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{
"count": 220489,
"next": "https://panelapp-aus.org/api/v1/activities/?format=api&page=971",
"previous": "https://panelapp-aus.org/api/v1/activities/?format=api&page=969",
"results": [
{
"created": "2022-02-23T18:27:24.040295+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4083",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TCTN3 as ready",
"entity_name": "TCTN3",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:27:24.031047+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4083",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tctn3 has been classified as Green List (High Evidence).",
"entity_name": "TCTN3",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:27:19.296412+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4083",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TCTN3 were changed from MOHR-MAJEWSKI SYNDROME to Joubert syndrome 18, OMIM #614815; Orofaciodigital syndrome IV, OMIM #258860",
"entity_name": "TCTN3",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:27:07.987906+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4082",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TCTN3 were set to ",
"entity_name": "TCTN3",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:26:24.727546+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4081",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TFAP2A as ready",
"entity_name": "TFAP2A",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:26:24.716664+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4081",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tfap2a has been classified as Green List (High Evidence).",
"entity_name": "TFAP2A",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:23:10.688111+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4081",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TFAP2A were changed from BRANCHIOOCULOFACIAL SYNDROME to Branchiooculofacial syndrome, MIM# 113620",
"entity_name": "TFAP2A",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:22:58.627841+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4080",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TFAP2A were set to ",
"entity_name": "TFAP2A",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:22:47.483817+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4079",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: TFAP2A was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "TFAP2A",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:22:05.560436+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4078",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TFAP2B as ready",
"entity_name": "TFAP2B",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:22:05.544370+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4078",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tfap2b has been classified as Green List (High Evidence).",
"entity_name": "TFAP2B",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:21:42.675819+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4078",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TFAP2B were changed from CHAR SYNDROME to Char syndrome, MIM# 169100; Syndromic craniosynostosis",
"entity_name": "TFAP2B",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:21:31.599161+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4077",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TFAP2B were set to ",
"entity_name": "TFAP2B",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:21:20.835741+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4076",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: TFAP2B was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "TFAP2B",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:21:07.249869+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4075",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: TFAP2B as Green List (high evidence)",
"entity_name": "TFAP2B",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:21:07.239729+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4075",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tfap2b has been classified as Green List (High Evidence).",
"entity_name": "TFAP2B",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:20:55.049751+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4074",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "changed review comment from: PDA, facial dysmorphism and clinodactyly unlikely to be detectable antenatally.; to: Char syndrome: PDA, facial dysmorphism and clinodactyly unlikely to be detectable antenatally.\r\n\r\nCraniosynostosis: Four individuals reported in PMID: 31292255 (Correction in PMID: 31405973) as part of a craniosynostosis cohort: 2 de novo and 2 inherited. There is evidence for reduced penetrance as in one case the variant was inherited from an unaffected parent (affected parent for the other inherited variant). ",
"entity_name": "TFAP2B",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:20:23.990881+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4074",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "edited their review of gene: TFAP2B: Changed rating: GREEN; Changed publications: 31292255; Changed phenotypes: Char syndrome, MIM# 169100, Syndromic craniosynostosis",
"entity_name": "TFAP2B",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:19:30.848098+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4074",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Classified gene: TFAP2B as Red List (low evidence)",
"entity_name": "TFAP2B",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:19:30.835143+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4074",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tfap2b has been classified as Red List (Low Evidence).",
"entity_name": "TFAP2B",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:19:17.384776+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4073",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: TFAP2B: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: Char syndrome, MIM# 169100; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "TFAP2B",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:17:00.366732+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4073",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TGFBR1 as ready",
"entity_name": "TGFBR1",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:17:00.350923+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4073",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tgfbr1 has been classified as Green List (High Evidence).",
"entity_name": "TGFBR1",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:16:01.758976+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4073",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TGFBR1 were changed from LOEYS-DIETZ SYNDROME TYPE 2A; AORTIC ANEURYSM FAMILIAL THORACIC TYPE 5; LOEYS-DIETZ SYNDROME TYPE 1A to Loeys-Dietz syndrome 1, MIM# 609192",
"entity_name": "TGFBR1",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:15:47.093829+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4072",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: TGFBR1 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "TGFBR1",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:15:34.982255+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4071",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: TGFBR1: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Loeys-Dietz syndrome 1, MIM# 609192; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "TGFBR1",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:14:40.520251+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4071",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TGFBR2 as ready",
"entity_name": "TGFBR2",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:14:40.510272+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4071",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tgfbr2 has been classified as Green List (High Evidence).",
"entity_name": "TGFBR2",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:14:37.145249+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4071",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TGFBR2 were changed from LOEYS-DIETZ SYNDROME; TGFBR2-RELATED LOEYS-DIETZ SYNDROME to Loeys-Dietz syndrome 2, MIM# 610168",
"entity_name": "TGFBR2",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:14:16.790048+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4070",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: TGFBR2 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "TGFBR2",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:14:04.465838+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4069",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: TGFBR2: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Loeys-Dietz syndrome 2 610168; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "TGFBR2",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:13:07.779572+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4069",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TGIF1 as ready",
"entity_name": "TGIF1",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:13:07.766171+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4069",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tgif1 has been classified as Green List (High Evidence).",
"entity_name": "TGIF1",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:13:01.412559+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4069",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TGIF1 were changed from HOLOPROSENCEPHALY; Holoprosencephaly 4 142946 to Holoprosencephaly 4, MIM# 142946; MONDO:0007734",
"entity_name": "TGIF1",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:12:49.653766+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4068",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TGIF1 were set to ",
"entity_name": "TGIF1",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:12:38.154533+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4067",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: TGIF1 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "TGIF1",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:12:07.809118+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4066",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TINF2 as ready",
"entity_name": "TINF2",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:12:07.798457+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4066",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tinf2 has been classified as Green List (High Evidence).",
"entity_name": "TINF2",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:12:04.190930+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4066",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TINF2 were changed from EXUDATIVE RETINOPATHY WITH BONE MARROW FAILURE to Revesz syndrome, MIM# 268130",
"entity_name": "TINF2",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:11:51.745294+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4065",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TINF2 were set to ",
"entity_name": "TINF2",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:11:39.962259+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4064",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: TINF2 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "TINF2",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:11:28.194747+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4063",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "changed review comment from: Bone marrow failure is the main presenting feature. DD is part of the phenotype, neurological involvement progressive.; to: IUGR.",
"entity_name": "TINF2",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:10:48.274118+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4063",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TMEM138 as ready",
"entity_name": "TMEM138",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:10:48.258048+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4063",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tmem138 has been classified as Green List (High Evidence).",
"entity_name": "TMEM138",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:10:44.652617+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4063",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TMEM138 were changed from Joubert syndrome 16 614465 to Joubert syndrome 16, MIM# 614465; MONDO:0013764",
"entity_name": "TMEM138",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:10:32.766334+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4062",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TMEM138 were set to ",
"entity_name": "TMEM138",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:10:04.193618+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4061",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TMEM165 as ready",
"entity_name": "TMEM165",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:10:04.176268+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4061",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tmem165 has been classified as Green List (High Evidence).",
"entity_name": "TMEM165",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:09:56.600697+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4061",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TMEM165 were changed from CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIK to Congenital disorder of glycosylation, type IIk, MIM# 614727; TMEM165-CDG, MONDO:0013870",
"entity_name": "TMEM165",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:09:43.725290+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4060",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TMEM165 were set to ",
"entity_name": "TMEM165",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:09:08.590871+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4059",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TMEM231 as ready",
"entity_name": "TMEM231",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:09:08.577470+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4059",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tmem231 has been classified as Green List (High Evidence).",
"entity_name": "TMEM231",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:09:04.910684+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4059",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TMEM231 were changed from Joubert syndrome 20 614970; Meckel syndrome 11 615397 to Joubert syndrome 20, MIM# 614970; MONDO:0013994; Meckel syndrome 11, MIM# 615397; MONDO:0014164",
"entity_name": "TMEM231",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:08:49.712607+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4058",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TMEM231 were set to ",
"entity_name": "TMEM231",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:08:19.702999+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4057",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TMEM237 as ready",
"entity_name": "TMEM237",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:08:19.692826+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4057",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tmem237 has been classified as Green List (High Evidence).",
"entity_name": "TMEM237",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:08:15.055704+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4057",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TMEM237 were changed from JOUBERT SYNDROME 14 to Joubert syndrome 14, MIM# 614424",
"entity_name": "TMEM237",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:08:03.110980+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4056",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TMEM237 were set to ",
"entity_name": "TMEM237",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:07:31.975587+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4055",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TMEM5 as ready",
"entity_name": "TMEM5",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:07:31.963768+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4055",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tmem5 has been classified as Green List (High Evidence).",
"entity_name": "TMEM5",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:07:24.751501+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4055",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TMEM5 were changed from SEVERE COBBLESTONE LISSENCEPHALY to Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 10, MIM# 615041, MONDO:0014022",
"entity_name": "TMEM5",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:07:12.884075+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4054",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TMEM5 were set to ",
"entity_name": "TMEM5",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:06:41.080576+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4053",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TMEM67 as ready",
"entity_name": "TMEM67",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:06:41.069368+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4053",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tmem67 has been classified as Green List (High Evidence).",
"entity_name": "TMEM67",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:06:37.317436+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4053",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TMEM67 were changed from COACH SYNDROM; JOUBERT SYNDROME TYPE 6; MECKEL SYNDROME TYPE 3; NEPHRONOPHTHISIS TYPE 11 to Joubert syndrome 6, MIM# 610688; Meckel syndrome 3, MIM# 607361",
"entity_name": "TMEM67",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:06:24.920035+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4052",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TMEM67 were set to ",
"entity_name": "TMEM67",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:05:50.899385+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4051",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TMEM94 as ready",
"entity_name": "TMEM94",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:05:50.889570+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4051",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tmem94 has been classified as Green List (High Evidence).",
"entity_name": "TMEM94",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:05:13.314926+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4051",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TOP3A as ready",
"entity_name": "TOP3A",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:05:13.297722+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4051",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: top3a has been classified as Green List (High Evidence).",
"entity_name": "TOP3A",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:05:09.656064+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4051",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TOP3A were changed from Bloom Syndrome like Disorder to Microcephaly, growth restriction, and increased sister chromatid exchange 2, MIM# 618097",
"entity_name": "TOP3A",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:04:59.246133+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4050",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TOP3A were set to 30193137",
"entity_name": "TOP3A",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:04:25.506615+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4049",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TP63 as ready",
"entity_name": "TP63",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:04:25.492872+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4049",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tp63 has been classified as Green List (High Evidence).",
"entity_name": "TP63",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:04:22.211210+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4049",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TP63 were changed from ANKYLOBLEPHARON-ECTODERMAL DEFECTS-CLEFT LIP/PALATE; ACRO-DERMATO-UNGUAL-LACRIMAL-TOOTH SYNDROME; ECTRODACTYLY-ECTODERMAL DYSPLASIA-CLEFT LIP/PALATE SYNDROME TYPE 3; SPLIT-HAND/FOOT MALFORMATION TYPE 4; ECTODERMAL DYSPLASIA RAPP-HODGKIN TYPE; NON-SYNDROMIC OROFACIAL CLEFT TYPE 8; LIMB-MAMMARY SYNDROME to ADULT syndrome, OMIM #103285; Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3, OMIM #604292; Hay-Wells syndrome, OMIM #106260; Limb-mammary syndrome, OMIM #603543; Orofacial cleft 8, OMIM #618149; Rapp-Hodgkin syndrome, OMIM #129400; Split-hand/foot malformation 4, OMIM #605289",
"entity_name": "TP63",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:04:04.556081+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4048",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: TP63 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "TP63",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:03:45.161863+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4047",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: TP63: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: ADULT syndrome, OMIM #103285, Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3, OMIM #604292, Hay-Wells syndrome, OMIM #106260, Limb-mammary syndrome, OMIM #603543, Orofacial cleft 8, OMIM #618149, Rapp-Hodgkin syndrome, OMIM #129400, Split-hand/foot malformation 4, OMIM #605289; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "TP63",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:03:05.711491+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4047",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TPM2 as ready",
"entity_name": "TPM2",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:03:05.701955+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4047",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: tpm2 has been classified as Green List (High Evidence).",
"entity_name": "TPM2",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:03:01.788674+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4047",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TPM2 were changed from Arthrogryposis multiplex congenita, distal, type 1, 108120; Arthrogryposis, distal, type 2B, 601680; ARTHROGRYPOSIS, DISTAL, TYPE 1 to Arthrogryposis multiplex congenita, distal, type 1, 108120; Arthrogryposis, distal, type 2B, 601680; Multiple pterygium syndrome",
"entity_name": "TPM2",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:02:43.104587+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4046",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TPM2 were set to 12592607; 17339586",
"entity_name": "TPM2",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:02:26.370472+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4045",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: TPM2 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "TPM2",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:01:56.515195+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4044",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TRAF7 as ready",
"entity_name": "TRAF7",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:01:56.503637+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4044",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: traf7 has been classified as Green List (High Evidence).",
"entity_name": "TRAF7",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:01:52.764510+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4044",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TRAF7 were changed from Developmental Delay, Congenital Anomalies, and Dysmorphic Features; Cardiac, facial, and digital anomalies with developmental delay, 618164 to Cardiac, facial, and digital anomalies with developmental delay, MIM# 618164",
"entity_name": "TRAF7",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:01:39.710320+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4043",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TRAF7 were set to 29961569",
"entity_name": "TRAF7",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:01:29.037105+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4042",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Mode of inheritance for gene: TRAF7 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "TRAF7",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:00:28.538072+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4041",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TRAPPC9 as ready",
"entity_name": "TRAPPC9",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:00:28.524920+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4041",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: trappc9 has been classified as Green List (High Evidence).",
"entity_name": "TRAPPC9",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:00:19.891772+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4041",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TRAPPC9 were changed from MENTAL RETARDATION AUTOSOMAL RECESSIVE TYPE 13 to Intellectual disability, autosomal recessive 13 (MIM# 613192)",
"entity_name": "TRAPPC9",
"entity_type": "gene"
},
{
"created": "2022-02-23T18:00:07.273160+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4040",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TRAPPC9 were set to ",
"entity_name": "TRAPPC9",
"entity_type": "gene"
},
{
"created": "2022-02-23T17:59:06.871044+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4039",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "changed review comment from: Note multiple intragenic CNVs reported for this gene.; to: Note multiple intragenic CNVs reported for this gene. Cleft lip and brain abnormalities reported.",
"entity_name": "TRAPPC9",
"entity_type": "gene"
},
{
"created": "2022-02-23T17:58:08.676122+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4039",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TRIM37 as ready",
"entity_name": "TRIM37",
"entity_type": "gene"
},
{
"created": "2022-02-23T17:58:08.657001+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4039",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: trim37 has been classified as Green List (High Evidence).",
"entity_name": "TRIM37",
"entity_type": "gene"
},
{
"created": "2022-02-23T17:58:04.122284+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4039",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TRIM37 were changed from MULIBREY NANISM to Mulibrey nanism, OMIM #253250",
"entity_name": "TRIM37",
"entity_type": "gene"
},
{
"created": "2022-02-23T17:57:43.478511+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4038",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: TRIM37: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Mulibrey nanism, OMIM #253250; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TRIM37",
"entity_type": "gene"
},
{
"created": "2022-02-23T16:44:32.571913+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4038",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Marked gene: TRIP11 as ready",
"entity_name": "TRIP11",
"entity_type": "gene"
},
{
"created": "2022-02-23T16:44:32.560960+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4038",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Gene: trip11 has been classified as Green List (High Evidence).",
"entity_name": "TRIP11",
"entity_type": "gene"
},
{
"created": "2022-02-23T16:44:28.445742+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4038",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Phenotypes for gene: TRIP11 were changed from ACHONDROGENESIS TYPE 1A to Achondrogenesis, type IA, MIM# 200600",
"entity_name": "TRIP11",
"entity_type": "gene"
},
{
"created": "2022-02-23T16:44:15.844397+11:00",
"panel_name": "Fetal anomalies",
"panel_id": 3763,
"panel_version": "0.4037",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "Publications for gene: TRIP11 were set to ",
"entity_name": "TRIP11",
"entity_type": "gene"
}
]
}