HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/json
Vary: Accept
{
"count": 221304,
"next": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1686",
"previous": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1684",
"results": [
{
"created": "2020-08-07T09:40:20.108555+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3707",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: hyls1 has been classified as Green List (High Evidence).",
"entity_name": "HYLS1",
"entity_type": "gene"
},
{
"created": "2020-08-07T09:39:03.990166+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3707",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Tag founder tag was added to gene: HYLS1.",
"entity_name": "HYLS1",
"entity_type": "gene"
},
{
"created": "2020-08-07T09:38:48.072349+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3707",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: HYLS1 were changed from to Hydrolethalus syndrome (MIM#236680)",
"entity_name": "HYLS1",
"entity_type": "gene"
},
{
"created": "2020-08-07T09:38:36.329760+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3706",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: HYLS1 were set to ",
"entity_name": "HYLS1",
"entity_type": "gene"
},
{
"created": "2020-08-07T09:38:06.758380+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3705",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: HYLS1 was changed from to Other",
"entity_name": "HYLS1",
"entity_type": "gene"
},
{
"created": "2020-08-07T09:37:52.147235+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3704",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: HYLS1 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "HYLS1",
"entity_type": "gene"
},
{
"created": "2020-08-07T09:08:43.166257+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3703",
"user_name": "Melanie Marty",
"item_type": "entity",
"text": "reviewed gene: HYLS1: Rating: AMBER; Mode of pathogenicity: Other; Publications: 15843405, 18648327, 19400947, 19656802, 32509774; Phenotypes: Hydrolethalus syndrome (MIM#236680); Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "HYLS1",
"entity_type": "gene"
},
{
"created": "2020-08-06T18:00:47.505945+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.144",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: RAC1 as Amber List (moderate evidence)",
"entity_name": "RAC1",
"entity_type": "gene"
},
{
"created": "2020-08-06T18:00:47.495997+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.144",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: rac1 has been classified as Amber List (Moderate Evidence).",
"entity_name": "RAC1",
"entity_type": "gene"
},
{
"created": "2020-08-06T18:00:20.223714+10:00",
"panel_name": "Microcephaly",
"panel_id": 138,
"panel_version": "0.143",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: RAC1: Rating: AMBER; Mode of pathogenicity: None; Publications: 30042656, 29276006, 30293988; Phenotypes: Mental retardation, autosomal dominant 48, MIM# 617751; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "RAC1",
"entity_type": "gene"
},
{
"created": "2020-08-06T17:57:47.693667+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2828",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: RAC1 as ready",
"entity_name": "RAC1",
"entity_type": "gene"
},
{
"created": "2020-08-06T17:57:47.683901+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2828",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: rac1 has been classified as Green List (High Evidence).",
"entity_name": "RAC1",
"entity_type": "gene"
},
{
"created": "2020-08-06T17:57:35.420512+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2828",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: RAC1 were changed from Mental retardation, autosomal dominant 48, MIM# 617751 to Mental retardation, autosomal dominant 48, MIM# 617751",
"entity_name": "RAC1",
"entity_type": "gene"
},
{
"created": "2020-08-06T17:57:22.219650+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2827",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: RAC1 were changed from Mental retardation, autosomal dominant 48 617751 to Mental retardation, autosomal dominant 48, MIM# 617751",
"entity_name": "RAC1",
"entity_type": "gene"
},
{
"created": "2020-08-06T17:57:03.327154+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2827",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: RAC1 were changed from to Mental retardation, autosomal dominant 48 617751",
"entity_name": "RAC1",
"entity_type": "gene"
},
{
"created": "2020-08-06T17:56:36.413784+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2826",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: RAC1 were set to ",
"entity_name": "RAC1",
"entity_type": "gene"
},
{
"created": "2020-08-06T17:55:23.428523+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2825",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: RAC1 was changed from to Other",
"entity_name": "RAC1",
"entity_type": "gene"
},
{
"created": "2020-08-06T17:54:59.389862+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2824",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: RAC1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "RAC1",
"entity_type": "gene"
},
{
"created": "2020-08-06T17:54:21.526228+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2823",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: RAC1: Changed phenotypes: Mental retardation, autosomal dominant 48 617751",
"entity_name": "RAC1",
"entity_type": "gene"
},
{
"created": "2020-08-06T17:54:15.225574+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3703",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: RAC1 were changed from Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies (MIM#618577), AD to Mental retardation, autosomal dominant 48, MIM#\t617751",
"entity_name": "RAC1",
"entity_type": "gene"
},
{
"created": "2020-08-06T17:53:26.131584+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2823",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: RAC1: Rating: GREEN; Mode of pathogenicity: Other; Publications: 30042656, 29276006, 30293988; Phenotypes: Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies (MIM#618577), AD; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "RAC1",
"entity_type": "gene"
},
{
"created": "2020-08-06T17:49:22.199990+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3702",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: RAC1 as ready",
"entity_name": "RAC1",
"entity_type": "gene"
},
{
"created": "2020-08-06T17:49:22.192254+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3702",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: rac1 has been classified as Green List (High Evidence).",
"entity_name": "RAC1",
"entity_type": "gene"
},
{
"created": "2020-08-06T17:49:15.617895+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3702",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: RAC1 were changed from to Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies (MIM#618577), AD",
"entity_name": "RAC1",
"entity_type": "gene"
},
{
"created": "2020-08-06T17:49:00.177309+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3701",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: RAC1 were set to ",
"entity_name": "RAC1",
"entity_type": "gene"
},
{
"created": "2020-08-06T17:48:42.767337+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3700",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: RAC1 was changed from to Other",
"entity_name": "RAC1",
"entity_type": "gene"
},
{
"created": "2020-08-06T17:48:27.918762+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3699",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: RAC1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "RAC1",
"entity_type": "gene"
},
{
"created": "2020-08-06T17:29:42.425501+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3698",
"user_name": "Kristin Rigbye",
"item_type": "entity",
"text": "reviewed gene: RAC1: Rating: GREEN; Mode of pathogenicity: Other; Publications: PMID: 30042656, 29276006, 30293988; Phenotypes: Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies (MIM#618577), AD; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "RAC1",
"entity_type": "gene"
},
{
"created": "2020-08-06T16:02:09.163922+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3698",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: FANCD2 as ready",
"entity_name": "FANCD2",
"entity_type": "gene"
},
{
"created": "2020-08-06T16:02:09.152840+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3698",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: fancd2 has been classified as Green List (High Evidence).",
"entity_name": "FANCD2",
"entity_type": "gene"
},
{
"created": "2020-08-06T16:01:45.839480+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3698",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: FANCD2 were changed from to Fanconi anemia, complementation group D2, MIM#227646",
"entity_name": "FANCD2",
"entity_type": "gene"
},
{
"created": "2020-08-06T16:01:23.481612+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3697",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: FANCD2 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "FANCD2",
"entity_type": "gene"
},
{
"created": "2020-08-06T15:16:32.938938+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3696",
"user_name": "Michelle Torres",
"item_type": "entity",
"text": "reviewed gene: FANCD2: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Fanconi anemia, complementation group D2, MIM#227646; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "FANCD2",
"entity_type": "gene"
},
{
"created": "2020-08-06T14:14:55.254443+10:00",
"panel_name": "Cardiomyopathy_Adult_SuperPanel",
"panel_id": 253,
"panel_version": "0.309",
"user_name": "Zornitza Stark",
"item_type": "panel",
"text": "Panel name changed from Cardiomyopathy_SuperPanel to Cardiomyopathy_Adult_SuperPanel\nChanged child panels to: Hypertrophic cardiomyopathy_HCM; Dilated Cardiomyopathy; Arrhythmogenic Cardiomyopathy",
"entity_name": null,
"entity_type": null
},
{
"created": "2020-08-06T07:14:30.293341+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.179",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: BCOR as ready",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T07:14:30.281476+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.179",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: bcor has been classified as Red List (Low Evidence).",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T07:14:27.227332+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.179",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: BCOR were changed from to Microphthalmia, syndromic 2, MIM# 300166; Oculofaciocardiodental syndrome; Lenz microphthalmia",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T07:14:01.142585+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.178",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: BCOR were set to ",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T07:13:36.591940+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.177",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: BCOR was changed from Unknown to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T07:13:14.861889+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.176",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: BCOR as Red List (low evidence)",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T07:13:14.851305+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.176",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: bcor has been classified as Red List (Low Evidence).",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T07:12:47.337585+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.175",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: BCOR: Rating: RED; Mode of pathogenicity: None; Publications: 29974297; Phenotypes: Microphthalmia, syndromic 2, MIM# 300166, Oculofaciocardiodental syndrome, Lenz microphthalmia; Mode of inheritance: X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T07:03:49.008088+10:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.55",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: BCOR as ready",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T07:03:48.993995+10:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.55",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: bcor has been classified as Green List (High Evidence).",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T07:03:46.062695+10:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.55",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: BCOR were changed from to Microphthalmia, syndromic 2, MIM# 300166; Oculofaciocardiodental syndrome; Lenz microphthalmia",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T07:03:28.700392+10:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.54",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: BCOR were set to ",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T07:03:08.080978+10:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.53",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: BCOR was changed from Unknown to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T07:02:43.903990+10:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.52",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: BCOR: Rating: GREEN; Mode of pathogenicity: None; Publications: 29974297; Phenotypes: Microphthalmia, syndromic 2, MIM# 300166, Oculofaciocardiodental syndrome, Lenz microphthalmia; Mode of inheritance: X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T07:02:04.141752+10:00",
"panel_name": "Cataract",
"panel_id": 66,
"panel_version": "0.225",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: BCOR as ready",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T07:02:04.133180+10:00",
"panel_name": "Cataract",
"panel_id": 66,
"panel_version": "0.225",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: bcor has been classified as Green List (High Evidence).",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T07:02:01.607627+10:00",
"panel_name": "Cataract",
"panel_id": 66,
"panel_version": "0.225",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: BCOR were changed from to Microphthalmia, syndromic 2, MIM# 300166; Oculofaciocardiodental syndrome; Lenz microphthalmia",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T07:01:26.279923+10:00",
"panel_name": "Cataract",
"panel_id": 66,
"panel_version": "0.224",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: BCOR were set to ",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T07:01:03.275284+10:00",
"panel_name": "Cataract",
"panel_id": 66,
"panel_version": "0.223",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: BCOR was changed from Unknown to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T07:00:37.721132+10:00",
"panel_name": "Cataract",
"panel_id": 66,
"panel_version": "0.222",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: BCOR: Rating: GREEN; Mode of pathogenicity: None; Publications: 29974297; Phenotypes: Microphthalmia, syndromic 2, MIM# 300166, Oculofaciocardiodental syndrome, Lenz microphthalmia; Mode of inheritance: X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:59:49.865719+10:00",
"panel_name": "Anophthalmia_Microphthalmia_Coloboma",
"panel_id": 42,
"panel_version": "0.65",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: BCOR as ready",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:59:49.854444+10:00",
"panel_name": "Anophthalmia_Microphthalmia_Coloboma",
"panel_id": 42,
"panel_version": "0.65",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: bcor has been classified as Green List (High Evidence).",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:59:46.742929+10:00",
"panel_name": "Anophthalmia_Microphthalmia_Coloboma",
"panel_id": 42,
"panel_version": "0.65",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: BCOR were changed from to Microphthalmia, syndromic 2, MIM# 300166; Oculofaciocardiodental syndrome; Lenz microphthalmia",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:59:26.856724+10:00",
"panel_name": "Anophthalmia_Microphthalmia_Coloboma",
"panel_id": 42,
"panel_version": "0.64",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: BCOR were set to ",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:58:58.074802+10:00",
"panel_name": "Anophthalmia_Microphthalmia_Coloboma",
"panel_id": 42,
"panel_version": "0.63",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: BCOR was changed from Unknown to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:58:30.107763+10:00",
"panel_name": "Anophthalmia_Microphthalmia_Coloboma",
"panel_id": 42,
"panel_version": "0.62",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: BCOR: Rating: GREEN; Mode of pathogenicity: None; Publications: 29974297; Phenotypes: Microphthalmia, syndromic 2, MIM# 300166, Oculofaciocardiodental syndrome, Lenz microphthalmia; Mode of inheritance: X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:57:44.734078+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3696",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: BCOR as ready",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:57:44.725118+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3696",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: bcor has been classified as Green List (High Evidence).",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:57:38.637396+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3696",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: BCOR were changed from to Microphthalmia, syndromic 2, MIM# 300166; Oculofaciocardiodental syndrome; Lenz microphthalmia",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:57:21.609263+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3695",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: BCOR were set to ",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:57:04.335925+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3694",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: BCOR was changed from Unknown to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:56:47.401479+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3693",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: BCOR: Rating: GREEN; Mode of pathogenicity: None; Publications: 29974297; Phenotypes: Microphthalmia, syndromic 2, MIM# 300166, Oculofaciocardiodental syndrome, Lenz microphthalmia; Mode of inheritance: X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:55:04.722761+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2823",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: BCOR as ready",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:55:04.712637+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2823",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: bcor has been classified as Green List (High Evidence).",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:55:00.937271+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2823",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: BCOR were changed from to Microphthalmia, syndromic 2, MIM# 300166; Oculofaciocardiodental syndrome; Lenz microphthalmia",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:54:36.758644+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2822",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: BCOR were set to ",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:54:09.282464+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2821",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: BCOR was changed from Unknown to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:53:34.870649+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2820",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: BCOR: Rating: GREEN; Mode of pathogenicity: None; Publications: 29974297; Phenotypes: Microphthalmia, syndromic 2, MIM# 300166, Oculofaciocardiodental syndrome, Lenz microphthalmia; Mode of inheritance: X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)",
"entity_name": "BCOR",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:33:08.519806+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3693",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: SLC25A10 were changed from Intractable epileptic encephalopathy to Intractable epileptic encephalopathy; Mitochondrial DNA depletion syndrome 19, MIM# 618972",
"entity_name": "SLC25A10",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:32:48.133422+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.3692",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: SLC25A10: Changed phenotypes: Intractable epileptic encephalopathy, Mitochondrial DNA depletion syndrome 19, MIM# 618972",
"entity_name": "SLC25A10",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:32:27.785913+10:00",
"panel_name": "Mitochondrial disease",
"panel_id": 203,
"panel_version": "0.459",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: SLC25A10 were changed from Intractable epileptic encephalopathy to Intractable epileptic encephalopathy; Mitochondrial DNA depletion syndrome 19, MIM# 618972",
"entity_name": "SLC25A10",
"entity_type": "gene"
},
{
"created": "2020-08-06T06:31:53.873067+10:00",
"panel_name": "Mitochondrial disease",
"panel_id": 203,
"panel_version": "0.458",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: SLC25A10: Rating: AMBER; Mode of pathogenicity: None; Publications: 29211846; Phenotypes: Mitochondrial DNA depletion syndrome 19, MIM# 618972; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "SLC25A10",
"entity_type": "gene"
},
{
"created": "2020-08-05T18:37:02.700139+10:00",
"panel_name": "Cardiomyopathy_SuperPanel",
"panel_id": 253,
"panel_version": "0.296",
"user_name": "Zornitza Stark",
"item_type": "panel",
"text": "Changed child panels to: Hypertrophic cardiomyopathy_HCM; Dilated Cardiomyopathy; Arrhythmogenic Cardiomyopathy; Left Ventricular Non-compaction Cardiomyopathy; Cardiomyopathy_Paediatric",
"entity_name": null,
"entity_type": null
},
{
"created": "2020-08-05T18:31:43.718607+10:00",
"panel_name": "Dilated Cardiomyopathy",
"panel_id": 95,
"panel_version": "0.83",
"user_name": "Zornitza Stark",
"item_type": "panel",
"text": "Panel types changed to Victorian Clinical Genetics Services; Rare Disease",
"entity_name": null,
"entity_type": null
},
{
"created": "2020-08-05T18:28:24.209607+10:00",
"panel_name": "Hypertrophic cardiomyopathy_HCM",
"panel_id": 111,
"panel_version": "0.153",
"user_name": "Zornitza Stark",
"item_type": "panel",
"text": "Panel types changed to Victorian Clinical Genetics Services; Rare Disease",
"entity_name": null,
"entity_type": null
},
{
"created": "2020-08-05T18:22:11.162249+10:00",
"panel_name": "Hypertrophic cardiomyopathy_HCM",
"panel_id": 111,
"panel_version": "0.152",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: GAA were changed from to Glycogen storage disease II, MIM#232300",
"entity_name": "GAA",
"entity_type": "gene"
},
{
"created": "2020-08-05T18:21:30.794069+10:00",
"panel_name": "Hypertrophic cardiomyopathy_HCM",
"panel_id": 111,
"panel_version": "0.151",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: GAA were set to ",
"entity_name": "GAA",
"entity_type": "gene"
},
{
"created": "2020-08-05T18:20:36.565297+10:00",
"panel_name": "Hypertrophic cardiomyopathy_HCM",
"panel_id": 111,
"panel_version": "0.150",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: GAA was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "GAA",
"entity_type": "gene"
},
{
"created": "2020-08-05T18:19:59.977220+10:00",
"panel_name": "Hypertrophic cardiomyopathy_HCM",
"panel_id": 111,
"panel_version": "0.149",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: FHL1 as ready",
"entity_name": "FHL1",
"entity_type": "gene"
},
{
"created": "2020-08-05T18:19:59.966981+10:00",
"panel_name": "Hypertrophic cardiomyopathy_HCM",
"panel_id": 111,
"panel_version": "0.149",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: fhl1 has been classified as Green List (High Evidence).",
"entity_name": "FHL1",
"entity_type": "gene"
},
{
"created": "2020-08-05T18:19:29.334389+10:00",
"panel_name": "Hypertrophic cardiomyopathy_HCM",
"panel_id": 111,
"panel_version": "0.149",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: FHL1 as Green List (high evidence)",
"entity_name": "FHL1",
"entity_type": "gene"
},
{
"created": "2020-08-05T18:19:29.324339+10:00",
"panel_name": "Hypertrophic cardiomyopathy_HCM",
"panel_id": 111,
"panel_version": "0.149",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: fhl1 has been classified as Green List (High Evidence).",
"entity_name": "FHL1",
"entity_type": "gene"
},
{
"created": "2020-08-05T18:18:52.668033+10:00",
"panel_name": "Hypertrophic cardiomyopathy_HCM",
"panel_id": 111,
"panel_version": "0.148",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "gene: FHL1 was added\ngene: FHL1 was added to Hypertrophic cardiomyopathy_HCM. Sources: Expert list\nMode of inheritance for gene: FHL1 was set to X-LINKED: hemizygous mutation in males, biallelic mutations in females\nPhenotypes for gene: FHL1 were set to Emery-Dreifuss muscular dystrophy 6, X-linked, MIM#\t300696\nReview for gene: FHL1 was set to GREEN\nAdded comment: HCM is part of the phenotype. \nSources: Expert list",
"entity_name": "FHL1",
"entity_type": "gene"
},
{
"created": "2020-08-05T18:16:54.749396+10:00",
"panel_name": "Hypertrophic cardiomyopathy_HCM",
"panel_id": 111,
"panel_version": "0.147",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: CACNA1C as ready",
"entity_name": "CACNA1C",
"entity_type": "gene"
},
{
"created": "2020-08-05T18:16:54.738434+10:00",
"panel_name": "Hypertrophic cardiomyopathy_HCM",
"panel_id": 111,
"panel_version": "0.147",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: cacna1c has been classified as Red List (Low Evidence).",
"entity_name": "CACNA1C",
"entity_type": "gene"
},
{
"created": "2020-08-05T18:16:40.450234+10:00",
"panel_name": "Hypertrophic cardiomyopathy_HCM",
"panel_id": 111,
"panel_version": "0.147",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "gene: CACNA1C was added\ngene: CACNA1C was added to Hypertrophic cardiomyopathy_HCM. Sources: Expert list\nMode of inheritance for gene: CACNA1C was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: CACNA1C were set to 26253506; 28490369; 28866666\nPhenotypes for gene: CACNA1C were set to Hypertrophic cardiomyopathy; congenital heart defects; conduction abnormalities\nReview for gene: CACNA1C was set to RED\nAdded comment: Recurrent missense at position p.Arg518Cys/His observed in three families with complex cardiac phenotype including HCM. Digenic/trigenic inheritance postulated in other families. \nSources: Expert list",
"entity_name": "CACNA1C",
"entity_type": "gene"
},
{
"created": "2020-08-05T18:10:33.130663+10:00",
"panel_name": "Dilated Cardiomyopathy",
"panel_id": 95,
"panel_version": "0.82",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: LAMA4 as ready",
"entity_name": "LAMA4",
"entity_type": "gene"
},
{
"created": "2020-08-05T18:10:33.122242+10:00",
"panel_name": "Dilated Cardiomyopathy",
"panel_id": 95,
"panel_version": "0.82",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: lama4 has been classified as Red List (Low Evidence).",
"entity_name": "LAMA4",
"entity_type": "gene"
},
{
"created": "2020-08-05T16:59:31.123606+10:00",
"panel_name": "Hypertrophic cardiomyopathy_HCM",
"panel_id": 111,
"panel_version": "0.146",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "changed review comment from: HOCM can be a presenting feature of Fabry.; to: HCM can be a presenting feature of Fabry.",
"entity_name": "GLA",
"entity_type": "gene"
},
{
"created": "2020-08-05T16:58:25.208488+10:00",
"panel_name": "Dilated Cardiomyopathy",
"panel_id": 95,
"panel_version": "0.82",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: LDB3 as ready",
"entity_name": "LDB3",
"entity_type": "gene"
},
{
"created": "2020-08-05T16:58:25.199960+10:00",
"panel_name": "Dilated Cardiomyopathy",
"panel_id": 95,
"panel_version": "0.82",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: ldb3 has been classified as Amber List (Moderate Evidence).",
"entity_name": "LDB3",
"entity_type": "gene"
},
{
"created": "2020-08-05T16:58:22.722415+10:00",
"panel_name": "Dilated Cardiomyopathy",
"panel_id": 95,
"panel_version": "0.82",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: LDB3 were changed from to Cardiomyopathy, dilated, 1C, with or without LVNC MIM#601493",
"entity_name": "LDB3",
"entity_type": "gene"
},
{
"created": "2020-08-05T16:57:47.993620+10:00",
"panel_name": "Dilated Cardiomyopathy",
"panel_id": 95,
"panel_version": "0.81",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: LDB3 were set to 26419279; 16427346; 14660611; 14662268",
"entity_name": "LDB3",
"entity_type": "gene"
},
{
"created": "2020-08-05T16:57:30.596251+10:00",
"panel_name": "Dilated Cardiomyopathy",
"panel_id": 95,
"panel_version": "0.81",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: LDB3 were set to ",
"entity_name": "LDB3",
"entity_type": "gene"
},
{
"created": "2020-08-05T16:57:10.033288+10:00",
"panel_name": "Dilated Cardiomyopathy",
"panel_id": 95,
"panel_version": "0.80",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: LDB3 was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "LDB3",
"entity_type": "gene"
},
{
"created": "2020-08-05T16:56:55.738000+10:00",
"panel_name": "Dilated Cardiomyopathy",
"panel_id": 95,
"panel_version": "0.80",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: LDB3 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "LDB3",
"entity_type": "gene"
}
]
}