GET /api/v1/activities/?format=api&page=1423
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{
    "count": 220263,
    "next": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1424",
    "previous": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1422",
    "results": [
        {
            "created": "2021-02-03T21:15:48.611858+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.25",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Publications for gene: GLIS3 were set to 26259131; 16715098",
            "entity_name": "GLIS3",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T21:15:32.890704+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.24",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "reviewed gene: GLIS3: Rating: GREEN; Mode of pathogenicity: None; Publications: 26259131, 16715098, 30555422, 28253873; Phenotypes: Diabetes mellitus, neonatal, with congenital hypothyroidism, MIM# 610199; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
            "entity_name": "GLIS3",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T21:12:24.242199+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.24",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Phenotypes for gene: FOXE1 were changed from Bamforth Lazarus syndrome, 241850 (hypothyroidism); Hypothyroidism, Thyroidal Or Athyroidal, With Spiky Hair And Cleft Palate, 241850 to Bamforth Lazarus syndrome, MIM#241850 (hypothyroidism); Hypothyroidism, Thyroidal Or Athyroidal, With Spiky Hair And Cleft Palate, 241850",
            "entity_name": "FOXE1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T21:12:03.016239+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.23",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Publications for gene: FOXE1 were set to 20484477; 9697705; 24219130 (gain-of-function mutation); 9697704 (mouse model)",
            "entity_name": "FOXE1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T21:10:57.965185+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.22",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "reviewed gene: FOXE1: Rating: GREEN; Mode of pathogenicity: None; Publications: 28928994, 28455095, 9697705], 12165566, 16882747; Phenotypes: Bamforth-Lazarus syndrome, MIM# 241850; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
            "entity_name": "FOXE1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:44:28.778353+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.22",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "reviewed gene: DUOXA2: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Thyroid dyshormonogenesis 5, MIM# 274900; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
            "entity_name": "DUOXA2",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:43:49.439257+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.22",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "reviewed gene: DUOX2: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Thyroid dyshormonogenesis 6, MIM# 607200; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
            "entity_name": "DUOX2",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:42:44.343145+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.22",
            "user_name": "Zornitza Stark",
            "item_type": "panel",
            "text": "Panel types changed to Victorian Clinical Genetics Services; Genetic Health Queensland; Rare Disease",
            "entity_name": null,
            "entity_type": null
        },
        {
            "created": "2021-02-03T20:41:22.156228+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6207",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Marked gene: TTF2 as ready",
            "entity_name": "TTF2",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:41:22.147515+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6207",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: ttf2 has been classified as Red List (Low Evidence).",
            "entity_name": "TTF2",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:41:11.560236+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6207",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "gene: TTF2 was added\ngene: TTF2 was added to Mendeliome. Sources: Expert Review\nMode of inheritance for gene: TTF2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: TTF2 were set to 30022773\nPhenotypes for gene: TTF2 were set to congenital hypothyroidism, thyroid dysgenesis, No OMIM #\nReview for gene: TTF2 was set to RED\nAdded comment: 1 case only \nSources: Expert Review",
            "entity_name": "TTF2",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:39:36.423331+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.21",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Marked gene: TTF2 as ready",
            "entity_name": "TTF2",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:39:36.411540+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.21",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: ttf2 has been classified as Red List (Low Evidence).",
            "entity_name": "TTF2",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:39:16.917389+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.21",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Marked gene: GATA6 as ready",
            "entity_name": "GATA6",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:39:16.909627+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.21",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: gata6 has been classified as Amber List (Moderate Evidence).",
            "entity_name": "GATA6",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:38:52.257398+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6206",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Marked gene: DUOXA1 as ready",
            "entity_name": "DUOXA1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:38:52.247417+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6206",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: duoxa1 has been classified as Amber List (Moderate Evidence).",
            "entity_name": "DUOXA1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:38:38.629379+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6206",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Classified gene: DUOXA1 as Amber List (moderate evidence)",
            "entity_name": "DUOXA1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:38:38.616071+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6206",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: duoxa1 has been classified as Amber List (Moderate Evidence).",
            "entity_name": "DUOXA1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:38:20.359217+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6205",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "gene: DUOXA1 was added\ngene: DUOXA1 was added to Mendeliome. Sources: Expert Review\nMode of inheritance for gene: DUOXA1 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal\nPublications for gene: DUOXA1 were set to 29650690\nPhenotypes for gene: DUOXA1 were set to congenital hypothyroidism, No OMIM #\nReview for gene: DUOXA1 was set to AMBER\nAdded comment: 12 cases, but digenic model with variants in other genes \nSources: Expert Review",
            "entity_name": "DUOXA1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:36:45.207676+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.21",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Marked gene: DUOXA1 as ready",
            "entity_name": "DUOXA1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:36:45.200489+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.21",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: duoxa1 has been classified as Amber List (Moderate Evidence).",
            "entity_name": "DUOXA1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:36:10.956508+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6204",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Marked gene: DUOX1 as ready",
            "entity_name": "DUOX1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:36:10.948402+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6204",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: duox1 has been classified as Amber List (Moderate Evidence).",
            "entity_name": "DUOX1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:36:00.971174+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6204",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Classified gene: DUOX1 as Amber List (moderate evidence)",
            "entity_name": "DUOX1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:36:00.960645+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6204",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: duox1 has been classified as Amber List (Moderate Evidence).",
            "entity_name": "DUOX1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:35:41.107468+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6203",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "gene: DUOX1 was added\ngene: DUOX1 was added to Mendeliome. Sources: Expert Review\nMode of inheritance for gene: DUOX1 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal\nPublications for gene: DUOX1 were set to 29650690\nPhenotypes for gene: DUOX1 were set to congenital hypothyroidism, No OMIM #\nReview for gene: DUOX1 was set to AMBER\nAdded comment: 11 cases, but digenic model, with variants in other genes. \nSources: Expert Review",
            "entity_name": "DUOX1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:33:15.174864+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.21",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Marked gene: DUOX1 as ready",
            "entity_name": "DUOX1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:33:15.164971+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.21",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: duox1 has been classified as Amber List (Moderate Evidence).",
            "entity_name": "DUOX1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:32:48.580780+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6202",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Marked gene: TTF1 as ready",
            "entity_name": "TTF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:32:48.570486+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6202",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: ttf1 has been classified as Amber List (Moderate Evidence).",
            "entity_name": "TTF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:32:41.199802+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6202",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Phenotypes for gene: TTF1 were changed from  to congenital hypothyroidism, thyroid dysgenesis, No OMIM #",
            "entity_name": "TTF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:32:18.642471+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6201",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Publications for gene: TTF1 were set to ",
            "entity_name": "TTF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:31:59.439910+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6200",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Mode of inheritance for gene: TTF1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
            "entity_name": "TTF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:31:41.201586+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6199",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Classified gene: TTF1 as Amber List (moderate evidence)",
            "entity_name": "TTF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:31:41.193783+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6199",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: ttf1 has been classified as Amber List (Moderate Evidence).",
            "entity_name": "TTF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:31:22.921561+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6198",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "reviewed gene: TTF1: Rating: AMBER; Mode of pathogenicity: None; Publications: 30022773; Phenotypes: congenital hypothyroidism, thyroid dysgenesis, No OMIM #; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
            "entity_name": "TTF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:29:37.318250+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.21",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Marked gene: TTF1 as ready",
            "entity_name": "TTF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:29:37.313430+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.21",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Added comment: Comment when marking as ready: Targeted sequencing panel study.",
            "entity_name": "TTF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:29:37.271354+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.21",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: ttf1 has been classified as Amber List (Moderate Evidence).",
            "entity_name": "TTF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:28:13.376505+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.21",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Marked gene: TUBB1 as ready",
            "entity_name": "TUBB1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:28:13.373136+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.21",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Added comment: Comment when marking as ready: Green for mono allelic variants, limited evidence for bi-allelic variants.",
            "entity_name": "TUBB1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:28:13.347254+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.21",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: tubb1 has been classified as Green List (High Evidence).",
            "entity_name": "TUBB1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:27:51.311273+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.21",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Phenotypes for gene: TUBB1 were changed from Primary congenital hypothyroidism, thyroid dysgenesis, macroplatelets to Macrothrombocytopenia, autosomal dominant, TUBB1-related, OMIM # 613112; Primary congenital hypothyroidism, thyroid dysgenesis, macroplatelets",
            "entity_name": "TUBB1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:27:37.664538+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.20",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Publications for gene: TUBB1 were set to 30446499",
            "entity_name": "TUBB1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:25:49.447946+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.19",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Marked gene: NKX2-5 as ready",
            "entity_name": "NKX2-5",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:25:49.438153+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.19",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: nkx2-5 has been classified as Green List (High Evidence).",
            "entity_name": "NKX2-5",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:25:18.367224+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6198",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Marked gene: CDCA8 as ready",
            "entity_name": "CDCA8",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:25:18.357740+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6198",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: cdca8 has been classified as Green List (High Evidence).",
            "entity_name": "CDCA8",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:25:09.303639+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6198",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Classified gene: CDCA8 as Green List (high evidence)",
            "entity_name": "CDCA8",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:25:09.296039+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6198",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: cdca8 has been classified as Green List (High Evidence).",
            "entity_name": "CDCA8",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:24:50.716498+11:00",
            "panel_name": "Mendeliome",
            "panel_id": 137,
            "panel_version": "0.6197",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "gene: CDCA8 was added\ngene: CDCA8 was added to Mendeliome. Sources: Expert Review\nMode of inheritance for gene: CDCA8 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal\nPublications for gene: CDCA8 were set to 28025328; 29546359\nPhenotypes for gene: CDCA8 were set to Congenital hypothyroidism, thyroid dysgenesis, no OMIM #\nMode of pathogenicity for gene: CDCA8 was set to Other\nReview for gene: CDCA8 was set to GREEN\nAdded comment: 4 families (1 with bilallelic variants [parent affected as HTZ], 3 with monoallelic variants) with functional evidence of variants. GREEN for mono allelic, RED for biallelic. \nSources: Expert Review",
            "entity_name": "CDCA8",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:22:25.327536+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.19",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Marked gene: CDCA8 as ready",
            "entity_name": "CDCA8",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T20:22:25.320203+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.19",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: cdca8 has been classified as Green List (High Evidence).",
            "entity_name": "CDCA8",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:34:52.609862+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.19",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "gene: TTF2 was added\ngene: TTF2 was added to Congenital hypothyroidism. Sources: Literature\nMode of inheritance for gene: TTF2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: TTF2 were set to PMID: 30022773\nPhenotypes for gene: TTF2 were set to congenital hypothyroidism, thyroid dysgenesis, No OMIM #\nReview for gene: TTF2 was set to RED\nAdded comment: 1 case only \nSources: Literature",
            "entity_name": "TTF2",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:34:17.507950+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.18",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "Classified gene: GATA6 as Amber List (moderate evidence)",
            "entity_name": "GATA6",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:34:17.500792+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.18",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "Gene: gata6 has been classified as Amber List (Moderate Evidence).",
            "entity_name": "GATA6",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:34:10.501508+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.17",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "gene: GATA6 was added\ngene: GATA6 was added to Congenital hypothyroidism. Sources: Literature\nMode of inheritance for gene: GATA6 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: GATA6 were set to PMID: 31271559, 32207556\nPhenotypes for gene: GATA6 were set to Pancreatic agenesis and congenital heart defects, OMIM# 600001\nReview for gene: GATA6 was set to AMBER\nAdded comment: 2 cases with congenital hypothyroidism so expansion of phenotype \nSources: Literature",
            "entity_name": "GATA6",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:32:44.064042+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.16",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "Classified gene: DUOXA1 as Amber List (moderate evidence)",
            "entity_name": "DUOXA1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:32:44.053835+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.16",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "Gene: duoxa1 has been classified as Amber List (Moderate Evidence).",
            "entity_name": "DUOXA1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:32:38.215536+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.15",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "gene: DUOXA1 was added\ngene: DUOXA1 was added to Congenital hypothyroidism. Sources: Literature\nMode of inheritance for gene: DUOXA1 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal\nPublications for gene: DUOXA1 were set to PMID: 29650690\nPhenotypes for gene: DUOXA1 were set to congenital hypothyroidism, No OMIM #\nReview for gene: DUOXA1 was set to AMBER\nAdded comment: 12 cases, but digenic model with variants in other genes \nSources: Literature",
            "entity_name": "DUOXA1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:31:40.221934+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.14",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "Classified gene: DUOX1 as Amber List (moderate evidence)",
            "entity_name": "DUOX1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:31:40.211569+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.14",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "Gene: duox1 has been classified as Amber List (Moderate Evidence).",
            "entity_name": "DUOX1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:31:33.630190+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.13",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "gene: DUOX1 was added\ngene: DUOX1 was added to Congenital hypothyroidism. Sources: Literature\nMode of inheritance for gene: DUOX1 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal\nPublications for gene: DUOX1 were set to PMID: 29650690\nPhenotypes for gene: DUOX1 were set to congenital hypothyroidism, No OMIM #\nAdded comment: 11 cases, but digenic model, with variants in other genes \nSources: Literature",
            "entity_name": "DUOX1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:30:35.331492+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.12",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "Classified gene: TTF1 as Amber List (moderate evidence)",
            "entity_name": "TTF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:30:35.321377+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.12",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "Gene: ttf1 has been classified as Amber List (Moderate Evidence).",
            "entity_name": "TTF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:30:27.832673+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.11",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "gene: TTF1 was added\ngene: TTF1 was added to Congenital hypothyroidism. Sources: Literature\nMode of inheritance for gene: TTF1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: TTF1 were set to PMID: 30022773\nPhenotypes for gene: TTF1 were set to congenital hypothyroidism, thyroid dysgenesis, No OMIM #\nReview for gene: TTF1 was set to AMBER\nAdded comment: 5 cases, but one paper with limited additional evidence \nSources: Literature",
            "entity_name": "TTF1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:29:44.202734+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.10",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "Classified gene: TUBB1 as Green List (high evidence)",
            "entity_name": "TUBB1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:29:44.192518+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.10",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "Gene: tubb1 has been classified as Green List (High Evidence).",
            "entity_name": "TUBB1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:29:33.175593+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.9",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "reviewed gene: TUBB1: Rating: GREEN; Mode of pathogenicity: None; Publications: PMID: 30446499, 31642429; Phenotypes: Macrothrombocytopenia, autosomal dominant, TUBB1-related, OMIM # 613112; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
            "entity_name": "TUBB1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:10:26.211344+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.9",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "Classified gene: NKX2-5 as Green List (high evidence)",
            "entity_name": "NKX2-5",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:10:26.198519+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.9",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "Gene: nkx2-5 has been classified as Green List (High Evidence).",
            "entity_name": "NKX2-5",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:10:18.940205+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.8",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "reviewed gene: NKX2-5: Rating: GREEN; Mode of pathogenicity: None; Publications: PMID: 16418214, 28749785, 27373559, 30022773; Phenotypes: Hypothyroidism, congenital nongoitrous, 5, OMIM # 225250, thyrioid ectopy, thyroid agenesis, congenital heart disease; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
            "entity_name": "NKX2-5",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:09:17.779853+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.8",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "Classified gene: CDCA8 as Green List (high evidence)",
            "entity_name": "CDCA8",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:09:17.770191+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.8",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "Gene: cdca8 has been classified as Green List (High Evidence).",
            "entity_name": "CDCA8",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T15:09:10.703693+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.7",
            "user_name": "Chirag Patel",
            "item_type": "entity",
            "text": "reviewed gene: CDCA8: Rating: GREEN; Mode of pathogenicity: None; Publications: PMID: 28025328, 29546359; Phenotypes: Congenital hypothyroidism, thyroid dysgenesis, no OMIM #; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
            "entity_name": "CDCA8",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:52:00.718868+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.6",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Marked gene: NKX2-1 as ready",
            "entity_name": "NKX2-1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:52:00.710635+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.6",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: nkx2-1 has been classified as Green List (High Evidence).",
            "entity_name": "NKX2-1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:51:58.192863+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.6",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Phenotypes for gene: NKX2-1 were changed from Choreoathetosis And Congenital Hypothyroidism With Or Without Pulmonary Dysfunction, 610978; Congenital hypothyroidism; Neurological abnormalities; CAHTP; neonatal respiratory distress syndrome; recurrent respiratory infections; Choreoathetosis, hypothyroidism, and neonatal respiratory distress, 610978; benign hereditary chorea to Choreoathetosis And Congenital Hypothyroidism With Or Without Pulmonary Dysfunction, 610978",
            "entity_name": "NKX2-1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:51:11.453072+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.5",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Marked gene: SLC16A2 as ready",
            "entity_name": "SLC16A2",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:51:11.442275+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.5",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: slc16a2 has been classified as Green List (High Evidence).",
            "entity_name": "SLC16A2",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:51:09.143957+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.5",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Phenotypes for gene: SLC16A2 were changed from MENTAL RETARDATION AND MUSCULAR ATROPHY; T3 RESISTANCE; MENTAL RETARDATION, X-LINKED, WITH HYPOTONIA; Monocarboxylate transporter 8 (MCT8) defect; MONOCARBOXYLATE TRANSPORTER 8 DEFICIENCY; TRIIODOTHYRONINE RESISTANCE; AHDS; Allan_Herndon_Dudley Syndrome; ALLAN-HERNDON SYNDROME; mental retardation, X-linked, with hypotonia; MCT8 (SLC16A2)-specific thyroid hormone cell transporter deficiency; Allan-Herndon-Dudley syndrome; ALLAN-HERNDON-DUDLEY SYNDROME; Allan-Herndon-Dudley syndrome, 300523; monocarboxylate transporter 8 (MCT8) deficiency; Allan-Herndon-Dudley Syndrome; 300523 to Allan-Herndon-Dudley syndrome, MIM#\t300523",
            "entity_name": "SLC16A2",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:50:17.217662+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.4",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Marked gene: FOXE1 as ready",
            "entity_name": "FOXE1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:50:17.207732+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.4",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: foxe1 has been classified as Green List (High Evidence).",
            "entity_name": "FOXE1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:50:14.658878+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.4",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Phenotypes for gene: FOXE1 were changed from choanal atresia; congenital hypothyroidism; Bamforth Lazarus syndrome, 241850 (hypothyroidism); spiky hair; thyroid agenesis; Hypothyroidism, Thyroidal Or Athyroidal, With Spiky Hair And Cleft Palate, 241850; cleft palate to Bamforth Lazarus syndrome, 241850 (hypothyroidism); Hypothyroidism, Thyroidal Or Athyroidal, With Spiky Hair And Cleft Palate, 241850",
            "entity_name": "FOXE1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:49:34.798614+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.3",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Marked gene: DUOXA2 as ready",
            "entity_name": "DUOXA2",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:49:34.788184+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.3",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: duoxa2 has been classified as Green List (High Evidence).",
            "entity_name": "DUOXA2",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:49:32.727454+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.3",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Phenotypes for gene: DUOXA2 were changed from transient congenital hypothyroidism; mild congenital hypothyroidism; eutopic gland-in-situ; Thyroid dyshormonogenesis 5, 274900; HYPOTHYROIDISM, CONGENITAL, DUE TO DYSHORMONOGENESIS, 5 to Thyroid dyshormonogenesis 5, 274900",
            "entity_name": "DUOXA2",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:47:06.781948+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.2",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Marked gene: DUOX2 as ready",
            "entity_name": "DUOX2",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:47:06.773855+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.2",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Gene: duox2 has been classified as Green List (High Evidence).",
            "entity_name": "DUOX2",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:47:04.188996+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.2",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "Phenotypes for gene: DUOX2 were changed from transient congenital hypothyroidism; borderline congenital hypothyroidism; iodide organification defect; Congenital hypothyroidism; Thryoid dyshormonogenesis 6, 607200; goitre; eutopic gland-in-situ; permanent congenital hypothyroidism to Thyroid dyshormonogenesis 6, 607200",
            "entity_name": "DUOX2",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:45:46.723320+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.1",
            "user_name": "Zornitza Stark",
            "item_type": "panel",
            "text": "Panel status changed from internal to public\nPanel types changed to Genetic Health Queensland; Rare Disease",
            "entity_name": null,
            "entity_type": null
        },
        {
            "created": "2021-02-03T14:45:11.458382+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.0",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "gene: SOX3 was added\ngene: SOX3 was added to Congenital hypothyroidism. Sources: Genomics England PanelApp,Expert Review Red\nMode of inheritance for gene: SOX3 was set to X-LINKED: hemizygous mutation in males, biallelic mutations in females\nPublications for gene: SOX3 were set to 15800844; 12428212; 26416826 (2015 review)\nPhenotypes for gene: SOX3 were set to Panhypopituitarism, X-linked, MONDO:0010712; Panhypopituitarism, X-linked, OMIM:312000; Intellectual disability, X-linked, with panhypopituitarism, MONDO:0010252; Mental retardation, X-linked, with isolated growth hormone deficiency, OMIM:300123",
            "entity_name": "SOX3",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:45:11.420020+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.0",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "gene: TUBB1 was added\ngene: TUBB1 was added to Congenital hypothyroidism. Sources: Expert Review Amber,Genomics England PanelApp\nMode of inheritance for gene: TUBB1 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal\nPublications for gene: TUBB1 were set to 30446499\nPhenotypes for gene: TUBB1 were set to Primary congenital hypothyroidism, thyroid dysgenesis, macroplatelets",
            "entity_name": "TUBB1",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:45:11.380714+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.0",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "gene: NKX2-5 was added\ngene: NKX2-5 was added to Congenital hypothyroidism. Sources: Expert Review Amber,Genomics England PanelApp\nMode of inheritance for gene: NKX2-5 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: NKX2-5 were set to 16418214\nPhenotypes for gene: NKX2-5 were set to Hypothyroidism, congenital nongoitrous, 5, 225250; thyrioid ectopy, thyroid agenesis, congenital heart disease\nMode of pathogenicity for gene: NKX2-5 was set to Other - please provide details in the comments",
            "entity_name": "NKX2-5",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:45:11.342549+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.0",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "gene: CDCA8 was added\ngene: CDCA8 was added to Congenital hypothyroidism. Sources: Expert Review Amber,Genomics England PanelApp\nMode of inheritance for gene: CDCA8 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal\nPublications for gene: CDCA8 were set to 28025328; 29546359\nPhenotypes for gene: CDCA8 were set to Congenital hypothyroidism; No OMIM number; thyroid dysgenesis\nMode of pathogenicity for gene: CDCA8 was set to Other",
            "entity_name": "CDCA8",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:45:11.300201+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.0",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "gene: TSHR was added\ngene: TSHR was added to Congenital hypothyroidism. Sources: Expert Review Green,Genomics England PanelApp\nMode of inheritance for gene: TSHR was set to BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal\nPublications for gene: TSHR were set to 16060907 (Camilot et al., 2005 report subclinical hypothyroid subjects with heterozygous substitutions; 22876533; 7528344; PMID:17526952 (Kanda et al., 2006) examine Japanese patients homozygous and heterozygous for the R450H mutation in the TSHR gene. Homozygous subjects displayed mild hypothyroidism/ Heterozygous patients also demonstrated hypothyroidism, but less severe than that of homozygous subjects.; 27525530 (Nicholas et al.,2016) identify a monogenic basis of disease.; PMID:14725684 (Park et al. 2004) suggest that heterozygosity for an inactivating TSHR mutation may be associated with compensated hypothyroidism and thyroid hypoplasia\nPhenotypes for gene: TSHR were set to Hypothyroidism, congenital, nongoitrous, 1 275200; thyroid dysgenesis; Congenital hypothyroidism; thyroid hypoplasia; compensated hypothryoidism; subclinical hypothyroidism; Hypothyroidism, Congenital, Nongoitrous, 1, 275200; eutopic gland-in-situ; TSH resistance",
            "entity_name": "TSHR",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:45:11.261831+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.0",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "gene: TSHB was added\ngene: TSHB was added to Congenital hypothyroidism. Sources: Expert Review Green,Genomics England PanelApp\nMode of inheritance for gene: TSHB was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: TSHB were set to 2792087; 27362444\nPhenotypes for gene: TSHB were set to Congenital hypothyroidism; Hypothryoidism, congenital, nongoitrous 4, 275100; severe isolated central hypothyroidism",
            "entity_name": "TSHB",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:45:11.221363+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.0",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "gene: TRHR was added\ngene: TRHR was added to Congenital hypothyroidism. Sources: Expert Review Green,Genomics England PanelApp\nMode of inheritance for gene: TRHR was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: TRHR were set to PMID: 19213692; PMID: 9141550\nPhenotypes for gene: TRHR were set to mild-moderate isolated central hypothyroidism; absent TSH and prolactin response to TRH; Thyrotropin-releasing hormone resistance, generalized",
            "entity_name": "TRHR",
            "entity_type": "gene"
        },
        {
            "created": "2021-02-03T14:45:11.181542+11:00",
            "panel_name": "Congenital hypothyroidism",
            "panel_id": 3471,
            "panel_version": "0.0",
            "user_name": "Zornitza Stark",
            "item_type": "entity",
            "text": "gene: TPO was added\ngene: TPO was added to Congenital hypothyroidism. Sources: Expert Review Green,Genomics England PanelApp\nMode of inheritance for gene: TPO was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: TPO were set to 12938097; 27166716; 8964831; 11061528; 8027236; 27525530 (Nicholas et al.,2016) identify a monogenic basis of disease\nPhenotypes for gene: TPO were set to Congenital hypothyroidism; Iodide organification defect; goitre; TDH2A; Thyroid dyshormonogenesis 2A,  274500",
            "entity_name": "TPO",
            "entity_type": "gene"
        }
    ]
}