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{
"count": 220497,
"next": "https://panelapp-aus.org/api/v1/activities/?format=api&page=92",
"previous": "https://panelapp-aus.org/api/v1/activities/?format=api&page=90",
"results": [
{
"created": "2025-12-12T15:46:43.666701+11:00",
"panel_name": "Hereditary Spastic Paraplegia",
"panel_id": 317,
"panel_version": "1.129",
"user_name": "Lucy Spencer",
"item_type": "entity",
"text": "Phenotypes for gene: IFRD1 were changed from autosomal dominant hereditary spastic paraplegia associated with peripheral neuropathy and ataxia to Hereditary spastic paraplegia MONDO:0019064, IFRD1-related",
"entity_name": "IFRD1",
"entity_type": "gene"
},
{
"created": "2025-12-12T15:46:28.901140+11:00",
"panel_name": "Ataxia",
"panel_id": 271,
"panel_version": "1.157",
"user_name": "Lucy Spencer",
"item_type": "entity",
"text": "Phenotypes for gene: IFRD1 were changed from Spinocerebellar ataxia 18 MIM#607458 to Hereditary spastic paraplegia MONDO:0019064, IFRD1-related",
"entity_name": "IFRD1",
"entity_type": "gene"
},
{
"created": "2025-12-12T15:45:33.274686+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3774",
"user_name": "Lucy Spencer",
"item_type": "entity",
"text": "Phenotypes for gene: IFRD1 were changed from Hereditary spastic paraplegia; peripheral neuropathy; ataxia to Hereditary spastic paraplegia MONDO:0019064, IFRD1-related",
"entity_name": "IFRD1",
"entity_type": "gene"
},
{
"created": "2025-12-12T11:09:12.233248+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3773",
"user_name": "Lucy Spencer",
"item_type": "entity",
"text": "Publications for gene: PLXNA1 were set to 34054129",
"entity_name": "PLXNA1",
"entity_type": "gene"
},
{
"created": "2025-12-12T11:08:53.584414+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3772",
"user_name": "Lucy Spencer",
"item_type": "entity",
"text": "changed review comment from: All 3 de novo missense variants in Dworschak et al. (2021) are present in gnomad v4 with 21, 2 and 4 heterozygotes. There is an additional de novo patient in Park 2017 PMID: 28464511, however their variant is also present in gnomad v4 with 5 heterozygotes. There is no new literature supporting the dominant association\r\n\r\nThe monoallelic assertion for this gene is now RED, still GREEN for biallelic; to: All 3 de novo missense variants in Dworschak et al. (2021) are present in gnomad v4 with 21, 2 and 4 heterozygotes. There is an additional de novo patient in Park 2017 PMID: 28464511, however their variant is also present in gnomad v4 with 5 heterozygotes. There is no recent literature supporting the dominant association\r\n\r\nThe monoallelic assertion for this gene is now RED, still GREEN for biallelic",
"entity_name": "PLXNA1",
"entity_type": "gene"
},
{
"created": "2025-12-12T11:00:20.511725+11:00",
"panel_name": "Lipodystrophy_Lipoatrophy",
"panel_id": 130,
"panel_version": "1.25",
"user_name": "Sinead OSullivan",
"item_type": "entity",
"text": "gene: ABL1 was added\ngene: ABL1 was added to Lipodystrophy_Lipoatrophy. Sources: Literature\nMode of inheritance for gene: ABL1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: ABL1 were set to PMID: 28288113; PMID: 32643838\nReview for gene: ABL1 was set to GREEN\nAdded comment: PMID: 32643838 reports three unrelated patients with lipodystrophy like features \nSources: Literature",
"entity_name": "ABL1",
"entity_type": "gene"
},
{
"created": "2025-12-12T10:56:37.829837+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3772",
"user_name": "Lucy Spencer",
"item_type": "entity",
"text": "edited their review of gene: PLXNA1: Changed rating: RED; Changed mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown",
"entity_name": "PLXNA1",
"entity_type": "gene"
},
{
"created": "2025-12-12T10:56:15.328363+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3772",
"user_name": "Lucy Spencer",
"item_type": "entity",
"text": "changed review comment from: All 3 de novo missense variants in Dworschak et al. (2021) are present in gnomad v4 with 21, 2 and 4 heterozygotes. There is an additional de novo patient in Park 2017 PMID: 28464511, however their variant is also present in gnomad v4 with 5 heterozygotes. There is no new literature supporting the dominant association\r\n\r\nThe monoallelic assertion for this gene is now RED, still GREEN for biallelic; to: All 3 de novo missense variants in Dworschak et al. (2021) are present in gnomad v4 with 21, 2 and 4 heterozygotes. There is an additional de novo patient in Park 2017 PMID: 28464511, however their variant is also present in gnomad v4 with 5 heterozygotes. There is no new literature supporting the dominant association\r\n\r\nThe monoallelic assertion for this gene is now RED, still GREEN for biallelic",
"entity_name": "PLXNA1",
"entity_type": "gene"
},
{
"created": "2025-12-12T10:55:32.996232+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3772",
"user_name": "Lucy Spencer",
"item_type": "entity",
"text": "Mode of inheritance for gene: PLXNA1 was changed from BOTH monoallelic and biallelic, autosomal or pseudoautosomal to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PLXNA1",
"entity_type": "gene"
},
{
"created": "2025-12-12T10:52:30.647923+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3771",
"user_name": "Lucy Spencer",
"item_type": "entity",
"text": "commented on gene: PLXNA1",
"entity_name": "PLXNA1",
"entity_type": "gene"
},
{
"created": "2025-12-12T10:28:05.207701+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3771",
"user_name": "Lucy Spencer",
"item_type": "entity",
"text": "Phenotypes for gene: ICE1 were changed from Intellectual disability, cerebral atrophy to Intellectual disability (MONDO:0001071), ICE1-related",
"entity_name": "ICE1",
"entity_type": "gene"
},
{
"created": "2025-12-12T10:25:58.204851+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3770",
"user_name": "Lucy Spencer",
"item_type": "entity",
"text": "commented on gene: IBA57",
"entity_name": "IBA57",
"entity_type": "gene"
},
{
"created": "2025-12-12T10:22:25.938118+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3770",
"user_name": "Lucy Spencer",
"item_type": "entity",
"text": "Phenotypes for gene: HUWE1 were changed from Mental retardation, X-linked syndromic, Turner type; Say-Meyer syndrome; Juberg-Marsidi syndrome to Intellectual developmental disorder, X-linked syndromic, Turner type MIM#309590",
"entity_name": "HUWE1",
"entity_type": "gene"
},
{
"created": "2025-12-12T10:20:09.146685+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3769",
"user_name": "Lucy Spencer",
"item_type": "entity",
"text": "Phenotypes for gene: HTRA1 were changed from {Macular degeneration, age-related, 7}, 6101493; {Macular degeneration, age-related, neovascular type}, 610149; CARASIL syndrome, 600142; Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2, 616779 to Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy 2 MIM#616779; Cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 2 MIM#600142",
"entity_name": "HTRA1",
"entity_type": "gene"
},
{
"created": "2025-12-12T10:12:12.879921+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3768",
"user_name": "Lucy Spencer",
"item_type": "entity",
"text": "commented on gene: HSPB1",
"entity_name": "HSPB1",
"entity_type": "gene"
},
{
"created": "2025-12-12T09:45:00.027499+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "1.3768",
"user_name": "Lucy Spencer",
"item_type": "entity",
"text": "Phenotypes for gene: HOXB6 were changed from Hypospadias to Hypospadias MONDO:0005345, HOXB6-related",
"entity_name": "HOXB6",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:51:25.618088+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.166",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: ZSWIM6 as ready",
"entity_name": "ZSWIM6",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:51:25.610376+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.166",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: zswim6 has been classified as Red List (Low Evidence).",
"entity_name": "ZSWIM6",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:51:17.634406+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.166",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: ZIC2 as ready",
"entity_name": "ZIC2",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:51:17.623769+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.166",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: zic2 has been classified as Red List (Low Evidence).",
"entity_name": "ZIC2",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:51:03.571773+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.166",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Mode of inheritance for gene: SLC20A1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "SLC20A1",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:50:58.701573+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.165",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: SLC20A1 as ready",
"entity_name": "SLC20A1",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:50:58.691695+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.165",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: slc20a1 has been classified as Red List (Low Evidence).",
"entity_name": "SLC20A1",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:50:57.537701+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.165",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Phenotypes for gene: SLC20A1 were changed from No OMIM number to Bladder-Exstrophy-Epispadias Complex (BEEC)",
"entity_name": "SLC20A1",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:50:39.553623+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.164",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: SLC15A4 as ready",
"entity_name": "SLC15A4",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:50:39.543344+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.164",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: slc15a4 has been classified as Red List (Low Evidence).",
"entity_name": "SLC15A4",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:50:32.995013+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.164",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: SIX3 as ready",
"entity_name": "SIX3",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:50:32.977624+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.164",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: six3 has been classified as Red List (Low Evidence).",
"entity_name": "SIX3",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:50:20.501471+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.164",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: SEMA3E as ready",
"entity_name": "SEMA3E",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:50:20.490938+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.164",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: sema3e has been classified as Red List (Low Evidence).",
"entity_name": "SEMA3E",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:50:12.890723+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.164",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: PTCH1 as ready",
"entity_name": "PTCH1",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:50:12.880474+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.164",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: ptch1 has been classified as Red List (Low Evidence).",
"entity_name": "PTCH1",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:49:52.040501+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.164",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: PSTPIP1 as ready",
"entity_name": "PSTPIP1",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:49:52.032856+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.164",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: pstpip1 has been classified as Red List (Low Evidence).",
"entity_name": "PSTPIP1",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:49:45.522582+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.164",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: PAX6 as ready",
"entity_name": "PAX6",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:49:45.512285+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.164",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: pax6 has been classified as Red List (Low Evidence).",
"entity_name": "PAX6",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:49:28.874624+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.164",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: NSMF as ready",
"entity_name": "NSMF",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:49:28.867333+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.164",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: nsmf has been classified as Red List (Low Evidence).",
"entity_name": "NSMF",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:49:22.607399+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.164",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: NODAL as ready",
"entity_name": "NODAL",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:49:22.600344+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.164",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: nodal has been classified as Red List (Low Evidence).",
"entity_name": "NODAL",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:49:21.259457+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.164",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Phenotypes for gene: NODAL were changed from Holoprosencephaly; Heterotaxy, visceral, 5 (270100) to Heterotaxy, visceral, 5 (270100)",
"entity_name": "NODAL",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:48:59.048966+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.163",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: NHLH2 as ready",
"entity_name": "NHLH2",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:48:59.037540+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.163",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: nhlh2 has been classified as Red List (Low Evidence).",
"entity_name": "NHLH2",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:47:13.701387+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.163",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: IL17RD as ready",
"entity_name": "IL17RD",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:47:13.693955+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.163",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: il17rd has been classified as Red List (Low Evidence).",
"entity_name": "IL17RD",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:47:06.382141+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.163",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: HS6ST1 as ready",
"entity_name": "HS6ST1",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:47:06.369839+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.163",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: hs6st1 has been classified as Red List (Low Evidence).",
"entity_name": "HS6ST1",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:46:59.043750+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.163",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: HNRNPU as ready",
"entity_name": "HNRNPU",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:46:59.026071+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.163",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: hnrnpu has been classified as Red List (Low Evidence).",
"entity_name": "HNRNPU",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:46:51.857996+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.163",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: HHIP as ready",
"entity_name": "HHIP",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:46:51.851044+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.163",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: hhip has been classified as Red List (Low Evidence).",
"entity_name": "HHIP",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:46:42.921311+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.163",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: GPR161 as ready",
"entity_name": "GPR161",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:46:42.914841+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.163",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: gpr161 has been classified as Red List (Low Evidence).",
"entity_name": "GPR161",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:46:36.268830+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.163",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: GHRH as ready",
"entity_name": "GHRH",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:46:36.241893+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.163",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: ghrh has been classified as Red List (Low Evidence).",
"entity_name": "GHRH",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:46:22.371329+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.163",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: FOXH1 as ready",
"entity_name": "FOXH1",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:46:22.363871+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.163",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: foxh1 has been classified as Red List (Low Evidence).",
"entity_name": "FOXH1",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:46:18.122898+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.163",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Mode of inheritance for gene: FOXH1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "FOXH1",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:46:05.355680+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: FLRT3 as ready",
"entity_name": "FLRT3",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:46:05.346913+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: flrt3 has been classified as Red List (Low Evidence).",
"entity_name": "FLRT3",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:46:01.027098+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: DUSP6 as ready",
"entity_name": "DUSP6",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:46:01.020028+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: dusp6 has been classified as Red List (Low Evidence).",
"entity_name": "DUSP6",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:45:55.472058+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: BMP2 as ready",
"entity_name": "BMP2",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:45:55.452152+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: bmp2 has been classified as Red List (Low Evidence).",
"entity_name": "BMP2",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:45:46.532101+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: AXL as ready",
"entity_name": "AXL",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:45:46.522343+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: axl has been classified as Red List (Low Evidence).",
"entity_name": "AXL",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:45:41.683950+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: TGIF1 as ready",
"entity_name": "TGIF1",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:45:41.673681+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: tgif1 has been classified as Amber List (Moderate Evidence).",
"entity_name": "TGIF1",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:45:36.765195+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: SPRY4 as ready",
"entity_name": "SPRY4",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:45:36.755225+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: spry4 has been classified as Amber List (Moderate Evidence).",
"entity_name": "SPRY4",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:45:30.996980+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: SHH as ready",
"entity_name": "SHH",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:45:30.990376+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: shh has been classified as Amber List (Moderate Evidence).",
"entity_name": "SHH",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:45:12.741944+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: PRDM13 as ready",
"entity_name": "PRDM13",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:45:12.725093+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: prdm13 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PRDM13",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:45:07.015694+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: NDNF as ready",
"entity_name": "NDNF",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:45:07.004648+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: ndnf has been classified as Amber List (Moderate Evidence).",
"entity_name": "NDNF",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:44:59.783784+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: KISS1 as ready",
"entity_name": "KISS1",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:44:59.776985+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: kiss1 has been classified as Amber List (Moderate Evidence).",
"entity_name": "KISS1",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:44:41.112418+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: FEZF1 as ready",
"entity_name": "FEZF1",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:44:41.102207+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: fezf1 has been classified as Amber List (Moderate Evidence).",
"entity_name": "FEZF1",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:42:31.082302+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: CLPP as ready",
"entity_name": "CLPP",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:42:31.067383+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: clpp has been classified as Amber List (Moderate Evidence).",
"entity_name": "CLPP",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:42:19.345875+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: CCDC141 as ready",
"entity_name": "CCDC141",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:42:19.339167+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: ccdc141 has been classified as Amber List (Moderate Evidence).",
"entity_name": "CCDC141",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:42:11.867975+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: ARNT2 as ready",
"entity_name": "ARNT2",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:42:11.859839+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: arnt2 has been classified as Amber List (Moderate Evidence).",
"entity_name": "ARNT2",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:41:53.431102+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: TFR2 as ready",
"entity_name": "TFR2",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:41:53.424185+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: tfr2 has been classified as Green List (High Evidence).",
"entity_name": "TFR2",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:40:26.035872+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.162",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Mode of inheritance for gene: TFR2 was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TFR2",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:40:06.008750+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.161",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Mode of inheritance for gene: TFR2 was changed from BIALLELIC, autosomal or pseudoautosomal to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "TFR2",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:39:49.229253+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.160",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: TCF12 as ready",
"entity_name": "TCF12",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:39:49.221919+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.160",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: tcf12 has been classified as Green List (High Evidence).",
"entity_name": "TCF12",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:39:43.268485+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.160",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: TBX19 as ready",
"entity_name": "TBX19",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:39:43.261587+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.160",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: tbx19 has been classified as Green List (High Evidence).",
"entity_name": "TBX19",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:39:30.567119+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.160",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: TACR3 as ready",
"entity_name": "TACR3",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:39:30.556606+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.160",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: tacr3 has been classified as Green List (High Evidence).",
"entity_name": "TACR3",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:39:24.679476+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.160",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: TAC3 as ready",
"entity_name": "TAC3",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:39:24.672576+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.160",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: tac3 has been classified as Green List (High Evidence).",
"entity_name": "TAC3",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:39:08.309682+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.160",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Marked gene: SOX2 as ready",
"entity_name": "SOX2",
"entity_type": "gene"
},
{
"created": "2025-12-11T16:39:08.302751+11:00",
"panel_name": "Pituitary hormone deficiency",
"panel_id": 3236,
"panel_version": "0.160",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "Gene: sox2 has been classified as Green List (High Evidence).",
"entity_name": "SOX2",
"entity_type": "gene"
}
]
}