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{
"count": 221304,
"next": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1870",
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"results": [
{
"created": "2020-04-11T17:41:29.277083+10:00",
"panel_name": "Phagocyte Defects",
"panel_id": 233,
"panel_version": "0.36",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: RAC2 was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "RAC2",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:40:56.280574+10:00",
"panel_name": "Phagocyte Defects",
"panel_id": 233,
"panel_version": "0.35",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: RAC2: Changed mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "RAC2",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:39:53.077160+10:00",
"panel_name": "Predominantly Antibody Deficiency",
"panel_id": 222,
"panel_version": "0.46",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: RAC2 was changed from BIALLELIC, autosomal or pseudoautosomal to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "RAC2",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:33:12.395763+10:00",
"panel_name": "Inflammatory bowel disease",
"panel_id": 123,
"panel_version": "0.21",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PTEN: Rating: AMBER; Mode of pathogenicity: None; Publications: 23962154, 24882466, 25352295, 22266152; Phenotypes: Colitis; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PTEN",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:13:17.197715+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2124",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PSMB9 were changed from to Proteasome-associated autoinflammatory syndrome 3, digenic, MIM# 617591",
"entity_name": "PSMB9",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:12:31.841244+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2123",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PSMB9 were set to ",
"entity_name": "PSMB9",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:12:18.285565+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2122",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PSMB9 was changed from Unknown to Other",
"entity_name": "PSMB9",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:12:00.806310+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2121",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: PSMB9 as Amber List (moderate evidence)",
"entity_name": "PSMB9",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:12:00.793517+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2121",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: psmb9 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PSMB9",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:11:31.968108+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2120",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PSMB9: Rating: AMBER; Mode of pathogenicity: None; Publications: 26524591; Phenotypes: Proteasome-associated autoinflammatory syndrome 3, digenic, MIM# 617591; Mode of inheritance: Other",
"entity_name": "PSMB9",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:10:40.488866+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.59",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PSMB9 as ready",
"entity_name": "PSMB9",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:10:40.479864+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.59",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: psmb9 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PSMB9",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:10:35.148720+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.59",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PSMB9 were changed from to Proteasome-associated autoinflammatory syndrome 3, digenic, MIM# 617591",
"entity_name": "PSMB9",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:09:17.476683+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.58",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PSMB9 were set to ",
"entity_name": "PSMB9",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:08:54.097562+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.57",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PSMB9 was changed from Unknown to Other",
"entity_name": "PSMB9",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:08:30.877786+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.56",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: PSMB9 as Amber List (moderate evidence)",
"entity_name": "PSMB9",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:08:30.864876+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.56",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: psmb9 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PSMB9",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:08:01.624918+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.55",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PSMB9: Rating: AMBER; Mode of pathogenicity: None; Publications: 26524591; Phenotypes: Proteasome-associated autoinflammatory syndrome 3, digenic, MIM# 617591; Mode of inheritance: Other",
"entity_name": "PSMB9",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:05:52.194218+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2120",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PSMB4 as ready",
"entity_name": "PSMB4",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:05:52.181085+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2120",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: psmb4 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PSMB4",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:05:44.318907+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2120",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PSMB4 were changed from to Proteasome-associated autoinflammatory syndrome 3 and digenic forms, MIM# 617591",
"entity_name": "PSMB4",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:05:28.515579+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2119",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PSMB4 were set to ",
"entity_name": "PSMB4",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:05:13.870426+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2118",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PSMB4 was changed from Unknown to Other",
"entity_name": "PSMB4",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:04:59.078045+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2117",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: PSMB4 as Amber List (moderate evidence)",
"entity_name": "PSMB4",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:04:59.069427+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2117",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: psmb4 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PSMB4",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:04:38.094315+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.55",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PSMB4 as ready",
"entity_name": "PSMB4",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:04:38.085449+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.55",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: psmb4 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PSMB4",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:03:54.630804+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.55",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PSMB4 were changed from to Proteasome-associated autoinflammatory syndrome 3 and digenic forms, MIM# 617591",
"entity_name": "PSMB4",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:03:33.821854+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.55",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PSMB4 were set to 26524591",
"entity_name": "PSMB4",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:03:17.379375+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2116",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PSMB4: Rating: AMBER; Mode of pathogenicity: None; Publications: 26524591; Phenotypes: Proteasome-associated autoinflammatory syndrome 3 and digenic forms, MIM# 617591; Mode of inheritance: Other",
"entity_name": "PSMB4",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:03:12.932660+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.54",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PSMB4 were set to ",
"entity_name": "PSMB4",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:02:52.452075+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.54",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PSMB4 was changed from Unknown to Other",
"entity_name": "PSMB4",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:02:20.648411+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.53",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: PSMB4 as Amber List (moderate evidence)",
"entity_name": "PSMB4",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:02:20.635524+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.53",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: psmb4 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PSMB4",
"entity_type": "gene"
},
{
"created": "2020-04-11T17:01:48.449394+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.52",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PSMB4: Rating: AMBER; Mode of pathogenicity: None; Publications: 26524591; Phenotypes: Proteasome-associated autoinflammatory syndrome 3 and digenic forms, MIM# 617591; Mode of inheritance: Other",
"entity_name": "PSMB4",
"entity_type": "gene"
},
{
"created": "2020-04-11T16:58:39.393720+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2116",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PSMA3 as ready",
"entity_name": "PSMA3",
"entity_type": "gene"
},
{
"created": "2020-04-11T16:58:39.380775+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2116",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: psma3 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PSMA3",
"entity_type": "gene"
},
{
"created": "2020-04-11T16:58:31.211459+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2116",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PSMA3 were set to ",
"entity_name": "PSMA3",
"entity_type": "gene"
},
{
"created": "2020-04-11T16:58:11.515301+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2115",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PSMA3 were changed from to Proteasome-associated autoinflammatory syndrome 1 and digenic forms, MIM#256040",
"entity_name": "PSMA3",
"entity_type": "gene"
},
{
"created": "2020-04-11T16:57:51.226552+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2114",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PSMA3 was changed from Unknown to Other",
"entity_name": "PSMA3",
"entity_type": "gene"
},
{
"created": "2020-04-11T16:57:32.988714+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2113",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: PSMA3 as Amber List (moderate evidence)",
"entity_name": "PSMA3",
"entity_type": "gene"
},
{
"created": "2020-04-11T16:57:32.974898+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2113",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: psma3 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PSMA3",
"entity_type": "gene"
},
{
"created": "2020-04-11T16:57:14.596041+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2112",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PSMA3: Rating: AMBER; Mode of pathogenicity: None; Publications: 26524591; Phenotypes: Proteasome-associated autoinflammatory syndrome 1 and digenic forms, MIM#256040; Mode of inheritance: Other",
"entity_name": "PSMA3",
"entity_type": "gene"
},
{
"created": "2020-04-11T16:56:20.591004+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.52",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PSMA3 as ready",
"entity_name": "PSMA3",
"entity_type": "gene"
},
{
"created": "2020-04-11T16:56:20.577487+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.52",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: psma3 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PSMA3",
"entity_type": "gene"
},
{
"created": "2020-04-11T16:56:17.007135+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.52",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PSMA3 were changed from to Proteasome-associated autoinflammatory syndrome 1 and digenic forms, MIM#256040",
"entity_name": "PSMA3",
"entity_type": "gene"
},
{
"created": "2020-04-11T16:55:52.763532+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.51",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PSMA3 were set to ",
"entity_name": "PSMA3",
"entity_type": "gene"
},
{
"created": "2020-04-11T16:55:30.001195+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.50",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PSMA3 was changed from Unknown to Other",
"entity_name": "PSMA3",
"entity_type": "gene"
},
{
"created": "2020-04-11T16:55:06.769887+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.49",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: PSMA3 as Amber List (moderate evidence)",
"entity_name": "PSMA3",
"entity_type": "gene"
},
{
"created": "2020-04-11T16:55:06.756390+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.49",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: psma3 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PSMA3",
"entity_type": "gene"
},
{
"created": "2020-04-11T16:54:04.653906+10:00",
"panel_name": "Systemic Autoinflammatory Disease_Periodic Fever",
"panel_id": 238,
"panel_version": "0.48",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PSMA3: Rating: AMBER; Mode of pathogenicity: None; Publications: 26524591; Phenotypes: Proteasome-associated autoinflammatory syndrome 1 and digenic forms, MIM#256040; Mode of inheritance: Other",
"entity_name": "PSMA3",
"entity_type": "gene"
},
{
"created": "2020-04-11T15:24:55.338345+10:00",
"panel_name": "Disorders of immune dysregulation",
"panel_id": 229,
"panel_version": "0.56",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: POMP as ready",
"entity_name": "POMP",
"entity_type": "gene"
},
{
"created": "2020-04-11T15:24:55.324516+10:00",
"panel_name": "Disorders of immune dysregulation",
"panel_id": 229,
"panel_version": "0.56",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: pomp has been classified as Green List (High Evidence).",
"entity_name": "POMP",
"entity_type": "gene"
},
{
"created": "2020-04-11T15:24:47.026079+10:00",
"panel_name": "Disorders of immune dysregulation",
"panel_id": 229,
"panel_version": "0.56",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: POMP as Green List (high evidence)",
"entity_name": "POMP",
"entity_type": "gene"
},
{
"created": "2020-04-11T15:24:47.008665+10:00",
"panel_name": "Disorders of immune dysregulation",
"panel_id": 229,
"panel_version": "0.56",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: pomp has been classified as Green List (High Evidence).",
"entity_name": "POMP",
"entity_type": "gene"
},
{
"created": "2020-04-11T15:24:17.856102+10:00",
"panel_name": "Disorders of immune dysregulation",
"panel_id": 229,
"panel_version": "0.55",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "gene: POMP was added\ngene: POMP was added to Disorders of immune dysregulation. Sources: Expert list\nMode of inheritance for gene: POMP was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: POMP were set to 29805043\nPhenotypes for gene: POMP were set to Combined immunodeficiency; Autoinflammation\nReview for gene: POMP was set to GREEN\nAdded comment: Two unrelated individuals, functional data. Truncating variants in penultimate exon, escape NMD, postulated to act through a dominant negative mechanism. \nSources: Expert list",
"entity_name": "POMP",
"entity_type": "gene"
},
{
"created": "2020-04-11T15:07:25.111028+10:00",
"panel_name": "Combined Immunodeficiency",
"panel_id": 223,
"panel_version": "0.119",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: POLE as ready",
"entity_name": "POLE",
"entity_type": "gene"
},
{
"created": "2020-04-11T15:07:25.097740+10:00",
"panel_name": "Combined Immunodeficiency",
"panel_id": 223,
"panel_version": "0.119",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: pole has been classified as Green List (High Evidence).",
"entity_name": "POLE",
"entity_type": "gene"
},
{
"created": "2020-04-11T15:07:22.509542+10:00",
"panel_name": "Combined Immunodeficiency",
"panel_id": 223,
"panel_version": "0.119",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: POLE were changed from to FILS syndrome, MIM# 615139; IMAGE-I syndrome, MIM# 618336",
"entity_name": "POLE",
"entity_type": "gene"
},
{
"created": "2020-04-11T15:06:55.382747+10:00",
"panel_name": "Combined Immunodeficiency",
"panel_id": 223,
"panel_version": "0.118",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: POLE were set to ",
"entity_name": "POLE",
"entity_type": "gene"
},
{
"created": "2020-04-11T15:06:29.992056+10:00",
"panel_name": "Combined Immunodeficiency",
"panel_id": 223,
"panel_version": "0.117",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Tag deep intronic tag was added to gene: POLE.",
"entity_name": "POLE",
"entity_type": "gene"
},
{
"created": "2020-04-11T15:06:27.383580+10:00",
"panel_name": "Combined Immunodeficiency",
"panel_id": 223,
"panel_version": "0.117",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: POLE was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "POLE",
"entity_type": "gene"
},
{
"created": "2020-04-11T15:05:56.465395+10:00",
"panel_name": "Combined Immunodeficiency",
"panel_id": 223,
"panel_version": "0.116",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: POLE: Rating: GREEN; Mode of pathogenicity: None; Publications: 30503519, 23230001, 25948378; Phenotypes: FILS syndrome, MIM# 615139, IMAGE-I syndrome, MIM# 618336; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "POLE",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:58:34.301875+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.120",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PMS2 as ready",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:58:34.288539+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.120",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: pms2 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:58:30.517803+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.120",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PMS2 were changed from to Mismatch repair cancer syndrome, MIM# 276300",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:58:07.031199+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.119",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PMS2 were set to ",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:57:41.427502+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.118",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PMS2 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:57:14.762302+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.117",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: PMS2 as Amber List (moderate evidence)",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:57:14.748310+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.117",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: pms2 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:56:45.310545+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.116",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PMS2: Rating: AMBER; Mode of pathogenicity: None; Publications: 22692065; Phenotypes: Mismatch repair cancer syndrome, MIM# 276300; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:55:26.664397+10:00",
"panel_name": "Combined Immunodeficiency",
"panel_id": 223,
"panel_version": "0.116",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: PMS2 as Amber List (moderate evidence)",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:55:26.650868+10:00",
"panel_name": "Combined Immunodeficiency",
"panel_id": 223,
"panel_version": "0.116",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: pms2 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:54:53.183849+10:00",
"panel_name": "Combined Immunodeficiency",
"panel_id": 223,
"panel_version": "0.115",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "changed review comment from: Sources: Expert list; to: Immunodeficiency is a rare manifestation of CMMRD. Sources: Expert list",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:54:34.569477+10:00",
"panel_name": "Combined Immunodeficiency",
"panel_id": 223,
"panel_version": "0.115",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: PMS2: Changed rating: AMBER",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:39:40.001204+10:00",
"panel_name": "Predominantly Antibody Deficiency",
"panel_id": 222,
"panel_version": "0.45",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NFKBID as ready",
"entity_name": "NFKBID",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:39:39.992762+10:00",
"panel_name": "Predominantly Antibody Deficiency",
"panel_id": 222,
"panel_version": "0.45",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nfkbid has been classified as Red List (Low Evidence).",
"entity_name": "NFKBID",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:39:36.799534+10:00",
"panel_name": "Predominantly Antibody Deficiency",
"panel_id": 222,
"panel_version": "0.45",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: NFKBID were set to ",
"entity_name": "NFKBID",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:39:07.487146+10:00",
"panel_name": "Predominantly Antibody Deficiency",
"panel_id": 222,
"panel_version": "0.44",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: NFKBID as Red List (low evidence)",
"entity_name": "NFKBID",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:39:07.477969+10:00",
"panel_name": "Predominantly Antibody Deficiency",
"panel_id": 222,
"panel_version": "0.44",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nfkbid has been classified as Red List (Low Evidence).",
"entity_name": "NFKBID",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:38:37.320642+10:00",
"panel_name": "Predominantly Antibody Deficiency",
"panel_id": 222,
"panel_version": "0.43",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: NFKBID: Rating: RED; Mode of pathogenicity: None; Publications: 26973645, 25347393, 22761313; Phenotypes: ; Mode of inheritance: None",
"entity_name": "NFKBID",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:37:59.705635+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2112",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NFKBID as ready",
"entity_name": "NFKBID",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:37:59.691302+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2112",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nfkbid has been classified as Red List (Low Evidence).",
"entity_name": "NFKBID",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:37:51.331507+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2112",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: NFKBID were set to ",
"entity_name": "NFKBID",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:37:24.866359+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2111",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: NFKBID as Red List (low evidence)",
"entity_name": "NFKBID",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:37:24.857038+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2111",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nfkbid has been classified as Red List (Low Evidence).",
"entity_name": "NFKBID",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:37:06.150257+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2110",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: NFKBID: Rating: RED; Mode of pathogenicity: None; Publications: 26973645, 25347393, 22761313; Phenotypes: ; Mode of inheritance: None",
"entity_name": "NFKBID",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:36:26.775372+10:00",
"panel_name": "Combined Immunodeficiency",
"panel_id": 223,
"panel_version": "0.115",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NFKBID as ready",
"entity_name": "NFKBID",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:36:26.762597+10:00",
"panel_name": "Combined Immunodeficiency",
"panel_id": 223,
"panel_version": "0.115",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nfkbid has been classified as Red List (Low Evidence).",
"entity_name": "NFKBID",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:36:23.935026+10:00",
"panel_name": "Combined Immunodeficiency",
"panel_id": 223,
"panel_version": "0.115",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: NFKBID were set to ",
"entity_name": "NFKBID",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:35:09.268622+10:00",
"panel_name": "Combined Immunodeficiency",
"panel_id": 223,
"panel_version": "0.114",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: NFKBID as Red List (low evidence)",
"entity_name": "NFKBID",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:35:09.259772+10:00",
"panel_name": "Combined Immunodeficiency",
"panel_id": 223,
"panel_version": "0.114",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nfkbid has been classified as Red List (Low Evidence).",
"entity_name": "NFKBID",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:34:38.214166+10:00",
"panel_name": "Combined Immunodeficiency",
"panel_id": 223,
"panel_version": "0.113",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: NFKBID: Rating: RED; Mode of pathogenicity: None; Publications: 26973645, 25347393, 22761313; Phenotypes: ; Mode of inheritance: None",
"entity_name": "NFKBID",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:27:52.668455+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2110",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: NFAT5 as ready",
"entity_name": "NFAT5",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:27:52.659969+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2110",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nfat5 has been classified as Red List (Low Evidence).",
"entity_name": "NFAT5",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:27:43.445142+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2110",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: NFAT5 were changed from to Recurrent infections; Autoimmune enterocolopathy",
"entity_name": "NFAT5",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:27:23.530980+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2109",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: NFAT5 were set to ",
"entity_name": "NFAT5",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:27:04.558157+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2108",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: NFAT5 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "NFAT5",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:26:46.241328+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2107",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: NFAT5 as Red List (low evidence)",
"entity_name": "NFAT5",
"entity_type": "gene"
},
{
"created": "2020-04-11T14:26:46.232833+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.2107",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: nfat5 has been classified as Red List (Low Evidence).",
"entity_name": "NFAT5",
"entity_type": "gene"
}
]
}