",
"entity_name": "INPP5K",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:58:30.060741+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10608",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: inpp5k has been classified as Green List (High Evidence).",
"entity_name": "INPP5K",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:58:20.867913+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10608",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: INPP5K were changed from to Muscular dystrophy, congenital, with cataracts and intellectual disability MIM#617404",
"entity_name": "INPP5K",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:58:01.397784+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10607",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: INPP5K were set to ",
"entity_name": "INPP5K",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:57:41.993934+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10606",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: INPP5K was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "INPP5K",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:45:26.682960+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1979",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: LAMB3 as ready",
"entity_name": "LAMB3",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:45:26.669189+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1979",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: lamb3 has been classified as Red List (Low Evidence).",
"entity_name": "LAMB3",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:45:18.043982+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1979",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: LAMB3 were set to ",
"entity_name": "LAMB3",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:45:01.510788+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1978",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: LAMB3: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: Epidermolysis bullosa, junctional, Herlitz type (MIM#226700), Epidermolysis bullosa, junctional, non-Herlitz type (MIM#226650); Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "LAMB3",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:43:08.481765+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10605",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: IGFBP7 as ready",
"entity_name": "IGFBP7",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:43:08.472085+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10605",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: igfbp7 has been classified as Amber List (Moderate Evidence).",
"entity_name": "IGFBP7",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:43:00.736498+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10605",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: IGFBP7 were changed from to Retinal arterial macroaneurysm with supravalvular pulmonic stenosis MIM#614224",
"entity_name": "IGFBP7",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:42:38.792886+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10604",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: IGFBP7 were set to ",
"entity_name": "IGFBP7",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:42:12.350355+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10603",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: IGFBP7 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "IGFBP7",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:41:54.843197+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10602",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: IGFBP7 as Amber List (moderate evidence)",
"entity_name": "IGFBP7",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:41:54.824082+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10602",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: igfbp7 has been classified as Amber List (Moderate Evidence).",
"entity_name": "IGFBP7",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:41:33.984129+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10601",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Tag founder tag was added to gene: IGFBP7.",
"entity_name": "IGFBP7",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:41:21.381119+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10601",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: IGFBP7: Rating: AMBER; Mode of pathogenicity: None; Publications: ; Phenotypes: Retinal arterial macroaneurysm with supravalvular pulmonic stenosis MIM#614224; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "IGFBP7",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:40:28.220340+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1978",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: IGFBP7 as ready",
"entity_name": "IGFBP7",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:40:28.205439+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1978",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: igfbp7 has been classified as Red List (Low Evidence).",
"entity_name": "IGFBP7",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:40:24.343762+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1978",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: IGFBP7 were changed from RETINAL ARTERIAL MACROANEURYSM WITH SUPRAVALVULAR PULMONIC STENOSIS to Retinal arterial macroaneurysm with supravalvular pulmonic stenosis MIM#614224",
"entity_name": "IGFBP7",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:40:11.253319+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1977",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: IGFBP7 were set to ",
"entity_name": "IGFBP7",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:39:58.261106+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1976",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: IGFBP7 as Red List (low evidence)",
"entity_name": "IGFBP7",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:39:58.246644+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1976",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: igfbp7 has been classified as Red List (Low Evidence).",
"entity_name": "IGFBP7",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:38:04.073267+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1975",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: LAMA3 as ready",
"entity_name": "LAMA3",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:38:04.051241+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1975",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: lama3 has been classified as Red List (Low Evidence).",
"entity_name": "LAMA3",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:37:59.517183+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1975",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: LAMA3 were changed from Epidermolysis bullosa, junctional 226700 to Epidermolysis bullosa, junctional, Herlitz type (MIM#226700)",
"entity_name": "LAMA3",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:37:44.553607+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1974",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: LAMA3 were set to ",
"entity_name": "LAMA3",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:37:27.600919+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1973",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: LAMA3: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: Epidermolysis bullosa, junctional, Herlitz type (MIM#226700), Epidermolysis bullosa, generalized atrophic benign (MIM#226650); Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "LAMA3",
"entity_type": "gene"
},
{
"created": "2022-01-13T14:36:02.034210+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1973",
"user_name": "Zornitza Stark",
"item_type": "panel",
"text": "removed gene:KIT from the panel",
"entity_name": null,
"entity_type": null
},
{
"created": "2022-01-13T12:12:41.684328+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1972",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NSD2 as ready",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2022-01-13T12:12:41.674184+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1972",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nsd2 has been classified as Green List (High Evidence).",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2022-01-13T12:12:36.552385+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1972",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: NSD2 as Green List (high evidence)",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2022-01-13T12:12:36.525432+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1972",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nsd2 has been classified as Green List (High Evidence).",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2022-01-13T12:12:22.486595+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1971",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "gene: NSD2 was added\ngene: NSD2 was added to Fetal anomalies. Sources: Literature\nMode of inheritance for gene: NSD2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: NSD2 were set to 30345613; 31171569\nPhenotypes for gene: NSD2 were set to Rauch-Steindl syndrome, MIM# 619695\nReview for gene: NSD2 was set to GREEN\nAdded comment: 7 unrelated individuals reported with LOF variants. Gene thought to be responsible for many of the features of Wolf-Hirschorn syndrome.\r\n\r\nPrenatal growth retardation is a feature. \nSources: Literature",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2022-01-13T12:08:42.269408+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.4433",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: NSD2 were changed from Microcephaly; intellectual disability to Rauch-Steindl syndrome, MIM# 619695; Microcephaly; intellectual disability",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2022-01-13T12:08:05.418286+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.4432",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: NSD2: Changed phenotypes: Rauch-Steindl syndrome, MIM# 619695, Microcephaly, intellectual disability",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2022-01-13T12:07:49.695569+11:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "1.92",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: NSD2 were changed from Microcephaly; intellectual disability to Rauch-Steindl syndrome, MIM# 619695; Microcephaly; intellectual disability",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2022-01-13T12:07:00.407571+11:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "1.91",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: NSD2: Changed phenotypes: Rauch-Steindl syndrome, MIM# 619695, Microcephaly, intellectual disability",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2022-01-13T12:06:41.084192+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10601",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: NSD2 were changed from Microcephaly; intellectual disability to Rauch-Steindl syndrome, MIM# 619695; Microcephaly; intellectual disability",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2022-01-13T12:06:20.179790+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10600",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: NSD2: Changed phenotypes: Rauch-Steindl syndrome, MIM# 619695, Microcephaly, intellectual disability",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2022-01-13T10:13:12.238936+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1970",
"user_name": "Seb Lunke",
"item_type": "entity",
"text": "Marked gene: SMAD4 as ready",
"entity_name": "SMAD4",
"entity_type": "gene"
},
{
"created": "2022-01-13T10:13:12.227515+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1970",
"user_name": "Seb Lunke",
"item_type": "entity",
"text": "Gene: smad4 has been classified as Green List (High Evidence).",
"entity_name": "SMAD4",
"entity_type": "gene"
},
{
"created": "2022-01-13T10:08:52.763939+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1970",
"user_name": "Seb Lunke",
"item_type": "entity",
"text": "Phenotypes for gene: SMAD4 were changed from JUVENILE POLYPOSIS SYNDROME; MYHRE SYNDROME; JUVENILE POLYPOSIS/HEREDITARY HEMORRHAGIC TELANGIECTASIA SYNDROME to Myhre syndrome, OMIM#139210, MONDO:0007688",
"entity_name": "SMAD4",
"entity_type": "gene"
},
{
"created": "2022-01-13T10:08:30.473331+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1969",
"user_name": "Seb Lunke",
"item_type": "entity",
"text": "reviewed gene: SMAD4: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Myhre syndrome, OMIM#139210, MONDO:0007688; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown",
"entity_name": "SMAD4",
"entity_type": "gene"
},
{
"created": "2022-01-13T09:32:24.301078+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1969",
"user_name": "Seb Lunke",
"item_type": "entity",
"text": "Marked gene: SMAD3 as ready",
"entity_name": "SMAD3",
"entity_type": "gene"
},
{
"created": "2022-01-13T09:32:24.287249+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1969",
"user_name": "Seb Lunke",
"item_type": "entity",
"text": "Gene: smad3 has been classified as Green List (High Evidence).",
"entity_name": "SMAD3",
"entity_type": "gene"
},
{
"created": "2022-01-13T09:32:08.289614+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1969",
"user_name": "Seb Lunke",
"item_type": "entity",
"text": "Phenotypes for gene: SMAD3 were changed from SMAD3-RELATED LOEYS-DIETZ SYNDROME to Loeys-Dietz syndrome, SMAD3 related, MIM#613795, MONDO:0018954",
"entity_name": "SMAD3",
"entity_type": "gene"
},
{
"created": "2022-01-13T09:31:23.629766+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1968",
"user_name": "Seb Lunke",
"item_type": "entity",
"text": "reviewed gene: SMAD3: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Loeys-Dietz syndrome, MIM#613795, MONDO:0018954; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown",
"entity_name": "SMAD3",
"entity_type": "gene"
},
{
"created": "2022-01-13T09:27:21.243025+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1968",
"user_name": "Seb Lunke",
"item_type": "entity",
"text": "Marked gene: SLC33A1 as ready",
"entity_name": "SLC33A1",
"entity_type": "gene"
},
{
"created": "2022-01-13T09:27:21.231836+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1968",
"user_name": "Seb Lunke",
"item_type": "entity",
"text": "Gene: slc33a1 has been classified as Green List (High Evidence).",
"entity_name": "SLC33A1",
"entity_type": "gene"
},
{
"created": "2022-01-13T09:27:07.104145+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1968",
"user_name": "Seb Lunke",
"item_type": "entity",
"text": "Phenotypes for gene: SLC33A1 were changed from AUTOSOMAL-RECESSIVE DISORDER WITH CONGENITAL CATARACTS, HEARING LOSS, AND LOW SERUM COPPER AND CERULOPLASMIN to CONGENITAL CATARACTS, HEARING LOSS, AND NEURODEGENERATION, OMIM#614482",
"entity_name": "SLC33A1",
"entity_type": "gene"
},
{
"created": "2022-01-13T09:26:49.015999+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1967",
"user_name": "Seb Lunke",
"item_type": "entity",
"text": "Publications for gene: SLC33A1 were set to ",
"entity_name": "SLC33A1",
"entity_type": "gene"
},
{
"created": "2022-01-13T09:26:26.976883+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1966",
"user_name": "Seb Lunke",
"item_type": "entity",
"text": "reviewed gene: SLC33A1: Rating: GREEN; Mode of pathogenicity: None; Publications: 31194315; Phenotypes: CONGENITAL CATARACTS, HEARING LOSS, AND NEURODEGENERATION, OMIM#614482; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes",
"entity_name": "SLC33A1",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:41:52.192270+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10600",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: KISS1R as ready",
"entity_name": "KISS1R",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:41:52.183045+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10600",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: kiss1r has been classified as Green List (High Evidence).",
"entity_name": "KISS1R",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:40:30.563069+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10600",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: KISS1R were changed from to Hypogonadotropic hypogonadism 8 with or without anosmia (MIM#614837)",
"entity_name": "KISS1R",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:40:09.965200+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10599",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: KISS1R were set to ",
"entity_name": "KISS1R",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:39:52.384094+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1966",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: KISS1R as ready",
"entity_name": "KISS1R",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:39:52.373455+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1966",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: kiss1r has been classified as Red List (Low Evidence).",
"entity_name": "KISS1R",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:36:52.450147+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10598",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: KISS1R was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "KISS1R",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:36:14.944586+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10597",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: KISS1R: Rating: GREEN; Mode of pathogenicity: None; Publications: 17164310, 31073722, 14573733; Phenotypes: Hypogonadotropic hypogonadism 8 with or without anosmia (MIM#614837); Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "KISS1R",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:35:07.952631+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1966",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: KISS1R were set to ",
"entity_name": "KISS1R",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:33:59.144344+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1965",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: KCTD7 as ready",
"entity_name": "KCTD7",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:33:59.130925+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1965",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: kctd7 has been classified as Red List (Low Evidence).",
"entity_name": "KCTD7",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:33:55.291555+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1965",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: KCTD7 were changed from PROGRESSIVE MYOCLONIC EPILEPSY TYPE 3; NEURONAL CEROID LIPOFUSCINOSIS to Epilepsy, progressive myoclonic 3, with or without intracellular inclusions (MIM#611726)",
"entity_name": "KCTD7",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:33:41.318402+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1964",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: KCTD7 were set to ",
"entity_name": "KCTD7",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:33:04.283580+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1963",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: IDH1 as ready",
"entity_name": "IDH1",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:33:04.272976+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1963",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: idh1 has been classified as Red List (Low Evidence).",
"entity_name": "IDH1",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:32:56.032832+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1963",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: IDH1 were changed from Maffucci syndrome 614569; Ollier disease/ Dyschondroplasia 166000; Metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria 614875 to Ollier disease MONDO:0008145; Maffucci syndrome MONDO:0013808",
"entity_name": "IDH1",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:32:35.112341+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1962",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: IDH1 were set to 22057234; 22057236; 22025298; 24049096",
"entity_name": "IDH1",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:32:01.496061+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1961",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: IDH1 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to Other",
"entity_name": "IDH1",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:31:50.608818+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1960",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: IDH1 as Red List (low evidence)",
"entity_name": "IDH1",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:31:50.599260+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.1960",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: idh1 has been classified as Red List (Low Evidence).",
"entity_name": "IDH1",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:29:29.656054+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10597",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: IDH1 as ready",
"entity_name": "IDH1",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:29:29.642891+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10597",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: idh1 has been classified as Green List (High Evidence).",
"entity_name": "IDH1",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:29:21.299222+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10597",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: IDH1 were changed from Ollier disease MONDO:0008145; Maffucci syndromeMONDO:0013808 to Ollier disease MONDO:0008145; Maffucci syndrome MONDO:0013808",
"entity_name": "IDH1",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:29:00.568470+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10596",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: IDH1 were changed from to Ollier disease MONDO:0008145; Maffucci syndromeMONDO:0013808",
"entity_name": "IDH1",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:27:43.743813+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10595",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: IDH1 were set to ",
"entity_name": "IDH1",
"entity_type": "gene"
},
{
"created": "2022-01-12T20:27:24.269087+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.10594",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: IDH1 was changed from Unknown to Other",
"entity_name": "IDH1",
"entity_type": "gene"
}
]
}