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{
"count": 220959,
"next": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1623",
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"results": [
{
"created": "2020-08-31T22:06:25.125466+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.238",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: OSGEP were changed from to Galloway-Mowat syndrome 3, MIM# 617729",
"entity_name": "OSGEP",
"entity_type": "gene"
},
{
"created": "2020-08-31T22:05:59.340388+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.237",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: OSGEP were set to ",
"entity_name": "OSGEP",
"entity_type": "gene"
},
{
"created": "2020-08-31T22:05:24.358878+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.236",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: OSGEP was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "OSGEP",
"entity_type": "gene"
},
{
"created": "2020-08-31T22:04:58.104905+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.235",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: OSGEP: Rating: GREEN; Mode of pathogenicity: None; Publications: 28805828, 28272532; Phenotypes: Galloway-Mowat syndrome 3, MIM# 617729; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "OSGEP",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:59:24.659379+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4045",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Tag founder tag was added to gene: NUP107.",
"entity_name": "NUP107",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:59:00.634783+10:00",
"panel_name": "Proteinuria",
"panel_id": 144,
"panel_version": "0.118",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NUP107 as ready",
"entity_name": "NUP107",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:59:00.615717+10:00",
"panel_name": "Proteinuria",
"panel_id": 144,
"panel_version": "0.118",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nup107 has been classified as Green List (High Evidence).",
"entity_name": "NUP107",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:58:57.711188+10:00",
"panel_name": "Proteinuria",
"panel_id": 144,
"panel_version": "0.118",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: NUP107 were changed from to Galloway-Mowat syndrome 7, MIM# 618348",
"entity_name": "NUP107",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:58:35.797318+10:00",
"panel_name": "Proteinuria",
"panel_id": 144,
"panel_version": "0.117",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: NUP107 were set to ",
"entity_name": "NUP107",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:58:09.318086+10:00",
"panel_name": "Proteinuria",
"panel_id": 144,
"panel_version": "0.116",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: NUP107 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "NUP107",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:57:48.832316+10:00",
"panel_name": "Proteinuria",
"panel_id": 144,
"panel_version": "0.115",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Tag founder tag was added to gene: NUP107.",
"entity_name": "NUP107",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:57:39.831879+10:00",
"panel_name": "Proteinuria",
"panel_id": 144,
"panel_version": "0.115",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: NUP107: Rating: GREEN; Mode of pathogenicity: None; Publications: 28280135, 28117080, 30179222, 25558065; Phenotypes: Galloway-Mowat syndrome 7, MIM# 618348; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "NUP107",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:57:04.853804+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4045",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NUP107 as ready",
"entity_name": "NUP107",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:57:04.843292+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4045",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nup107 has been classified as Green List (High Evidence).",
"entity_name": "NUP107",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:56:58.864096+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4045",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: NUP107 were changed from to Galloway-Mowat syndrome 7, MIM# 618348",
"entity_name": "NUP107",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:56:44.382292+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4044",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: NUP107 were set to ",
"entity_name": "NUP107",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:56:29.448895+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4043",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: NUP107 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "NUP107",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:56:12.187730+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4042",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: NUP107: Rating: GREEN; Mode of pathogenicity: None; Publications: 28280135, 28117080, 30179222, 25558065; Phenotypes: Galloway-Mowat syndrome 7, MIM# 618348; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "NUP107",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:55:12.561140+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.235",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NUP107 as ready",
"entity_name": "NUP107",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:55:12.552720+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.235",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nup107 has been classified as Green List (High Evidence).",
"entity_name": "NUP107",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:55:08.400517+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.235",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Tag founder tag was added to gene: NUP107.",
"entity_name": "NUP107",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:55:00.235624+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.235",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: NUP107 were changed from to Galloway-Mowat syndrome 7, MIM# 618348",
"entity_name": "NUP107",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:54:43.367473+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.234",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: NUP107 were set to ",
"entity_name": "NUP107",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:54:06.646555+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.233",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: NUP107 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "NUP107",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:53:37.232951+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.232",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: NUP107: Rating: GREEN; Mode of pathogenicity: None; Publications: 28280135, 28117080, 30179222, 25558065; Phenotypes: Galloway-Mowat syndrome 7, MIM# 618348; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "NUP107",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:25:02.088682+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.232",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: VRK1 as ready",
"entity_name": "VRK1",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:25:02.068922+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.232",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: vrk1 has been classified as Green List (High Evidence).",
"entity_name": "VRK1",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:24:16.821936+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.232",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: VRK1 were changed from to Pontocerebellar hypoplasia type 1A MIM#607596",
"entity_name": "VRK1",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:23:57.950214+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.231",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: VRK1 were set to ",
"entity_name": "VRK1",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:23:25.483042+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.230",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: VRK1 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "VRK1",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:19:25.534824+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.229",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: BRD4 as ready",
"entity_name": "BRD4",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:19:25.526301+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.229",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: brd4 has been classified as Amber List (Moderate Evidence).",
"entity_name": "BRD4",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:19:22.408042+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.229",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Tag SV/CNV tag was added to gene: BRD4.",
"entity_name": "BRD4",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:19:15.056184+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.229",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: BRD4 were changed from to Cornelia de Lange-like syndrome",
"entity_name": "BRD4",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:18:52.553523+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.228",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: BRD4 were set to ",
"entity_name": "BRD4",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:18:25.995534+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.227",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: BRD4 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "BRD4",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:18:05.526857+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.226",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: BRD4 as Amber List (moderate evidence)",
"entity_name": "BRD4",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:18:05.516184+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.226",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: brd4 has been classified as Amber List (Moderate Evidence).",
"entity_name": "BRD4",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:16:59.778762+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.225",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: WDR4 as ready",
"entity_name": "WDR4",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:16:59.767909+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.225",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: wdr4 has been classified as Green List (High Evidence).",
"entity_name": "WDR4",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:16:53.914724+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.225",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: WDR4 were changed from to Galloway-Mowat syndrome 6 MIM#618347",
"entity_name": "WDR4",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:15:54.069309+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.224",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: WDR4 were set to ",
"entity_name": "WDR4",
"entity_type": "gene"
},
{
"created": "2020-08-31T21:15:08.837263+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.223",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: WDR4 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "WDR4",
"entity_type": "gene"
},
{
"created": "2020-08-31T19:05:55.729791+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2908",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NSD2 as ready",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2020-08-31T19:05:55.720712+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2908",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nsd2 has been classified as Green List (High Evidence).",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2020-08-31T19:05:50.966486+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2908",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: NSD2 were set to ",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2020-08-31T19:05:17.392096+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2907",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: NSD2 were changed from to Microcephaly; intellectual disability",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2020-08-31T19:04:14.288000+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.222",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NSD2 as ready",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2020-08-31T19:04:14.279118+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.222",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nsd2 has been classified as Green List (High Evidence).",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2020-08-31T19:03:14.489571+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2906",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: NSD2 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2020-08-31T19:02:47.785399+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2905",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: NSD2: Rating: GREEN; Mode of pathogenicity: None; Publications: 30345613, 31171569; Phenotypes: Microcephaly, intellectual disability; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2020-08-31T19:01:56.482618+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4042",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NSD2 as ready",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2020-08-31T19:01:56.472091+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4042",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nsd2 has been classified as Green List (High Evidence).",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2020-08-31T19:01:49.795901+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4042",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: NSD2 were changed from to Microcephaly; intellectual disability",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2020-08-31T19:01:34.287969+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4041",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: NSD2 were set to ",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2020-08-31T19:01:17.499338+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4040",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: NSD2 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2020-08-31T19:01:00.724571+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4039",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "changed review comment from: Microcephaly reported in 6 of 7 individuals with LOF variants in this gene.; to: 7 individuals with LOF variants in this gene, gene thought to be responsible for key features of Wolf-Hirschorn syndrome.",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2020-08-31T19:00:21.420375+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4039",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: NSD2: Rating: GREEN; Mode of pathogenicity: None; Publications: 30345613, 31171569; Phenotypes: Microcephaly, intellectual disability; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:59:40.383518+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.222",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: NSD2 were changed from to Microcephaly; intellectual disability",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:58:57.280394+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.221",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: NSD2 were set to ",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:58:14.979959+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.220",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: NSD2 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:57:51.462503+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.219",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: NSD2: Rating: GREEN; Mode of pathogenicity: None; Publications: 30345613, 31171569; Phenotypes: Microcephaly, intellectual disability; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "NSD2",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:54:18.989675+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.219",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NIPBL as ready",
"entity_name": "NIPBL",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:54:18.977948+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.219",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nipbl has been classified as Green List (High Evidence).",
"entity_name": "NIPBL",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:54:14.990865+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.219",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: NIPBL as Green List (high evidence)",
"entity_name": "NIPBL",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:54:14.982596+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.219",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nipbl has been classified as Green List (High Evidence).",
"entity_name": "NIPBL",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:53:58.578358+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.218",
"user_name": "Paul De Fazio",
"item_type": "entity",
"text": "reviewed gene: VRK1: Rating: GREEN; Mode of pathogenicity: None; Publications: 19646678, 24126608, 27281532, 31560180; Phenotypes: Pontocerebellar hypoplasia type 1A MIM#607596; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes",
"entity_name": "VRK1",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:53:45.867525+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.218",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "gene: NIPBL was added\ngene: NIPBL was added to Microcephaly. Sources: Expert list\nMode of inheritance for gene: NIPBL was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: NIPBL were set to Cornelia de Lange syndrome 1, MIM#\t122470\nReview for gene: NIPBL was set to GREEN\nAdded comment: Well established gene-disease association, microcephaly is a prominent feature of the phenotype. \nSources: Expert list",
"entity_name": "NIPBL",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:51:53.168926+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4039",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NCAPH as ready",
"entity_name": "NCAPH",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:51:53.160034+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4039",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: ncaph has been classified as Red List (Low Evidence).",
"entity_name": "NCAPH",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:50:59.716329+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4039",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: NCAPH were changed from to Microcephaly 23, primary, autosomal recessive 617985",
"entity_name": "NCAPH",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:50:42.252539+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4038",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: NCAPH were set to ",
"entity_name": "NCAPH",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:49:23.724584+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4037",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: NCAPH was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "NCAPH",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:44:56.979130+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4036",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: NCAPH as Red List (low evidence)",
"entity_name": "NCAPH",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:44:56.968034+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4036",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: ncaph has been classified as Red List (Low Evidence).",
"entity_name": "NCAPH",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:44:40.470559+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4035",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: NCAPH: Rating: RED; Mode of pathogenicity: None; Publications: 27737959; Phenotypes: Microcephaly 23, primary, autosomal recessive 617985; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "NCAPH",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:44:08.246538+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.217",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NCAPH as ready",
"entity_name": "NCAPH",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:44:08.235530+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.217",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: ncaph has been classified as Red List (Low Evidence).",
"entity_name": "NCAPH",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:44:05.845296+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.217",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: NCAPH were changed from to Microcephaly 23, primary, autosomal recessive 617985",
"entity_name": "NCAPH",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:43:38.421859+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.216",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: NCAPH were set to ",
"entity_name": "NCAPH",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:43:17.186309+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.215",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: NCAPH was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "NCAPH",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:41:23.082086+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.214",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: NCAPH as Red List (low evidence)",
"entity_name": "NCAPH",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:41:23.067049+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.214",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: ncaph has been classified as Red List (Low Evidence).",
"entity_name": "NCAPH",
"entity_type": "gene"
},
{
"created": "2020-08-31T18:40:43.225480+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.213",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: NCAPH: Rating: RED; Mode of pathogenicity: None; Publications: 27737959; Phenotypes: Microcephaly 23, primary, autosomal recessive 617985; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "NCAPH",
"entity_type": "gene"
},
{
"created": "2020-08-31T17:42:28.219234+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.213",
"user_name": "Ain Roesley",
"item_type": "entity",
"text": "reviewed gene: BRD4: Rating: AMBER; Mode of pathogenicity: None; Publications: 29379197, 30302754; Phenotypes: Cornelia de Lange-like syndrome; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown",
"entity_name": "BRD4",
"entity_type": "gene"
},
{
"created": "2020-08-31T17:40:00.787209+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.213",
"user_name": "Paul De Fazio",
"item_type": "entity",
"text": "reviewed gene: WDR4: Rating: GREEN; Mode of pathogenicity: None; Publications: 26416026, 28617965, 30079490, 29597095; Phenotypes: Galloway-Mowat syndrome 6 MIM#618347; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes",
"entity_name": "WDR4",
"entity_type": "gene"
},
{
"created": "2020-08-31T17:00:44.406488+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.213",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NCAPD3 as ready",
"entity_name": "NCAPD3",
"entity_type": "gene"
},
{
"created": "2020-08-31T17:00:44.392621+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.213",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: ncapd3 has been classified as Amber List (Moderate Evidence).",
"entity_name": "NCAPD3",
"entity_type": "gene"
},
{
"created": "2020-08-31T17:00:42.175704+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.213",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: NCAPD3 were changed from to Microcephaly 22, primary, autosomal recessive, MIM# 617984",
"entity_name": "NCAPD3",
"entity_type": "gene"
},
{
"created": "2020-08-31T17:00:24.910857+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.212",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: NCAPD3 were set to 27737959",
"entity_name": "NCAPD3",
"entity_type": "gene"
},
{
"created": "2020-08-31T16:59:49.450236+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.211",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: BRCA2 as ready",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2020-08-31T16:59:49.438836+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.211",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: brca2 has been classified as Green List (High Evidence).",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2020-08-31T16:59:44.632362+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.211",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: BRCA2 as Green List (high evidence)",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2020-08-31T16:59:44.622354+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.211",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: brca2 has been classified as Green List (High Evidence).",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2020-08-31T16:58:19.989893+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.210",
"user_name": "Ain Roesley",
"item_type": "entity",
"text": "gene: BRCA2 was added\ngene: BRCA2 was added to Microcephaly. Sources: Literature\nMode of inheritance for gene: BRCA2 was set to BIALLELIC, autosomal or pseudoautosomal\nPhenotypes for gene: BRCA2 were set to Fanconi anemia, complementation group D1\t(MIM#605724)\nPenetrance for gene: BRCA2 were set to unknown\nReview for gene: BRCA2 was set to GREEN\nAdded comment: Approx 75% of FA patients present with microcephaly and approx 3% of FA patients have variants in BRCA2 (GeneReviews) \nSources: Literature",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2020-08-31T16:57:41.996735+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4035",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: ATRIP as ready",
"entity_name": "ATRIP",
"entity_type": "gene"
},
{
"created": "2020-08-31T16:57:41.986871+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4035",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: atrip has been classified as Red List (Low Evidence).",
"entity_name": "ATRIP",
"entity_type": "gene"
},
{
"created": "2020-08-31T16:57:27.324109+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4035",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: ATRIP as Red List (low evidence)",
"entity_name": "ATRIP",
"entity_type": "gene"
},
{
"created": "2020-08-31T16:57:27.315682+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.4035",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: atrip has been classified as Red List (Low Evidence).",
"entity_name": "ATRIP",
"entity_type": "gene"
},
{
"created": "2020-08-31T16:56:22.630734+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.210",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: WDR73 as ready",
"entity_name": "WDR73",
"entity_type": "gene"
}
]
}