HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/json
Vary: Accept
{
"count": 221304,
"next": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1912",
"previous": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1910",
"results": [
{
"created": "2020-03-04T10:44:01.137985+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1613",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: WNT3 were changed from to Tetra-amelia syndrome 1, MIM# 273395",
"entity_name": "WNT3",
"entity_type": "gene"
},
{
"created": "2020-03-04T10:43:40.332051+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1612",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: WNT3 were set to ",
"entity_name": "WNT3",
"entity_type": "gene"
},
{
"created": "2020-03-04T10:43:20.356031+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1611",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: WNT3 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "WNT3",
"entity_type": "gene"
},
{
"created": "2020-03-04T10:43:03.250802+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1610",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: WNT3 as Red List (low evidence)",
"entity_name": "WNT3",
"entity_type": "gene"
},
{
"created": "2020-03-04T10:43:03.237368+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1610",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: wnt3 has been classified as Red List (Low Evidence).",
"entity_name": "WNT3",
"entity_type": "gene"
},
{
"created": "2020-03-04T10:42:40.400194+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1609",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: WNT3: Rating: RED; Mode of pathogenicity: None; Publications: 14872406; Phenotypes: Tetra-amelia syndrome 1, MIM# 273395; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "WNT3",
"entity_type": "gene"
},
{
"created": "2020-03-04T10:42:01.563130+11:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.100",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: WNT3 as ready",
"entity_name": "WNT3",
"entity_type": "gene"
},
{
"created": "2020-03-04T10:42:01.548191+11:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.100",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: wnt3 has been classified as Red List (Low Evidence).",
"entity_name": "WNT3",
"entity_type": "gene"
},
{
"created": "2020-03-04T10:41:57.500525+11:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.100",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: WNT3 were changed from to Tetra-amelia syndrome 1, MIM# 273395",
"entity_name": "WNT3",
"entity_type": "gene"
},
{
"created": "2020-03-04T10:41:25.961565+11:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.99",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: WNT3 were set to ",
"entity_name": "WNT3",
"entity_type": "gene"
},
{
"created": "2020-03-04T10:41:01.825876+11:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.98",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: WNT3 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "WNT3",
"entity_type": "gene"
},
{
"created": "2020-03-04T10:40:35.446774+11:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.97",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: WNT3 as Red List (low evidence)",
"entity_name": "WNT3",
"entity_type": "gene"
},
{
"created": "2020-03-04T10:40:35.432469+11:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.97",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: wnt3 has been classified as Red List (Low Evidence).",
"entity_name": "WNT3",
"entity_type": "gene"
},
{
"created": "2020-03-04T10:39:54.667757+11:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.96",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: WNT3: Rating: RED; Mode of pathogenicity: None; Publications: 14872406; Phenotypes: Tetra-amelia syndrome 1, MIM# 273395; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "WNT3",
"entity_type": "gene"
},
{
"created": "2020-03-04T10:14:38.529609+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2361",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: WFS1 were changed from to Wolfram syndrome 1, MIM# 222300; Wolfram-like syndrome, autosomal dominant, MIM# 614296",
"entity_name": "WFS1",
"entity_type": "gene"
},
{
"created": "2020-03-04T10:14:09.910291+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2360",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: WFS1 was changed from Unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "WFS1",
"entity_type": "gene"
},
{
"created": "2020-03-04T10:13:16.865428+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2359",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: WFS1 as Amber List (moderate evidence)",
"entity_name": "WFS1",
"entity_type": "gene"
},
{
"created": "2020-03-04T10:13:16.852681+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2359",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: wfs1 has been classified as Amber List (Moderate Evidence).",
"entity_name": "WFS1",
"entity_type": "gene"
},
{
"created": "2020-03-04T10:12:37.004382+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2358",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: WFS1: Rating: AMBER; Mode of pathogenicity: None; Publications: ; Phenotypes: Wolfram syndrome 1, MIM# 222300, Wolfram-like syndrome, autosomal dominant, MIM# 614296; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "WFS1",
"entity_type": "gene"
},
{
"created": "2020-03-04T10:06:59.276505+11:00",
"panel_name": "Congenital Myasthenia",
"panel_id": 3078,
"panel_version": "0.17",
"user_name": "Ain Roesley",
"item_type": "entity",
"text": "reviewed gene: MYO9A: Rating: GREEN; Mode of pathogenicity: None; Publications: PMID: 26752647, 27259756; Phenotypes: Myasthenic syndrome, congenital, 24, presynaptic (MIM# 618198); Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "MYO9A",
"entity_type": "gene"
},
{
"created": "2020-03-04T09:53:50.503653+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2358",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: WDR81 as ready",
"entity_name": "WDR81",
"entity_type": "gene"
},
{
"created": "2020-03-04T09:53:50.490462+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2358",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: wdr81 has been classified as Green List (High Evidence).",
"entity_name": "WDR81",
"entity_type": "gene"
},
{
"created": "2020-03-04T09:53:43.915839+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2358",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: WDR81 were changed from to Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 2, 610185; Hydrocephalus, congenital, 3, with brain anomalies, 617967",
"entity_name": "WDR81",
"entity_type": "gene"
},
{
"created": "2020-03-04T09:53:13.630193+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2357",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: WDR81 were set to ",
"entity_name": "WDR81",
"entity_type": "gene"
},
{
"created": "2020-03-04T09:52:25.529820+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2356",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: WDR81 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "WDR81",
"entity_type": "gene"
},
{
"created": "2020-03-04T09:48:14.771081+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2355",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: WDR4 as ready",
"entity_name": "WDR4",
"entity_type": "gene"
},
{
"created": "2020-03-04T09:48:14.767022+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2355",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Added comment: Comment when marking as ready: Borderline Green rating: three families but two have the same homozygous variant; some functional data to support gene-disease association.",
"entity_name": "WDR4",
"entity_type": "gene"
},
{
"created": "2020-03-04T09:48:14.736770+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2355",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: wdr4 has been classified as Green List (High Evidence).",
"entity_name": "WDR4",
"entity_type": "gene"
},
{
"created": "2020-03-04T09:46:58.266036+11:00",
"panel_name": "Regression",
"panel_id": 206,
"panel_version": "0.85",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: SPG11 as ready",
"entity_name": "SPG11",
"entity_type": "gene"
},
{
"created": "2020-03-04T09:46:58.253178+11:00",
"panel_name": "Regression",
"panel_id": 206,
"panel_version": "0.85",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: spg11 has been classified as Green List (High Evidence).",
"entity_name": "SPG11",
"entity_type": "gene"
},
{
"created": "2020-03-04T09:46:50.194384+11:00",
"panel_name": "Regression",
"panel_id": 206,
"panel_version": "0.85",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: SPG11 as Green List (high evidence)",
"entity_name": "SPG11",
"entity_type": "gene"
},
{
"created": "2020-03-04T09:46:50.185302+11:00",
"panel_name": "Regression",
"panel_id": 206,
"panel_version": "0.85",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: spg11 has been classified as Green List (High Evidence).",
"entity_name": "SPG11",
"entity_type": "gene"
},
{
"created": "2020-03-04T09:46:19.209633+11:00",
"panel_name": "Regression",
"panel_id": 206,
"panel_version": "0.84",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "gene: SPG11 was added\ngene: SPG11 was added to Regression. Sources: Expert Review\nMode of inheritance for gene: SPG11 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: SPG11 were set to 21381113; 22554690; 19224311; 18067136; 27820618\nPhenotypes for gene: SPG11 were set to Spastic paraplegia 11, autosomal recessive, MIM#604360; Charcot-Marie-Tooth disease, axonal, type 2X, MIM#616668; Amyotrophic lateral sclerosis 5, juvenile, MIM#602099\nReview for gene: SPG11 was set to GREEN\ngene: SPG11 was marked as current diagnostic\nAdded comment: Complex neurological phenotypes with onset in first and second decade, characterised by gradual deterioration. \nSources: Expert Review",
"entity_name": "SPG11",
"entity_type": "gene"
},
{
"created": "2020-03-04T09:29:43.212866+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2355",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: WDR4 as ready",
"entity_name": "WDR4",
"entity_type": "gene"
},
{
"created": "2020-03-04T09:29:43.204140+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2355",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: wdr4 has been classified as Green List (High Evidence).",
"entity_name": "WDR4",
"entity_type": "gene"
},
{
"created": "2020-03-04T09:29:33.090576+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2355",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: WDR4 were set to PubMed: 26416026, 30079490, 29597095, 28617965",
"entity_name": "WDR4",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:56:55.319598+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1609",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: RS1 as ready",
"entity_name": "RS1",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:56:55.305480+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1609",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: rs1 has been classified as Green List (High Evidence).",
"entity_name": "RS1",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:56:41.543774+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1609",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: RS1 were changed from to Retinoschisis, MIM#312700",
"entity_name": "RS1",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:55:48.160172+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1608",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: RS1 were set to ",
"entity_name": "RS1",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:55:32.157169+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1607",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: RS1 was changed from Unknown to X-LINKED: hemizygous mutation in males, biallelic mutations in females",
"entity_name": "RS1",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:54:37.429586+11:00",
"panel_name": "Hypertrichosis syndromes",
"panel_id": 120,
"panel_version": "0.9",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: SMC1A as ready",
"entity_name": "SMC1A",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:54:37.417680+11:00",
"panel_name": "Hypertrichosis syndromes",
"panel_id": 120,
"panel_version": "0.9",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: smc1a has been classified as Green List (High Evidence).",
"entity_name": "SMC1A",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:54:32.812778+11:00",
"panel_name": "Hypertrichosis syndromes",
"panel_id": 120,
"panel_version": "0.9",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: SMC1A were changed from to Cornelia de Lange syndrome 2, MIM# 300590",
"entity_name": "SMC1A",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:54:03.215911+11:00",
"panel_name": "Hypertrichosis syndromes",
"panel_id": 120,
"panel_version": "0.8",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: SMC1A were set to ",
"entity_name": "SMC1A",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:53:40.722905+11:00",
"panel_name": "Hypertrichosis syndromes",
"panel_id": 120,
"panel_version": "0.7",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: SMC1A was changed from Unknown to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)",
"entity_name": "SMC1A",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:53:10.833054+11:00",
"panel_name": "Hypertrichosis syndromes",
"panel_id": 120,
"panel_version": "0.6",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: SMC1A: Rating: GREEN; Mode of pathogenicity: None; Publications: 17273969, 22106055, 19701948, 26752331, 28166369; Phenotypes: Cornelia de Lange syndrome 2, MIM# 300590; Mode of inheritance: X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)",
"entity_name": "SMC1A",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:51:01.271940+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1606",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: SMC1A as ready",
"entity_name": "SMC1A",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:51:01.258425+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1606",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: smc1a has been classified as Green List (High Evidence).",
"entity_name": "SMC1A",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:50:52.542702+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1606",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: SMC1A were changed from to Cornelia de Lange syndrome 2, MIM# 300590",
"entity_name": "SMC1A",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:50:34.276149+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1605",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: SMC1A were set to ",
"entity_name": "SMC1A",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:47:46.948135+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1604",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: SMC1A was changed from Unknown to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)",
"entity_name": "SMC1A",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:46:05.012409+11:00",
"panel_name": "Disorders of immune dysregulation",
"panel_id": 229,
"panel_version": "0.23",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: AIRE as ready",
"entity_name": "AIRE",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:46:05.002828+11:00",
"panel_name": "Disorders of immune dysregulation",
"panel_id": 229,
"panel_version": "0.23",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: aire has been classified as Green List (High Evidence).",
"entity_name": "AIRE",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:45:59.202506+11:00",
"panel_name": "Disorders of immune dysregulation",
"panel_id": 229,
"panel_version": "0.23",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: AIRE were changed from to Autoimmune polyendocrinopathy syndrome , type I, with or without reversible metaphyseal dysplasia, MIM#240300",
"entity_name": "AIRE",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:45:30.078592+11:00",
"panel_name": "Disorders of immune dysregulation",
"panel_id": 229,
"panel_version": "0.22",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: AIRE was changed from Unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "AIRE",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:44:57.476277+11:00",
"panel_name": "Disorders of immune dysregulation",
"panel_id": 229,
"panel_version": "0.21",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: AIRE: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Autoimmune polyendocrinopathy syndrome , type I, with or without reversible metaphyseal dysplasia, MIM#240300; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "AIRE",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:43:00.505623+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1603",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: LOXHD1 as ready",
"entity_name": "LOXHD1",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:43:00.492227+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1603",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: loxhd1 has been classified as Green List (High Evidence).",
"entity_name": "LOXHD1",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:42:43.289289+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1603",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: AIRE as ready",
"entity_name": "AIRE",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:42:43.276408+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1603",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: aire has been classified as Green List (High Evidence).",
"entity_name": "AIRE",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:42:31.629223+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1603",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: AIRE were changed from to Autoimmune polyendocrinopathy syndrome , type I, with or without reversible metaphyseal dysplasia, MIM#240300",
"entity_name": "AIRE",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:41:46.468544+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1602",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: AIRE was changed from to Other",
"entity_name": "AIRE",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:41:21.506587+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1601",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: AIRE was changed from BIALLELIC, autosomal or pseudoautosomal to BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "AIRE",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:40:40.462398+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1600",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: AIRE was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "AIRE",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:39:20.052284+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1599",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: LOXHD1 were changed from to Deafness, autosomal recessive 77, MIM# 613079",
"entity_name": "LOXHD1",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:39:17.401070+11:00",
"panel_name": "Deafness",
"panel_id": 209,
"panel_version": "0.328",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: LOXHD1 as ready",
"entity_name": "LOXHD1",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:39:17.387759+11:00",
"panel_name": "Deafness",
"panel_id": 209,
"panel_version": "0.328",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: loxhd1 has been classified as Green List (High Evidence).",
"entity_name": "LOXHD1",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:39:00.666014+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1598",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: LOXHD1 were set to ",
"entity_name": "LOXHD1",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:38:37.848179+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1597",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: LOXHD1 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "LOXHD1",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:37:56.854342+11:00",
"panel_name": "Deafness",
"panel_id": 209,
"panel_version": "0.328",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: LOXHD1 were changed from to Deafness, autosomal recessive 77, MIM# 613079",
"entity_name": "LOXHD1",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:37:32.847429+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1596",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: LOXHD1: Rating: GREEN; Mode of pathogenicity: None; Publications: 19732867, 25792669; Phenotypes: Deafness, autosomal recessive 77, MIM# 613079; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "LOXHD1",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:37:06.108042+11:00",
"panel_name": "Deafness",
"panel_id": 209,
"panel_version": "0.327",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: LOXHD1 were set to ",
"entity_name": "LOXHD1",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:36:05.586367+11:00",
"panel_name": "Deafness",
"panel_id": 209,
"panel_version": "0.326",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: LOXHD1 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "LOXHD1",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:35:15.108311+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1596",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: WFS1 as ready",
"entity_name": "WFS1",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:35:15.099384+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1596",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: wfs1 has been classified as Green List (High Evidence).",
"entity_name": "WFS1",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:35:05.225207+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1596",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: WFS1 were changed from to ?Cataract 41; Deafness, autosomal dominant 6/14/38; Wolfram syndrome, autosomal recessive 1; Wolfram-like syndrome, autosomal dominant; {Diabetes mellitus, noninsulin-dependent, association with}",
"entity_name": "WFS1",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:34:30.468600+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1595",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: WFS1 were set to ",
"entity_name": "WFS1",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:34:15.333719+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1594",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: WFS1 was changed from Unknown to BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal",
"entity_name": "WFS1",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:32:04.539851+11:00",
"panel_name": "Arthrogryposis",
"panel_id": 47,
"panel_version": "0.25",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PIEZO2 as ready",
"entity_name": "PIEZO2",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:32:04.526738+11:00",
"panel_name": "Arthrogryposis",
"panel_id": 47,
"panel_version": "0.25",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: piezo2 has been classified as Green List (High Evidence).",
"entity_name": "PIEZO2",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:32:00.075541+11:00",
"panel_name": "Arthrogryposis",
"panel_id": 47,
"panel_version": "0.25",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PIEZO2 were changed from to Arthrogryposis, distal, with impaired proprioception and touch (MIM # 617146)",
"entity_name": "PIEZO2",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:31:29.576361+11:00",
"panel_name": "Arthrogryposis",
"panel_id": 47,
"panel_version": "0.24",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PIEZO2 were set to ",
"entity_name": "PIEZO2",
"entity_type": "gene"
},
{
"created": "2020-03-03T20:31:00.811854+11:00",
"panel_name": "Arthrogryposis",
"panel_id": 47,
"panel_version": "0.23",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PIEZO2 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PIEZO2",
"entity_type": "gene"
},
{
"created": "2020-03-03T12:35:05.434616+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1593",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: ING3 as ready",
"entity_name": "ING3",
"entity_type": "gene"
},
{
"created": "2020-03-03T12:35:05.425702+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1593",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: ing3 has been classified as Red List (Low Evidence).",
"entity_name": "ING3",
"entity_type": "gene"
},
{
"created": "2020-03-03T12:34:56.595541+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1593",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: ING3 as Red List (low evidence)",
"entity_name": "ING3",
"entity_type": "gene"
},
{
"created": "2020-03-03T12:34:56.582355+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1593",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: ing3 has been classified as Red List (Low Evidence).",
"entity_name": "ING3",
"entity_type": "gene"
},
{
"created": "2020-03-03T12:34:33.714419+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1592",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: ING3: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "ING3",
"entity_type": "gene"
},
{
"created": "2020-03-03T12:11:18.083367+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1592",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: SYN3 as ready",
"entity_name": "SYN3",
"entity_type": "gene"
},
{
"created": "2020-03-03T12:11:18.073717+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1592",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: syn3 has been classified as Red List (Low Evidence).",
"entity_name": "SYN3",
"entity_type": "gene"
},
{
"created": "2020-03-03T12:11:07.077170+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1592",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: SYN3 as Red List (low evidence)",
"entity_name": "SYN3",
"entity_type": "gene"
},
{
"created": "2020-03-03T12:11:07.064211+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1592",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: syn3 has been classified as Red List (Low Evidence).",
"entity_name": "SYN3",
"entity_type": "gene"
},
{
"created": "2020-03-03T12:10:45.755613+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1591",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: SYN3: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "SYN3",
"entity_type": "gene"
},
{
"created": "2020-03-03T12:07:09.046297+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1591",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: SIM1 as ready",
"entity_name": "SIM1",
"entity_type": "gene"
},
{
"created": "2020-03-03T12:07:09.033155+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1591",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: sim1 has been classified as Red List (Low Evidence).",
"entity_name": "SIM1",
"entity_type": "gene"
},
{
"created": "2020-03-03T12:06:42.340285+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1591",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: SIM1 as Red List (low evidence)",
"entity_name": "SIM1",
"entity_type": "gene"
},
{
"created": "2020-03-03T12:06:42.327408+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1591",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: sim1 has been classified as Red List (Low Evidence).",
"entity_name": "SIM1",
"entity_type": "gene"
},
{
"created": "2020-03-03T12:06:17.729628+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1590",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: SIM1: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "SIM1",
"entity_type": "gene"
},
{
"created": "2020-03-03T11:58:21.532140+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1590",
"user_name": "Kristin Rigbye",
"item_type": "entity",
"text": "reviewed gene: RS1: Rating: GREEN; Mode of pathogenicity: None; Publications: 15932525, 23453514, 23847049; Phenotypes: Retinoschisis, 312700; Mode of inheritance: X-LINKED: hemizygous mutation in males, biallelic mutations in females",
"entity_name": "RS1",
"entity_type": "gene"
}
]
}