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{
"count": 221415,
"next": "https://panelapp-aus.org/api/v1/activities/?format=api&page=558",
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"results": [
{
"created": "2023-08-22T17:21:29.201845+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.291",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Marked gene: MAPT as ready",
"entity_name": "MAPT",
"entity_type": "gene"
},
{
"created": "2023-08-22T17:21:29.185439+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.291",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Gene: mapt has been classified as Green List (High Evidence).",
"entity_name": "MAPT",
"entity_type": "gene"
},
{
"created": "2023-08-22T17:21:07.808946+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.291",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Phenotypes for gene: MAPT were changed from to Supranuclear palsy, progressive (MIM# 601104) AD; Supranuclear palsy, progressive atypical (MIM# 260540) AR",
"entity_name": "MAPT",
"entity_type": "gene"
},
{
"created": "2023-08-22T17:20:28.634613+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.290",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Publications for gene: MAPT were set to ",
"entity_name": "MAPT",
"entity_type": "gene"
},
{
"created": "2023-08-22T17:19:06.025048+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.289",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Mode of inheritance for gene: MAPT was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "MAPT",
"entity_type": "gene"
},
{
"created": "2023-08-22T17:18:41.494491+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.288",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Tag adult onset neurodegenerative tag was added to gene: MAPT.",
"entity_name": "MAPT",
"entity_type": "gene"
},
{
"created": "2023-08-22T17:18:12.463302+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.288",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Marked gene: LRRK2 as ready",
"entity_name": "LRRK2",
"entity_type": "gene"
},
{
"created": "2023-08-22T17:18:12.450232+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.288",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Gene: lrrk2 has been classified as Green List (High Evidence).",
"entity_name": "LRRK2",
"entity_type": "gene"
},
{
"created": "2023-08-22T17:17:55.902414+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.288",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Phenotypes for gene: LRRK2 were changed from to Parkinson Disease type 8 (MONDO:0005180, MIM#607060)",
"entity_name": "LRRK2",
"entity_type": "gene"
},
{
"created": "2023-08-22T17:17:07.548533+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.287",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: LRRK2 was changed from to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments",
"entity_name": "LRRK2",
"entity_type": "gene"
},
{
"created": "2023-08-22T17:07:27.892475+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.286",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Publications for gene: LRRK2 were set to ",
"entity_name": "LRRK2",
"entity_type": "gene"
},
{
"created": "2023-08-22T17:06:15.085160+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.285",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Mode of inheritance for gene: LRRK2 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "LRRK2",
"entity_type": "gene"
},
{
"created": "2023-08-22T17:05:38.079513+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.284",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Tag adult onset neurodegenerative tag was added to gene: LRRK2.",
"entity_name": "LRRK2",
"entity_type": "gene"
},
{
"created": "2023-08-22T16:41:28.641929+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.284",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Publications for gene: LDLR were set to ",
"entity_name": "LDLR",
"entity_type": "gene"
},
{
"created": "2023-08-22T16:40:58.202357+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.283",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Marked gene: LDLR as ready",
"entity_name": "LDLR",
"entity_type": "gene"
},
{
"created": "2023-08-22T16:40:58.187224+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.283",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Gene: ldlr has been classified as Green List (High Evidence).",
"entity_name": "LDLR",
"entity_type": "gene"
},
{
"created": "2023-08-22T16:19:56.017352+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.283",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Phenotypes for gene: LDLR were changed from to Hypercholesterolemia, familial, 1, MIM# 143890",
"entity_name": "LDLR",
"entity_type": "gene"
},
{
"created": "2023-08-22T16:19:42.513303+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.282",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Tag cardiac tag was added to gene: LDLR.",
"entity_name": "LDLR",
"entity_type": "gene"
},
{
"created": "2023-08-22T16:07:37.739934+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.282",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Mode of inheritance for gene: LDLR was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "LDLR",
"entity_type": "gene"
},
{
"created": "2023-08-22T16:05:55.473423+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.281",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Tag adult onset neurodegenerative tag was added to gene: ITM2B.",
"entity_name": "ITM2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T16:05:44.860023+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.281",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Marked gene: ITM2B as ready",
"entity_name": "ITM2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T16:05:44.848026+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.281",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Gene: itm2b has been classified as Green List (High Evidence).",
"entity_name": "ITM2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T15:50:21.296219+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.281",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Publications for gene: ITM2B were set to ",
"entity_name": "ITM2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T15:45:53.191517+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.280",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: ITM2B was changed from None to Other",
"entity_name": "ITM2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T15:45:05.371159+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.279",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Marked gene: GRN as ready",
"entity_name": "GRN",
"entity_type": "gene"
},
{
"created": "2023-08-22T15:45:05.339602+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.279",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Gene: grn has been classified as Green List (High Evidence).",
"entity_name": "GRN",
"entity_type": "gene"
},
{
"created": "2023-08-22T15:44:40.713607+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.279",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Phenotypes for gene: GRN were changed from to frontotemporal dementia and/or amyotrophic lateral sclerosis MONDO:0030923",
"entity_name": "GRN",
"entity_type": "gene"
},
{
"created": "2023-08-22T15:36:28.690087+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.278",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Publications for gene: GRN were set to ",
"entity_name": "GRN",
"entity_type": "gene"
},
{
"created": "2023-08-22T15:33:49.783886+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.277",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Mode of inheritance for gene: GRN was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "GRN",
"entity_type": "gene"
},
{
"created": "2023-08-22T15:33:19.521072+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.276",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Tag adult onset neurodegenerative tag was added to gene: GRN.",
"entity_name": "GRN",
"entity_type": "gene"
},
{
"created": "2023-08-22T15:33:00.332353+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.276",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Marked gene: GBA as ready",
"entity_name": "GBA",
"entity_type": "gene"
},
{
"created": "2023-08-22T15:33:00.322930+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.276",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Gene: gba has been classified as Green List (High Evidence).",
"entity_name": "GBA",
"entity_type": "gene"
},
{
"created": "2023-08-22T14:01:21.212722+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.276",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Publications for gene: GBA were set to ",
"entity_name": "GBA",
"entity_type": "gene"
},
{
"created": "2023-08-22T13:59:16.787229+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.275",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Phenotypes for gene: GBA were changed from to Parkinson's disease, MONDO:0005180, GBA-related",
"entity_name": "GBA",
"entity_type": "gene"
},
{
"created": "2023-08-22T13:58:06.159801+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.274",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Mode of inheritance for gene: GBA was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "GBA",
"entity_type": "gene"
},
{
"created": "2023-08-22T13:57:22.364216+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.273",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Tag adult onset neurodegenerative tag was added to gene: GBA.",
"entity_name": "GBA",
"entity_type": "gene"
},
{
"created": "2023-08-22T13:11:25.729385+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.273",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Marked gene: FUS as ready",
"entity_name": "FUS",
"entity_type": "gene"
},
{
"created": "2023-08-22T13:11:25.720709+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.273",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Gene: fus has been classified as Green List (High Evidence).",
"entity_name": "FUS",
"entity_type": "gene"
},
{
"created": "2023-08-22T13:11:22.268137+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.273",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Tag adult onset neurodegenerative tag was added to gene: FUS.",
"entity_name": "FUS",
"entity_type": "gene"
},
{
"created": "2023-08-22T13:10:17.721268+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.273",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Phenotypes for gene: FUS were changed from to Amyotrophic lateral sclerosis 6, with or without frontotemporal dementia, MIM# 608030",
"entity_name": "FUS",
"entity_type": "gene"
},
{
"created": "2023-08-22T13:09:42.756486+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.272",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Publications for gene: FUS were set to ",
"entity_name": "FUS",
"entity_type": "gene"
},
{
"created": "2023-08-22T12:01:22.244968+10:00",
"panel_name": "Deafness_IsolatedAndComplex",
"panel_id": 209,
"panel_version": "1.160",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: GJB6 was changed from Unknown to Other",
"entity_name": "GJB6",
"entity_type": "gene"
},
{
"created": "2023-08-22T12:00:48.510226+10:00",
"panel_name": "Deafness_IsolatedAndComplex",
"panel_id": 209,
"panel_version": "1.159",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: GJB6: Changed mode of inheritance: Other",
"entity_name": "GJB6",
"entity_type": "gene"
},
{
"created": "2023-08-22T12:00:33.771075+10:00",
"panel_name": "Deafness_IsolatedAndComplex",
"panel_id": 209,
"panel_version": "1.159",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: GJB6 as Green List (high evidence)",
"entity_name": "GJB6",
"entity_type": "gene"
},
{
"created": "2023-08-22T12:00:33.759191+10:00",
"panel_name": "Deafness_IsolatedAndComplex",
"panel_id": 209,
"panel_version": "1.159",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: gjb6 has been classified as Green List (High Evidence).",
"entity_name": "GJB6",
"entity_type": "gene"
},
{
"created": "2023-08-22T12:00:06.354015+10:00",
"panel_name": "Deafness_IsolatedAndComplex",
"panel_id": 209,
"panel_version": "1.158",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Tag SV/CNV tag was added to gene: GJB6.",
"entity_name": "GJB6",
"entity_type": "gene"
},
{
"created": "2023-08-22T11:59:55.811261+10:00",
"panel_name": "Deafness_IsolatedAndComplex",
"panel_id": 209,
"panel_version": "1.158",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "changed review comment from: Association with deafness classified as REFUTED by ClinGen.; to: Association os SNVs in this gene with isolated deafness classified as REFUTED by ClinGen.\r\n\r\nThe GJB6-D13S1830 deletion is a relatively common disease allele in many populations and is classified as pathogenic for hearing loss, frequently identified in homozygosity or in trans with a pathogenic GJB2 variant. This is a deletion of approximately 309kb of DNA including the 5' end of GJB6 and a region upstream of both GJB6 and the GJB2 gene. It has been proposed that GJB6 and GJB2 are co-regulated by a cis-acting element (Ahmad 2007 PMID 17227867). \r\n\r\nGREEN rating on the panel relates to the DELETION ONLY.",
"entity_name": "GJB6",
"entity_type": "gene"
},
{
"created": "2023-08-22T11:58:48.514467+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.271",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Mode of inheritance for gene: FUS was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "FUS",
"entity_type": "gene"
},
{
"created": "2023-08-22T11:57:05.224368+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.270",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Marked gene: FTL as ready",
"entity_name": "FTL",
"entity_type": "gene"
},
{
"created": "2023-08-22T11:57:05.204539+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.270",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Gene: ftl has been classified as Green List (High Evidence).",
"entity_name": "FTL",
"entity_type": "gene"
},
{
"created": "2023-08-22T11:57:00.407175+10:00",
"panel_name": "Deafness_IsolatedAndComplex",
"panel_id": 209,
"panel_version": "1.158",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: GJB6: Changed rating: GREEN",
"entity_name": "GJB6",
"entity_type": "gene"
},
{
"created": "2023-08-22T11:56:24.038033+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.270",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Phenotypes for gene: FTL were changed from to Neurodegeneration with brain iron accumulation 3, MIM# 606159",
"entity_name": "FTL",
"entity_type": "gene"
},
{
"created": "2023-08-22T11:07:39.590693+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.269",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Publications for gene: FTL were set to ",
"entity_name": "FTL",
"entity_type": "gene"
},
{
"created": "2023-08-22T10:12:11.138125+10:00",
"panel_name": "Motor Neurone Disease",
"panel_id": 25,
"panel_version": "1.4",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Marked gene: CHMP2B as ready",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T10:12:11.123869+10:00",
"panel_name": "Motor Neurone Disease",
"panel_id": 25,
"panel_version": "1.4",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Gene: chmp2b has been classified as Green List (High Evidence).",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T10:12:03.147281+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.268",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Mode of inheritance for gene: FTL was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "FTL",
"entity_type": "gene"
},
{
"created": "2023-08-22T10:11:54.864693+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.267",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Tag neurological tag was added to gene: FTL.",
"entity_name": "FTL",
"entity_type": "gene"
},
{
"created": "2023-08-22T10:11:19.235619+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.267",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Tag review tag was added to gene: FIG4.",
"entity_name": "FIG4",
"entity_type": "gene"
},
{
"created": "2023-08-22T10:09:35.235733+10:00",
"panel_name": "Motor Neurone Disease",
"panel_id": 25,
"panel_version": "1.4",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Phenotypes for gene: CHMP2B were changed from to Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 (MIM#600795, MONDO:0010936)",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T10:07:29.400056+10:00",
"panel_name": "Motor Neurone Disease",
"panel_id": 25,
"panel_version": "1.3",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Publications for gene: CHMP2B were set to ",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:53:47.372172+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.267",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Tag cancer tag was added to gene: DICER1.",
"entity_name": "DICER1",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:53:21.044091+10:00",
"panel_name": "Motor Neurone Disease",
"panel_id": 25,
"panel_version": "1.2",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: CHMP2B was changed from to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:52:34.205687+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.267",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Tag cancer tag was added to gene: DDX41.",
"entity_name": "DDX41",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:52:05.432411+10:00",
"panel_name": "Motor Neurone Disease",
"panel_id": 25,
"panel_version": "1.1",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Mode of inheritance for gene: CHMP2B was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:51:44.492265+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.267",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Marked gene: CLU as ready",
"entity_name": "CLU",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:51:44.477471+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.267",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Gene: clu has been classified as Red List (Low Evidence).",
"entity_name": "CLU",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:51:03.701611+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.267",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Phenotypes for gene: CLU were changed from to Alzheimer's Disease (MIM#104300)",
"entity_name": "CLU",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:50:50.809459+10:00",
"panel_name": "Early-onset Dementia",
"panel_id": 24,
"panel_version": "1.5",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Marked gene: CHMP2B as ready",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:50:50.795603+10:00",
"panel_name": "Early-onset Dementia",
"panel_id": 24,
"panel_version": "1.5",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Gene: chmp2b has been classified as Green List (High Evidence).",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:48:58.628133+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.266",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Classified gene: CLU as Red List (low evidence)",
"entity_name": "CLU",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:48:58.614071+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.266",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Gene: clu has been classified as Red List (Low Evidence).",
"entity_name": "CLU",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:48:49.572479+10:00",
"panel_name": "Early-onset Dementia",
"panel_id": 24,
"panel_version": "1.5",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Phenotypes for gene: CHMP2B were changed from to Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 (MIM#600795; MONDO:0010936)",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:47:31.042024+10:00",
"panel_name": "Early-onset Dementia",
"panel_id": 24,
"panel_version": "1.4",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Publications for gene: CHMP2B were set to ",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:46:53.893162+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.265",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Marked gene: CHMP2B as ready",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:46:53.878475+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.265",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Gene: chmp2b has been classified as Green List (High Evidence).",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:46:50.883022+10:00",
"panel_name": "Early-onset Dementia",
"panel_id": 24,
"panel_version": "1.3",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: CHMP2B was changed from Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:46:48.868695+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.265",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Tag adult onset neurodegenerative tag was added to gene: CHMP2B.",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:46:31.195928+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.265",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Phenotypes for gene: CHMP2B were changed from to Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 (MIM#600795; MONDO:0010936)",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:46:20.300613+10:00",
"panel_name": "Early-onset Dementia",
"panel_id": 24,
"panel_version": "1.2",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: CHMP2B was changed from to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:45:58.743837+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.264",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Publications for gene: CHMP2B were set to ",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:44:47.647941+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.263",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Mode of pathogenicity for gene: CHMP2B was changed from to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:44:33.843101+10:00",
"panel_name": "Early-onset Dementia",
"panel_id": 24,
"panel_version": "1.1",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Mode of inheritance for gene: CHMP2B was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:44:25.699321+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.262",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Mode of inheritance for gene: CHMP2B was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:43:18.210692+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.262",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Mode of inheritance for gene: CHMP2B was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:43:18.163674+10:00",
"panel_name": "Early-onset Dementia",
"panel_id": 24,
"panel_version": "1.1",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Mode of inheritance for gene: CHMP2B was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "CHMP2B",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:41:02.623965+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.261",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Tag cancer tag was added to gene: CHEK2.",
"entity_name": "CHEK2",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:40:19.276815+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.261",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Marked gene: CHCHD2 as ready",
"entity_name": "CHCHD2",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:40:19.267160+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.261",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Gene: chchd2 has been classified as Green List (High Evidence).",
"entity_name": "CHCHD2",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:40:12.771756+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.261",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Tag adult onset neurodegenerative tag was added to gene: CHCHD2.",
"entity_name": "CHCHD2",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:26:33.195092+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.261",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Tag cancer tag was added to gene: CDH1.",
"entity_name": "CDH1",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:25:45.331835+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.261",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Classified gene: CCNF as Amber List (moderate evidence)",
"entity_name": "CCNF",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:25:45.327055+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.261",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Added comment: Comment on list classification: Limited gene-disease validity assessment by ClinGen ALS spectrum disorders GCEP - 05/04/2022",
"entity_name": "CCNF",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:25:45.299539+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.261",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Gene: ccnf has been classified as Amber List (Moderate Evidence).",
"entity_name": "CCNF",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:25:18.486470+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.260",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Classified gene: CCNF as Amber List (moderate evidence)",
"entity_name": "CCNF",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:25:18.472541+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.260",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Gene: ccnf has been classified as Amber List (Moderate Evidence).",
"entity_name": "CCNF",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:24:19.346319+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.259",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Tag cardiac tag was added to gene: CACNA1C.",
"entity_name": "CACNA1C",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:23:57.073633+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.259",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Marked gene: CALHM1 as ready",
"entity_name": "CALHM1",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:23:57.061129+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.259",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Gene: calhm1 has been classified as Red List (Low Evidence).",
"entity_name": "CALHM1",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:23:24.966576+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.259",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Classified gene: CALHM1 as Red List (low evidence)",
"entity_name": "CALHM1",
"entity_type": "gene"
},
{
"created": "2023-08-22T09:23:24.954659+10:00",
"panel_name": "Incidentalome",
"panel_id": 126,
"panel_version": "0.259",
"user_name": "Bryony Thompson",
"item_type": "entity",
"text": "Gene: calhm1 has been classified as Red List (Low Evidence).",
"entity_name": "CALHM1",
"entity_type": "gene"
}
]
}