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{
"count": 220313,
"next": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1438",
"previous": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1436",
"results": [
{
"created": "2021-01-20T16:26:21.856114+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.33",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: stk11 has been classified as Amber List (Moderate Evidence).",
"entity_name": "STK11",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:25:53.517055+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.32",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "reviewed gene: STK11: Rating: AMBER; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "STK11",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:24:56.528582+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.32",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Classified gene: SUFU as Red List (low evidence)",
"entity_name": "SUFU",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:24:56.522450+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.32",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Added comment: Comment on list classification: may present in childhood",
"entity_name": "SUFU",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:24:56.498150+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.32",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: sufu has been classified as Red List (Low Evidence).",
"entity_name": "SUFU",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:24:45.178275+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.31",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "reviewed gene: SUFU: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "SUFU",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:23:50.979982+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.31",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Classified gene: TACC1 as Red List (low evidence)",
"entity_name": "TACC1",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:23:50.972170+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.31",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: tacc1 has been classified as Red List (Low Evidence).",
"entity_name": "TACC1",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:23:41.246422+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.30",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "reviewed gene: TACC1: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "TACC1",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:23:17.724005+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.30",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Classified gene: TACC3 as Red List (low evidence)",
"entity_name": "TACC3",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:23:17.718881+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.30",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Added comment: Comment on list classification: not a clear cause of Mendelian disease",
"entity_name": "TACC3",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:23:17.694549+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.30",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: tacc3 has been classified as Red List (Low Evidence).",
"entity_name": "TACC3",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:23:06.061305+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.29",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "reviewed gene: TACC3: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "TACC3",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:22:26.373898+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.29",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Classified gene: TAF15 as Red List (low evidence)",
"entity_name": "TAF15",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:22:26.368858+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.29",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Added comment: Comment on list classification: not clearly a cause of germline inherited disease",
"entity_name": "TAF15",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:22:26.329327+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.29",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: taf15 has been classified as Red List (Low Evidence).",
"entity_name": "TAF15",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:21:03.787380+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.28",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Marked gene: TARDBP as ready",
"entity_name": "TARDBP",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:21:03.784118+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.28",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Added comment: Comment when marking as ready: Adult onset neurological condition - should be kept on this list",
"entity_name": "TARDBP",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:21:03.759182+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.28",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: tardbp has been classified as Green List (High Evidence).",
"entity_name": "TARDBP",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:19:58.464256+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.28",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Marked gene: TBL1XR1 as ready",
"entity_name": "TBL1XR1",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:19:58.452706+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.28",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: tbl1xr1 has been classified as Red List (Low Evidence).",
"entity_name": "TBL1XR1",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:19:54.515687+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.28",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Classified gene: TBL1XR1 as Red List (low evidence)",
"entity_name": "TBL1XR1",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:19:54.511723+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.28",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Added comment: Comment on list classification: may present in childhood",
"entity_name": "TBL1XR1",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:19:54.481932+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.28",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: tbl1xr1 has been classified as Red List (Low Evidence).",
"entity_name": "TBL1XR1",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:19:10.630308+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.27",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Marked gene: TFG as ready",
"entity_name": "TFG",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:19:10.625590+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.27",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Added comment: Comment when marking as ready: may present in childhood",
"entity_name": "TFG",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:19:10.601775+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.27",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: tfg has been classified as Red List (Low Evidence).",
"entity_name": "TFG",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:19:03.635800+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.27",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Classified gene: TFG as Red List (low evidence)",
"entity_name": "TFG",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:19:03.628081+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.27",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: tfg has been classified as Red List (Low Evidence).",
"entity_name": "TFG",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:18:53.046704+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.26",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "edited their review of gene: TFG: Added comment: may present in childhood; Changed rating: RED",
"entity_name": "TFG",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:18:30.054579+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.26",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Classified gene: TGFBR1 as Red List (low evidence)",
"entity_name": "TGFBR1",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:18:30.049551+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.26",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Added comment: Comment on list classification: may present in childhood",
"entity_name": "TGFBR1",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:18:30.019968+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.26",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: tgfbr1 has been classified as Red List (Low Evidence).",
"entity_name": "TGFBR1",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:17:59.319782+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.25",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Classified gene: TGFBR2 as Red List (low evidence)",
"entity_name": "TGFBR2",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:17:59.314952+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.25",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Added comment: Comment on list classification: may present in childhood",
"entity_name": "TGFBR2",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:17:59.289041+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.25",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: tgfbr2 has been classified as Red List (Low Evidence).",
"entity_name": "TGFBR2",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:17:44.919131+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.24",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "edited their review of gene: TGFBR2: Added comment: may present in childhood; Changed rating: RED",
"entity_name": "TGFBR2",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:17:09.739546+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.24",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Classified gene: TNNI3 as Red List (low evidence)",
"entity_name": "TNNI3",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:17:09.736381+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.24",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Added comment: Comment on list classification: Disease has been observed in childhood",
"entity_name": "TNNI3",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:17:09.719267+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.24",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: tnni3 has been classified as Red List (Low Evidence).",
"entity_name": "TNNI3",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:15:59.856937+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.23",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Classified gene: TNNT2 as Red List (low evidence)",
"entity_name": "TNNT2",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:15:59.853421+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.23",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Added comment: Comment on list classification: may present in childhood",
"entity_name": "TNNT2",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:15:59.834839+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.23",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: tnnt2 has been classified as Red List (Low Evidence).",
"entity_name": "TNNT2",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:14:53.759026+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.22",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Classified gene: TREM2 as Amber List (moderate evidence)",
"entity_name": "TREM2",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:14:53.755817+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.22",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Added comment: Comment on list classification: Neurological symptoms appear not to present in childhood - needs review for a final decision",
"entity_name": "TREM2",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:14:53.737472+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.22",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: trem2 has been classified as Amber List (Moderate Evidence).",
"entity_name": "TREM2",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:12:33.479945+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.21",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Classified gene: TET2 as Red List (low evidence)",
"entity_name": "TET2",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:12:33.475388+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.21",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Added comment: Comment on list classification: may present in childhood",
"entity_name": "TET2",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:12:33.450951+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.21",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: tet2 has been classified as Red List (Low Evidence).",
"entity_name": "TET2",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:11:51.384031+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.20",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Classified gene: TCF12 as Red List (low evidence)",
"entity_name": "TCF12",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:11:51.371532+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.20",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: tcf12 has been classified as Red List (Low Evidence).",
"entity_name": "TCF12",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:11:49.956984+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6101",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Marked gene: ZMYND15 as ready",
"entity_name": "ZMYND15",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:11:49.949492+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6101",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Gene: zmynd15 has been classified as Green List (High Evidence).",
"entity_name": "ZMYND15",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:11:33.651949+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.19",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "reviewed gene: TCF12: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "TCF12",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:10:49.773512+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.19",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "reviewed gene: TET2: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "TET2",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:09:00.676823+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.19",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "reviewed gene: TFG: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "TFG",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:08:19.044441+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.19",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "reviewed gene: TGFBR1: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "TGFBR1",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:07:46.562534+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.19",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "reviewed gene: TGFBR2: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "TGFBR2",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:06:46.426434+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.19",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Classified gene: TMEM43 as Amber List (moderate evidence)",
"entity_name": "TMEM43",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:06:46.419306+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.19",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Added comment: Comment on list classification: unclear whether disease presents in childhood - needs review",
"entity_name": "TMEM43",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:06:46.378767+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.19",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: tmem43 has been classified as Amber List (Moderate Evidence).",
"entity_name": "TMEM43",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:05:15.256591+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6101",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Classified gene: ZMYND15 as Green List (high evidence)",
"entity_name": "ZMYND15",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:05:15.248330+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6101",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Gene: zmynd15 has been classified as Green List (High Evidence).",
"entity_name": "ZMYND15",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:04:53.863347+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.18",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "reviewed gene: TNNI3: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "TNNI3",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:04:43.775886+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6100",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "gene: ZMYND15 was added\ngene: ZMYND15 was added to Mendeliome. Sources: Literature\nMode of inheritance for gene: ZMYND15 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: ZMYND15 were set to 24431330; 33169450; 20675388\nPhenotypes for gene: ZMYND15 were set to Severe oligozoospermia\nReview for gene: ZMYND15 was set to GREEN\nAdded comment: 4 unrelated consanguineous cases with homozygous loss of function variants. Zmynd15-null male mice display reduced testis weight and azoospermia \nSources: Literature",
"entity_name": "ZMYND15",
"entity_type": "gene"
},
{
"created": "2021-01-20T16:04:07.413996+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.18",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "reviewed gene: TNNT2: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "TNNT2",
"entity_type": "gene"
},
{
"created": "2021-01-20T15:47:49.321742+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.18",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Classified gene: TP53 as Amber List (moderate evidence)",
"entity_name": "TP53",
"entity_type": "gene"
},
{
"created": "2021-01-20T15:47:49.317065+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.18",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Added comment: Comment on list classification: Needs discussion - could be removed as early age of onset possible",
"entity_name": "TP53",
"entity_type": "gene"
},
{
"created": "2021-01-20T15:47:49.279953+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.18",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: tp53 has been classified as Amber List (Moderate Evidence).",
"entity_name": "TP53",
"entity_type": "gene"
},
{
"created": "2021-01-20T15:46:36.382475+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.17",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Classified gene: TPM1 as Amber List (moderate evidence)",
"entity_name": "TPM1",
"entity_type": "gene"
},
{
"created": "2021-01-20T15:46:36.378610+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.17",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Added comment: Comment on list classification: May cause a treatable cardiomyopathy - should be reviewed for exclusion",
"entity_name": "TPM1",
"entity_type": "gene"
},
{
"created": "2021-01-20T15:46:36.349907+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.17",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: tpm1 has been classified as Amber List (Moderate Evidence).",
"entity_name": "TPM1",
"entity_type": "gene"
},
{
"created": "2021-01-20T15:44:38.070404+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.16",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Classified gene: TPR as Red List (low evidence)",
"entity_name": "TPR",
"entity_type": "gene"
},
{
"created": "2021-01-20T15:44:38.061941+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.16",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: tpr has been classified as Red List (Low Evidence).",
"entity_name": "TPR",
"entity_type": "gene"
},
{
"created": "2021-01-20T15:44:07.392933+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.15",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "reviewed gene: TPR: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "TPR",
"entity_type": "gene"
},
{
"created": "2021-01-20T15:42:11.140706+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.15",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "reviewed gene: TREM2: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "TREM2",
"entity_type": "gene"
},
{
"created": "2021-01-20T15:40:19.512206+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.15",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Classified gene: TRIM24 as Red List (low evidence)",
"entity_name": "TRIM24",
"entity_type": "gene"
},
{
"created": "2021-01-20T15:40:19.500343+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.15",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: trim24 has been classified as Red List (Low Evidence).",
"entity_name": "TRIM24",
"entity_type": "gene"
},
{
"created": "2021-01-20T15:39:56.091262+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.14",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Marked gene: TRIM24 as ready",
"entity_name": "TRIM24",
"entity_type": "gene"
},
{
"created": "2021-01-20T15:39:56.078915+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.14",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "Gene: trim24 has been classified as Green List (High Evidence).",
"entity_name": "TRIM24",
"entity_type": "gene"
},
{
"created": "2021-01-20T15:39:07.877786+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.14",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "changed review comment from: Not a known Mendelian disease gene; to: Not a known Mendelian disease gene",
"entity_name": "TRIM24",
"entity_type": "gene"
},
{
"created": "2021-01-20T15:36:34.641916+11:00",
"panel_name": "Incidentalome_PREGEN_DRAFT",
"panel_id": 3437,
"panel_version": "0.14",
"user_name": "Tony Roscioli",
"item_type": "entity",
"text": "reviewed gene: TRIM24: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "TRIM24",
"entity_type": "gene"
},
{
"created": "2021-01-20T11:52:17.133728+11:00",
"panel_name": "Ichthyosis",
"panel_id": 124,
"panel_version": "1.0",
"user_name": "Zornitza Stark",
"item_type": "panel",
"text": "promoted panel to version 1.0",
"entity_name": null,
"entity_type": null
},
{
"created": "2021-01-20T11:51:14.672915+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6099",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PNPLA1 as ready",
"entity_name": "PNPLA1",
"entity_type": "gene"
},
{
"created": "2021-01-20T11:51:14.662738+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6099",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: pnpla1 has been classified as Green List (High Evidence).",
"entity_name": "PNPLA1",
"entity_type": "gene"
},
{
"created": "2021-01-20T11:51:04.591828+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6099",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PNPLA1 were changed from to Ichthyosis, congenital, autosomal recessive 10, MIM# 615024",
"entity_name": "PNPLA1",
"entity_type": "gene"
},
{
"created": "2021-01-20T11:50:41.408857+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6098",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PNPLA1 were set to ",
"entity_name": "PNPLA1",
"entity_type": "gene"
},
{
"created": "2021-01-20T11:50:19.772340+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6097",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PNPLA1 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PNPLA1",
"entity_type": "gene"
},
{
"created": "2021-01-20T11:50:01.951292+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.6096",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PNPLA1: Rating: GREEN; Mode of pathogenicity: None; Publications: 22246504, 24344921, 26691440; Phenotypes: Ichthyosis, congenital, autosomal recessive 10, MIM# 615024; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PNPLA1",
"entity_type": "gene"
},
{
"created": "2021-01-20T11:49:11.957119+11:00",
"panel_name": "Ichthyosis",
"panel_id": 124,
"panel_version": "0.123",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PNPLA1 as ready",
"entity_name": "PNPLA1",
"entity_type": "gene"
},
{
"created": "2021-01-20T11:49:11.949932+11:00",
"panel_name": "Ichthyosis",
"panel_id": 124,
"panel_version": "0.123",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: pnpla1 has been classified as Green List (High Evidence).",
"entity_name": "PNPLA1",
"entity_type": "gene"
},
{
"created": "2021-01-20T11:49:08.967228+11:00",
"panel_name": "Ichthyosis",
"panel_id": 124,
"panel_version": "0.123",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PNPLA1 were changed from to Ichthyosis, congenital, autosomal recessive 10, MIM# 615024",
"entity_name": "PNPLA1",
"entity_type": "gene"
},
{
"created": "2021-01-20T11:48:36.456562+11:00",
"panel_name": "Ichthyosis",
"panel_id": 124,
"panel_version": "0.122",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PNPLA1 were set to ",
"entity_name": "PNPLA1",
"entity_type": "gene"
},
{
"created": "2021-01-20T11:48:07.059948+11:00",
"panel_name": "Ichthyosis",
"panel_id": 124,
"panel_version": "0.121",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PNPLA1 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PNPLA1",
"entity_type": "gene"
},
{
"created": "2021-01-20T11:47:38.079190+11:00",
"panel_name": "Ichthyosis",
"panel_id": 124,
"panel_version": "0.120",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PNPLA1: Rating: GREEN; Mode of pathogenicity: None; Publications: 22246504, 24344921, 26691440; Phenotypes: Ichthyosis, congenital, autosomal recessive 10, MIM# 615024; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PNPLA1",
"entity_type": "gene"
},
{
"created": "2021-01-20T11:45:43.444103+11:00",
"panel_name": "Ichthyosis",
"panel_id": 124,
"panel_version": "0.120",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: STS: Changed mode of inheritance: X-LINKED: hemizygous mutation in males, biallelic mutations in females",
"entity_name": "STS",
"entity_type": "gene"
},
{
"created": "2021-01-20T11:45:35.428381+11:00",
"panel_name": "Ichthyosis",
"panel_id": 124,
"panel_version": "0.120",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: STS as ready",
"entity_name": "STS",
"entity_type": "gene"
},
{
"created": "2021-01-20T11:45:35.420042+11:00",
"panel_name": "Ichthyosis",
"panel_id": 124,
"panel_version": "0.120",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: sts has been classified as Green List (High Evidence).",
"entity_name": "STS",
"entity_type": "gene"
},
{
"created": "2021-01-20T11:45:32.725713+11:00",
"panel_name": "Ichthyosis",
"panel_id": 124,
"panel_version": "0.120",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: STS were changed from to Ichthyosis, X-linked, MIM# 308100",
"entity_name": "STS",
"entity_type": "gene"
},
{
"created": "2021-01-20T11:45:03.042940+11:00",
"panel_name": "Ichthyosis",
"panel_id": 124,
"panel_version": "0.119",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: STS was changed from Unknown to X-LINKED: hemizygous mutation in males, biallelic mutations in females",
"entity_name": "STS",
"entity_type": "gene"
}
]
}