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{
"count": 220403,
"next": "https://panelapp-aus.org/api/v1/activities/?format=api&page=946",
"previous": "https://panelapp-aus.org/api/v1/activities/?format=api&page=944",
"results": [
{
"created": "2022-03-07T19:20:03.131513+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11180",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: KRT85 were set to ",
"entity_name": "KRT85",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:19:44.050183+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11179",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: KRT85 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "KRT85",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:18:41.569126+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11178",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: KRT86 as ready",
"entity_name": "KRT86",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:18:41.558311+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11178",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: krt86 has been classified as Green List (High Evidence).",
"entity_name": "KRT86",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:18:29.093093+11:00",
"panel_name": "Hair disorders",
"panel_id": 3269,
"panel_version": "0.51",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: KRT86 as ready",
"entity_name": "KRT86",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:18:29.081237+11:00",
"panel_name": "Hair disorders",
"panel_id": 3269,
"panel_version": "0.51",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: krt86 has been classified as Green List (High Evidence).",
"entity_name": "KRT86",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:18:27.062719+11:00",
"panel_name": "Hair disorders",
"panel_id": 3269,
"panel_version": "0.51",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: KRT86 were changed from Monilethrix, 158000 to Monilethrix, MIM# 158000",
"entity_name": "KRT86",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:18:19.899794+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11178",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: KRT86 were changed from to Monilethrix, MIM# 158000",
"entity_name": "KRT86",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:18:08.832040+11:00",
"panel_name": "Hair disorders",
"panel_id": 3269,
"panel_version": "0.50",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: KRT86: Rating: GREEN; Mode of pathogenicity: None; Publications: 9241275; Phenotypes: Monilethrix, MIM# 158000; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "KRT86",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:17:54.415216+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11177",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: KRT86 were set to ",
"entity_name": "KRT86",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:17:39.589671+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11176",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: KRT86 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "KRT86",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:08:48.360744+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11175",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: KRT86: Rating: GREEN; Mode of pathogenicity: None; Publications: 9241275; Phenotypes: Monilethrix, MIM# 158000; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "KRT86",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:05:29.109034+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11175",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: KRT9 as ready",
"entity_name": "KRT9",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:05:29.097451+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11175",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: krt9 has been classified as Green List (High Evidence).",
"entity_name": "KRT9",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:05:21.629913+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11175",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: KRT9 were changed from to Palmoplantar keratoderma, epidermolytic (MIM#144200)",
"entity_name": "KRT9",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:04:54.378997+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11174",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: KRT9 were set to ",
"entity_name": "KRT9",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:04:35.815448+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11173",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: KRT9 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "KRT9",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:04:18.752536+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11172",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: KRT9: Rating: GREEN; Mode of pathogenicity: None; Publications: 31525823, 29044727, 7512862; Phenotypes: Palmoplantar keratoderma, epidermolytic (MIM#144200); Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "KRT9",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:02:21.039979+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11172",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: KY as ready",
"entity_name": "KY",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:02:21.023478+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11172",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: ky has been classified as Green List (High Evidence).",
"entity_name": "KY",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:02:12.029886+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11172",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: KY were changed from to Myopathy, myofibrillar, 7, MIM#617114",
"entity_name": "KY",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:01:53.711359+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11171",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: KY were set to ",
"entity_name": "KY",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:01:34.785910+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11170",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: KY was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "KY",
"entity_type": "gene"
},
{
"created": "2022-03-07T19:01:17.151617+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11169",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: KY: Rating: GREEN; Mode of pathogenicity: None; Publications: 11136708, 27485408, 27484770, 30591934; Phenotypes: Myopathy, myofibrillar, 7, MIM#617114; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "KY",
"entity_type": "gene"
},
{
"created": "2022-03-07T17:38:17.900597+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11169",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: KYNU as ready",
"entity_name": "KYNU",
"entity_type": "gene"
},
{
"created": "2022-03-07T17:38:17.889244+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11169",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: kynu has been classified as Green List (High Evidence).",
"entity_name": "KYNU",
"entity_type": "gene"
},
{
"created": "2022-03-07T17:38:09.998561+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11169",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: KYNU were changed from to Hydroxykynureninuria MIM#236800; Vertebral, cardiac, renal, and limb defects syndrome 2 MIM#617661; Disorders of histidine, tryptophan or lysine metabolism",
"entity_name": "KYNU",
"entity_type": "gene"
},
{
"created": "2022-03-07T17:37:49.934133+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11168",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: KYNU were set to ",
"entity_name": "KYNU",
"entity_type": "gene"
},
{
"created": "2022-03-07T17:37:28.520485+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11167",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: KYNU was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "KYNU",
"entity_type": "gene"
},
{
"created": "2022-03-07T12:59:27.121977+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11166",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: JAG1 as ready",
"entity_name": "JAG1",
"entity_type": "gene"
},
{
"created": "2022-03-07T12:59:27.111518+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11166",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: jag1 has been classified as Green List (High Evidence).",
"entity_name": "JAG1",
"entity_type": "gene"
},
{
"created": "2022-03-07T12:59:19.450927+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11166",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: JAG1 were changed from to Alagille syndrome 1, MIM# 118450; Charcot-Marie-Tooth disease, axonal, type 2HH, MIM# 619574",
"entity_name": "JAG1",
"entity_type": "gene"
},
{
"created": "2022-03-07T12:58:10.716327+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11165",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: JAG1 were set to ",
"entity_name": "JAG1",
"entity_type": "gene"
},
{
"created": "2022-03-07T12:57:50.523441+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11164",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: JAG1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "JAG1",
"entity_type": "gene"
},
{
"created": "2022-03-07T12:56:40.154343+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11163",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "changed review comment from: Two unrelated families reported with CMT type 2. Affected individuals in both families exhibited severe vocal fold paresis, a rare feature of peripheral nerve disease that can be life-threatening. Studies of mutant protein posttranslational modification and localization indicated that the mutations (p.Ser577Arg, p.Ser650Pro) impair protein glycosylation and reduce JAG1 cell surface expression. Mice harboring heterozygous CMT2-associated mutations exhibited mild peripheral neuropathy, and homozygous expression resulted in embryonic lethality by midgestation. Pre-existing rat model. \nSources: Literature; to: Association with Alagille is very well established.\r\n\r\nTwo unrelated families reported with CMT type 2. Affected individuals in both families exhibited severe vocal fold paresis, a rare feature of peripheral nerve disease that can be life-threatening. Studies of mutant protein posttranslational modification and localization indicated that the mutations (p.Ser577Arg, p.Ser650Pro) impair protein glycosylation and reduce JAG1 cell surface expression. Mice harboring heterozygous CMT2-associated mutations exhibited mild peripheral neuropathy, and homozygous expression resulted in embryonic lethality by midgestation. Pre-existing rat model. \r\nSources: Literature",
"entity_name": "JAG1",
"entity_type": "gene"
},
{
"created": "2022-03-07T12:56:20.363322+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11163",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: JAG1: Changed phenotypes: Alagille syndrome 1, MIM# 118450, Charcot-Marie-Tooth disease, axonal, type 2HH, MIM# 619574",
"entity_name": "JAG1",
"entity_type": "gene"
},
{
"created": "2022-03-07T12:53:25.069824+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11163",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: JUP as ready",
"entity_name": "JUP",
"entity_type": "gene"
},
{
"created": "2022-03-07T12:53:25.054148+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11163",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: jup has been classified as Green List (High Evidence).",
"entity_name": "JUP",
"entity_type": "gene"
},
{
"created": "2022-03-07T12:53:06.130730+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11163",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: JUP were changed from to Arrhythmogenic right ventricular dysplasia 12, MIM# 611528; Naxos disease, MIM# 601214",
"entity_name": "JUP",
"entity_type": "gene"
},
{
"created": "2022-03-07T12:52:43.823926+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11162",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: JUP were set to ",
"entity_name": "JUP",
"entity_type": "gene"
},
{
"created": "2022-03-07T12:52:21.918520+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11161",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: JUP was changed from Unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "JUP",
"entity_type": "gene"
},
{
"created": "2022-03-07T12:52:00.415307+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11160",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: JUP: Changed phenotypes: Arrhythmogenic right ventricular dysplasia 12, MIM# 611528, Naxos disease, MIM# 601214",
"entity_name": "JUP",
"entity_type": "gene"
},
{
"created": "2022-03-07T12:51:41.352968+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11160",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: JUP: Rating: GREEN; Mode of pathogenicity: None; Publications: 2945574, 21668431, 2945574, 9610536, 18937352, 10902626, 15851108, 27170944, 11691526, 16893920, 29802319, 31275992, 25820315, 25820315, 25765472, 25705887, 25087486, 21668431, 20130592, 17924338, 20031617, 10902626, 20130592, 21320868, 32212272; Phenotypes: Arrhythmogenic right ventricular dysplasia 12, MIM# 611528; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "JUP",
"entity_type": "gene"
},
{
"created": "2022-03-07T12:42:49.038988+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11160",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: JPT1 as ready",
"entity_name": "JPT1",
"entity_type": "gene"
},
{
"created": "2022-03-07T12:42:49.024426+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11160",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: jpt1 has been classified as Red List (Low Evidence).",
"entity_name": "JPT1",
"entity_type": "gene"
},
{
"created": "2022-03-07T12:42:37.466221+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11160",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: JPT1 as Red List (low evidence)",
"entity_name": "JPT1",
"entity_type": "gene"
},
{
"created": "2022-03-07T12:42:37.456981+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11160",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: jpt1 has been classified as Red List (Low Evidence).",
"entity_name": "JPT1",
"entity_type": "gene"
},
{
"created": "2022-03-07T09:17:51.906710+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11159",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: JAK2 as ready",
"entity_name": "JAK2",
"entity_type": "gene"
},
{
"created": "2022-03-07T09:17:51.895435+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11159",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: jak2 has been classified as Amber List (Moderate Evidence).",
"entity_name": "JAK2",
"entity_type": "gene"
},
{
"created": "2022-03-07T09:17:41.893852+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11159",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: JAK2 were changed from to Thrombocythaemia 3, MIM# 614521",
"entity_name": "JAK2",
"entity_type": "gene"
},
{
"created": "2022-03-07T09:17:19.452899+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11158",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: JAK2 were set to ",
"entity_name": "JAK2",
"entity_type": "gene"
},
{
"created": "2022-03-07T09:16:59.305331+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11157",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: JAK2 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "JAK2",
"entity_type": "gene"
},
{
"created": "2022-03-07T09:16:41.725553+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11156",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: JAK2 as Amber List (moderate evidence)",
"entity_name": "JAK2",
"entity_type": "gene"
},
{
"created": "2022-03-07T09:16:41.714590+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11156",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: jak2 has been classified as Amber List (Moderate Evidence).",
"entity_name": "JAK2",
"entity_type": "gene"
},
{
"created": "2022-03-07T09:16:24.932605+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11155",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Tag somatic tag was added to gene: JAK2.",
"entity_name": "JAK2",
"entity_type": "gene"
},
{
"created": "2022-03-07T09:16:10.723008+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11155",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: JAK2: Rating: AMBER; Mode of pathogenicity: None; Publications: 22397670, 35129130; Phenotypes: Thrombocythaemia 3, MIM# 614521; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "JAK2",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:22:26.575709+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11155",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: ZNF644 as ready",
"entity_name": "ZNF644",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:22:26.565785+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11155",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: znf644 has been classified as Green List (High Evidence).",
"entity_name": "ZNF644",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:22:18.082045+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11155",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: ZNF644 were changed from to Myopia 21, autosomal dominant, MIM# 614167",
"entity_name": "ZNF644",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:21:58.703742+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11154",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: ZNF644 were set to ",
"entity_name": "ZNF644",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:21:38.257147+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11153",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: ZNF644 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "ZNF644",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:21:19.487627+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11152",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: ZNF644: Rating: GREEN; Mode of pathogenicity: None; Publications: 21695231, 30834109, 31560770, 24991186; Phenotypes: Myopia 21, autosomal dominant, MIM# 614167; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "ZNF644",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:17:16.003231+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11152",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: ZNF513 as ready",
"entity_name": "ZNF513",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:17:15.991679+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11152",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: znf513 has been classified as Amber List (Moderate Evidence).",
"entity_name": "ZNF513",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:17:08.334913+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11152",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: ZNF513 were changed from to Retinitis pigmentosa 58 MIM#613617",
"entity_name": "ZNF513",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:16:48.543940+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11151",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: ZNF513 were set to ",
"entity_name": "ZNF513",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:16:28.668927+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11150",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: ZNF513 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "ZNF513",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:16:10.098410+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11149",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: ZNF513 as Amber List (moderate evidence)",
"entity_name": "ZNF513",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:16:10.086754+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11149",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: znf513 has been classified as Amber List (Moderate Evidence).",
"entity_name": "ZNF513",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:15:48.183135+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11148",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: ZNF513: Rating: AMBER; Mode of pathogenicity: None; Publications: 20797688; Phenotypes: Retinitis pigmentosa 58 MIM#613617; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "ZNF513",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:12:40.227002+11:00",
"panel_name": "Retinitis pigmentosa_Autosomal Recessive/X-linked",
"panel_id": 277,
"panel_version": "0.107",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: ZNF408 as ready",
"entity_name": "ZNF408",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:12:40.215118+11:00",
"panel_name": "Retinitis pigmentosa_Autosomal Recessive/X-linked",
"panel_id": 277,
"panel_version": "0.107",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: znf408 has been classified as Green List (High Evidence).",
"entity_name": "ZNF408",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:12:37.926809+11:00",
"panel_name": "Retinitis pigmentosa_Autosomal Recessive/X-linked",
"panel_id": 277,
"panel_version": "0.107",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: ZNF408 were changed from Retinitis pigmentosa 72; Familial exudative vitreoretinopathy (FEVR) to Retinitis pigmentosa 72, MIM# 616469",
"entity_name": "ZNF408",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:12:25.134808+11:00",
"panel_name": "Retinitis pigmentosa_Autosomal Recessive/X-linked",
"panel_id": 277,
"panel_version": "0.106",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: ZNF408 were set to ",
"entity_name": "ZNF408",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:12:08.080819+11:00",
"panel_name": "Retinitis pigmentosa_Autosomal Recessive/X-linked",
"panel_id": 277,
"panel_version": "0.105",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: ZNF408 was changed from BOTH monoallelic and biallelic, autosomal or pseudoautosomal to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "ZNF408",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:11:56.227913+11:00",
"panel_name": "Retinitis pigmentosa_Autosomal Recessive/X-linked",
"panel_id": 277,
"panel_version": "0.104",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: ZNF408: Rating: GREEN; Mode of pathogenicity: None; Publications: 25882705, 34259982, 28095122; Phenotypes: Retinitis pigmentosa 72, MIM# 616469; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "ZNF408",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:10:17.468020+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11148",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: ZNF408 as ready",
"entity_name": "ZNF408",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:10:17.457027+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11148",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: znf408 has been classified as Green List (High Evidence).",
"entity_name": "ZNF408",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:10:08.249965+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11148",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: ZNF408 were changed from to Exudative vitreoretinopathy 6, MIM# 616468; Retinitis pigmentosa 72, MIM# 616469",
"entity_name": "ZNF408",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:09:49.180660+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11147",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: ZNF408 were set to ",
"entity_name": "ZNF408",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:09:28.755041+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11146",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: ZNF408 was changed from Unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "ZNF408",
"entity_type": "gene"
},
{
"created": "2022-03-06T12:09:09.389336+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11145",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: ZNF408: Rating: GREEN; Mode of pathogenicity: None; Publications: 23716654, 32530348, 32097476, 32238352, 30998249, 29982478, 25882705, 34259982, 28095122; Phenotypes: Exudative vitreoretinopathy 6, MIM# 616468, Retinitis pigmentosa 72, MIM# 616469; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "ZNF408",
"entity_type": "gene"
},
{
"created": "2022-03-05T14:02:25.121554+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11145",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: ZNF335 as ready",
"entity_name": "ZNF335",
"entity_type": "gene"
},
{
"created": "2022-03-05T14:02:25.102873+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11145",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: znf335 has been classified as Green List (High Evidence).",
"entity_name": "ZNF335",
"entity_type": "gene"
},
{
"created": "2022-03-05T14:02:19.596238+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "1.3",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: ZNF335 as ready",
"entity_name": "ZNF335",
"entity_type": "gene"
},
{
"created": "2022-03-05T14:02:19.585069+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "1.3",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: znf335 has been classified as Green List (High Evidence).",
"entity_name": "ZNF335",
"entity_type": "gene"
},
{
"created": "2022-03-05T14:02:14.338139+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "1.3",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: ZNF335 as Green List (high evidence)",
"entity_name": "ZNF335",
"entity_type": "gene"
},
{
"created": "2022-03-05T14:02:14.329027+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "1.3",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: znf335 has been classified as Green List (High Evidence).",
"entity_name": "ZNF335",
"entity_type": "gene"
},
{
"created": "2022-03-05T14:02:03.179756+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "1.2",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "gene: ZNF335 was added\ngene: ZNF335 was added to Fetal anomalies. Sources: Expert Review\nMode of inheritance for gene: ZNF335 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: ZNF335 were set to 23178126; 27540107; 29652087; 34982360\nPhenotypes for gene: ZNF335 were set to Microcephaly 10, primary, autosomal recessive (MIM#615095)\nReview for gene: ZNF335 was set to GREEN\nAdded comment: Microcephaly is generally primary, including reports of -9SD at birth. \nSources: Expert Review",
"entity_name": "ZNF335",
"entity_type": "gene"
},
{
"created": "2022-03-05T14:00:38.853675+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11145",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: ZNF335 were changed from to Microcephaly 10, primary, autosomal recessive (MIM#615095)",
"entity_name": "ZNF335",
"entity_type": "gene"
},
{
"created": "2022-03-05T13:59:57.643801+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11144",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: ZNF335 were set to ",
"entity_name": "ZNF335",
"entity_type": "gene"
},
{
"created": "2022-03-05T13:59:15.508199+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11143",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: ZNF335 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "ZNF335",
"entity_type": "gene"
},
{
"created": "2022-03-05T13:58:42.285138+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11142",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: ZNF335: Rating: GREEN; Mode of pathogenicity: None; Publications: 23178126, 27540107, 29652087; Phenotypes: Microcephaly 10, primary, autosomal recessive (MIM#615095); Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "ZNF335",
"entity_type": "gene"
},
{
"created": "2022-03-05T13:53:38.282051+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11142",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: ZMYND11 as ready",
"entity_name": "ZMYND11",
"entity_type": "gene"
},
{
"created": "2022-03-05T13:53:38.269153+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11142",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: zmynd11 has been classified as Green List (High Evidence).",
"entity_name": "ZMYND11",
"entity_type": "gene"
},
{
"created": "2022-03-05T13:53:30.154188+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11142",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: ZMYND11 were changed from to Mental retardation, autosomal dominant 30, MIM# 616083",
"entity_name": "ZMYND11",
"entity_type": "gene"
},
{
"created": "2022-03-05T13:53:05.394228+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11141",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: ZMYND11 were set to ",
"entity_name": "ZMYND11",
"entity_type": "gene"
},
{
"created": "2022-03-05T13:52:46.921779+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11140",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: ZMYND11 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "ZMYND11",
"entity_type": "gene"
},
{
"created": "2022-03-05T13:52:27.454553+11:00",
"panel_name": "Mendeliome",
"panel_id": 137,
"panel_version": "0.11139",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: ZMYND11: Rating: GREEN; Mode of pathogenicity: None; Publications: 32097528, 34216016; Phenotypes: Mental retardation, autosomal dominant 30 MIM# 616083; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "ZMYND11",
"entity_type": "gene"
},
{
"created": "2022-03-05T13:50:49.716834+11:00",
"panel_name": "Congenital Heart Defect",
"panel_id": 76,
"panel_version": "0.199",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: ZFPM2 as ready",
"entity_name": "ZFPM2",
"entity_type": "gene"
}
]
}