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{
"count": 220212,
"next": "https://panelapp-aus.org/api/v1/activities/?format=api&page=881",
"previous": "https://panelapp-aus.org/api/v1/activities/?format=api&page=879",
"results": [
{
"created": "2022-04-18T11:25:38.200648+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.13004",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: prkcg has been classified as Green List (High Evidence).",
"entity_name": "PRKCG",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:25:33.865738+10:00",
"panel_name": "Ataxia - paediatric",
"panel_id": 271,
"panel_version": "0.334",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PRKCG as ready",
"entity_name": "PRKCG",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:25:33.854107+10:00",
"panel_name": "Ataxia - paediatric",
"panel_id": 271,
"panel_version": "0.334",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: prkcg has been classified as Amber List (Moderate Evidence).",
"entity_name": "PRKCG",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:25:28.954875+10:00",
"panel_name": "Regression",
"panel_id": 206,
"panel_version": "0.469",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PRKCG as ready",
"entity_name": "PRKCG",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:25:28.925372+10:00",
"panel_name": "Regression",
"panel_id": 206,
"panel_version": "0.469",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: prkcg has been classified as Red List (Low Evidence).",
"entity_name": "PRKCG",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:25:10.738647+10:00",
"panel_name": "Regression",
"panel_id": 206,
"panel_version": "0.469",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PRKCG were changed from to Spinocerebellar ataxia 14, MIM# 605361",
"entity_name": "PRKCG",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:24:41.245297+10:00",
"panel_name": "Regression",
"panel_id": 206,
"panel_version": "0.468",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PRKCG were set to ",
"entity_name": "PRKCG",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:24:18.649070+10:00",
"panel_name": "Ataxia - paediatric",
"panel_id": 271,
"panel_version": "0.334",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: PRKCG as Amber List (moderate evidence)",
"entity_name": "PRKCG",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:24:18.639268+10:00",
"panel_name": "Ataxia - paediatric",
"panel_id": 271,
"panel_version": "0.334",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: prkcg has been classified as Amber List (Moderate Evidence).",
"entity_name": "PRKCG",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:24:08.724971+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.13004",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PRKCG were changed from to Spinocerebellar ataxia 14, MIM# 605361",
"entity_name": "PRKCG",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:24:05.680527+10:00",
"panel_name": "Regression",
"panel_id": 206,
"panel_version": "0.467",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PRKCG was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PRKCG",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:23:37.186267+10:00",
"panel_name": "Regression",
"panel_id": 206,
"panel_version": "0.466",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: PRKCG as Red List (low evidence)",
"entity_name": "PRKCG",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:23:37.173397+10:00",
"panel_name": "Regression",
"panel_id": 206,
"panel_version": "0.466",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: prkcg has been classified as Red List (Low Evidence).",
"entity_name": "PRKCG",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:23:15.053067+10:00",
"panel_name": "Ataxia - paediatric",
"panel_id": 271,
"panel_version": "0.333",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "gene: PRKCG was added\ngene: PRKCG was added to Ataxia - paediatric. Sources: Expert Review\nMode of inheritance for gene: PRKCG was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: PRKCG were set to 34292398\nPhenotypes for gene: PRKCG were set to Spinocerebellar ataxia 14, MIM# 605361\nReview for gene: PRKCG was set to AMBER\nAdded comment: Typically adult onset, but note two individuals reported with severe paediatric onset. \nSources: Expert Review",
"entity_name": "PRKCG",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:22:42.012382+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.13003",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PRKCG were set to ",
"entity_name": "PRKCG",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:22:21.817133+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.13002",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PRKCG was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PRKCG",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:21:29.626468+10:00",
"panel_name": "Genetic Epilepsy",
"panel_id": 202,
"panel_version": "0.1561",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PRMT7 as ready",
"entity_name": "PRMT7",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:21:29.613127+10:00",
"panel_name": "Genetic Epilepsy",
"panel_id": 202,
"panel_version": "0.1561",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: prmt7 has been classified as Green List (High Evidence).",
"entity_name": "PRMT7",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:21:26.043408+10:00",
"panel_name": "Genetic Epilepsy",
"panel_id": 202,
"panel_version": "0.1561",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PRMT7 were changed from to Short stature, brachydactyly, intellectual developmental disability, and seizures, MIM# 617157",
"entity_name": "PRMT7",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:20:43.257890+10:00",
"panel_name": "Regression",
"panel_id": 206,
"panel_version": "0.465",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PRKCG: Rating: RED; Mode of pathogenicity: None; Publications: 12644968, 14676051, 14694043, 16193476, 33739604, 34292398; Phenotypes: Spinocerebellar ataxia 14, MIM# 605361; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PRKCG",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:19:43.305136+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.13001",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PRKCG: Rating: GREEN; Mode of pathogenicity: None; Publications: 12644968, 14676051, 14694043, 16193476, 33739604, 34292398; Phenotypes: Spinocerebellar ataxia 14, MIM# 605361; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PRKCG",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:16:32.586747+10:00",
"panel_name": "Genetic Epilepsy",
"panel_id": 202,
"panel_version": "0.1560",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PRMT7 were set to ",
"entity_name": "PRMT7",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:14:49.062056+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.13001",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PRKG1 as ready",
"entity_name": "PRKG1",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:14:49.049586+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.13001",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: prkg1 has been classified as Green List (High Evidence).",
"entity_name": "PRKG1",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:14:35.705367+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.13001",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PRKG1 were changed from to Aortic aneurysm, familial thoracic 8, MIM# 615436",
"entity_name": "PRKG1",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:14:12.717662+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.13000",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PRKG1 were set to ",
"entity_name": "PRKG1",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:13:51.947902+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12999",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PRKG1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PRKG1",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:13:32.184925+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12998",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PRKG1: Rating: GREEN; Mode of pathogenicity: None; Publications: 30071989, 23910461, 30577811; Phenotypes: Aortic aneurysm, familial thoracic 8, MIM# 615436; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PRKG1",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:11:48.486927+10:00",
"panel_name": "Genetic Epilepsy",
"panel_id": 202,
"panel_version": "0.1559",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PRMT7 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PRMT7",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:11:10.906366+10:00",
"panel_name": "Genetic Epilepsy",
"panel_id": 202,
"panel_version": "0.1558",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PRMT7: Rating: GREEN; Mode of pathogenicity: None; Publications: 26437029, 27718516, 30513135; Phenotypes: Short stature, brachydactyly, intellectual developmental disability, and seizures, MIM# 617157; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PRMT7",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:10:32.988694+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.4680",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PRMT7 as ready",
"entity_name": "PRMT7",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:10:32.977723+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.4680",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: prmt7 has been classified as Green List (High Evidence).",
"entity_name": "PRMT7",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:10:27.920846+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.4680",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PRMT7 were changed from to Short stature, brachydactyly, intellectual developmental disability, and seizures, MIM# 617157",
"entity_name": "PRMT7",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:10:00.418349+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12998",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PRMT7 as ready",
"entity_name": "PRMT7",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:10:00.396142+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12998",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: prmt7 has been classified as Green List (High Evidence).",
"entity_name": "PRMT7",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:09:53.445608+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.4679",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PRMT7 were set to ",
"entity_name": "PRMT7",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:09:51.208031+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12998",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PRMT7 were changed from to Short stature, brachydactyly, intellectual developmental disability, and seizures, MIM# 617157",
"entity_name": "PRMT7",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:09:30.949736+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12997",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PRMT7 were set to ",
"entity_name": "PRMT7",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:09:18.718274+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.4678",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PRMT7 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PRMT7",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:08:51.335885+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12996",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PRMT7 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PRMT7",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:08:35.462880+10:00",
"panel_name": "Intellectual disability syndromic and non-syndromic",
"panel_id": 250,
"panel_version": "0.4677",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PRMT7: Rating: GREEN; Mode of pathogenicity: None; Publications: 26437029, 27718516, 30513135; Phenotypes: Short stature, brachydactyly, intellectual developmental disability, and seizures, MIM# 617157; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PRMT7",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:07:50.104204+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12995",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PRMT7: Rating: GREEN; Mode of pathogenicity: None; Publications: 26437029, 27718516, 30513135; Phenotypes: Short stature, brachydactyly, intellectual developmental disability, and seizures, MIM# 617157; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PRMT7",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:06:11.051071+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12995",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PRODH as ready",
"entity_name": "PRODH",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:06:11.041781+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12995",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: prodh has been classified as Green List (High Evidence).",
"entity_name": "PRODH",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:05:50.605364+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12995",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PRODH were changed from to Hyperprolinaemia, type I 239500; Proline oxidase deficiency",
"entity_name": "PRODH",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:05:28.338395+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12994",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PRODH were set to ",
"entity_name": "PRODH",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:05:05.723543+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12993",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PRODH was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PRODH",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:03:59.038842+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12992",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PROK2 as ready",
"entity_name": "PROK2",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:03:59.027084+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12992",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: prok2 has been classified as Green List (High Evidence).",
"entity_name": "PROK2",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:03:41.063074+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.435",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PROK2 as ready",
"entity_name": "PROK2",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:03:41.049725+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.435",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: prok2 has been classified as Red List (Low Evidence).",
"entity_name": "PROK2",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:03:35.104102+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.435",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PROK2 were changed from to Hypogonadotropic hypogonadism 4 with or without anosmia, MIM# 610628",
"entity_name": "PROK2",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:03:01.595311+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.434",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PROK2 were set to ",
"entity_name": "PROK2",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:02:24.853765+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.433",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PROK2 was changed from Unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "PROK2",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:01:56.278254+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.432",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: PROK2 as Red List (low evidence)",
"entity_name": "PROK2",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:01:56.267899+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.432",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: prok2 has been classified as Red List (Low Evidence).",
"entity_name": "PROK2",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:01:21.679017+10:00",
"panel_name": "Callosome",
"panel_id": 205,
"panel_version": "0.431",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PROK2: Rating: RED; Mode of pathogenicity: None; Publications: 18559922, 17054399, 17959774, 18285834; Phenotypes: Hypogonadotropic hypogonadism 4 with or without anosmia, MIM# 610628; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "PROK2",
"entity_type": "gene"
},
{
"created": "2022-04-18T11:00:10.824659+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12992",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PROK2 were changed from to Hypogonadotropic hypogonadism 4 with or without anosmia, MIM# 610628",
"entity_name": "PROK2",
"entity_type": "gene"
},
{
"created": "2022-04-18T10:59:14.403546+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12991",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PROK2 were set to ",
"entity_name": "PROK2",
"entity_type": "gene"
},
{
"created": "2022-04-18T10:58:36.650813+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12990",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PROK2 was changed from Unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "PROK2",
"entity_type": "gene"
},
{
"created": "2022-04-18T10:58:16.368077+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12989",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PROK2: Rating: GREEN; Mode of pathogenicity: None; Publications: 18559922, 17054399, 17959774, 18285834; Phenotypes: Hypogonadotropic hypogonadism 4 with or without anosmia, MIM# 610628; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "PROK2",
"entity_type": "gene"
},
{
"created": "2022-04-18T10:54:56.593539+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12989",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PROM1 as ready",
"entity_name": "PROM1",
"entity_type": "gene"
},
{
"created": "2022-04-18T10:54:56.584431+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12989",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: prom1 has been classified as Green List (High Evidence).",
"entity_name": "PROM1",
"entity_type": "gene"
},
{
"created": "2022-04-18T10:54:35.314296+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12989",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PROM1 were changed from to Inherited retinal dystrophy, MONDO:0019118; Cone-rod dystrophy 12, MIM# 612657; Macular dystrophy, retinal, 2, MI# 608051; Retinitis pigmentosa 41, MIM# 612095; Stargardt disease 4, MIM# 603786",
"entity_name": "PROM1",
"entity_type": "gene"
},
{
"created": "2022-04-18T10:53:56.369362+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12988",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PROM1 were set to ",
"entity_name": "PROM1",
"entity_type": "gene"
},
{
"created": "2022-04-18T10:53:34.884473+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12987",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PROM1 was changed from Unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "PROM1",
"entity_type": "gene"
},
{
"created": "2022-04-18T10:53:14.089116+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12986",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PROM1: Rating: GREEN; Mode of pathogenicity: None; Publications: 10587575, 17605048, 18654668, 29416601, 31576780, 34664634, 32820593; Phenotypes: Inherited retinal dystrophy, MONDO:0019118, Cone-rod dystrophy 12, MIM# 612657, Macular dystrophy, retinal, 2, MI# 608051, Retinitis pigmentosa 41, MIM# 612095, Stargardt disease 4, MIM# 603786; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "PROM1",
"entity_type": "gene"
},
{
"created": "2022-04-16T16:00:38.243475+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12986",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PROS1 as ready",
"entity_name": "PROS1",
"entity_type": "gene"
},
{
"created": "2022-04-16T16:00:38.231551+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12986",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: pros1 has been classified as Green List (High Evidence).",
"entity_name": "PROS1",
"entity_type": "gene"
},
{
"created": "2022-04-16T16:00:28.920845+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12986",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PROS1 were changed from to Thrombophilia 5 due to protein S deficiency, autosomal dominant, MIM# 612336; Thrombophilia 5 due to protein S deficiency, autosomal recessive, MIM# 614514",
"entity_name": "PROS1",
"entity_type": "gene"
},
{
"created": "2022-04-16T16:00:07.371536+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12985",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PROS1 were set to ",
"entity_name": "PROS1",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:59:46.455896+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12984",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PROS1 was changed from Unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "PROS1",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:59:26.812109+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12983",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PROS1: Rating: GREEN; Mode of pathogenicity: None; Publications: 7545463, 19466456, 10063989, 20484936, 19729839; Phenotypes: Thrombophilia 5 due to protein S deficiency, autosomal dominant, MIM# 612336, Thrombophilia 5 due to protein S deficiency, autosomal recessive, MIM# 614514; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "PROS1",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:55:07.406078+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12983",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PRPF3 as ready",
"entity_name": "PRPF3",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:55:07.389608+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12983",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: prpf3 has been classified as Green List (High Evidence).",
"entity_name": "PRPF3",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:54:42.456518+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12983",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PRPF3 were changed from to Retinitis pigmentosa 18, MIM# 601414",
"entity_name": "PRPF3",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:54:27.430866+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12982",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PRPF3 were set to ",
"entity_name": "PRPF3",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:54:06.175923+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12981",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PRPF3 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PRPF3",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:53:45.340131+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12980",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PRPF3: Rating: GREEN; Mode of pathogenicity: None; Publications: 11773002, 27886254; Phenotypes: Retinitis pigmentosa 18, MIM# 601414; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PRPF3",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:50:19.754164+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12980",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PRPF4 as ready",
"entity_name": "PRPF4",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:50:19.741867+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12980",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: prpf4 has been classified as Green List (High Evidence).",
"entity_name": "PRPF4",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:50:09.966802+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12980",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PRPF4 were changed from to Retinitis pigmentosa 70, MIM# 615922",
"entity_name": "PRPF4",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:49:46.837270+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12979",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PRPF4 were set to ",
"entity_name": "PRPF4",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:49:23.537775+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12978",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PRPF4 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PRPF4",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:48:25.424306+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12977",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PRPF4: Rating: GREEN; Mode of pathogenicity: None; Publications: 24419317, 25383878; Phenotypes: Retinitis pigmentosa 70, MIM# 615922; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PRPF4",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:44:48.203151+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12977",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PRPF6 as ready",
"entity_name": "PRPF6",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:44:48.177671+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12977",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: prpf6 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PRPF6",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:44:35.385363+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12977",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PRPF6 were changed from to Retinitis pigmentosa 60, MIM# 613983",
"entity_name": "PRPF6",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:43:59.912351+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12976",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PRPF6 were set to ",
"entity_name": "PRPF6",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:43:37.585301+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12975",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: PRPF6 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PRPF6",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:43:15.106559+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12974",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: PRPF6 as Amber List (moderate evidence)",
"entity_name": "PRPF6",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:43:15.091717+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12974",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: prpf6 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PRPF6",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:42:39.755172+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12973",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PRPF6: Rating: AMBER; Mode of pathogenicity: None; Publications: 21549338, 32335390; Phenotypes: Retinitis pigmentosa 60, MIM# 613983; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PRPF6",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:37:28.790223+10:00",
"panel_name": "Motor Neurone Disease",
"panel_id": 25,
"panel_version": "0.134",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PRPH as ready",
"entity_name": "PRPH",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:37:28.770753+10:00",
"panel_name": "Motor Neurone Disease",
"panel_id": 25,
"panel_version": "0.134",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: prph has been classified as Amber List (Moderate Evidence).",
"entity_name": "PRPH",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:37:21.629545+10:00",
"panel_name": "Motor Neurone Disease",
"panel_id": 25,
"panel_version": "0.134",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PRPH were changed from to {Amyotrophic lateral sclerosis, susceptibility to}, 105400",
"entity_name": "PRPH",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:36:39.887598+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12973",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: PRPH as ready",
"entity_name": "PRPH",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:36:39.875146+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12973",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: prph has been classified as Amber List (Moderate Evidence).",
"entity_name": "PRPH",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:36:30.413559+10:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.12973",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: PRPH were changed from to {Amyotrophic lateral sclerosis, susceptibility to}, 105400",
"entity_name": "PRPH",
"entity_type": "gene"
},
{
"created": "2022-04-16T15:36:30.014251+10:00",
"panel_name": "Motor Neurone Disease",
"panel_id": 25,
"panel_version": "0.133",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: PRPH were set to ",
"entity_name": "PRPH",
"entity_type": "gene"
}
]
}