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{
"count": 220790,
"next": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1597",
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"results": [
{
"created": "2020-09-11T21:12:36.099459+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.67",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: RIT1: Rating: GREEN; Mode of pathogenicity: Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments; Publications: 23791108, 25124994, 24939608, 27101134; Phenotypes: Noonan syndrome 8, MIM# 615355; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "RIT1",
"entity_type": "gene"
},
{
"created": "2020-09-11T21:06:06.999173+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.67",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: RAF1 as ready",
"entity_name": "RAF1",
"entity_type": "gene"
},
{
"created": "2020-09-11T21:06:06.965902+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.67",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: raf1 has been classified as Green List (High Evidence).",
"entity_name": "RAF1",
"entity_type": "gene"
},
{
"created": "2020-09-11T21:06:03.652327+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.67",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: RAF1 were changed from to Noonan syndrome 5, MIM# 611553",
"entity_name": "RAF1",
"entity_type": "gene"
},
{
"created": "2020-09-11T21:05:38.942719+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.66",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: RAF1 were set to ",
"entity_name": "RAF1",
"entity_type": "gene"
},
{
"created": "2020-09-11T21:05:09.037263+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.65",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: RAF1 was changed from to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments",
"entity_name": "RAF1",
"entity_type": "gene"
},
{
"created": "2020-09-11T21:04:44.600799+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.64",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: RAF1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "RAF1",
"entity_type": "gene"
},
{
"created": "2020-09-11T21:04:16.887229+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.63",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: RAF1: Rating: GREEN; Mode of pathogenicity: Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments; Publications: 17603483, 17603482, 31145547, 31030682, 29271604; Phenotypes: Noonan syndrome 5, MIM# 611553; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "RAF1",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:59:26.140399+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4347",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NRAS as ready",
"entity_name": "NRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:59:26.129681+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4347",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nras has been classified as Green List (High Evidence).",
"entity_name": "NRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:59:19.491956+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4347",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: NRAS were changed from to Noonan syndrome 6, MIM# 613224",
"entity_name": "NRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:59:01.982676+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4346",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: NRAS were set to ",
"entity_name": "NRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:58:45.837075+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4345",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: NRAS was changed from to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments",
"entity_name": "NRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:57:52.375393+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4344",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: NRAS was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "NRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:54:26.191901+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4343",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: NRAS: Rating: GREEN; Mode of pathogenicity: Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments; Publications: 19966803, 26467218, 28594414; Phenotypes: Noonan syndrome 6, MIM# 613224; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "NRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:53:29.213797+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.63",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NRAS as ready",
"entity_name": "NRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:53:29.202751+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.63",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nras has been classified as Green List (High Evidence).",
"entity_name": "NRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:53:26.288706+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.63",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: NRAS were changed from to Noonan syndrome 6, MIM# 613224",
"entity_name": "NRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:53:04.382673+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.62",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: NRAS were set to ",
"entity_name": "NRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:47:29.644759+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.61",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: NRAS was changed from to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments",
"entity_name": "NRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:47:05.500036+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.60",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: NRAS was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "NRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:46:37.388196+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.59",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: NRAS: Rating: GREEN; Mode of pathogenicity: Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments; Publications: 19966803, 26467218, 28594414; Phenotypes: Noonan syndrome 6, MIM# 613224; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "NRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:44:04.836336+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.59",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NF1 as ready",
"entity_name": "NF1",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:44:04.824806+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.59",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nf1 has been classified as Green List (High Evidence).",
"entity_name": "NF1",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:44:01.483533+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.59",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: NF1 were changed from to Neurofibromatosis, type 1, MIM# 162200; Neurofibromatosis-Noonan syndrome, MIM# 601321",
"entity_name": "NF1",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:42:57.416689+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.58",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: NF1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "NF1",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:42:29.824048+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.57",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: NF1: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Neurofibromatosis, type 1, MIM# 162200, Neurofibromatosis-Noonan syndrome, MIM# 601321; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "NF1",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:41:07.501945+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4343",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: MAP2K2 as ready",
"entity_name": "MAP2K2",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:41:07.491219+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4343",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: map2k2 has been classified as Green List (High Evidence).",
"entity_name": "MAP2K2",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:41:01.177742+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4343",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: MAP2K2 were changed from to Cardiofaciocutaneous syndrome 4, MIM# 615280",
"entity_name": "MAP2K2",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:40:42.950629+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4342",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: MAP2K2 were set to ",
"entity_name": "MAP2K2",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:40:24.062610+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4341",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: MAP2K2 was changed from to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments",
"entity_name": "MAP2K2",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:40:07.768837+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4340",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: MAP2K2 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "MAP2K2",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:39:46.477092+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4339",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: MAP2K2: Rating: GREEN; Mode of pathogenicity: Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments; Publications: 20358587, 16439621, 18042262; Phenotypes: Cardiofaciocutaneous syndrome 4, MIM# 615280; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "MAP2K2",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:38:31.040245+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.57",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: MAP2K2 as ready",
"entity_name": "MAP2K2",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:38:31.029442+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.57",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: map2k2 has been classified as Green List (High Evidence).",
"entity_name": "MAP2K2",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:38:27.239011+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.57",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: MAP2K2 were changed from to Cardiofaciocutaneous syndrome 4, MIM# 615280",
"entity_name": "MAP2K2",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:38:04.218219+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.56",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: MAP2K2 were set to ",
"entity_name": "MAP2K2",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:37:38.101860+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.55",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: MAP2K2 was changed from to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments",
"entity_name": "MAP2K2",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:37:11.915471+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.54",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: MAP2K2 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "MAP2K2",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:36:43.186556+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.53",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: MAP2K2: Rating: GREEN; Mode of pathogenicity: Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments; Publications: 20358587, 16439621, 18042262; Phenotypes: Cardiofaciocutaneous syndrome 4, MIM# 615280; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "MAP2K2",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:34:45.288851+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4339",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: MAP2K1 as ready",
"entity_name": "MAP2K1",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:34:45.266357+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4339",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: map2k1 has been classified as Green List (High Evidence).",
"entity_name": "MAP2K1",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:34:38.704282+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4339",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: MAP2K1 were changed from to Cardiofaciocutaneous syndrome 3, MIM# 615279",
"entity_name": "MAP2K1",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:34:21.161630+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4338",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: MAP2K1 were set to ",
"entity_name": "MAP2K1",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:34:04.913925+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4337",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: MAP2K1 was changed from to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments",
"entity_name": "MAP2K1",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:33:48.955649+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4336",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: MAP2K1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "MAP2K1",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:33:31.216545+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4335",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: MAP2K1: Rating: GREEN; Mode of pathogenicity: Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments; Publications: 16439621, 17551924, 18042262, 20301365; Phenotypes: Cardiofaciocutaneous syndrome 3, MIM# 615279; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "MAP2K1",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:32:30.108367+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.53",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: MAP2K1 as ready",
"entity_name": "MAP2K1",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:32:30.098752+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.53",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: map2k1 has been classified as Green List (High Evidence).",
"entity_name": "MAP2K1",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:32:27.731939+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.53",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: MAP2K1 were changed from to Cardiofaciocutaneous syndrome 3, MIM# 615279",
"entity_name": "MAP2K1",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:32:11.110005+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.52",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: MAP2K1 were set to ",
"entity_name": "MAP2K1",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:31:43.455391+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.51",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: MAP2K1 was changed from to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments",
"entity_name": "MAP2K1",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:31:18.616265+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.50",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: MAP2K1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "MAP2K1",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:30:50.790613+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.49",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: MAP2K1: Rating: GREEN; Mode of pathogenicity: Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments; Publications: 16439621, 17551924, 18042262, 20301365; Phenotypes: Cardiofaciocutaneous syndrome 3, MIM# 615279; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "MAP2K1",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:27:39.962580+10:00",
"panel_name": "Cardiomyopathy_Paediatric",
"panel_id": 3270,
"panel_version": "0.9",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: KRAS as ready",
"entity_name": "KRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:27:39.954341+10:00",
"panel_name": "Cardiomyopathy_Paediatric",
"panel_id": 3270,
"panel_version": "0.9",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: kras has been classified as Green List (High Evidence).",
"entity_name": "KRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:27:32.115712+10:00",
"panel_name": "Cardiomyopathy_Paediatric",
"panel_id": 3270,
"panel_version": "0.9",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: KRAS were changed from Noonan syndrome 3; Cardiofaciocutaneous Syndrome; Cardio-Facio-Cutaneous syndrome; Cardiofaciocutaneous syndrome 2 615278; Cardiofaciocutaneous syndrome 2; CFC syndrome; Noonan syndrome; Noonan syndrome 3 609942 to Cardiofaciocutaneous syndrome 2, MIM# 615278; Noonan syndrome 3, MIM# 609942",
"entity_name": "KRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:25:36.974863+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.49",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: KRAS as ready",
"entity_name": "KRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:25:36.965583+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.49",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: kras has been classified as Green List (High Evidence).",
"entity_name": "KRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:25:33.447593+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.49",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: KRAS were changed from to Noonan syndrome 3, MIM# 609942; Cardiofaciocutaneous syndrome 2, MIM# 615278",
"entity_name": "KRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:25:07.094577+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.48",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: KRAS were set to 16474404; 16474405; 16773572; 17056636",
"entity_name": "KRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:24:32.753475+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.47",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: KRAS: Changed publications: 21797849, 16474404, 16474405, 16773572, 17056636",
"entity_name": "KRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:24:03.542767+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.47",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: KRAS: Changed publications: 21797849",
"entity_name": "KRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:23:46.655558+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.47",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: KRAS were set to ",
"entity_name": "KRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:23:24.687191+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.46",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: KRAS was changed from to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments",
"entity_name": "KRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:23:04.019259+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.45",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: KRAS was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "KRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:22:36.457051+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.44",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: KRAS: Rating: GREEN; Mode of pathogenicity: None; Publications: 16474404, 16474405, 16773572, 17056636; Phenotypes: Noonan syndrome 3, MIM# 609942, Cardiofaciocutaneous syndrome 2, MIM# 615278; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "KRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:17:47.349875+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2987",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: HRAS as ready",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:17:47.339439+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2987",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: hras has been classified as Green List (High Evidence).",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:17:42.871573+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2987",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: HRAS were changed from to Costello syndrome, MIM# 218040",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:17:17.415718+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2986",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: HRAS were set to ",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:16:53.864411+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2985",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: HRAS was changed from to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:16:34.377147+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2984",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: HRAS was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:16:07.581057+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2983",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: HRAS: Rating: GREEN; Mode of pathogenicity: Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments; Publications: 16329078, 16372351, 16443854; Phenotypes: Costello syndrome, MIM# 218040; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:15:08.418449+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4335",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: HRAS as ready",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:15:08.408157+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4335",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: hras has been classified as Green List (High Evidence).",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:15:00.690574+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4335",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: HRAS were changed from to Costello syndrome, MIM# 218040",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:14:43.433384+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4334",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: HRAS were set to ",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:14:24.549953+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4333",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: HRAS was changed from to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:14:08.468071+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4332",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: HRAS was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:13:52.130407+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4331",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: HRAS: Rating: GREEN; Mode of pathogenicity: Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments; Publications: 16329078, 16372351, 16443854; Phenotypes: Costello syndrome, MIM# 218040; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:12:53.413546+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.44",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: HRAS as ready",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:12:53.403869+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.44",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: hras has been classified as Green List (High Evidence).",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:12:50.757258+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.44",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: HRAS were changed from to Costello syndrome, MIM# 218040",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:12:23.933953+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.43",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: HRAS was changed from to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:12:01.561979+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.42",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: HRAS were set to ",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:11:38.859502+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.41",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: HRAS was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:11:10.799578+10:00",
"panel_name": "Rasopathy",
"panel_id": 164,
"panel_version": "0.40",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: HRAS: Rating: GREEN; Mode of pathogenicity: Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments; Publications: 16329078, 16372351, 16443854; Phenotypes: Costello syndrome, MIM# 218040; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:06:48.420781+10:00",
"panel_name": "Hydrops fetalis",
"panel_id": 116,
"panel_version": "0.193",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: CBL as ready",
"entity_name": "CBL",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:06:48.407586+10:00",
"panel_name": "Hydrops fetalis",
"panel_id": 116,
"panel_version": "0.193",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: cbl has been classified as Green List (High Evidence).",
"entity_name": "CBL",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:06:46.102448+10:00",
"panel_name": "Hydrops fetalis",
"panel_id": 116,
"panel_version": "0.193",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: CBL were changed from to Noonan syndrome-like disorder with or without juvenile myelomonocytic leukaemia, MIM# 613563",
"entity_name": "CBL",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:06:19.753324+10:00",
"panel_name": "Hydrops fetalis",
"panel_id": 116,
"panel_version": "0.192",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: CBL were set to ",
"entity_name": "CBL",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:05:57.688031+10:00",
"panel_name": "Hydrops fetalis",
"panel_id": 116,
"panel_version": "0.191",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: CBL was changed from to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments",
"entity_name": "CBL",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:05:32.492700+10:00",
"panel_name": "Hydrops fetalis",
"panel_id": 116,
"panel_version": "0.190",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: CBL was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "CBL",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:05:02.519564+10:00",
"panel_name": "Hydrops fetalis",
"panel_id": 116,
"panel_version": "0.189",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: CBL: Rating: GREEN; Mode of pathogenicity: Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments; Publications: 25358541, 20619386, 20543203, 20694012; Phenotypes: Noonan syndrome-like disorder with or without juvenile myelomonocytic leukaemia, MIM# 613563; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "CBL",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:02:33.240551+10:00",
"panel_name": "Cancer Predisposition_Paediatric",
"panel_id": 152,
"panel_version": "0.87",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: CBL as ready",
"entity_name": "CBL",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:02:33.229662+10:00",
"panel_name": "Cancer Predisposition_Paediatric",
"panel_id": 152,
"panel_version": "0.87",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: cbl has been classified as Green List (High Evidence).",
"entity_name": "CBL",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:02:30.465854+10:00",
"panel_name": "Cancer Predisposition_Paediatric",
"panel_id": 152,
"panel_version": "0.87",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: CBL were changed from to Noonan syndrome-like disorder with or without juvenile myelomonocytic leukaemia, MIM# 613563",
"entity_name": "CBL",
"entity_type": "gene"
},
{
"created": "2020-09-11T20:02:12.751055+10:00",
"panel_name": "Cancer Predisposition_Paediatric",
"panel_id": 152,
"panel_version": "0.86",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: CBL were set to ",
"entity_name": "CBL",
"entity_type": "gene"
}
]
}