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{
"count": 220482,
"next": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1532",
"previous": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1530",
"results": [
{
"created": "2020-10-19T13:07:45.535174+11:00",
"panel_name": "Dystonia - complex",
"panel_id": 290,
"panel_version": "0.151",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Marked STR: C9orf72 as ready",
"entity_name": "C9orf72",
"entity_type": "str"
},
{
"created": "2020-10-19T13:07:45.525535+11:00",
"panel_name": "Dystonia - complex",
"panel_id": 290,
"panel_version": "0.151",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Str: c9orf72 has been classified as Green List (High Evidence).",
"entity_name": "C9orf72",
"entity_type": "str"
},
{
"created": "2020-10-19T13:07:38.712697+11:00",
"panel_name": "Dystonia - complex",
"panel_id": 290,
"panel_version": "0.151",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Classified STR: C9orf72 as Green List (high evidence)",
"entity_name": "C9orf72",
"entity_type": "str"
},
{
"created": "2020-10-19T13:07:38.673477+11:00",
"panel_name": "Dystonia - complex",
"panel_id": 290,
"panel_version": "0.151",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Str: c9orf72 has been classified as Green List (High Evidence).",
"entity_name": "C9orf72",
"entity_type": "str"
},
{
"created": "2020-10-19T13:07:24.581504+11:00",
"panel_name": "Dystonia - complex",
"panel_id": 290,
"panel_version": "0.150",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "STR: C9orf72 was added\nSTR: C9orf72 was added to Dystonia - complex. Sources: Expert list\nSTR tags were added to STR: C9orf72.\nMode of inheritance for STR: C9orf72 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for STR: C9orf72 were set to 26166205; 24363131; 26187722; 25577942\nPhenotypes for STR: C9orf72 were set to Dystonia; Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 MIM#105550\nReview for STR: C9orf72 was set to GREEN\nSTR: C9orf72 was marked as clinically relevant\nAdded comment: NG_031977.1:g.5321GGGGCC[X]\r\nRepeat expansion affects the protein degradation pathways and may contribute to TDP‐43 accumulation\r\nNormal alleles: ≤25 G4C2 hexanucleotide repeat units generally considered normal\r\nPathogenic high-penetrance alleles: ≥60 G4C2 hexanucleotide repeat units are considered pathogenic\r\nNote: The minimal size of a G4C2 pathogenic repeat is under debate: some studies consider repeats of >30 G4C2 hexanucleotide repeat units as pathogenic, whereas others use a cutoff of 60 G4C2 hexanucleotide repeat units. \nSources: Expert list",
"entity_name": "C9orf72",
"entity_type": "str"
},
{
"created": "2020-10-19T13:04:38.004515+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5042",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: ARHGEF9 was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to X-LINKED: hemizygous mutation in males, biallelic mutations in females",
"entity_name": "ARHGEF9",
"entity_type": "gene"
},
{
"created": "2020-10-19T13:04:16.181589+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5041",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: ARHGEF9: Changed mode of inheritance: X-LINKED: hemizygous mutation in males, biallelic mutations in females",
"entity_name": "ARHGEF9",
"entity_type": "gene"
},
{
"created": "2020-10-19T09:01:31.477391+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "1.0",
"user_name": "Zornitza Stark",
"item_type": "panel",
"text": "promoted panel to version 1.0",
"entity_name": null,
"entity_type": null
},
{
"created": "2020-10-19T09:00:35.449647+11:00",
"panel_name": "Ciliary Dyskinesia",
"panel_id": 82,
"panel_version": "1.0",
"user_name": "Zornitza Stark",
"item_type": "panel",
"text": "promoted panel to version 1.0",
"entity_name": null,
"entity_type": null
},
{
"created": "2020-10-18T21:45:38.583531+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5041",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: ZMYND10 as ready",
"entity_name": "ZMYND10",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:45:38.565080+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5041",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: zmynd10 has been classified as Green List (High Evidence).",
"entity_name": "ZMYND10",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:45:31.897982+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5041",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: ZMYND10 were changed from to Ciliary dyskinesia, primary, 22, MIM#615444",
"entity_name": "ZMYND10",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:45:13.748329+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5040",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: ZMYND10 were set to ",
"entity_name": "ZMYND10",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:44:55.444418+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5039",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: ZMYND10 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "ZMYND10",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:44:36.761100+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5038",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: ZMYND10: Rating: GREEN; Mode of pathogenicity: None; Publications: 23891471, 23891469; Phenotypes: Ciliary dyskinesia, primary, 22, MIM#615444; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "ZMYND10",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:43:31.943189+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.161",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: ZMYND10: Rating: GREEN; Mode of pathogenicity: None; Publications: 23891471, 23891469; Phenotypes: Ciliary dyskinesia, primary, 22, MIM#615444; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "ZMYND10",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:25:53.447795+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.161",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: HYDIN as ready",
"entity_name": "HYDIN",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:25:53.437370+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.161",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: hydin has been classified as Red List (Low Evidence).",
"entity_name": "HYDIN",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:25:50.999252+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.161",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: HYDIN were changed from to Ciliary dyskinesia, primary, 5 (MIM#08647)",
"entity_name": "HYDIN",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:25:17.751053+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5038",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: SPAG1 as ready",
"entity_name": "SPAG1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:25:17.740910+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5038",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: spag1 has been classified as Green List (High Evidence).",
"entity_name": "SPAG1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:25:01.821172+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5038",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: SPAG1 were changed from to Ciliary dyskinesia, primary, 28 (MIM#615505)",
"entity_name": "SPAG1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:24:43.045027+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5037",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: SPAG1 were set to ",
"entity_name": "SPAG1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:24:23.613642+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5036",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: SPAG1 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "SPAG1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:24:04.873017+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5035",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: SPAG1: Rating: GREEN; Mode of pathogenicity: None; Publications: 32622824, 32502479, 24055112; Phenotypes: Ciliary dyskinesia, primary, 28 (MIM#615505); Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "SPAG1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:23:25.345776+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.160",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "changed review comment from: At least 5 unrelated families reported.; to: At least 15 unrelated families reported.",
"entity_name": "SPAG1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:23:15.371369+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.160",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: SPAG1 as ready",
"entity_name": "SPAG1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:23:15.362618+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.160",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: spag1 has been classified as Green List (High Evidence).",
"entity_name": "SPAG1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:23:10.010500+11:00",
"panel_name": "Ciliary Dyskinesia",
"panel_id": 82,
"panel_version": "0.185",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "changed review comment from: At least 5 unrelated families reported.; to: At least 15 unrelated families reported.",
"entity_name": "SPAG1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:22:47.915819+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.160",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: SPAG1 were changed from to Ciliary dyskinesia, primary, 28 (MIM#615505)",
"entity_name": "SPAG1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:22:42.377539+11:00",
"panel_name": "Ciliary Dyskinesia",
"panel_id": 82,
"panel_version": "0.185",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: SPAG1 were set to 24055112",
"entity_name": "SPAG1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:22:05.288827+11:00",
"panel_name": "Ciliary Dyskinesia",
"panel_id": 82,
"panel_version": "0.184",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: SPAG1: Rating: GREEN; Mode of pathogenicity: None; Publications: 32622824, 32502479, 24055112; Phenotypes: Ciliary dyskinesia, primary, 28 (MIM#615505); Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "SPAG1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:22:03.631885+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.159",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: SPAG1 were set to ",
"entity_name": "SPAG1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:21:37.321331+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.158",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: SPAG1 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "SPAG1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:21:09.281961+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.157",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: SPAG1: Rating: GREEN; Mode of pathogenicity: None; Publications: 24055112, 32622824, 32502479; Phenotypes: Ciliary dyskinesia, primary, 28 (MIM#615505); Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "SPAG1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:19:13.019598+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.157",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: HYDIN were set to ",
"entity_name": "HYDIN",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:18:29.321068+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.156",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: HYDIN was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "HYDIN",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:18:07.868417+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.155",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: HYDIN as Red List (low evidence)",
"entity_name": "HYDIN",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:18:07.858273+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.155",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: hydin has been classified as Red List (Low Evidence).",
"entity_name": "HYDIN",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:17:05.954002+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5035",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: MMP21 as ready",
"entity_name": "MMP21",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:17:05.944462+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5035",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: mmp21 has been classified as Green List (High Evidence).",
"entity_name": "MMP21",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:16:57.050153+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5035",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: MMP21 were changed from to Heterotaxy, visceral, 7, autosomal,MIM# 616749",
"entity_name": "MMP21",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:16:38.801182+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5034",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: MMP21 were set to ",
"entity_name": "MMP21",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:16:19.993590+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5033",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: MMP21 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "MMP21",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:16:02.159801+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5032",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: MMP21: Rating: GREEN; Mode of pathogenicity: None; Publications: 26429889, 26437028, 26437029; Phenotypes: Heterotaxy, visceral, 7, autosomal,MIM# 616749; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "MMP21",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:15:18.159405+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.154",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: MMP21 as ready",
"entity_name": "MMP21",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:15:18.147678+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.154",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: mmp21 has been classified as Green List (High Evidence).",
"entity_name": "MMP21",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:15:15.794536+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.154",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: MMP21 were changed from to Heterotaxy, visceral, 7, autosomal,MIM# 616749",
"entity_name": "MMP21",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:14:49.205531+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.153",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: MMP21 were set to ",
"entity_name": "MMP21",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:14:21.930442+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.152",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: MMP21 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "MMP21",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:13:53.445828+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.151",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: MMP21: Rating: GREEN; Mode of pathogenicity: None; Publications: 26429889, 26437028, 26437029; Phenotypes: Heterotaxy, visceral, 7, autosomal,MIM# 616749; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "MMP21",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:12:05.720157+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5032",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: DNAAF1 as ready",
"entity_name": "DNAAF1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:12:05.709563+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5032",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: dnaaf1 has been classified as Green List (High Evidence).",
"entity_name": "DNAAF1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:11:56.602419+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5032",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: DNAAF1 were changed from to Ciliary dyskinesia, primary, 13, MIM# 613193",
"entity_name": "DNAAF1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:11:38.031857+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5031",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: DNAAF1 were set to ",
"entity_name": "DNAAF1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:11:19.745792+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5030",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: DNAAF1 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "DNAAF1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:11:00.921189+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5029",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: DNAAF1: Rating: GREEN; Mode of pathogenicity: None; Publications: 19944400, 19944405, 32502479, 29228333, 27261005; Phenotypes: Ciliary dyskinesia, primary, 13, MIM# 613193; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "DNAAF1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:10:16.359268+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.151",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: DNAAF1 as ready",
"entity_name": "DNAAF1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:10:16.345954+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.151",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: dnaaf1 has been classified as Green List (High Evidence).",
"entity_name": "DNAAF1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:10:13.888542+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.151",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: DNAAF1 were changed from to Ciliary dyskinesia, primary, 13, MIM# 613193",
"entity_name": "DNAAF1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:09:47.154324+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.150",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: DNAAF1 were set to ",
"entity_name": "DNAAF1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:09:19.491977+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.149",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: DNAAF1 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "DNAAF1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:08:51.677626+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.148",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: DNAAF1: Rating: GREEN; Mode of pathogenicity: None; Publications: 19944400, 19944405, 32502479, 29228333, 27261005; Phenotypes: Ciliary dyskinesia, primary, 13, MIM# 613193; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "DNAAF1",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:04:35.962822+11:00",
"panel_name": "Ciliary Dyskinesia",
"panel_id": 82,
"panel_version": "0.184",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: HYDIN as ready",
"entity_name": "HYDIN",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:04:35.955090+11:00",
"panel_name": "Ciliary Dyskinesia",
"panel_id": 82,
"panel_version": "0.184",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: hydin has been classified as Green List (High Evidence).",
"entity_name": "HYDIN",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:04:33.656526+11:00",
"panel_name": "Ciliary Dyskinesia",
"panel_id": 82,
"panel_version": "0.184",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: HYDIN were changed from to Ciliary dyskinesia, primary, 5 (MIM#608647)",
"entity_name": "HYDIN",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:04:07.406944+11:00",
"panel_name": "Ciliary Dyskinesia",
"panel_id": 82,
"panel_version": "0.183",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: HYDIN were set to ",
"entity_name": "HYDIN",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:03:40.625257+11:00",
"panel_name": "Ciliary Dyskinesia",
"panel_id": 82,
"panel_version": "0.182",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: HYDIN was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "HYDIN",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:02:59.344184+11:00",
"panel_name": "Ciliary Dyskinesia",
"panel_id": 82,
"panel_version": "0.181",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: DNAI2 as ready",
"entity_name": "DNAI2",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:02:59.334003+11:00",
"panel_name": "Ciliary Dyskinesia",
"panel_id": 82,
"panel_version": "0.181",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: dnai2 has been classified as Green List (High Evidence).",
"entity_name": "DNAI2",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:02:07.968680+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.147",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: LRRC6 as ready",
"entity_name": "LRRC6",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:02:07.958218+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.147",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: lrrc6 has been classified as Green List (High Evidence).",
"entity_name": "LRRC6",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:02:05.540147+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.147",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: LRRC6 were changed from to Ciliary dyskinesia, primary, 19, MIM# 614935",
"entity_name": "LRRC6",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:01:51.222469+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5029",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: LRRC6 as ready",
"entity_name": "LRRC6",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:01:51.204203+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5029",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: lrrc6 has been classified as Green List (High Evidence).",
"entity_name": "LRRC6",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:01:44.360639+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.146",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: LRRC6 were set to ",
"entity_name": "LRRC6",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:01:43.625022+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5029",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: LRRC6 were changed from to Ciliary dyskinesia, primary, 19, MIM# 614935",
"entity_name": "LRRC6",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:01:25.163419+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5028",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: LRRC6 were set to ",
"entity_name": "LRRC6",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:01:12.966836+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.145",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: LRRC6 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "LRRC6",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:01:08.355059+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5027",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: LRRC6 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "LRRC6",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:00:43.541030+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5026",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: LRRC6: Rating: GREEN; Mode of pathogenicity: None; Publications: 23122589, 23891469, 32622824, 29511670; Phenotypes: Ciliary dyskinesia, primary, 19, MIM# 614935; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "LRRC6",
"entity_type": "gene"
},
{
"created": "2020-10-18T21:00:39.694849+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.144",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: LRRC6: Rating: GREEN; Mode of pathogenicity: None; Publications: 23122589, 23891469, 32622824, 29511670; Phenotypes: Ciliary dyskinesia, primary, 19, MIM# 614935; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "LRRC6",
"entity_type": "gene"
},
{
"created": "2020-10-18T20:59:15.249256+11:00",
"panel_name": "Ciliary Dyskinesia",
"panel_id": 82,
"panel_version": "0.181",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: LRRC6 as ready",
"entity_name": "LRRC6",
"entity_type": "gene"
},
{
"created": "2020-10-18T20:59:15.227826+11:00",
"panel_name": "Ciliary Dyskinesia",
"panel_id": 82,
"panel_version": "0.181",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: lrrc6 has been classified as Green List (High Evidence).",
"entity_name": "LRRC6",
"entity_type": "gene"
},
{
"created": "2020-10-18T20:59:12.945922+11:00",
"panel_name": "Ciliary Dyskinesia",
"panel_id": 82,
"panel_version": "0.181",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: LRRC6 were changed from to Ciliary dyskinesia, primary, 19, MIM# 614935",
"entity_name": "LRRC6",
"entity_type": "gene"
},
{
"created": "2020-10-18T20:58:46.870196+11:00",
"panel_name": "Ciliary Dyskinesia",
"panel_id": 82,
"panel_version": "0.180",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: LRRC6 were set to ",
"entity_name": "LRRC6",
"entity_type": "gene"
},
{
"created": "2020-10-18T20:58:20.141874+11:00",
"panel_name": "Ciliary Dyskinesia",
"panel_id": 82,
"panel_version": "0.179",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: LRRC6 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "LRRC6",
"entity_type": "gene"
},
{
"created": "2020-10-18T20:57:52.877942+11:00",
"panel_name": "Ciliary Dyskinesia",
"panel_id": 82,
"panel_version": "0.178",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: LRRC6: Rating: GREEN; Mode of pathogenicity: None; Publications: 23122589, 23891469, 32622824, 29511670; Phenotypes: Ciliary dyskinesia, primary, 19, MIM# 614935; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "LRRC6",
"entity_type": "gene"
},
{
"created": "2020-10-18T20:55:44.990826+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5026",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: GAS8 as ready",
"entity_name": "GAS8",
"entity_type": "gene"
},
{
"created": "2020-10-18T20:55:44.983477+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5026",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: gas8 has been classified as Green List (High Evidence).",
"entity_name": "GAS8",
"entity_type": "gene"
},
{
"created": "2020-10-18T20:55:37.514178+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5026",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: GAS8 were changed from to Ciliary dyskinesia, primary, 33, MIM#616726",
"entity_name": "GAS8",
"entity_type": "gene"
},
{
"created": "2020-10-18T20:54:45.503479+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5025",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: GAS8 were set to ",
"entity_name": "GAS8",
"entity_type": "gene"
},
{
"created": "2020-10-18T20:54:26.187765+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5024",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: GAS8 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "GAS8",
"entity_type": "gene"
},
{
"created": "2020-10-18T20:54:08.155021+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.5023",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: GAS8: Rating: GREEN; Mode of pathogenicity: None; Publications: 26387594, 27120127; Phenotypes: Ciliary dyskinesia, primary, 33, mIM# 616726; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "GAS8",
"entity_type": "gene"
},
{
"created": "2020-10-18T20:53:20.642248+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.144",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: DNAI2 as ready",
"entity_name": "DNAI2",
"entity_type": "gene"
},
{
"created": "2020-10-18T20:53:20.634489+11:00",
"panel_name": "Heterotaxy",
"panel_id": 108,
"panel_version": "0.144",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: dnai2 has been classified as Green List (High Evidence).",
"entity_name": "DNAI2",
"entity_type": "gene"
},
{
"created": "2020-10-18T20:53:13.324690+11:00",
"panel_name": "Ciliary Dyskinesia",
"panel_id": 82,
"panel_version": "0.178",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: GAS8 as ready",
"entity_name": "GAS8",
"entity_type": "gene"
},
{
"created": "2020-10-18T20:53:13.314718+11:00",
"panel_name": "Ciliary Dyskinesia",
"panel_id": 82,
"panel_version": "0.178",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: gas8 has been classified as Green List (High Evidence).",
"entity_name": "GAS8",
"entity_type": "gene"
},
{
"created": "2020-10-18T20:53:10.031853+11:00",
"panel_name": "Ciliary Dyskinesia",
"panel_id": 82,
"panel_version": "0.178",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: GAS8 were changed from to Ciliary dyskinesia, primary, 33, mIM# 616726",
"entity_name": "GAS8",
"entity_type": "gene"
},
{
"created": "2020-10-18T20:52:46.692724+11:00",
"panel_name": "Ciliary Dyskinesia",
"panel_id": 82,
"panel_version": "0.177",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: GAS8 were set to ",
"entity_name": "GAS8",
"entity_type": "gene"
}
]
}