HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/json
Vary: Accept
{
"count": 220451,
"next": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1289",
"previous": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1287",
"results": [
{
"created": "2021-06-21T18:10:45.763869+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.83",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: abl1 has been classified as Green List (High Evidence).",
"entity_name": "ABL1",
"entity_type": "gene"
},
{
"created": "2021-06-21T18:10:28.990044+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.83",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: ABL1 as Green List (high evidence)",
"entity_name": "ABL1",
"entity_type": "gene"
},
{
"created": "2021-06-21T18:10:28.980132+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.83",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: abl1 has been classified as Green List (High Evidence).",
"entity_name": "ABL1",
"entity_type": "gene"
},
{
"created": "2021-06-21T18:10:05.541742+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.82",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "gene: ABL1 was added\ngene: ABL1 was added to Congenital diaphragmatic hernia. Sources: Literature\nMode of inheritance for gene: ABL1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: ABL1 were set to 33461977; 28288113\nPhenotypes for gene: ABL1 were set to Congenital heart defects and skeletal malformations syndrome, MIM#\t617602\nReview for gene: ABL1 was set to GREEN\nAdded comment: Congenital diaphragmatic hernia reported in at least 3 individuals. \nSources: Literature",
"entity_name": "ABL1",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:54:49.061583+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.8087",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: SLIT3 as ready",
"entity_name": "SLIT3",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:54:49.051173+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.8087",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: slit3 has been classified as Amber List (Moderate Evidence).",
"entity_name": "SLIT3",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:54:39.119039+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.8087",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: SLIT3 as Amber List (moderate evidence)",
"entity_name": "SLIT3",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:54:39.106751+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.8087",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: slit3 has been classified as Amber List (Moderate Evidence).",
"entity_name": "SLIT3",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:54:21.824601+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.8086",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "gene: SLIT3 was added\ngene: SLIT3 was added to Mendeliome. Sources: Literature\nMode of inheritance for gene: SLIT3 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: SLIT3 were set to 33933663\nPhenotypes for gene: SLIT3 were set to Congenital diaphragmatic hernia\nReview for gene: SLIT3 was set to AMBER\nAdded comment: Two affected individuals, single family, supportive mouse model. \nSources: Literature",
"entity_name": "SLIT3",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:54:03.569495+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.81",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: SLIT3 as ready",
"entity_name": "SLIT3",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:54:03.559012+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.81",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: slit3 has been classified as Amber List (Moderate Evidence).",
"entity_name": "SLIT3",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:53:28.979622+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.81",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: SLIT3 as Amber List (moderate evidence)",
"entity_name": "SLIT3",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:53:28.969190+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.81",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: slit3 has been classified as Amber List (Moderate Evidence).",
"entity_name": "SLIT3",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:53:03.808916+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.80",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "gene: SLIT3 was added\ngene: SLIT3 was added to Congenital diaphragmatic hernia. Sources: Literature\nMode of inheritance for gene: SLIT3 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: SLIT3 were set to 33933663\nPhenotypes for gene: SLIT3 were set to Congenital diaphragmatic hernia\nReview for gene: SLIT3 was set to AMBER\nAdded comment: Two affected individuals, single family, supportive mouse model. \nSources: Literature",
"entity_name": "SLIT3",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:50:02.465555+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.79",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: WT1 as ready",
"entity_name": "WT1",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:50:02.453305+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.79",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: wt1 has been classified as Green List (High Evidence).",
"entity_name": "WT1",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:49:59.866618+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.79",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: WT1 were changed from to Denys-Drash syndrome, MIM# 194080",
"entity_name": "WT1",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:49:37.336893+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.78",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: WT1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "WT1",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:49:12.529599+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.77",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: WT1: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Denys-Drash syndrome, MIM# 194080; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "WT1",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:46:10.898460+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.77",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: SMC3 as ready",
"entity_name": "SMC3",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:46:10.888602+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.77",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: smc3 has been classified as Amber List (Moderate Evidence).",
"entity_name": "SMC3",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:46:08.273406+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.77",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: SMC3 were changed from to Cornelia de Lange syndrome 3, MIM# 610759",
"entity_name": "SMC3",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:45:46.082452+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.76",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: SMC3 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "SMC3",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:45:01.085478+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.75",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: SMC3 as Amber List (moderate evidence)",
"entity_name": "SMC3",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:45:01.074553+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.75",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: smc3 has been classified as Amber List (Moderate Evidence).",
"entity_name": "SMC3",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:44:30.524283+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.74",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: SMC3: Rating: AMBER; Mode of pathogenicity: None; Publications: ; Phenotypes: Cornelia de Lange syndrome 3, MIM# 610759; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "SMC3",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:43:11.864552+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.74",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: SMC1A as ready",
"entity_name": "SMC1A",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:43:11.855325+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.74",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: smc1a has been classified as Amber List (Moderate Evidence).",
"entity_name": "SMC1A",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:43:07.987415+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.74",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: SMC1A were changed from to Cornelia de Lange syndrome 2, MIM# 300590",
"entity_name": "SMC1A",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:42:46.215562+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.73",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: SMC1A was changed from Unknown to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)",
"entity_name": "SMC1A",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:42:25.136483+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.72",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: SMC1A as Amber List (moderate evidence)",
"entity_name": "SMC1A",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:42:25.126832+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.72",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: smc1a has been classified as Amber List (Moderate Evidence).",
"entity_name": "SMC1A",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:42:01.811012+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.71",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: SMC1A: Rating: AMBER; Mode of pathogenicity: None; Publications: ; Phenotypes: Cornelia de Lange syndrome 2, MIM# 300590; Mode of inheritance: X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)",
"entity_name": "SMC1A",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:40:52.856877+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.71",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: RAD21 as ready",
"entity_name": "RAD21",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:40:52.846027+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.71",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: rad21 has been classified as Green List (High Evidence).",
"entity_name": "RAD21",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:40:48.962853+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.71",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: RAD21 were changed from to Cornelia de Lange syndrome 4, MIM# 614701",
"entity_name": "RAD21",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:40:25.062772+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.70",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: RAD21 were set to ",
"entity_name": "RAD21",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:40:03.026197+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.69",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: RAD21 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "RAD21",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:39:33.989981+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.68",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: RAD21: Rating: GREEN; Mode of pathogenicity: None; Publications: 30125677; Phenotypes: Cornelia de Lange syndrome 4, MIM# 614701; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "RAD21",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:36:34.029187+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.68",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: OFD1 as ready",
"entity_name": "OFD1",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:36:34.016191+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.68",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: ofd1 has been classified as Amber List (Moderate Evidence).",
"entity_name": "OFD1",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:36:31.221427+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.68",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: OFD1 were changed from to Simpson-Golabi-Behmel syndrome, type 2, MIM# 300209",
"entity_name": "OFD1",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:34:22.755402+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.67",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: OFD1 were set to ",
"entity_name": "OFD1",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:33:54.650647+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.66",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: OFD1 was changed from Unknown to X-LINKED: hemizygous mutation in males, biallelic mutations in females",
"entity_name": "OFD1",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:33:32.859458+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.65",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: OFD1 as Amber List (moderate evidence)",
"entity_name": "OFD1",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:33:32.848041+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.65",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: ofd1 has been classified as Amber List (Moderate Evidence).",
"entity_name": "OFD1",
"entity_type": "gene"
},
{
"created": "2021-06-21T17:33:02.762076+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.64",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: OFD1: Rating: AMBER; Mode of pathogenicity: None; Publications: 16783569, 27589329; Phenotypes: Simpson-Golabi-Behmel syndrome, type 2, MIM# 300209; Mode of inheritance: None",
"entity_name": "OFD1",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:47:59.181803+10:00",
"panel_name": "Clefting disorders",
"panel_id": 3368,
"panel_version": "0.130",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: IGF2 as ready",
"entity_name": "IGF2",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:47:59.171970+10:00",
"panel_name": "Clefting disorders",
"panel_id": 3368,
"panel_version": "0.130",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: igf2 has been classified as Green List (High Evidence).",
"entity_name": "IGF2",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:47:55.685233+10:00",
"panel_name": "Clefting disorders",
"panel_id": 3368,
"panel_version": "0.130",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: IGF2 as Green List (high evidence)",
"entity_name": "IGF2",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:47:55.675004+10:00",
"panel_name": "Clefting disorders",
"panel_id": 3368,
"panel_version": "0.130",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: igf2 has been classified as Green List (High Evidence).",
"entity_name": "IGF2",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:47:42.111278+10:00",
"panel_name": "Pierre Robin Sequence",
"panel_id": 160,
"panel_version": "0.32",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: IGF2 as ready",
"entity_name": "IGF2",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:47:42.101188+10:00",
"panel_name": "Pierre Robin Sequence",
"panel_id": 160,
"panel_version": "0.32",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: igf2 has been classified as Green List (High Evidence).",
"entity_name": "IGF2",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:46:31.950070+10:00",
"panel_name": "Pierre Robin Sequence",
"panel_id": 160,
"panel_version": "0.32",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: IGF2 as Green List (high evidence)",
"entity_name": "IGF2",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:46:31.940848+10:00",
"panel_name": "Pierre Robin Sequence",
"panel_id": 160,
"panel_version": "0.32",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: igf2 has been classified as Green List (High Evidence).",
"entity_name": "IGF2",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:45:53.138458+10:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.117",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: IGF2 as ready",
"entity_name": "IGF2",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:45:53.109352+10:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.117",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: igf2 has been classified as Green List (High Evidence).",
"entity_name": "IGF2",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:43:50.779538+10:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.117",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: IGF2 as Green List (high evidence)",
"entity_name": "IGF2",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:43:50.769765+10:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.117",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: igf2 has been classified as Green List (High Evidence).",
"entity_name": "IGF2",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:43:22.064466+10:00",
"panel_name": "Differences of Sex Development",
"panel_id": 99,
"panel_version": "0.209",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: IGF2 as ready",
"entity_name": "IGF2",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:43:22.053614+10:00",
"panel_name": "Differences of Sex Development",
"panel_id": 99,
"panel_version": "0.209",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: igf2 has been classified as Green List (High Evidence).",
"entity_name": "IGF2",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:43:18.975128+10:00",
"panel_name": "Differences of Sex Development",
"panel_id": 99,
"panel_version": "0.209",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: IGF2 as Green List (high evidence)",
"entity_name": "IGF2",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:43:18.966218+10:00",
"panel_name": "Differences of Sex Development",
"panel_id": 99,
"panel_version": "0.209",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: igf2 has been classified as Green List (High Evidence).",
"entity_name": "IGF2",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:41:55.234342+10:00",
"panel_name": "Muscular dystrophy_Paediatric",
"panel_id": 141,
"panel_version": "0.91",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: ATP6V1A as ready",
"entity_name": "ATP6V1A",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:41:55.229954+10:00",
"panel_name": "Muscular dystrophy_Paediatric",
"panel_id": 141,
"panel_version": "0.91",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Added comment: Comment when marking as ready: CK markedly raised in some.",
"entity_name": "ATP6V1A",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:41:55.197369+10:00",
"panel_name": "Muscular dystrophy_Paediatric",
"panel_id": 141,
"panel_version": "0.91",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: atp6v1a has been classified as Green List (High Evidence).",
"entity_name": "ATP6V1A",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:41:52.431534+10:00",
"panel_name": "Muscular dystrophy_Paediatric",
"panel_id": 141,
"panel_version": "0.91",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: ATP6V1A were changed from Cutis laxa, autosomal recessive, type IID MIM#617403; Developmental and epileptic encephalopathy 93 MIM#618012 to Cutis laxa, autosomal recessive, type IID MIM#617403",
"entity_name": "ATP6V1A",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:41:28.977365+10:00",
"panel_name": "Muscular dystrophy_Paediatric",
"panel_id": 141,
"panel_version": "0.90",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: ATP6V1A as Green List (high evidence)",
"entity_name": "ATP6V1A",
"entity_type": "gene"
},
{
"created": "2021-06-21T13:41:28.966036+10:00",
"panel_name": "Muscular dystrophy_Paediatric",
"panel_id": 141,
"panel_version": "0.90",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: atp6v1a has been classified as Green List (High Evidence).",
"entity_name": "ATP6V1A",
"entity_type": "gene"
},
{
"created": "2021-06-21T12:26:06.119974+10:00",
"panel_name": "Clefting disorders",
"panel_id": 3368,
"panel_version": "0.129",
"user_name": "Elena Savva",
"item_type": "entity",
"text": "gene: IGF2 was added\ngene: IGF2 was added to Clefting disorders. Sources: Literature\nMode of inheritance for gene: IGF2 was set to MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)\nPublications for gene: IGF2 were set to PMID: 31544945\nPhenotypes for gene: IGF2 were set to Silver-Russell syndrome 3 MIM#616489\nReview for gene: IGF2 was set to GREEN\nAdded comment: PMID: 31544945 - cleft palate reported in 6/14 patients with SRS \nSources: Literature",
"entity_name": "IGF2",
"entity_type": "gene"
},
{
"created": "2021-06-21T12:25:15.275808+10:00",
"panel_name": "Pierre Robin Sequence",
"panel_id": 160,
"panel_version": "0.31",
"user_name": "Elena Savva",
"item_type": "entity",
"text": "gene: IGF2 was added\ngene: IGF2 was added to Pierre Robin Sequence. Sources: Literature\nMode of inheritance for gene: IGF2 was set to MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)\nPublications for gene: IGF2 were set to PMID: 31544945\nPhenotypes for gene: IGF2 were set to Silver-Russell syndrome 3 MIM#616489\nReview for gene: IGF2 was set to GREEN\nAdded comment: PMID: 31544945 - micrognathia (100%, 8 families) and cleft palate (43%, 6/14 families) both reported in patients with SRS \nSources: Literature",
"entity_name": "IGF2",
"entity_type": "gene"
},
{
"created": "2021-06-21T12:23:50.124371+10:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.116",
"user_name": "Elena Savva",
"item_type": "entity",
"text": "gene: IGF2 was added\ngene: IGF2 was added to Congenital Heart Defect. Sources: Literature\nMode of inheritance for gene: IGF2 was set to MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)\nPublications for gene: IGF2 were set to PMID: 31544945\nPhenotypes for gene: IGF2 were set to Silver-Russell syndrome 3 MIM#616489\nReview for gene: IGF2 was set to GREEN\nAdded comment: PMID: 31544945 - cardiovascular anomalies reported in 50% of patients \nSources: Literature",
"entity_name": "IGF2",
"entity_type": "gene"
},
{
"created": "2021-06-21T12:22:21.645009+10:00",
"panel_name": "Differences of Sex Development",
"panel_id": 99,
"panel_version": "0.208",
"user_name": "Elena Savva",
"item_type": "entity",
"text": "gene: IGF2 was added\ngene: IGF2 was added to Differences of Sex Development. Sources: Literature\nMode of inheritance for gene: IGF2 was set to MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)\nPublications for gene: IGF2 were set to PMID: 31544945\nPhenotypes for gene: IGF2 were set to Silver-Russell syndrome 3 MIM#616489\nReview for gene: IGF2 was set to GREEN\nAdded comment: PMID: 31544945 - 60% of patients reported some form of DSD including hypospadias, cryptochidism, abnormal scrotum etc. \nSources: Literature",
"entity_name": "IGF2",
"entity_type": "gene"
},
{
"created": "2021-06-21T11:45:31.181682+10:00",
"panel_name": "Muscular dystrophy_Paediatric",
"panel_id": 141,
"panel_version": "0.89",
"user_name": "Elena Savva",
"item_type": "entity",
"text": "gene: ATP6V1A was added\ngene: ATP6V1A was added to Muscular dystrophy_Paediatric. Sources: Literature\nMode of inheritance for gene: ATP6V1A was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: ATP6V1A were set to PMID: 28065471; 33320377\nPhenotypes for gene: ATP6V1A were set to Cutis laxa, autosomal recessive, type IID MIM#617403; Developmental and epileptic encephalopathy 93 MIM#618012\nReview for gene: ATP6V1A was set to GREEN\nAdded comment: 3 families were reported with elevated CK levels in patients with cutis laxa AR phenotype \nSources: Literature",
"entity_name": "ATP6V1A",
"entity_type": "gene"
},
{
"created": "2021-06-20T20:17:19.582354+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.64",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NSD1 as ready",
"entity_name": "NSD1",
"entity_type": "gene"
},
{
"created": "2021-06-20T20:17:19.570827+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.64",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nsd1 has been classified as Red List (Low Evidence).",
"entity_name": "NSD1",
"entity_type": "gene"
},
{
"created": "2021-06-20T20:17:08.501820+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.64",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: NSD1 were changed from to Sotos syndrome 1, MIM# 117550",
"entity_name": "NSD1",
"entity_type": "gene"
},
{
"created": "2021-06-20T20:16:45.496083+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.63",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: NSD1 were set to ",
"entity_name": "NSD1",
"entity_type": "gene"
},
{
"created": "2021-06-20T20:16:03.924606+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.62",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: NSD1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "NSD1",
"entity_type": "gene"
},
{
"created": "2021-06-20T20:15:36.727486+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.61",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: NSD1 as Red List (low evidence)",
"entity_name": "NSD1",
"entity_type": "gene"
},
{
"created": "2021-06-20T20:15:36.717116+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.61",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nsd1 has been classified as Red List (Low Evidence).",
"entity_name": "NSD1",
"entity_type": "gene"
},
{
"created": "2021-06-20T20:15:13.129595+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.60",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: NSD1: Rating: RED; Mode of pathogenicity: None; Publications: 29966037; Phenotypes: Sotos syndrome 1, MIM# 117550; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "NSD1",
"entity_type": "gene"
},
{
"created": "2021-06-20T20:12:59.131577+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.60",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NIPBL as ready",
"entity_name": "NIPBL",
"entity_type": "gene"
},
{
"created": "2021-06-20T20:12:59.119645+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.60",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nipbl has been classified as Green List (High Evidence).",
"entity_name": "NIPBL",
"entity_type": "gene"
},
{
"created": "2021-06-20T20:12:56.281563+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.60",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: NIPBL were changed from to Cornelia de Lange syndrome 1, MIM# 122470",
"entity_name": "NIPBL",
"entity_type": "gene"
},
{
"created": "2021-06-20T20:12:23.759933+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.59",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: NIPBL was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "NIPBL",
"entity_type": "gene"
},
{
"created": "2021-06-20T20:11:52.668234+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.58",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: NIPBL: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Cornelia de Lange syndrome 1, MIM# 122470; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "NIPBL",
"entity_type": "gene"
},
{
"created": "2021-06-20T19:53:57.023389+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.58",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: LRP2 as ready",
"entity_name": "LRP2",
"entity_type": "gene"
},
{
"created": "2021-06-20T19:53:57.000790+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.58",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: lrp2 has been classified as Green List (High Evidence).",
"entity_name": "LRP2",
"entity_type": "gene"
},
{
"created": "2021-06-20T19:53:53.664660+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.58",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: LRP2 were changed from to Donnai-Barrow syndrome, MIM# 222448",
"entity_name": "LRP2",
"entity_type": "gene"
},
{
"created": "2021-06-20T19:53:23.051569+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.57",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: LRP2 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "LRP2",
"entity_type": "gene"
},
{
"created": "2021-06-20T19:52:54.784369+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.56",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: LRP2: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Donnai-Barrow syndrome, MIM# 222448; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "LRP2",
"entity_type": "gene"
},
{
"created": "2021-06-20T19:52:07.462753+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.56",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: KMT2D as Green List (high evidence)",
"entity_name": "KMT2D",
"entity_type": "gene"
},
{
"created": "2021-06-20T19:52:07.451218+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.56",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: kmt2d has been classified as Green List (High Evidence).",
"entity_name": "KMT2D",
"entity_type": "gene"
},
{
"created": "2021-06-20T19:51:45.107613+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.55",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "changed review comment from: Rare reports of CDH in Kabuki syndrome, not a characteristic or common feature.; to: Rare reports of CDH in Kabuki syndrome, not a characteristic or common feature; however, 4 identified in this CDH cohort.",
"entity_name": "KMT2D",
"entity_type": "gene"
},
{
"created": "2021-06-20T19:51:31.402355+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.55",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: KMT2D: Changed rating: GREEN",
"entity_name": "KMT2D",
"entity_type": "gene"
},
{
"created": "2021-06-20T19:50:57.418511+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.55",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: KMT2D as ready",
"entity_name": "KMT2D",
"entity_type": "gene"
},
{
"created": "2021-06-20T19:50:57.408312+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.55",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: kmt2d has been classified as Amber List (Moderate Evidence).",
"entity_name": "KMT2D",
"entity_type": "gene"
},
{
"created": "2021-06-20T19:50:54.704868+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.55",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: KMT2D were changed from to Kabuki syndrome 1, MIM# 147920",
"entity_name": "KMT2D",
"entity_type": "gene"
},
{
"created": "2021-06-20T19:50:37.236437+10:00",
"panel_name": "Congenital diaphragmatic hernia",
"panel_id": 69,
"panel_version": "0.54",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: KMT2D were set to ",
"entity_name": "KMT2D",
"entity_type": "gene"
}
]
}