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{
"count": 220497,
"next": "https://panelapp-aus.org/api/v1/activities/?format=api&page=95",
"previous": "https://panelapp-aus.org/api/v1/activities/?format=api&page=93",
"results": [
{
"created": "2025-12-11T10:55:27.561642+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.71",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene IL17RD from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:55:27.497444+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.71",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: IL17RD was added\ngene: IL17RD was added to Hypogonadotropic hypogonadism. Sources: Expert Review Red,Victorian Clinical Genetics Services\ndisputed tags were added to gene: IL17RD.\nMode of inheritance for gene: IL17RD was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal\nPublications for gene: IL17RD were set to 23643382; 32389901\nPhenotypes for gene: IL17RD were set to Hypogonadotropic hypogonadism 18 with or without anosmia, MIM# 615267",
"entity_name": "IL17RD",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:55:21.764022+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.70",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene NDNF from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:55:21.692634+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.70",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: NDNF was added\ngene: NDNF was added to Hypogonadotropic hypogonadism. Sources: Expert Review Amber,Literature\nMode of inheritance for gene: NDNF was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: NDNF were set to 31883645; 40788466\nPhenotypes for gene: NDNF were set to Hypogonadotropic hypogonadism 25 with anosmia MIM#618841",
"entity_name": "NDNF",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:55:15.651418+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.69",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene KISS1 from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:55:15.583159+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.69",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: KISS1 was added\ngene: KISS1 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Amber,Expert list\nMode of inheritance for gene: KISS1 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: KISS1 were set to 22335740; 25783047; 22766261; 17563351\nPhenotypes for gene: KISS1 were set to Hypogonadotropic hypogonadism 13 with or without anosmia, MIM#\t614842",
"entity_name": "KISS1",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:53:09.402217+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.68",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene PRDM13 from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:53:09.356926+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.68",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: PRDM13 was added\ngene: PRDM13 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Amber,Literature\nfounder tags were added to gene: PRDM13.\nMode of inheritance for gene: PRDM13 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: PRDM13 were set to 34730112\nPhenotypes for gene: PRDM13 were set to Cerebellar dysfunction, impaired intellectual development, and hypogonadotropic hypogonadism, MIM# 619761",
"entity_name": "PRDM13",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:53:03.790072+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.67",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene RAX from panel Pituitary hormone deficiency",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:53:03.729294+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.67",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: RAX was added\ngene: RAX was added to Hypogonadotropic hypogonadism. Sources: Expert Review Amber,Literature\nMode of inheritance for gene: RAX was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: RAX were set to 30811539, 40321348\nPhenotypes for gene: RAX were set to Microphthalmia, syndromic 16, MIM#611038",
"entity_name": "RAX",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:52:58.919139+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.66",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene RBM28 from panel Pituitary hormone deficiency",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:52:58.875918+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.66",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: RBM28 was added\ngene: RBM28 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Amber,Genomics England PanelApp\nMode of inheritance for gene: RBM28 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: RBM28 were set to 20231366; 18439547; 33941690\nPhenotypes for gene: RBM28 were set to ANE syndrome; Alopecia, neurologic defects, and endocrinopathy syndrome (612079)",
"entity_name": "RBM28",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:52:53.462512+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.65",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene SPRY4 from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:52:53.392239+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.65",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: SPRY4 was added\ngene: SPRY4 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Amber,Expert list\ndisputed tags were added to gene: SPRY4.\nMode of inheritance for gene: SPRY4 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: SPRY4 were set to 23643382\nPhenotypes for gene: SPRY4 were set to Hypogonadotropic hypogonadism 17 with or without anosmia, MIM#\t615266",
"entity_name": "SPRY4",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:51:23.571997+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.64",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene ARNT2 from panel Pituitary hormone deficiency",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:51:23.492438+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.64",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: ARNT2 was added\ngene: ARNT2 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Amber,Expert Review Amber,Literature,Genomics England PanelApp,Genetic Health Queensland\nMode of inheritance for gene: ARNT2 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: ARNT2 were set to 24022475, 11381139\nPhenotypes for gene: ARNT2 were set to Webb-Dattani syndrome 615926",
"entity_name": "ARNT2",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:51:18.397513+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.63",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene CCDC141 from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:51:18.355487+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.63",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: CCDC141 was added\ngene: CCDC141 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Amber,Expert Review\nMode of inheritance for gene: CCDC141 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal\nPublications for gene: CCDC141 were set to 251920460; 28324054; 32520725; 27014940\nPhenotypes for gene: CCDC141 were set to congenital hypogonadotropic hypogonadism, MONDO:0015770, CCDC141-related",
"entity_name": "CCDC141",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:51:13.069658+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.62",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene CLPP from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:51:13.001395+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.62",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: CLPP was added\ngene: CLPP was added to Hypogonadotropic hypogonadism. Sources: Expert Review Amber,Expert Review\nMode of inheritance for gene: CLPP was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: CLPP were set to 23541340; 25956234; 26970254; 27087618; 27650058; 27650058; 27899912\nPhenotypes for gene: CLPP were set to Perrault syndrome 3, MIM# 614129",
"entity_name": "CLPP",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:51:07.688402+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.61",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene ESRP2 from panel Pituitary hormone deficiency",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:51:07.646906+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.61",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: ESRP2 was added\ngene: ESRP2 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Amber,Expert list\nMode of inheritance for gene: ESRP2 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPublications for gene: ESRP2 were set to 29805042\nPhenotypes for gene: ESRP2 were set to Cleft palate, MONDO:0016064; Hypopituitarism MONDO:0005152",
"entity_name": "ESRP2",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:49:32.550239+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.60",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene SEMA3E from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:49:32.486541+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.60",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: SEMA3E was added\ngene: SEMA3E was added to Hypogonadotropic hypogonadism. Sources: Expert Review Red,Expert Review\nMode of inheritance for gene: SEMA3E was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: SEMA3E were set to 25985275\nPhenotypes for gene: SEMA3E were set to ?CHARGE syndrome (MIM#214800)",
"entity_name": "SEMA3E",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:49:24.904620+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.59",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene NSMF from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:49:24.860481+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.59",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: NSMF was added\ngene: NSMF was added to Hypogonadotropic hypogonadism. Sources: Expert Review Red,Expert list\nMode of inheritance for gene: NSMF was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: NSMF were set to 15362570; 17235395; 21700882\nPhenotypes for gene: NSMF were set to Hypogonadotropic hypogonadism 9 with or without anosmia, MIM#\t614838",
"entity_name": "NSMF",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:49:19.400181+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.58",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene NHLH2 from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:49:19.361492+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.58",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: NHLH2 was added\ngene: NHLH2 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Red,Expert Review\nMode of inheritance for gene: NHLH2 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: NHLH2 were set to 35066646\nPhenotypes for gene: NHLH2 were set to Hypogonadotropic hypogonadism 27 without anosmia , MIM#\t619755",
"entity_name": "NHLH2",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:47:26.595868+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.57",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene HS6ST1 from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:47:26.554126+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.57",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: HS6ST1 was added\ngene: HS6ST1 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Red,Victorian Clinical Genetics Services\nMode of inheritance for gene: HS6ST1 was set to Other\nPublications for gene: HS6ST1 were set to 21700882\nPhenotypes for gene: HS6ST1 were set to {Hypogonadotropic hypogonadism 15 with or without anosmia} 614880",
"entity_name": "HS6ST1",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:47:21.720293+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.56",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene FLRT3 from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:47:21.671802+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.56",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: FLRT3 was added\ngene: FLRT3 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Red,Victorian Clinical Genetics Services\nMode of inheritance for gene: FLRT3 was set to Unknown\nPublications for gene: FLRT3 were set to 23643382; 31200363\nPhenotypes for gene: FLRT3 were set to Hypogonadotropic hypogonadism 21 with anosmia (MIM# 615271)",
"entity_name": "FLRT3",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:47:13.898006+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.55",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene DUSP6 from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:47:13.862002+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.55",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: DUSP6 was added\ngene: DUSP6 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Red,Victorian Clinical Genetics Services\nMode of inheritance for gene: DUSP6 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: DUSP6 were set to 23643382; 32389901\nPhenotypes for gene: DUSP6 were set to Hypogonadotropic hypogonadism 19 with or without anosmia - MIM#615269",
"entity_name": "DUSP6",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:47:09.007179+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.54",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene AXL from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:47:08.964652+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.54",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: AXL was added\ngene: AXL was added to Hypogonadotropic hypogonadism. Sources: Expert Review Red,Expert Review\nMode of inheritance for gene: AXL was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: AXL were set to 24476074\nPhenotypes for gene: AXL were set to Hypogonadotropic hypogonadism, MONDO:0018555, AXL-related",
"entity_name": "AXL",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:43:13.059618+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.53",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "commented on gene: TFR2",
"entity_name": "TFR2",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:43:04.083383+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.53",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene TFR2 from panel Mendeliome",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:43:04.013722+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.53",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: TFR2 was added\ngene: TFR2 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Victorian Clinical Genetics Services\nMode of inheritance for gene: TFR2 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: TFR2 were set to 24847265; 29743178\nPhenotypes for gene: TFR2 were set to Haemochromatosis, type 3 (MIM#604250)",
"entity_name": "TFR2",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:42:56.265679+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.52",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene WDR11 from panel Pituitary hormone deficiency",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:42:56.197054+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.52",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: WDR11 was added\ngene: WDR11 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Expert List,Genomics England PanelApp\nMode of inheritance for gene: WDR11 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPhenotypes for gene: WDR11 were set to Hypogonadotropic hypogonadism 14 with or without anosmia (614858)",
"entity_name": "WDR11",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:42:51.172787+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.51",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene ZRSR2 from panel Pituitary hormone deficiency",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:42:51.098181+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.51",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: ZRSR2 was added\ngene: ZRSR2 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Literature\nMode of inheritance for gene: ZRSR2 was set to X-LINKED: hemizygous mutation in males, biallelic mutations in females\nPublications for gene: ZRSR2 were set to 38158857\nPhenotypes for gene: ZRSR2 were set to Orofaciodigital syndrome XXI, MIM# 301132",
"entity_name": "ZRSR2",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:41:01.317847+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.50",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene TAC3 from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:41:01.193768+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.50",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: TAC3 was added\ngene: TAC3 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Victorian Clinical Genetics Services\nMode of inheritance for gene: TAC3 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: TAC3 were set to 19079066; 20332248; 23329188; 22031817\nPhenotypes for gene: TAC3 were set to Hypogonadotropic hypogonadism 10 with or without anosmia (MIM#614839)",
"entity_name": "TAC3",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:40:54.375562+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.49",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene TACR3 from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:40:54.303309+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.49",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: TACR3 was added\ngene: TACR3 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Expert list\nMode of inheritance for gene: TACR3 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: TACR3 were set to 20332248; 19079066\nPhenotypes for gene: TACR3 were set to Hypogonadotropic hypogonadism 11 with or without anosmia, MIM#\t614840",
"entity_name": "TACR3",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:40:47.348387+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.48",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene TBC1D32 from panel Pituitary hormone deficiency",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:40:47.273404+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.48",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: TBC1D32 was added\ngene: TBC1D32 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Literature\nMode of inheritance for gene: TBC1D32 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: TBC1D32 were set to 32573025; 32060556; 24285566; 31130284; 36826837; 40319332\nPhenotypes for gene: TBC1D32 were set to Syndromic hypopituitarism",
"entity_name": "TBC1D32",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:40:41.263887+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.47",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene TCF12 from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:40:41.207750+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.47",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: TCF12 was added\ngene: TCF12 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Literature\nMode of inheritance for gene: TCF12 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal\nPublications for gene: TCF12 were set to 32620954\nPhenotypes for gene: TCF12 were set to Hypogonadotropic hypogonadism 26 with or without anosmia, MIM# 619718; Kallmann syndrome",
"entity_name": "TCF12",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:39:46.865436+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.46",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "commented on gene: SLC40A1",
"entity_name": "SLC40A1",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:39:30.568327+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.46",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene SLC40A1 from panel Mendeliome",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:39:30.502208+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.46",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: SLC40A1 was added\ngene: SLC40A1 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Victorian Clinical Genetics Services\nMode of inheritance for gene: SLC40A1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: SLC40A1 were set to 11431687; 11518736; 15956209; 16351644\nPhenotypes for gene: SLC40A1 were set to Haemochromatosis, type 4, MIM# 606069",
"entity_name": "SLC40A1",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:39:21.291697+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.45",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene SOX10 from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:39:21.253317+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.45",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: SOX10 was added\ngene: SOX10 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Expert Review\nMode of inheritance for gene: SOX10 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPublications for gene: SOX10 were set to 23643381; 15004559\nPhenotypes for gene: SOX10 were set to Kallman syndrome; PCWH syndrome (MIM#609136); Waardenburg syndrome, type 2E, with or without neurologic involvement (MIM#611584); Waardenburg syndrome, type 4C (MIM#613266)\nMode of pathogenicity for gene: SOX10 was set to Other",
"entity_name": "SOX10",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:39:15.473218+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.44",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene SOX2 from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:39:15.405470+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.44",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: SOX2 was added\ngene: SOX2 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Literature\nMode of inheritance for gene: SOX2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: SOX2 were set to PMID: 20301477\nPhenotypes for gene: SOX2 were set to Anophthalmia/microphthalmia-esophageal atresia syndrome MONDO:0008799; Microphthalmia, syndromic 3, MIM# 206900; Optic nerve hypoplasia and abnormalities of the central nervous system, MIM# 206900",
"entity_name": "SOX2",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:39:09.875265+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.43",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene SOX3 from panel Pituitary hormone deficiency",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:39:09.803426+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.43",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: SOX3 was added\ngene: SOX3 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Genomics England PanelApp\nSV/CNV tags were added to gene: SOX3.\nMode of inheritance for gene: SOX3 was set to X-LINKED: hemizygous mutation in males, biallelic mutations in females\nPublications for gene: SOX3 were set to 24346842; 15800844; 21289259; 24737742\nPhenotypes for gene: SOX3 were set to Panhypopituitarism, X-linked (312000); Mental retardation, X-linked, with isolated growth hormone deficiency (300123)",
"entity_name": "SOX3",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:37:40.506194+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.42",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "commented on gene: SLC29A3",
"entity_name": "SLC29A3",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:37:24.914654+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.42",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene ROBO1 from panel Pituitary hormone deficiency",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:37:24.872607+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.42",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: ROBO1 was added\ngene: ROBO1 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Literature\nMode of inheritance for gene: ROBO1 was set to BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal\nPublications for gene: ROBO1 were set to PMID: 30530901; 30692597; 33270637; 28402530\nPhenotypes for gene: ROBO1 were set to Pituitary hormone deficiency, combined or isolated, 8, MIM#\t620303",
"entity_name": "ROBO1",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:37:17.176731+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.41",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene SEMA3A from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:37:17.106719+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.41",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: SEMA3A was added\ngene: SEMA3A was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Expert Review\nMode of inheritance for gene: SEMA3A was set to BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal\nPublications for gene: SEMA3A were set to 28075028; 33369061; 20301509; 21059704; 24124006; 22927827\nPhenotypes for gene: SEMA3A were set to Hypogonadotropic hypogonadism 16 with or without anosmia - MIM#614897",
"entity_name": "SEMA3A",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:37:11.118110+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.40",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene SEMA3F from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:37:11.067990+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.40",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: SEMA3F was added\ngene: SEMA3F was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Literature\nMode of inheritance for gene: SEMA3F was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: SEMA3F were set to PMID: 33495532\nPhenotypes for gene: SEMA3F were set to Hypogonadotropic hypogonadism",
"entity_name": "SEMA3F",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:37:04.083313+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.39",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene SLC29A3 from panel Mendeliome",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:37:04.017770+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.39",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: SLC29A3 was added\ngene: SLC29A3 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Victorian Clinical Genetics Services\nMode of inheritance for gene: SLC29A3 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: SLC29A3 were set to 18940313; 19336477; 22238637\nPhenotypes for gene: SLC29A3 were set to Histiocytosis-lymphadenopathy plus syndrome, MIM# 602782",
"entity_name": "SLC29A3",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:35:34.961274+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.38",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene PROP1 from panel Pituitary hormone deficiency",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:35:34.897945+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.38",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: PROP1 was added\ngene: PROP1 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Genomics England PanelApp\nMode of inheritance for gene: PROP1 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: PROP1 were set to 20301521, 31090814\nPhenotypes for gene: PROP1 were set to Pituitary hormone deficiency, combined, 2 MIM# 262600",
"entity_name": "PROP1",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:35:29.363671+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.37",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene PROKR2 from panel Pituitary hormone deficiency",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:35:29.299155+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.37",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: PROKR2 was added\ngene: PROKR2 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Genomics England PanelApp\nMode of inheritance for gene: PROKR2 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal\nPublications for gene: PROKR2 were set to 22319038; 25678757; 25759380; 18826963; 29161432\nPhenotypes for gene: PROKR2 were set to Hypogonadotropic hypogonadism 3 with or without anosmia (244200)",
"entity_name": "PROKR2",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:35:23.918183+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.36",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene POLR3B from panel Pituitary hormone deficiency",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:35:23.875218+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.36",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: POLR3B was added\ngene: POLR3B was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Literature,Literature\nMode of inheritance for gene: POLR3B was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: POLR3B were set to 27512013; 23355746; 22036171; 22036172; 25339210; 33005949; 22855961\nPhenotypes for gene: POLR3B were set to Leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism; OMIM #614381",
"entity_name": "POLR3B",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:35:15.998977+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.35",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene POLR3A from panel Pituitary hormone deficiency",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:35:15.909492+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.35",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: POLR3A was added\ngene: POLR3A was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Genomics England PanelApp,Victorian Clinical Genetics Services\nMode of inheritance for gene: POLR3A was set to BIALLELIC, autosomal or pseudoautosomal\nPhenotypes for gene: POLR3A were set to Leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism (607694)",
"entity_name": "POLR3A",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:33:32.082708+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.34",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene PROK2 from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:33:32.009787+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.34",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: PROK2 was added\ngene: PROK2 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Victorian Clinical Genetics Services\nMode of inheritance for gene: PROK2 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal\nPublications for gene: PROK2 were set to 18559922; 17054399; 17959774; 18285834\nPhenotypes for gene: PROK2 were set to Hypogonadotropic hypogonadism 4 with or without anosmia (MIM#610628)",
"entity_name": "PROK2",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:33:27.373493+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.33",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene PNPLA6 from panel Pituitary hormone deficiency",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:33:27.286443+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.33",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: PNPLA6 was added\ngene: PNPLA6 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Genomics England PanelApp,Expert Review Green,Expert list,Expert Review Green,Expert Review Green,Expert list,Victorian Clinical Genetics Services\nMode of inheritance for gene: PNPLA6 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: PNPLA6 were set to 25033069\nPhenotypes for gene: PNPLA6 were set to Oliver-McFarlane syndrome (275400); Spastic paraplegia 39, autosomal recessive (612020); Boucher-Neuhauser syndrome (215470)",
"entity_name": "PNPLA6",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:33:19.183286+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.32",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene PLXNA3 from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:33:19.120671+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.32",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: PLXNA3 was added\ngene: PLXNA3 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Literature\nMode of inheritance for gene: PLXNA3 was set to X-LINKED: hemizygous mutation in males, biallelic mutations in females\nPublications for gene: PLXNA3 were set to PMID: 33495532\nPhenotypes for gene: PLXNA3 were set to Hypogonadotropic hypogonadism",
"entity_name": "PLXNA3",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:33:14.359731+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.31",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene OTX2 from panel Pituitary hormone deficiency",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:33:14.295505+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.31",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: OTX2 was added\ngene: OTX2 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Genomics England PanelApp\nMode of inheritance for gene: OTX2 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPublications for gene: OTX2 were set to 19965921; 22715480; 18628516; 18728160\nPhenotypes for gene: OTX2 were set to Pituitary hormone deficiency, combined, 6 (613986); Microphthalmia, syndromic 5 (610125)",
"entity_name": "OTX2",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:30:55.464246+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.30",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "commented on gene: NR0B1",
"entity_name": "NR0B1",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:30:44.385151+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.30",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene NR0B1 from panel Mendeliome",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:30:44.307639+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.30",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: NR0B1 was added\ngene: NR0B1 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Victorian Clinical Genetics Services\nSV/CNV tags were added to gene: NR0B1.\nMode of inheritance for gene: NR0B1 was set to X-LINKED: hemizygous mutation in males, biallelic mutations in females\nPublications for gene: NR0B1 were set to 19508677; 26030781\nPhenotypes for gene: NR0B1 were set to Adrenal hypoplasia, congenital (MIM# 300200); 46XY sex reversal 2, dosage-sensitive, MIM#\t300018",
"entity_name": "NR0B1",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:30:33.274215+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.29",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene NOS1 from panel Pituitary hormone deficiency",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:30:33.208535+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.29",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: NOS1 was added\ngene: NOS1 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Literature\nMode of inheritance for gene: NOS1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: NOS1 were set to 36197968\nPhenotypes for gene: NOS1 were set to Hypogonadotropic hypogonadism, MONDO:0018555",
"entity_name": "NOS1",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:30:28.717527+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.28",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene LHX4 from panel Pituitary hormone deficiency",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:30:28.680766+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.28",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: LHX4 was added\ngene: LHX4 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Genomics England PanelApp\ntreatable tags were added to gene: LHX4.\nMode of inheritance for gene: LHX4 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPublications for gene: LHX4 were set to 18073311; 18445675; 11567216\nPhenotypes for gene: LHX4 were set to Pituitary hormone deficiency, combined, 4 (262700)",
"entity_name": "LHX4",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:30:24.078458+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.27",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene LHX3 from panel Pituitary hormone deficiency",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:30:24.022648+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.27",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: LHX3 was added\ngene: LHX3 was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Genomics England PanelApp\ntreatable tags were added to gene: LHX3.\nMode of inheritance for gene: LHX3 was set to BIALLELIC, autosomal or pseudoautosomal\nPhenotypes for gene: LHX3 were set to Pituitary hormone deficiency, combined, 3 (221750)",
"entity_name": "LHX3",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:28:29.815659+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.26",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene LHB from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:28:29.777983+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.26",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: LHB was added\ngene: LHB was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Victorian Clinical Genetics Services\nMode of inheritance for gene: LHB was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: LHB were set to 17761593; 28092701; 29476300; 22723313; 15602022\nPhenotypes for gene: LHB were set to Hypogonadotropic hypogonadism 23 with or without anosmia (MIM#228300)",
"entity_name": "LHB",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:28:25.154922+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.25",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene KLB from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:28:25.090306+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.25",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: KLB was added\ngene: KLB was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Literature\nMode of inheritance for gene: KLB was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: KLB were set to 28754744\nPhenotypes for gene: KLB were set to Hypogonadotropic hypogonadism",
"entity_name": "KLB",
"entity_type": "gene"
},
{
"created": "2025-12-11T10:28:19.973616+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.24",
"user_name": "Chirag Patel",
"item_type": "panel",
"text": "Copied gene KISS1R from panel Differences of Sex Development",
"entity_name": null,
"entity_type": null
},
{
"created": "2025-12-11T10:28:19.904481+11:00",
"panel_name": "Hypogonadotropic hypogonadism",
"panel_id": 4521,
"panel_version": "0.24",
"user_name": "Chirag Patel",
"item_type": "entity",
"text": "gene: KISS1R was added\ngene: KISS1R was added to Hypogonadotropic hypogonadism. Sources: Expert Review Green,Victorian Clinical Genetics Services\nMode of inheritance for gene: KISS1R was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: KISS1R were set to 17164310; 31073722; 14573733\nPhenotypes for gene: KISS1R were set to Hypogonadotropic hypogonadism 8 with or without anosmia (MIM#614837)",
"entity_name": "KISS1R",
"entity_type": "gene"
}
]
}