HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/json
Vary: Accept
{
"count": 220212,
"next": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1384",
"previous": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1382",
"results": [
{
"created": "2021-03-14T19:21:56.766331+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.210",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: ALS2 were set to ",
"entity_name": "ALS2",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:21:42.342537+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.209",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: ALS2: Rating: GREEN; Mode of pathogenicity: None; Publications: 12145748, 12509863, 24315819; Phenotypes: Spastic paralysis, infantile onset ascending, MIM# 607225; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "ALS2",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:11:08.493631+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.209",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: SLC1A4 were changed from Spastic tetraplegia, thin corpus callosum, and progressive microcephaly, 616657 to Spastic tetraplegia, thin corpus callosum, and progressive microcephaly, 616657; MONDO:0014725",
"entity_name": "SLC1A4",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:10:46.425422+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.3519",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: SLC1A4 were changed from Spastic tetraplegia, thin corpus callosum, and progressive microcephaly, MIM#\t616657 to Spastic tetraplegia, thin corpus callosum, and progressive microcephaly, MIM#\t616657; MONDO:0014725",
"entity_name": "SLC1A4",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:10:13.811265+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.3518",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Tag founder tag was added to gene: SLC1A4.",
"entity_name": "SLC1A4",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:09:38.459863+11:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.545",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: SLC1A4 were changed from Spastic tetraplegia, thin corpus callosum, and progressive microcephaly, MIM# 616657 to Spastic tetraplegia, thin corpus callosum, and progressive microcephaly, MIM# 616657; MONDO:0014725",
"entity_name": "SLC1A4",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:08:53.359436+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6724",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: SLC1A4 were changed from Spastic tetraplegia, thin corpus callosum, and progressive microcephaly, MIM# 616657 to Spastic tetraplegia, thin corpus callosum, and progressive microcephaly, MIM# 616657; MONDO:0014725",
"entity_name": "SLC1A4",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:08:29.664557+11:00",
"panel_name": "Genetic Epilepsy",
"panel_id": 202,
"panel_version": "0.1039",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: SLC1A4 were changed from Spastic tetraplegia, thin corpus callosum, and progressive microcephaly, MIM#\t616657 to Spastic tetraplegia, thin corpus callosum, and progressive microcephaly, MIM#\t616657; MONDO:0014725",
"entity_name": "SLC1A4",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:07:42.659557+11:00",
"panel_name": "Genetic Epilepsy",
"panel_id": 202,
"panel_version": "0.1038",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Tag founder tag was added to gene: SLC1A4.",
"entity_name": "SLC1A4",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:07:34.977741+11:00",
"panel_name": "Genetic Epilepsy",
"panel_id": 202,
"panel_version": "0.1038",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "changed review comment from: Multiple affected individuals reported in the literature, seizures/EE are part of the phenotype. While initial reports identified a recurrent missense variant in individuals of Ashkenazi Jewish ancestry, there have been more recent reports of individuals from other ethnic backgrounds with different variants \nSources: Expert list; to: Multiple affected individuals reported in the literature, seizures/EE are part of the phenotype. While initial reports identified a recurrent missense variant in individuals of Ashkenazi Jewish ancestry (p.Glu256Lys), there have been more recent reports of individuals from other ethnic backgrounds with different variants \r\nSources: Expert list",
"entity_name": "SLC1A4",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:06:50.300424+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6723",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: SLC1A4 as ready",
"entity_name": "SLC1A4",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:06:50.291301+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6723",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: slc1a4 has been classified as Green List (High Evidence).",
"entity_name": "SLC1A4",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:06:43.134210+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6723",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: SLC1A4 were changed from to Spastic tetraplegia, thin corpus callosum, and progressive microcephaly, MIM# 616657",
"entity_name": "SLC1A4",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:06:26.066622+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6722",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: SLC1A4 were set to ",
"entity_name": "SLC1A4",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:06:07.005574+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6721",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: SLC1A4 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "SLC1A4",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:05:49.005701+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6720",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Tag founder tag was added to gene: SLC1A4.",
"entity_name": "SLC1A4",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:05:15.016948+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.208",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Tag founder tag was added to gene: SLC1A4.",
"entity_name": "SLC1A4",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:05:06.816403+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.208",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: SLC1A4 as ready",
"entity_name": "SLC1A4",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:05:06.805167+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.208",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: slc1a4 has been classified as Green List (High Evidence).",
"entity_name": "SLC1A4",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:05:03.389290+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.208",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: SLC1A4 were set to ",
"entity_name": "SLC1A4",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:04:48.381176+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.207",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: SLC1A4: Rating: GREEN; Mode of pathogenicity: None; Publications: 25930971, 26138499, 26041762, 27193218, 29989513; Phenotypes: Spastic tetraplegia, thin corpus callosum, and progressive microcephaly, MIM# 616657; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "SLC1A4",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:02:32.159032+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.207",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: SERAC1 as ready",
"entity_name": "SERAC1",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:02:32.151629+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.207",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: serac1 has been classified as Green List (High Evidence).",
"entity_name": "SERAC1",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:02:19.224786+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.207",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: SERAC1 were changed from MEGDEL syndrome; 3-MEthylGlutaconic aciduria, Dystonia-Deafness, Hepatopathy, Encephalopathy, Leigh-like syndrome; 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome, Autosomal dominant, 614739; MEGDHEL syndrome to 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome, MIM# 614739",
"entity_name": "SERAC1",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:02:00.582278+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.206",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: SERAC1: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome, MIM# 614739; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "SERAC1",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:00:39.685326+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.206",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: CLPP as ready",
"entity_name": "CLPP",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:00:39.674913+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.206",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: clpp has been classified as Red List (Low Evidence).",
"entity_name": "CLPP",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:00:36.933521+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.206",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: CLPP were changed from Perrault syndrome 3 to Perrault syndrome 3 MIM#614129",
"entity_name": "CLPP",
"entity_type": "gene"
},
{
"created": "2021-03-14T19:00:15.790590+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.205",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: CLPP were set to ",
"entity_name": "CLPP",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:59:45.899984+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.204",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: ATP1A1 as ready",
"entity_name": "ATP1A1",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:59:45.890927+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.204",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: atp1a1 has been classified as Red List (Low Evidence).",
"entity_name": "ATP1A1",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:59:11.723015+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.204",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: USP8 as ready",
"entity_name": "USP8",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:59:11.703300+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.204",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: usp8 has been classified as Amber List (Moderate Evidence).",
"entity_name": "USP8",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:57:41.668085+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.204",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: IFIH1 as ready",
"entity_name": "IFIH1",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:57:41.660007+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.204",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: ifih1 has been classified as Green List (High Evidence).",
"entity_name": "IFIH1",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:57:32.527394+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.204",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: IFIH1 were changed from Aicardi-Goutieres syndrome 7 to Aicardi-Goutieres syndrome 7 MIM#615846",
"entity_name": "IFIH1",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:57:17.717661+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.203",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: IFIH1 were set to ",
"entity_name": "IFIH1",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:57:07.254290+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.202",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: IFIH1 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "IFIH1",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:56:21.033074+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6720",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TFG as ready",
"entity_name": "TFG",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:56:21.025581+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6720",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tfg has been classified as Green List (High Evidence).",
"entity_name": "TFG",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:55:23.381651+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6720",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TFG were changed from to Hereditary motor and sensory neuropathy, Okinawa type, MIM# 604484; Spastic paraplegia 57, autosomal recessive, MIM# 615658",
"entity_name": "TFG",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:54:35.570122+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6719",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: TFG was changed from Unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "TFG",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:54:17.302461+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6718",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: TFG: Rating: GREEN; Mode of pathogenicity: None; Publications: 30467354, 30157421, 28124177, 27601211, 27492651, 23479643, 25098539, 23553329, 22883144, 31449671, 31111683; Phenotypes: Hereditary motor and sensory neuropathy, Okinawa type, MIM# 604484, Spastic paraplegia 57, autosomal recessive, MIM# 615658; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "TFG",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:50:05.146705+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.201",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TFG as ready",
"entity_name": "TFG",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:50:05.131468+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.201",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tfg has been classified as Green List (High Evidence).",
"entity_name": "TFG",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:50:01.811157+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.201",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TFG were changed from ?Spastic paraplegia 57, autosomal recessive 615658,AR; Hereditary motor and sensory neuropathy, Okinawa type, 604484, AD to Spastic paraplegia 57, autosomal recessive, MIM# 615658",
"entity_name": "TFG",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:49:44.497015+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.200",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TFG were set to ",
"entity_name": "TFG",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:49:28.380212+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.199",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: TFG: Rating: GREEN; Mode of pathogenicity: None; Publications: 30467354, 30157421, 28124177, 27601211, 27492651, 23479643; Phenotypes: Spastic paraplegia 57, autosomal recessive, MIM# 615658; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TFG",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:42:00.951161+11:00",
"panel_name": "Regression",
"panel_id": 206,
"panel_version": "0.249",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: UCHL1 as ready",
"entity_name": "UCHL1",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:42:00.942579+11:00",
"panel_name": "Regression",
"panel_id": 206,
"panel_version": "0.249",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: uchl1 has been classified as Green List (High Evidence).",
"entity_name": "UCHL1",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:41:57.917775+11:00",
"panel_name": "Regression",
"panel_id": 206,
"panel_version": "0.249",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: UCHL1 were changed from to Spastic paraplegia 79, autosomal recessive, MIM# 615491; MONDO:0014209",
"entity_name": "UCHL1",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:41:30.217476+11:00",
"panel_name": "Regression",
"panel_id": 206,
"panel_version": "0.248",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: UCHL1 were set to ",
"entity_name": "UCHL1",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:41:01.255163+11:00",
"panel_name": "Regression",
"panel_id": 206,
"panel_version": "0.247",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: UCHL1 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "UCHL1",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:40:28.426542+11:00",
"panel_name": "Regression",
"panel_id": 206,
"panel_version": "0.246",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: UCHL1: Rating: GREEN; Mode of pathogenicity: None; Publications: 23359680, 3340629, 28007905, 32656641, 29735986, 28007905; Phenotypes: Spastic paraplegia 79, autosomal recessive, MIM# 615491, MONDO:0014209; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "UCHL1",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:39:01.238982+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.199",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: UCHL1 as ready",
"entity_name": "UCHL1",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:39:01.229128+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.199",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: uchl1 has been classified as Green List (High Evidence).",
"entity_name": "UCHL1",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:38:58.516725+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.199",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: UCHL1 were changed from Spastic paraplegia 79, autosomal recessive, 615491, AR to Spastic paraplegia 79, autosomal recessive, 615491; MONDO:0014209",
"entity_name": "UCHL1",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:37:36.154821+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.198",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: UCHL1 were set to ",
"entity_name": "UCHL1",
"entity_type": "gene"
},
{
"created": "2021-03-14T18:37:15.811292+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.197",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: UCHL1: Rating: GREEN; Mode of pathogenicity: None; Publications: 23359680, 3340629, 28007905, 32656641, 29735986, 28007905; Phenotypes: Spastic paraplegia 79, autosomal recessive, MIM# 615491; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "UCHL1",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:57:37.965133+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.3518",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: WDR45B as ready",
"entity_name": "WDR45B",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:57:37.951853+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.3518",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: wdr45b has been classified as Green List (High Evidence).",
"entity_name": "WDR45B",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:57:34.429527+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.3518",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: WDR45B were changed from to Neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures, MIM# 617977",
"entity_name": "WDR45B",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:57:03.061401+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.3517",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: WDR45B were set to ",
"entity_name": "WDR45B",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:56:31.551558+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.3516",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: WDR45B was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "WDR45B",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:56:00.777411+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.3515",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: WDR45B: Rating: GREEN; Mode of pathogenicity: None; Publications: 21937992, 28503735, 27431290; Phenotypes: Neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures, MIM# 617977; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "WDR45B",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:55:15.614495+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6718",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: WDR45B as ready",
"entity_name": "WDR45B",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:55:15.604774+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6718",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: wdr45b has been classified as Green List (High Evidence).",
"entity_name": "WDR45B",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:55:07.863657+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6718",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: WDR45B were changed from to Neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures, MIM# 617977",
"entity_name": "WDR45B",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:54:48.929384+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6717",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: WDR45B were set to ",
"entity_name": "WDR45B",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:54:31.310125+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6716",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: WDR45B was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "WDR45B",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:54:11.873456+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6715",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: WDR45B: Rating: GREEN; Mode of pathogenicity: None; Publications: 21937992, 28503735, 27431290; Phenotypes: Neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures, MIM# 617977; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "WDR45B",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:53:26.138369+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.197",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: WDR45B as ready",
"entity_name": "WDR45B",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:53:26.126881+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.197",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: wdr45b has been classified as Green List (High Evidence).",
"entity_name": "WDR45B",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:53:23.329170+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.197",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: WDR45B were changed from Profound developmental delay, early-onset refractory epilepsy, progressive spastic quadriplegia and contractures, and brain malformations. Omim-Neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures, 617977 to Profound developmental delay, early-onset refractory epilepsy, progressive spastic quadriplegia and contractures, and brain malformations; Neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures, MIM#617977",
"entity_name": "WDR45B",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:52:13.435029+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.196",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: WDR45B were set to ",
"entity_name": "WDR45B",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:52:00.228908+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.195",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: WDR45B: Rating: GREEN; Mode of pathogenicity: None; Publications: 21937992, 28503735, 27431290; Phenotypes: Neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures, MIM# 617977; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "WDR45B",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:50:27.933736+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6715",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: REEP2 as ready",
"entity_name": "REEP2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:50:27.923109+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6715",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: reep2 has been classified as Green List (High Evidence).",
"entity_name": "REEP2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:50:20.240323+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6715",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: REEP2 were changed from to Spastic paraplegia 72, dominant and recessive, MIM# 615625; MONDO:0014282",
"entity_name": "REEP2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:49:44.644352+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6714",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: REEP2 were set to ",
"entity_name": "REEP2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:49:23.193282+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6713",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: REEP2 was changed from Unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "REEP2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:48:26.099863+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6712",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: REEP2: Rating: GREEN; Mode of pathogenicity: None; Publications: 33526816, 28491902, 24388663; Phenotypes: Spastic paraplegia 72, dominant and recessive, MIM# 615625, MONDO:0014282; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "REEP2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:47:43.065257+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.195",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: REEP2 as ready",
"entity_name": "REEP2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:47:43.054139+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.195",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: reep2 has been classified as Green List (High Evidence).",
"entity_name": "REEP2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:47:37.373354+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.195",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: REEP2 were changed from ?Spastic paraplegia 72, autosomal dominant,615625; ?Spastic paraplegia 72, autosomal recessive, 615625; ?Spastic paraplegia 72, autosomal dominant, 615625 to Spastic paraplegia 72, dominant and recessive, MIM# 615625; MONDO:0014282",
"entity_name": "REEP2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:47:02.636667+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.194",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: REEP2 were set to ",
"entity_name": "REEP2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:46:48.594842+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.193",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: REEP2: Rating: GREEN; Mode of pathogenicity: None; Publications: 33526816, 28491902, 24388663; Phenotypes: Spastic paraplegia 72, dominant and recessive, MIM# 615625; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "REEP2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:42:31.878784+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.3515",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NT5C2 as ready",
"entity_name": "NT5C2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:42:31.867080+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.3515",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nt5c2 has been classified as Green List (High Evidence).",
"entity_name": "NT5C2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:42:26.369851+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.3515",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: NT5C2 were changed from to Spastic paraplegia 45, autosomal recessive, MIM# 613162; MONDO:0013165",
"entity_name": "NT5C2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:41:54.053053+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.3514",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: NT5C2 were set to ",
"entity_name": "NT5C2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:41:21.239058+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.3513",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: NT5C2 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "NT5C2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:40:48.254112+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.3512",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: NT5C2: Rating: GREEN; Mode of pathogenicity: None; Publications: 24482476, 32153630, 29123918, 28884889, 28327087; Phenotypes: Spastic paraplegia 45, autosomal recessive, MIM# 613162, MONDO:0013165; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "NT5C2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:40:08.259019+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6712",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NT5C2 as ready",
"entity_name": "NT5C2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:40:08.247721+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6712",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nt5c2 has been classified as Green List (High Evidence).",
"entity_name": "NT5C2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:40:00.434492+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6712",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: NT5C2 were changed from to Spastic paraplegia 45, autosomal recessive, MIM# 613162; MONDO:0013165",
"entity_name": "NT5C2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:39:41.151898+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6711",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: NT5C2 were set to ",
"entity_name": "NT5C2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:39:22.171959+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6710",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: NT5C2 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "NT5C2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:39:03.218785+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6709",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: NT5C2: Rating: GREEN; Mode of pathogenicity: None; Publications: 24482476, 32153630, 29123918, 28884889, 28327087; Phenotypes: Spastic paraplegia 45, autosomal recessive, MIM# 613162, MONDO:0013165; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "NT5C2",
"entity_type": "gene"
},
{
"created": "2021-03-14T17:38:06.824388+11:00",
"panel_name": "Hereditary Spastic Paraplegia - paediatric",
"panel_id": 317,
"panel_version": "0.193",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NT5C2 as ready",
"entity_name": "NT5C2",
"entity_type": "gene"
}
]
}