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{
"count": 220314,
"next": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1336",
"previous": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1334",
"results": [
{
"created": "2021-04-28T09:15:31.355700+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.105",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PSMB8 were set to ",
"entity_name": "PSMB8",
"entity_type": "gene"
},
{
"created": "2021-04-28T09:15:00.670917+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.104",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PSMB8 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PSMB8",
"entity_type": "gene"
},
{
"created": "2021-04-28T09:14:26.057138+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.103",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PSMB8: Rating: GREEN; Mode of pathogenicity: None; Publications: 21129723, 21881205, 21852578, 21953331; Phenotypes: Proteasome-associated autoinflammatory syndrome 1, MIM# 256040, MONDO:0054698; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PSMB8",
"entity_type": "gene"
},
{
"created": "2021-04-28T09:13:32.258383+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7392",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PSMB8 as ready",
"entity_name": "PSMB8",
"entity_type": "gene"
},
{
"created": "2021-04-28T09:13:32.247718+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7392",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: psmb8 has been classified as Green List (High Evidence).",
"entity_name": "PSMB8",
"entity_type": "gene"
},
{
"created": "2021-04-28T09:13:23.438147+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7392",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PSMB8 were changed from to Proteasome-associated autoinflammatory syndrome 1, MIM# 256040; MONDO:0054698",
"entity_name": "PSMB8",
"entity_type": "gene"
},
{
"created": "2021-04-28T09:13:02.807286+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7391",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PSMB8 were set to ",
"entity_name": "PSMB8",
"entity_type": "gene"
},
{
"created": "2021-04-28T09:12:43.410532+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7390",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PSMB8 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PSMB8",
"entity_type": "gene"
},
{
"created": "2021-04-28T09:12:25.606999+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7389",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PSMB8: Rating: GREEN; Mode of pathogenicity: None; Publications: 21129723, 21881205, 21852578, 21953331; Phenotypes: Proteasome-associated autoinflammatory syndrome 1, MIM# 256040, MONDO:0054698; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PSMB8",
"entity_type": "gene"
},
{
"created": "2021-04-28T09:11:44.330466+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.83",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PSMB8 as ready",
"entity_name": "PSMB8",
"entity_type": "gene"
},
{
"created": "2021-04-28T09:11:44.319452+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.83",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: psmb8 has been classified as Green List (High Evidence).",
"entity_name": "PSMB8",
"entity_type": "gene"
},
{
"created": "2021-04-28T09:11:41.234833+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.83",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PSMB8 were changed from to Proteasome-associated autoinflammatory syndrome 1, MIM# 256040; MONDO:0054698",
"entity_name": "PSMB8",
"entity_type": "gene"
},
{
"created": "2021-04-28T09:10:32.645078+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.82",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PSMB8 were set to ",
"entity_name": "PSMB8",
"entity_type": "gene"
},
{
"created": "2021-04-28T09:10:07.016180+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.81",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PSMB8 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PSMB8",
"entity_type": "gene"
},
{
"created": "2021-04-28T09:09:35.718037+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.80",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PSMB8: Rating: GREEN; Mode of pathogenicity: None; Publications: 21129723, 21881205, 21852578, 21953331; Phenotypes: Proteasome-associated autoinflammatory syndrome 1, MIM# 256040; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PSMB8",
"entity_type": "gene"
},
{
"created": "2021-04-28T09:03:25.852432+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7389",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: EFEMP1 were set to 32006683; 31792352",
"entity_name": "EFEMP1",
"entity_type": "gene"
},
{
"created": "2021-04-28T09:02:52.320060+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7388",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: EFEMP1: Added comment: PMID 33807164: third unrelated family reported with CTD phenotype, single affected individual with bi-alllelic LoF variant, cutis laxa and multiple herniations.; Changed publications: 32006683, 31792352, 33807164",
"entity_name": "EFEMP1",
"entity_type": "gene"
},
{
"created": "2021-04-28T09:00:51.017446+10:00",
"panel_name": "Aortopathy_Connective Tissue Disorders",
"panel_id": 44,
"panel_version": "1.27",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: EFEMP1 were changed from EFEMP1-related connective tissue disorder to EFEMP1-related connective tissue disorder; cutis laxa",
"entity_name": "EFEMP1",
"entity_type": "gene"
},
{
"created": "2021-04-28T09:00:24.595136+10:00",
"panel_name": "Aortopathy_Connective Tissue Disorders",
"panel_id": 44,
"panel_version": "1.26",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: EFEMP1 were set to 32006683; 31792352",
"entity_name": "EFEMP1",
"entity_type": "gene"
},
{
"created": "2021-04-28T08:59:57.454786+10:00",
"panel_name": "Aortopathy_Connective Tissue Disorders",
"panel_id": 44,
"panel_version": "1.25",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: EFEMP1 as Green List (high evidence)",
"entity_name": "EFEMP1",
"entity_type": "gene"
},
{
"created": "2021-04-28T08:59:57.443896+10:00",
"panel_name": "Aortopathy_Connective Tissue Disorders",
"panel_id": 44,
"panel_version": "1.25",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: efemp1 has been classified as Green List (High Evidence).",
"entity_name": "EFEMP1",
"entity_type": "gene"
},
{
"created": "2021-04-28T08:59:27.988607+10:00",
"panel_name": "Aortopathy_Connective Tissue Disorders",
"panel_id": 44,
"panel_version": "1.24",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: EFEMP1: Rating: GREEN; Mode of pathogenicity: None; Publications: 33807164; Phenotypes: EFEMP1-related connective tissue disorder, cutis laxa; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "EFEMP1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:51:38.724959+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7388",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PPARG as ready",
"entity_name": "PPARG",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:51:38.714681+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7388",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: pparg has been classified as Green List (High Evidence).",
"entity_name": "PPARG",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:51:13.681994+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7388",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PPARG were changed from to Lipodystrophy, familial partial, type 3, MIM# 604367; MONDO:0011448",
"entity_name": "PPARG",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:50:54.406134+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7387",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PPARG were set to ",
"entity_name": "PPARG",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:50:36.431959+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7386",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PPARG was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PPARG",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:50:18.807520+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7385",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PPARG: Rating: GREEN; Mode of pathogenicity: None; Publications: 10622252, 12453919, 11788685, 31863320; Phenotypes: Lipodystrophy, familial partial, type 3, MIM# 604367, MONDO:0011448; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PPARG",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:49:32.262410+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.79",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PPARG as ready",
"entity_name": "PPARG",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:49:32.246403+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.79",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: pparg has been classified as Green List (High Evidence).",
"entity_name": "PPARG",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:49:20.007699+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.79",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PPARG were changed from to Lipodystrophy, familial partial, type 3, MIM# 604367; MONDO:0011448",
"entity_name": "PPARG",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:48:53.097804+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.78",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PPARG were set to ",
"entity_name": "PPARG",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:48:35.785117+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.77",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PPARG was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PPARG",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:48:05.289601+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.76",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PPARG: Rating: GREEN; Mode of pathogenicity: None; Publications: 10622252, 12453919, 11788685, 31863320; Phenotypes: Lipodystrophy, familial partial, type 3, MIM# 604367; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PPARG",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:41:40.513282+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.76",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: POLD1 as ready",
"entity_name": "POLD1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:41:40.503022+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.76",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: pold1 has been classified as Green List (High Evidence).",
"entity_name": "POLD1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:41:29.821240+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7385",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: POLD1 as ready",
"entity_name": "POLD1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:41:29.811020+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7385",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: pold1 has been classified as Green List (High Evidence).",
"entity_name": "POLD1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:41:22.919493+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7385",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: POLD1 were changed from to Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome, MIM# 615381; MONDO:0014157",
"entity_name": "POLD1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:41:05.913195+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7384",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: POLD1 were set to ",
"entity_name": "POLD1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:40:48.949660+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7383",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: POLD1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "POLD1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:40:30.799862+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7382",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: POLD1: Rating: GREEN; Mode of pathogenicity: None; Publications: 23770608, 33618333, 33369179, 32826474, 30023403, 29199204, 28791128; Phenotypes: Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome, MIM# 615381, MONDO:0014157; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "POLD1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:40:30.536177+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.76",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: POLD1 were changed from to Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome, MIM# 615381; MONDO:0014157",
"entity_name": "POLD1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:39:59.792492+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.75",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: POLD1 were set to ",
"entity_name": "POLD1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:39:29.090958+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.74",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: POLD1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "POLD1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:39:00.219257+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.73",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: POLD1: Rating: GREEN; Mode of pathogenicity: None; Publications: 23770608, 33618333, 33369179, 32826474, 30023403, 29199204, 28791128; Phenotypes: Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome, MIM# 615381, MONDO:0014157; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "POLD1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:35:49.698478+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7382",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Tag disputed tag was added to gene: PLIN1.",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:35:32.722833+10:00",
"panel_name": "Monogenic Diabetes",
"panel_id": 3093,
"panel_version": "0.15",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Tag disputed tag was added to gene: PLIN1.",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:35:09.774812+10:00",
"panel_name": "Monogenic Diabetes",
"panel_id": 3093,
"panel_version": "0.15",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PLIN1 as ready",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:35:09.764047+10:00",
"panel_name": "Monogenic Diabetes",
"panel_id": 3093,
"panel_version": "0.15",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: plin1 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:35:06.579100+10:00",
"panel_name": "Monogenic Diabetes",
"panel_id": 3093,
"panel_version": "0.15",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PLIN1 were changed from Lipodystrophy, familial partial, type 4, 613877; partial lipodystrophy, severe dyslipidemia, and insulin-resistant diabetes; Severe insulin resistance, partial lipodystrophy and diabetes to Lipodystrophy, familial partial, type 4, 613877; Severe insulin resistance, partial lipodystrophy and diabetes",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:34:38.557050+10:00",
"panel_name": "Monogenic Diabetes",
"panel_id": 3093,
"panel_version": "0.14",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: PLIN1 as Amber List (moderate evidence)",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:34:38.541681+10:00",
"panel_name": "Monogenic Diabetes",
"panel_id": 3093,
"panel_version": "0.14",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: plin1 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:34:29.996921+10:00",
"panel_name": "Monogenic Diabetes",
"panel_id": 3093,
"panel_version": "0.13",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PLIN1: Rating: AMBER; Mode of pathogenicity: None; Publications: 21345103, 31504636, 30020498, 25114292; Phenotypes: Lipodystrophy, familial partial, type 4, MIM# 613877; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:33:46.449626+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7382",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PLIN1 as ready",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:33:46.439892+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7382",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: plin1 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:33:39.306240+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7382",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PLIN1 were changed from to Lipodystrophy, familial partial, type 4, MIM# 613877",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:33:20.791186+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7381",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PLIN1 were set to ",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:33:02.594031+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7380",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PLIN1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:32:44.045000+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7379",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: PLIN1 as Amber List (moderate evidence)",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:32:44.035560+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7379",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: plin1 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:32:23.982729+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7378",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PLIN1: Rating: AMBER; Mode of pathogenicity: None; Publications: 21345103, 31504636, 30020498, 25114292; Phenotypes: Lipodystrophy, familial partial, type 4, MIM# 613877; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:31:25.815272+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.73",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PLIN1 as ready",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:31:25.803612+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.73",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: plin1 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:31:22.443645+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.73",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PLIN1 were changed from to Lipodystrophy, familial partial, type 4, MIM# 613877",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:30:57.621409+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.72",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PLIN1 were set to ",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:30:28.900574+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.71",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PLIN1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:30:07.784323+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.70",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: PLIN1 as Amber List (moderate evidence)",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:30:07.774276+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.70",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: plin1 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:29:46.194865+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.69",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Tag disputed tag was added to gene: PLIN1.",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:29:36.855304+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.69",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PLIN1: Rating: AMBER; Mode of pathogenicity: None; Publications: 21345103, 31504636, 30020498, 25114292; Phenotypes: Lipodystrophy, familial partial, type 4, MIM# 613877; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PLIN1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:22:09.607046+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.69",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PIK3R1 as ready",
"entity_name": "PIK3R1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:22:09.597517+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.69",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: pik3r1 has been classified as Green List (High Evidence).",
"entity_name": "PIK3R1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:22:04.513352+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.69",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PIK3R1 were changed from to SHORT syndrome, MIM# 269880; Lipodystrophy; insulin resistance",
"entity_name": "PIK3R1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:21:40.587214+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.68",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PIK3R1 were set to ",
"entity_name": "PIK3R1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:05:31.905663+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.67",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PIK3R1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PIK3R1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:05:03.519919+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.66",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: PIK3R1: Changed mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PIK3R1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:04:53.303880+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.66",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: PIK3R1: Changed rating: GREEN",
"entity_name": "PIK3R1",
"entity_type": "gene"
},
{
"created": "2021-04-27T20:04:47.605240+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.66",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PIK3R1: Rating: ; Mode of pathogenicity: None; Publications: 32439336, 28472977, 26974159, 24886349, 24830046; Phenotypes: SHORT syndrome, MIM# 269880, Lipodystrophy, insulin resistance; Mode of inheritance: None",
"entity_name": "PIK3R1",
"entity_type": "gene"
},
{
"created": "2021-04-27T19:02:20.290481+10:00",
"panel_name": "Mitochondrial disease",
"panel_id": 203,
"panel_version": "0.605",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: MORC2 as ready",
"entity_name": "MORC2",
"entity_type": "gene"
},
{
"created": "2021-04-27T19:02:20.285734+10:00",
"panel_name": "Mitochondrial disease",
"panel_id": 203,
"panel_version": "0.605",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Added comment: Comment when marking as ready: Phenotypic overlap.",
"entity_name": "MORC2",
"entity_type": "gene"
},
{
"created": "2021-04-27T19:02:20.249851+10:00",
"panel_name": "Mitochondrial disease",
"panel_id": 203,
"panel_version": "0.605",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: morc2 has been classified as Green List (High Evidence).",
"entity_name": "MORC2",
"entity_type": "gene"
},
{
"created": "2021-04-27T19:01:58.334927+10:00",
"panel_name": "Mitochondrial disease",
"panel_id": 203,
"panel_version": "0.605",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: MORC2 as Green List (high evidence)",
"entity_name": "MORC2",
"entity_type": "gene"
},
{
"created": "2021-04-27T19:01:58.324522+10:00",
"panel_name": "Mitochondrial disease",
"panel_id": 203,
"panel_version": "0.605",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: morc2 has been classified as Green List (High Evidence).",
"entity_name": "MORC2",
"entity_type": "gene"
},
{
"created": "2021-04-27T19:00:36.978505+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7378",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PCYT1A as ready",
"entity_name": "PCYT1A",
"entity_type": "gene"
},
{
"created": "2021-04-27T19:00:36.967242+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7378",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: pcyt1a has been classified as Green List (High Evidence).",
"entity_name": "PCYT1A",
"entity_type": "gene"
},
{
"created": "2021-04-27T19:00:29.991062+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7378",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PCYT1A were changed from to Spondylometaphyseal dysplasia with cone-rod dystrophy, MIM# 608940; Congenital lipodystrophy",
"entity_name": "PCYT1A",
"entity_type": "gene"
},
{
"created": "2021-04-27T19:00:12.450826+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7377",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PCYT1A were set to ",
"entity_name": "PCYT1A",
"entity_type": "gene"
},
{
"created": "2021-04-27T18:59:48.227519+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7376",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PCYT1A was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PCYT1A",
"entity_type": "gene"
},
{
"created": "2021-04-27T18:59:28.870597+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.7375",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PCYT1A: Rating: GREEN; Mode of pathogenicity: None; Publications: 24387990, 24387991, 24889630; Phenotypes: Spondylometaphyseal dysplasia with cone-rod dystrophy, MIM# 608940, Congenital lipodystrophy; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PCYT1A",
"entity_type": "gene"
},
{
"created": "2021-04-27T18:57:40.457618+10:00",
"panel_name": "Syndromic Retinopathy",
"panel_id": 3099,
"panel_version": "0.166",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PCYT1A as ready",
"entity_name": "PCYT1A",
"entity_type": "gene"
},
{
"created": "2021-04-27T18:57:40.443380+10:00",
"panel_name": "Syndromic Retinopathy",
"panel_id": 3099,
"panel_version": "0.166",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: pcyt1a has been classified as Green List (High Evidence).",
"entity_name": "PCYT1A",
"entity_type": "gene"
},
{
"created": "2021-04-27T18:57:28.502104+10:00",
"panel_name": "Syndromic Retinopathy",
"panel_id": 3099,
"panel_version": "0.166",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PCYT1A were set to ",
"entity_name": "PCYT1A",
"entity_type": "gene"
},
{
"created": "2021-04-27T18:57:07.263721+10:00",
"panel_name": "Syndromic Retinopathy",
"panel_id": 3099,
"panel_version": "0.165",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PCYT1A: Rating: GREEN; Mode of pathogenicity: None; Publications: 24387990, 24387991; Phenotypes: Spondylometaphyseal dysplasia with cone-rod dystrophy, MIM# 608940; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PCYT1A",
"entity_type": "gene"
},
{
"created": "2021-04-27T18:54:57.881014+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.65",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: PCYT1A: Changed publications: 24889630",
"entity_name": "PCYT1A",
"entity_type": "gene"
},
{
"created": "2021-04-27T18:54:27.729077+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.65",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PCYT1A as ready",
"entity_name": "PCYT1A",
"entity_type": "gene"
},
{
"created": "2021-04-27T18:54:27.719110+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.65",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: pcyt1a has been classified as Amber List (Moderate Evidence).",
"entity_name": "PCYT1A",
"entity_type": "gene"
},
{
"created": "2021-04-27T18:54:23.868605+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.65",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PCYT1A were changed from to Congenital lipodystrophy; fatty liver disease",
"entity_name": "PCYT1A",
"entity_type": "gene"
},
{
"created": "2021-04-27T18:54:06.818733+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.64",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PCYT1A were set to ",
"entity_name": "PCYT1A",
"entity_type": "gene"
},
{
"created": "2021-04-27T18:53:33.491157+10:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "0.63",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PCYT1A was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PCYT1A",
"entity_type": "gene"
}
]
}