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{
"count": 221304,
"next": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1916",
"previous": "https://panelapp-aus.org/api/v1/activities/?format=api&page=1914",
"results": [
{
"created": "2020-03-01T16:03:04.279214+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.27",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tmem260 has been classified as Amber List (Moderate Evidence).",
"entity_name": "TMEM260",
"entity_type": "gene"
},
{
"created": "2020-03-01T16:02:59.178320+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.27",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: TMEM260 as Amber List (moderate evidence)",
"entity_name": "TMEM260",
"entity_type": "gene"
},
{
"created": "2020-03-01T16:02:59.164907+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.27",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tmem260 has been classified as Amber List (Moderate Evidence).",
"entity_name": "TMEM260",
"entity_type": "gene"
},
{
"created": "2020-03-01T16:02:23.373373+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.26",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "gene: TMEM260 was added\ngene: TMEM260 was added to Congenital Heart Defect. Sources: Expert list\nMode of inheritance for gene: TMEM260 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: TMEM260 were set to 28318500\nPhenotypes for gene: TMEM260 were set to Structural heart defects and renal anomalies syndrome, MIM# 617478\nReview for gene: TMEM260 was set to AMBER\nAdded comment: Two unrelated families with complex severe congenital heart disease. \nSources: Expert list",
"entity_name": "TMEM260",
"entity_type": "gene"
},
{
"created": "2020-03-01T16:00:40.506940+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1552",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TMEM260 as ready",
"entity_name": "TMEM260",
"entity_type": "gene"
},
{
"created": "2020-03-01T16:00:40.493037+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1552",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tmem260 has been classified as Amber List (Moderate Evidence).",
"entity_name": "TMEM260",
"entity_type": "gene"
},
{
"created": "2020-03-01T16:00:32.330578+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2308",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TMEM260 as ready",
"entity_name": "TMEM260",
"entity_type": "gene"
},
{
"created": "2020-03-01T16:00:32.320841+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2308",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tmem260 has been classified as Red List (Low Evidence).",
"entity_name": "TMEM260",
"entity_type": "gene"
},
{
"created": "2020-03-01T16:00:23.138129+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1552",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TMEM260 were changed from to Structural heart defects and renal anomalies syndrome, MIM# 617478",
"entity_name": "TMEM260",
"entity_type": "gene"
},
{
"created": "2020-03-01T16:00:05.819009+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1551",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TMEM260 were set to ",
"entity_name": "TMEM260",
"entity_type": "gene"
},
{
"created": "2020-03-01T15:59:52.852288+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2308",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TMEM260 were changed from to Structural heart defects and renal anomalies syndrome, MIM# 617478",
"entity_name": "TMEM260",
"entity_type": "gene"
},
{
"created": "2020-03-01T15:59:41.515625+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1550",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: TMEM260 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TMEM260",
"entity_type": "gene"
},
{
"created": "2020-03-01T15:59:08.998871+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1549",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: TMEM260 as Amber List (moderate evidence)",
"entity_name": "TMEM260",
"entity_type": "gene"
},
{
"created": "2020-03-01T15:59:08.985435+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1549",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tmem260 has been classified as Amber List (Moderate Evidence).",
"entity_name": "TMEM260",
"entity_type": "gene"
},
{
"created": "2020-03-01T15:58:48.350568+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1548",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: TMEM260: Rating: AMBER; Mode of pathogenicity: None; Publications: 28318500; Phenotypes: Structural heart defects and renal anomalies syndrome, MIM# 617478; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TMEM260",
"entity_type": "gene"
},
{
"created": "2020-03-01T15:58:44.863469+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2307",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TMEM260 were set to ",
"entity_name": "TMEM260",
"entity_type": "gene"
},
{
"created": "2020-03-01T15:57:56.351501+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2306",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: TMEM260 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TMEM260",
"entity_type": "gene"
},
{
"created": "2020-03-01T15:57:30.457807+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2305",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: TMEM260 as Red List (low evidence)",
"entity_name": "TMEM260",
"entity_type": "gene"
},
{
"created": "2020-03-01T15:57:30.445210+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2305",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tmem260 has been classified as Red List (Low Evidence).",
"entity_name": "TMEM260",
"entity_type": "gene"
},
{
"created": "2020-03-01T15:56:56.269902+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2304",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: TMEM260: Rating: RED; Mode of pathogenicity: None; Publications: 28318500; Phenotypes: Structural heart defects and renal anomalies syndrome, MIM# 617478; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TMEM260",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:38:55.656188+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1548",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TKT as ready",
"entity_name": "TKT",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:38:55.642123+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1548",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tkt has been classified as Amber List (Moderate Evidence).",
"entity_name": "TKT",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:38:46.614373+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1548",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TKT were changed from to Short stature, developmental delay, and congenital heart defects; OMIM #617044",
"entity_name": "TKT",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:38:30.290098+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1547",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TKT were set to ",
"entity_name": "TKT",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:38:10.146530+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1546",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: TKT was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TKT",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:37:52.164671+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1545",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: TKT as Amber List (moderate evidence)",
"entity_name": "TKT",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:37:52.151163+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1545",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tkt has been classified as Amber List (Moderate Evidence).",
"entity_name": "TKT",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:37:29.073666+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1544",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: TKT: Rating: AMBER; Mode of pathogenicity: None; Publications: 27259054; Phenotypes: Short stature, developmental delay, and congenital heart defects, OMIM #617044; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TKT",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:35:48.028984+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2304",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: TKT as Amber List (moderate evidence)",
"entity_name": "TKT",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:35:48.015906+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2304",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tkt has been classified as Amber List (Moderate Evidence).",
"entity_name": "TKT",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:35:11.076423+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2303",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: TKT: Rating: AMBER; Mode of pathogenicity: None; Publications: 27259054; Phenotypes: Short stature, developmental delay, and congenital heart defects, OMIM #617044; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TKT",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:25:51.875268+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2303",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TINF2 as ready",
"entity_name": "TINF2",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:25:51.865945+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2303",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tinf2 has been classified as Green List (High Evidence).",
"entity_name": "TINF2",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:25:43.742665+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2303",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TINF2 were changed from to Revesz syndrome, MIM# 268130",
"entity_name": "TINF2",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:25:10.063241+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2302",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TINF2 were set to ",
"entity_name": "TINF2",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:24:30.238046+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2301",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: TINF2 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "TINF2",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:23:51.966693+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2300",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: TINF2: Rating: GREEN; Mode of pathogenicity: None; Publications: 1404302, 18252230, 21477109; Phenotypes: Revesz syndrome, MIM# 268130; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "TINF2",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:17:29.040834+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2300",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TIMM50 as ready",
"entity_name": "TIMM50",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:17:29.027381+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2300",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: timm50 has been classified as Green List (High Evidence).",
"entity_name": "TIMM50",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:17:20.088163+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2300",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: TIMM50 as Green List (high evidence)",
"entity_name": "TIMM50",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:17:20.079219+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2300",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: timm50 has been classified as Green List (High Evidence).",
"entity_name": "TIMM50",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:16:45.256527+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2299",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "gene: TIMM50 was added\ngene: TIMM50 was added to Intellectual disability syndromic and non-syndromic. Sources: Expert list\nMode of inheritance for gene: TIMM50 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: TIMM50 were set to 27573165; 30190335; 31058414\nPhenotypes for gene: TIMM50 were set to 3-methylglutaconic aciduria, type IX, MIM#617698\nReview for gene: TIMM50 was set to GREEN\nAdded comment: Four unrelated families reported, ID is part of the phenotype. \nSources: Expert list",
"entity_name": "TIMM50",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:12:00.763357+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2298",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "changed review comment from: ID is not part of the phenotype.; to: ID is not generally part of the phenotype but a couple of more severe presentations including ID reported.",
"entity_name": "THRB",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:11:38.468402+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2298",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: THRB: Changed rating: AMBER; Changed publications: 22319036, 1682340",
"entity_name": "THRB",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:11:10.298722+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2298",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: THRB as ready",
"entity_name": "THRB",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:11:10.285943+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2298",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: thrb has been classified as Amber List (Moderate Evidence).",
"entity_name": "THRB",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:10:53.123468+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2298",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: THRB were changed from to Thyroid hormone resistance, autosomal recessive, MIM# 274300; Thyroid hormone resistance, autosomal dominant, MIM# 188570",
"entity_name": "THRB",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:10:24.902893+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2297",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: THRB were set to ",
"entity_name": "THRB",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:09:57.366458+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2296",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: THRB was changed from Unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "THRB",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:09:28.254790+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2295",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: THRB as Amber List (moderate evidence)",
"entity_name": "THRB",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:09:28.241917+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2295",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: thrb has been classified as Amber List (Moderate Evidence).",
"entity_name": "THRB",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:07:52.992556+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2294",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: THRB as Red List (low evidence)",
"entity_name": "THRB",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:07:52.978972+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2294",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: thrb has been classified as Red List (Low Evidence).",
"entity_name": "THRB",
"entity_type": "gene"
},
{
"created": "2020-03-01T13:07:19.401065+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2293",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: THRB: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: Thyroid hormone resistance, autosomal recessive, MIM# 274300, Thyroid hormone resistance, autosomal dominant, MIM# 188570; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "THRB",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:54:49.873147+11:00",
"panel_name": "Inflammatory bowel disease",
"panel_id": 123,
"panel_version": "0.7",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TGFB1 as ready",
"entity_name": "TGFB1",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:54:49.858433+11:00",
"panel_name": "Inflammatory bowel disease",
"panel_id": 123,
"panel_version": "0.7",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tgfb1 has been classified as Amber List (Moderate Evidence).",
"entity_name": "TGFB1",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:54:45.146532+11:00",
"panel_name": "Inflammatory bowel disease",
"panel_id": 123,
"panel_version": "0.7",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: TGFB1 as Amber List (moderate evidence)",
"entity_name": "TGFB1",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:54:45.137419+11:00",
"panel_name": "Inflammatory bowel disease",
"panel_id": 123,
"panel_version": "0.7",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tgfb1 has been classified as Amber List (Moderate Evidence).",
"entity_name": "TGFB1",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:54:14.135651+11:00",
"panel_name": "Inflammatory bowel disease",
"panel_id": 123,
"panel_version": "0.6",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "gene: TGFB1 was added\ngene: TGFB1 was added to Inflammatory bowel disease. Sources: Expert list\nMode of inheritance for gene: TGFB1 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: TGFB1 were set to 29483653\nPhenotypes for gene: TGFB1 were set to Inflammatory bowel disease, immunodeficiency, and encephalopathy, MIM# 618213\nReview for gene: TGFB1 was set to AMBER\nAdded comment: Three individuals from two unrelated families reported. DD/ID and seizures in addition to IBD/immunodeficiency. \nSources: Expert list",
"entity_name": "TGFB1",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:52:40.098277+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2293",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: TGFB1 as Amber List (moderate evidence)",
"entity_name": "TGFB1",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:52:40.084968+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2293",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tgfb1 has been classified as Amber List (Moderate Evidence).",
"entity_name": "TGFB1",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:52:07.756258+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2292",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "gene: TGFB1 was added\ngene: TGFB1 was added to Intellectual disability syndromic and non-syndromic. Sources: Expert list\nMode of inheritance for gene: TGFB1 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: TGFB1 were set to 29483653\nPhenotypes for gene: TGFB1 were set to Inflammatory bowel disease, immunodeficiency, and encephalopathy, MIM# 618213\nReview for gene: TGFB1 was set to AMBER\nAdded comment: Three individuals from two unrelated families reported. DD/ID and seizures in addition to IBD/immunodeficiency. \nSources: Expert list",
"entity_name": "TGFB1",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:46:43.442477+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2291",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: TERT: Rating: GREEN; Mode of pathogenicity: None; Publications: 18042801, 17785587; Phenotypes: Hoyeraal-Hreidarsson syndrome; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TERT",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:34:49.722515+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1544",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TELO2 as ready",
"entity_name": "TELO2",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:34:49.714011+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1544",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: telo2 has been classified as Green List (High Evidence).",
"entity_name": "TELO2",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:34:39.561954+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1544",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TELO2 were changed from to You-Hoover-Fong syndrome, MIM#616954; Syndromic intellectual disability",
"entity_name": "TELO2",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:34:22.388162+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1543",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TELO2 were set to ",
"entity_name": "TELO2",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:34:08.295316+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1542",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: TELO2 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TELO2",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:33:44.376864+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1541",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: TELO2: Rating: GREEN; Mode of pathogenicity: None; Publications: 27132593, 28944240; Phenotypes: You-Hoover-Fong syndrome, MIM#616954, Syndromic intellectual disability; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TELO2",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:32:10.164023+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2291",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TELO2 as ready",
"entity_name": "TELO2",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:32:10.154915+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2291",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: telo2 has been classified as Green List (High Evidence).",
"entity_name": "TELO2",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:32:02.767281+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2291",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: TELO2 as Green List (high evidence)",
"entity_name": "TELO2",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:32:02.754000+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2291",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: telo2 has been classified as Green List (High Evidence).",
"entity_name": "TELO2",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:31:26.299428+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2290",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "gene: TELO2 was added\ngene: TELO2 was added to Intellectual disability syndromic and non-syndromic. Sources: Expert list\nMode of inheritance for gene: TELO2 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: TELO2 were set to 27132593; 28944240\nPhenotypes for gene: TELO2 were set to You-Hoover-Fong syndrome, MIM#616954; Syndromic intellectual disability\nReview for gene: TELO2 was set to GREEN\nAdded comment: Five unrelated families reported. \nSources: Expert list",
"entity_name": "TELO2",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:21:40.033323+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2289",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TECR as ready",
"entity_name": "TECR",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:21:40.024620+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2289",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tecr has been classified as Red List (Low Evidence).",
"entity_name": "TECR",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:21:26.440564+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2289",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TECR were changed from to Mental retardation, autosomal recessive, MIM#614020",
"entity_name": "TECR",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:20:09.258043+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2288",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TECR were set to ",
"entity_name": "TECR",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:19:41.903932+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1541",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TECR as ready",
"entity_name": "TECR",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:19:41.891153+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1541",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tecr has been classified as Red List (Low Evidence).",
"entity_name": "TECR",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:19:31.031561+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1541",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TECR were changed from to Mental retardation, autosomal recessive, MIM#614020",
"entity_name": "TECR",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:19:11.014372+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1540",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TECR were set to ",
"entity_name": "TECR",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:18:51.404163+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1539",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: TECR was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TECR",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:18:31.188017+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1538",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: TECR as Red List (low evidence)",
"entity_name": "TECR",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:18:31.177089+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1538",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tecr has been classified as Red List (Low Evidence).",
"entity_name": "TECR",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:18:03.307702+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1537",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: TECR: Rating: RED; Mode of pathogenicity: None; Publications: 21212097; Phenotypes: Mental retardation, autosomal recessive, MIM#614020; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TECR",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:17:49.558618+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2287",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: TECR was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TECR",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:17:22.429819+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2286",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: TECR as Red List (low evidence)",
"entity_name": "TECR",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:17:22.415776+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2286",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tecr has been classified as Red List (Low Evidence).",
"entity_name": "TECR",
"entity_type": "gene"
},
{
"created": "2020-03-01T11:16:27.942124+11:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.2285",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: TECR: Rating: RED; Mode of pathogenicity: None; Publications: 21212097; Phenotypes: Mental retardation, autosomal recessive, MIM#614020; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TECR",
"entity_type": "gene"
},
{
"created": "2020-02-29T20:44:28.988309+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1537",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TBC1D7 as ready",
"entity_name": "TBC1D7",
"entity_type": "gene"
},
{
"created": "2020-02-29T20:44:28.978843+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1537",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tbc1d7 has been classified as Amber List (Moderate Evidence).",
"entity_name": "TBC1D7",
"entity_type": "gene"
},
{
"created": "2020-02-29T20:44:15.392347+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1537",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TBC1D7 were changed from to Macrocephaly/megalencephaly syndrome, autosomal recessive, MIM# 248000",
"entity_name": "TBC1D7",
"entity_type": "gene"
},
{
"created": "2020-02-29T20:43:54.841696+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1536",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TBC1D7 were set to ",
"entity_name": "TBC1D7",
"entity_type": "gene"
},
{
"created": "2020-02-29T20:43:33.569896+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1535",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: TBC1D7 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TBC1D7",
"entity_type": "gene"
},
{
"created": "2020-02-29T20:43:15.165234+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1534",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: TBC1D7 as Amber List (moderate evidence)",
"entity_name": "TBC1D7",
"entity_type": "gene"
},
{
"created": "2020-02-29T20:43:15.156654+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1534",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tbc1d7 has been classified as Amber List (Moderate Evidence).",
"entity_name": "TBC1D7",
"entity_type": "gene"
},
{
"created": "2020-02-29T20:42:55.537248+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.1533",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: TBC1D7: Rating: AMBER; Mode of pathogenicity: None; Publications: 24515783, 23687350; Phenotypes: Macrocephaly/megalencephaly syndrome, autosomal recessive, MIM# 248000; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TBC1D7",
"entity_type": "gene"
},
{
"created": "2020-02-29T20:42:06.844950+11:00",
"panel_name": "Macrocephaly_Megalencephaly",
"panel_id": 135,
"panel_version": "0.31",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TBC1D7 as ready",
"entity_name": "TBC1D7",
"entity_type": "gene"
},
{
"created": "2020-02-29T20:42:06.830296+11:00",
"panel_name": "Macrocephaly_Megalencephaly",
"panel_id": 135,
"panel_version": "0.31",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tbc1d7 has been classified as Amber List (Moderate Evidence).",
"entity_name": "TBC1D7",
"entity_type": "gene"
}
]
}