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{
"count": 220521,
"next": "https://panelapp-aus.org/api/v1/activities/?format=api&page=111",
"previous": "https://panelapp-aus.org/api/v1/activities/?format=api&page=109",
"results": [
{
"created": "2025-11-27T11:07:53.384666+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.503",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: COL1A2 was added\ngene: COL1A2 was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: COL1A2.\nMode of inheritance for gene: COL1A2 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal\nPhenotypes for gene: COL1A2 were set to Congenital heart disease, MONDO:0005453\nReview for gene: COL1A2 was set to RED\nAdded comment: ClinGen DISPUTED - Sep 2024 \nSources: ClinGen",
"entity_name": "COL1A2",
"entity_type": "gene"
},
{
"created": "2025-11-27T11:06:59.434321+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3687",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TRA2B were changed from Neurodevelopmental disorder, TRA2B-related, MONDO# 0700092 to Ramond-Elliott neurodevelopmental syndrome, MIM# 621421",
"entity_name": "TRA2B",
"entity_type": "gene"
},
{
"created": "2025-11-27T11:06:37.336099+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3686",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: TRA2B: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Ramond-Elliott neurodevelopmental syndrome, MIM# 621421; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "TRA2B",
"entity_type": "gene"
},
{
"created": "2025-11-27T11:06:00.737764+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.502",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: SCN5A as ready",
"entity_name": "SCN5A",
"entity_type": "gene"
},
{
"created": "2025-11-27T11:06:00.728957+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.502",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: scn5a has been classified as Red List (Low Evidence).",
"entity_name": "SCN5A",
"entity_type": "gene"
},
{
"created": "2025-11-27T11:05:42.284141+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.502",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: SCN5A was added\ngene: SCN5A was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: SCN5A.\nMode of inheritance for gene: SCN5A was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: SCN5A were set to Congenital heart disease, MONDO:0005453\nReview for gene: SCN5A was set to RED\nAdded comment: ClinGen DISPUTED - Dec 2024 \nSources: ClinGen",
"entity_name": "SCN5A",
"entity_type": "gene"
},
{
"created": "2025-11-27T11:03:42.048617+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.501",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: ID2 was added\ngene: ID2 was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: ID2.\nMode of inheritance for gene: ID2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: ID2 were set to Congenital heart disease, MONDO:0005453\nReview for gene: ID2 was set to RED\nAdded comment: ClinGen DISPUTED - Nov 2023 \nSources: ClinGen",
"entity_name": "ID2",
"entity_type": "gene"
},
{
"created": "2025-11-27T11:03:24.321598+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.501",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: ID2 was added\ngene: ID2 was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: ID2.\nMode of inheritance for gene: ID2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: ID2 were set to Congenital heart disease, MONDO:0005453\nReview for gene: ID2 was set to RED\nAdded comment: ClinGen DISPUTED - Nov 2023 \nSources: ClinGen",
"entity_name": "ID2",
"entity_type": "gene"
},
{
"created": "2025-11-27T11:01:28.070216+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3686",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Added reviews for gene DAND5 from panel Heterotaxy",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-11-27T11:00:56.363255+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.500",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: DAND5 was added\ngene: DAND5 was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: DAND5.\nMode of inheritance for gene: DAND5 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: DAND5 were set to Congenital heart disease, MONDO:0005453\nReview for gene: DAND5 was set to RED\nAdded comment: ClinGen DISPUTED - Jun 2024 \nSources: ClinGen",
"entity_name": "DAND5",
"entity_type": "gene"
},
{
"created": "2025-11-27T11:00:43.590538+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.500",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: DAND5 was added\ngene: DAND5 was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: DAND5.\nMode of inheritance for gene: DAND5 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: DAND5 were set to Congenital heart disease, MONDO:0005453\nReview for gene: DAND5 was set to RED\nAdded comment: ClinGen DISPUTED - Jun 2024 \nSources: ClinGen",
"entity_name": "DAND5",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:59:45.468181+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3685",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Added reviews for gene UGDH from panel Congenital Heart Defect",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-11-27T10:59:40.654647+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3684",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Added reviews for gene NFATC2 from panel Congenital Heart Defect",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-11-27T10:59:24.336351+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3684",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene PROX1 from panel Congenital Heart Defect",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-11-27T10:59:22.744541+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3684",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: PROX1 was added\ngene: PROX1 was added to Mendeliome. Sources: Expert Review Red,ClinGen\ndisputed tags were added to gene: PROX1.\nMode of inheritance for gene: PROX1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: PROX1 were set to Congenital heart disease, MONDO:0005453",
"entity_name": "PROX1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:58:55.955644+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.499",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: PROX1 as ready",
"entity_name": "PROX1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:58:55.944076+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.499",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: prox1 has been classified as Red List (Low Evidence).",
"entity_name": "PROX1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:58:52.517695+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.499",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: NFATC2 as ready",
"entity_name": "NFATC2",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:58:52.507501+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.499",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: nfatc2 has been classified as Red List (Low Evidence).",
"entity_name": "NFATC2",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:58:48.618986+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.499",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: UGDH as ready",
"entity_name": "UGDH",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:58:48.610939+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.499",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: ugdh has been classified as Red List (Low Evidence).",
"entity_name": "UGDH",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:58:26.032369+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.499",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: PROX1 was added\ngene: PROX1 was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: PROX1.\nMode of inheritance for gene: PROX1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: PROX1 were set to Congenital heart disease, MONDO:0005453\nReview for gene: PROX1 was set to RED\nAdded comment: ClinGen DISPUTED - Aug 2024 \nSources: ClinGen",
"entity_name": "PROX1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:58:08.335717+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.498",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: NFATC2 was added\ngene: NFATC2 was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: NFATC2.\nMode of inheritance for gene: NFATC2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: NFATC2 were set to Congenital heart disease, MONDO:0005453\nReview for gene: NFATC2 was set to RED\nAdded comment: ClinGen DISPUTED - Mar 2024 \nSources: ClinGen",
"entity_name": "NFATC2",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:57:54.088044+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.498",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: UGDH was added\ngene: UGDH was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: UGDH.\nMode of inheritance for gene: UGDH was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: UGDH were set to Congenital heart disease, MONDO:0005453\nReview for gene: UGDH was set to RED\nAdded comment: ClinGen DISPUTED - Jun 2024 \nSources: ClinGen",
"entity_name": "UGDH",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:56:13.161477+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3683",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene RAI2 from panel Congenital Heart Defect",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-11-27T10:56:12.554468+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3683",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: RAI2 was added\ngene: RAI2 was added to Mendeliome. Sources: Expert Review Red,ClinGen\ndisputed tags were added to gene: RAI2.\nMode of inheritance for gene: RAI2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: RAI2 were set to Congenital heart disease, MONDO:0005453",
"entity_name": "RAI2",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:55:55.528412+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3682",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Added reviews for gene NFATC1 from panel Congenital Heart Defect",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-11-27T10:55:53.042424+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.497",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: RAI2 as ready",
"entity_name": "RAI2",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:55:53.035619+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.497",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: rai2 has been classified as Red List (Low Evidence).",
"entity_name": "RAI2",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:55:49.847263+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.497",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: RAI2 was added\ngene: RAI2 was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: RAI2.\nMode of inheritance for gene: RAI2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: RAI2 were set to Congenital heart disease, MONDO:0005453\nReview for gene: RAI2 was set to RED\nAdded comment: ClinGen DISPUTED - Apr 2024 \nSources: ClinGen",
"entity_name": "RAI2",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:55:38.527170+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.496",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: NFATC1 as ready",
"entity_name": "NFATC1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:55:38.519327+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.496",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: nfatc1 has been classified as Red List (Low Evidence).",
"entity_name": "NFATC1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:55:01.402141+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.496",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: NFATC1 was added\ngene: NFATC1 was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: NFATC1.\nMode of inheritance for gene: NFATC1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: NFATC1 were set to Congenital heart disease, MONDO:0005453\nReview for gene: NFATC1 was set to RED\nAdded comment: ClinGen DISPUTED - Jul 2023 \nSources: ClinGen",
"entity_name": "NFATC1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:54:03.089875+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3681",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Added reviews for gene CTNNA3 from panel Congenital Heart Defect",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-11-27T10:53:45.509515+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.495",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: CTNNA3 as ready",
"entity_name": "CTNNA3",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:53:45.499483+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.495",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: ctnna3 has been classified as Red List (Low Evidence).",
"entity_name": "CTNNA3",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:53:41.054631+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.495",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: CTNNA3 was added\ngene: CTNNA3 was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: CTNNA3.\nMode of inheritance for gene: CTNNA3 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: CTNNA3 were set to Congenital heart disease, MONDO:0005453\nReview for gene: CTNNA3 was set to RED\nAdded comment: ClinGen DISPUTED - Oct 2023 \nSources: ClinGen",
"entity_name": "CTNNA3",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:51:49.756205+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3680",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene NTRK3 from panel Congenital Heart Defect",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-11-27T10:51:49.106868+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3680",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: NTRK3 was added\ngene: NTRK3 was added to Mendeliome. Sources: Expert Review Red,ClinGen\ndisputed tags were added to gene: NTRK3.\nMode of inheritance for gene: NTRK3 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: NTRK3 were set to Congenital heart disease, MONDO:0005453",
"entity_name": "NTRK3",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:51:40.436168+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3680",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene HEY1 from panel Congenital Heart Defect",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-11-27T10:51:38.749621+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3680",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: HEY1 was added\ngene: HEY1 was added to Mendeliome. Sources: Expert Review Red,ClinGen\ndisputed tags were added to gene: HEY1.\nMode of inheritance for gene: HEY1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: HEY1 were set to Congenital heart disease, MONDO:0005453",
"entity_name": "HEY1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:51:15.313380+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.494",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: HEY1 as ready",
"entity_name": "HEY1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:51:15.306479+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.494",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: hey1 has been classified as Red List (Low Evidence).",
"entity_name": "HEY1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:51:00.423623+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.494",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: NTRK3 as ready",
"entity_name": "NTRK3",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:51:00.415285+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.494",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: ntrk3 has been classified as Red List (Low Evidence).",
"entity_name": "NTRK3",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:50:24.621683+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.494",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: NTRK3 was added\ngene: NTRK3 was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: NTRK3.\nMode of inheritance for gene: NTRK3 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: NTRK3 were set to Congenital heart disease, MONDO:0005453\nReview for gene: NTRK3 was set to RED\nAdded comment: ClinGen DISPUTED - Feb 2024 \nSources: ClinGen",
"entity_name": "NTRK3",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:50:07.505757+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.494",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: HEY1 was added\ngene: HEY1 was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: HEY1.\nMode of inheritance for gene: HEY1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: HEY1 were set to Congenital heart disease, MONDO:0005453\nReview for gene: HEY1 was set to RED\nAdded comment: ClinGen DISPUTED - Aug 2024 \nSources: ClinGen",
"entity_name": "HEY1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:48:56.025133+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.493",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: OSR1 as ready",
"entity_name": "OSR1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:48:56.017985+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.493",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: osr1 has been classified as Red List (Low Evidence).",
"entity_name": "OSR1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:48:51.567299+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3679",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "changed review comment from: ClinGen DISPUTED - Aug 2024; to: ClinGen DISPUTED - Apr 2024",
"entity_name": "OSR1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:48:51.438196+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.493",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: OSR1 was added\ngene: OSR1 was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: OSR1.\nMode of inheritance for gene: OSR1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: OSR1 were set to Congenital heart disease, MONDO:0005453\nReview for gene: OSR1 was set to RED\nAdded comment: ClinGen DISPUTED - Apr 2024 \nSources: ClinGen",
"entity_name": "OSR1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:47:48.487279+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3679",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "reviewed gene: OSR1: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "OSR1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:47:33.642212+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3679",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Mode of inheritance for gene: OSR1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "OSR1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:47:31.963885+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3679",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Phenotypes for gene: OSR1 were changed from to Congenital heart disease, MONDO:0005453",
"entity_name": "OSR1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:46:48.978425+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3678",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Added reviews for gene LEFTY2 from panel Congenital Heart Defect",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-11-27T10:46:31.750880+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.492",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: LEFTY2 as ready",
"entity_name": "LEFTY2",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:46:31.743156+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.492",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: lefty2 has been classified as Red List (Low Evidence).",
"entity_name": "LEFTY2",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:46:27.048206+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.492",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: LEFTY2 was added\ngene: LEFTY2 was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: LEFTY2.\nMode of inheritance for gene: LEFTY2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: LEFTY2 were set to Congenital heart disease, MONDO:0005453\nReview for gene: LEFTY2 was set to RED\nAdded comment: ClinGen DISPUTED - Feb 2024 \nSources: ClinGen",
"entity_name": "LEFTY2",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:45:38.740909+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3677",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene CSRP1 from panel Congenital Heart Defect",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-11-27T10:45:38.097282+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3677",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: CSRP1 was added\ngene: CSRP1 was added to Mendeliome. Sources: Expert Review Red,ClinGen\ndisputed tags were added to gene: CSRP1.\nMode of inheritance for gene: CSRP1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: CSRP1 were set to Congenital heart disease, MONDO:0005453",
"entity_name": "CSRP1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:45:27.546433+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3677",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene ATE1 from panel Congenital Heart Defect",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-11-27T10:45:25.040387+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3677",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: ATE1 was added\ngene: ATE1 was added to Mendeliome. Sources: Expert Review Red,ClinGen\ndisputed tags were added to gene: ATE1.\nMode of inheritance for gene: ATE1 was set to BIALLELIC, autosomal or pseudoautosomal\nPhenotypes for gene: ATE1 were set to Congenital heart disease, MONDO:0005453",
"entity_name": "ATE1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:45:18.657323+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.491",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: CSRP1 as ready",
"entity_name": "CSRP1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:45:18.645804+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.491",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: csrp1 has been classified as Red List (Low Evidence).",
"entity_name": "CSRP1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:45:15.488633+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.491",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: CSRP1 was added\ngene: CSRP1 was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: CSRP1.\nMode of inheritance for gene: CSRP1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: CSRP1 were set to Congenital heart disease, MONDO:0005453\nReview for gene: CSRP1 was set to RED\nAdded comment: ClinGen DISPUTED - Jul 2024 \nSources: ClinGen",
"entity_name": "CSRP1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:45:06.013505+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.490",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: ATE1 as ready",
"entity_name": "ATE1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:45:05.998086+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.490",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: ate1 has been classified as Red List (Low Evidence).",
"entity_name": "ATE1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:44:44.223865+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.490",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: ATE1 was added\ngene: ATE1 was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: ATE1.\nMode of inheritance for gene: ATE1 was set to BIALLELIC, autosomal or pseudoautosomal\nPhenotypes for gene: ATE1 were set to Congenital heart disease, MONDO:0005453\nReview for gene: ATE1 was set to RED\nAdded comment: ClinGen DISPUTED - Aug 2023 \nSources: ClinGen",
"entity_name": "ATE1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:43:23.536753+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.489",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: DCHS1 as ready",
"entity_name": "DCHS1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:43:23.529801+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.489",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: dchs1 has been classified as Red List (Low Evidence).",
"entity_name": "DCHS1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:43:11.732183+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3676",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Phenotypes for gene: FOXL1 were changed from Otosclerosis 11 #MIM620576 to Otosclerosis 11 #MIM620576; Congenital heart disease, MONDO:0005453",
"entity_name": "FOXL1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:42:55.865080+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.489",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: DCHS1 was added\ngene: DCHS1 was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: DCHS1.\nMode of inheritance for gene: DCHS1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: DCHS1 were set to Congenital heart disease, MONDO:0005453\nReview for gene: DCHS1 was set to RED\nAdded comment: ClinGen DISPUTED - Feb 2024 \nSources: ClinGen",
"entity_name": "DCHS1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:41:52.688453+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3675",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Added reviews for gene FOXL1 from panel Congenital Heart Defect",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-11-27T10:41:33.844584+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.488",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: FOXL1 as ready",
"entity_name": "FOXL1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:41:33.833679+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.488",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: foxl1 has been classified as Red List (Low Evidence).",
"entity_name": "FOXL1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:41:24.066504+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.488",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: FOXL1 was added\ngene: FOXL1 was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: FOXL1.\nMode of inheritance for gene: FOXL1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: FOXL1 were set to Congenital heart disease, MONDO:0005453\nReview for gene: FOXL1 was set to RED\nAdded comment: ClinGen DISPUTED - Nov 2023 \nSources: ClinGen",
"entity_name": "FOXL1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:40:36.210047+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3674",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene FMO5 from panel Congenital Heart Defect",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-11-27T10:40:34.946832+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3674",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: FMO5 was added\ngene: FMO5 was added to Mendeliome. Sources: Expert Review Red,ClinGen\ndisputed tags were added to gene: FMO5.\nMode of inheritance for gene: FMO5 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: FMO5 were set to Congenital heart disease, MONDO:0005453",
"entity_name": "FMO5",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:40:14.676624+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.487",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: FMO5 as ready",
"entity_name": "FMO5",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:40:14.668897+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.487",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: fmo5 has been classified as Red List (Low Evidence).",
"entity_name": "FMO5",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:40:00.211886+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.487",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: FMO5 was added\ngene: FMO5 was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: FMO5.\nMode of inheritance for gene: FMO5 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: FMO5 were set to Congenital heart disease, MONDO:0005453\nReview for gene: FMO5 was set to RED\nAdded comment: ClinGen DISPUTED - Nov 2023 \nSources: ClinGen",
"entity_name": "FMO5",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:39:52.513130+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.486",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: DTNA as ready",
"entity_name": "DTNA",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:39:52.501908+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.486",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: dtna has been classified as Red List (Low Evidence).",
"entity_name": "DTNA",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:39:06.662305+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3673",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Added reviews for gene DTNA from panel Congenital Heart Defect",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-11-27T10:36:26.937933+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3672",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Added reviews for gene DTNA from panel Congenital Heart Defect",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-11-27T10:35:42.115833+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.486",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: DTNA was added\ngene: DTNA was added to Congenital Heart Defect. Sources: ClinGen\ndisputed tags were added to gene: DTNA.\nMode of inheritance for gene: DTNA was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: DTNA were set to Congenital heart disease, MONDO:0005453\nReview for gene: DTNA was set to RED\nAdded comment: ClinGen DISPUTED - Feb 2024 \nSources: ClinGen",
"entity_name": "DTNA",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:32:16.015685+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.485",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Classified gene: FOXP1 as Red List (low evidence)",
"entity_name": "FOXP1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:32:15.999784+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.485",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: foxp1 has been classified as Red List (Low Evidence).",
"entity_name": "FOXP1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:31:58.444759+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.485",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Classified gene: FOXP1 as Red List (low evidence)",
"entity_name": "FOXP1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:31:58.428529+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.485",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: foxp1 has been classified as Red List (Low Evidence).",
"entity_name": "FOXP1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:31:37.385515+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.484",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Tag disputed tag was added to gene: FOXP1.",
"entity_name": "FOXP1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:31:30.658354+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.484",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "reviewed gene: FOXP1: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: congenital heart disease, MONDO:0005453; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "FOXP1",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:19:26.943809+11:00",
"panel_name": "Genetic Epilepsy",
"panel_id": 202,
"panel_version": "1.286",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Tag disputed tag was added to gene: ZDHHC15.",
"entity_name": "ZDHHC15",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:18:17.429048+11:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.573",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Mode of inheritance for gene: LAMC3 was changed from BIALLELIC, autosomal or pseudoautosomal to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "LAMC3",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:18:04.224044+11:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.573",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Mode of inheritance for gene: LAMC3 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "LAMC3",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:17:51.184800+11:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.572",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Phenotypes for gene: LAMC3 were changed from Cortical malformations, occipital, MIM#614115 to Cortical malformations, occipital, MIM#614115",
"entity_name": "LAMC3",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:17:30.998506+11:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.572",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Phenotypes for gene: LAMC3 were changed from Cortical malformations, occipital, MIM#614115 to Cortical malformations, occipital, MIM#614115",
"entity_name": "LAMC3",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:17:13.123990+11:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.571",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Phenotypes for gene: LAMC3 were changed from Cortical malformations, occipital, MIM#614115 to Cortical malformations, occipital, MIM#614115",
"entity_name": "LAMC3",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:16:59.849692+11:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.571",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Phenotypes for gene: LAMC3 were changed from to Cortical malformations, occipital, MIM#614115",
"entity_name": "LAMC3",
"entity_type": "gene"
},
{
"created": "2025-11-27T10:16:30.207528+11:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.570",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Deleted their comment",
"entity_name": "LAMC3",
"entity_type": "gene"
}
]
}