{"count":220313,"next":"https://panelapp-aus.org/api/v1/activities/?format=json&page=1362","previous":"https://panelapp-aus.org/api/v1/activities/?format=json&page=1360","results":[{"created":"2021-04-07T18:00:30.323383+10:00","panel_name":"Lysosomal Storage Disorder","panel_id":181,"panel_version":"0.70","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: AGA were changed from  to Aspartylglucosaminuria, MIM# 208400","entity_name":"AGA","entity_type":"gene"},{"created":"2021-04-07T18:00:04.849654+10:00","panel_name":"Lysosomal Storage Disorder","panel_id":181,"panel_version":"0.69","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: AGA were set to ","entity_name":"AGA","entity_type":"gene"},{"created":"2021-04-07T17:59:33.861894+10:00","panel_name":"Lysosomal Storage Disorder","panel_id":181,"panel_version":"0.68","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: AGA was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"AGA","entity_type":"gene"},{"created":"2021-04-07T17:59:01.936088+10:00","panel_name":"Lysosomal Storage Disorder","panel_id":181,"panel_version":"0.67","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: AGA: Rating: GREEN; Mode of pathogenicity: None; Publications: 1703489, 1904874, 8064811, 8946839; Phenotypes: Aspartylglucosaminuria, MIM# 208400; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"AGA","entity_type":"gene"},{"created":"2021-04-07T17:48:29.422358+10:00","panel_name":"Regression","panel_id":206,"panel_version":"0.282","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: ATCAY as ready","entity_name":"ATCAY","entity_type":"gene"},{"created":"2021-04-07T17:48:29.411940+10:00","panel_name":"Regression","panel_id":206,"panel_version":"0.282","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: atcay has been classified as Red List (Low Evidence).","entity_name":"ATCAY","entity_type":"gene"},{"created":"2021-04-07T17:48:26.855180+10:00","panel_name":"Regression","panel_id":206,"panel_version":"0.282","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: ATCAY were changed from  to Ataxia, cerebellar, Cayman type, MIM# 601238; MONDO:0011025","entity_name":"ATCAY","entity_type":"gene"},{"created":"2021-04-07T17:48:03.851580+10:00","panel_name":"Regression","panel_id":206,"panel_version":"0.281","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: ATCAY were set to ","entity_name":"ATCAY","entity_type":"gene"},{"created":"2021-04-07T17:47:26.512049+10:00","panel_name":"Regression","panel_id":206,"panel_version":"0.280","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: ATCAY was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"ATCAY","entity_type":"gene"},{"created":"2021-04-07T17:46:57.682970+10:00","panel_name":"Regression","panel_id":206,"panel_version":"0.279","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: ATCAY as Red List (low evidence)","entity_name":"ATCAY","entity_type":"gene"},{"created":"2021-04-07T17:46:57.669905+10:00","panel_name":"Regression","panel_id":206,"panel_version":"0.279","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: atcay has been classified as Red List (Low Evidence).","entity_name":"ATCAY","entity_type":"gene"},{"created":"2021-04-07T17:46:33.459115+10:00","panel_name":"Regression","panel_id":206,"panel_version":"0.278","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: ATCAY: Rating: RED; Mode of pathogenicity: None; Publications: 29449188, 23226316, 26343454, 14556008; Phenotypes: Ataxia, cerebellar, Cayman type, MIM# 601238, MONDO:0011025; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"ATCAY","entity_type":"gene"},{"created":"2021-04-07T17:45:16.246021+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7032","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: ATCAY as ready","entity_name":"ATCAY","entity_type":"gene"},{"created":"2021-04-07T17:45:16.236842+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7032","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: atcay has been classified as Green List (High Evidence).","entity_name":"ATCAY","entity_type":"gene"},{"created":"2021-04-07T17:45:07.705111+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7032","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: ATCAY were changed from  to Ataxia, cerebellar, Cayman type, MIM# 601238; MONDO:0011025","entity_name":"ATCAY","entity_type":"gene"},{"created":"2021-04-07T17:44:50.022289+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7031","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: ATCAY were set to ","entity_name":"ATCAY","entity_type":"gene"},{"created":"2021-04-07T17:44:32.929277+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7030","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: ATCAY was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"ATCAY","entity_type":"gene"},{"created":"2021-04-07T17:44:14.720469+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7029","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: ATCAY: Added comment: Report of a variant c.599_605del, p.Pro200Profs*20 (PMID 29449188), which is in addition to the previously reported linked variants in the Cayman population (c.965+3G > T & p.S301R)(PMID 29449188). Mouse and zebra fish models share phenotypic features with humans with Ataxia, cerebellar, Cayman type (OMIM:601238)(PMID 14556008; 26343454).; Changed rating: GREEN; Changed publications: 14556008, 29449188, 23226316, 26343454; Changed phenotypes: Ataxia, cerebellar, Cayman type, MIM# 601238, MONDO:0011025","entity_name":"ATCAY","entity_type":"gene"},{"created":"2021-04-07T17:42:57.196954+10:00","panel_name":"Ataxia - paediatric","panel_id":271,"panel_version":"0.277","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: ATCAY were changed from Ataxia, cerebellar, Cayman type, MIM# 601238 to Ataxia, cerebellar, Cayman type, MIM# 601238; MONDO:0011025","entity_name":"ATCAY","entity_type":"gene"},{"created":"2021-04-07T17:17:58.203463+10:00","panel_name":"Ataxia - paediatric","panel_id":271,"panel_version":"0.276","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: ATCAY were set to 14556008","entity_name":"ATCAY","entity_type":"gene"},{"created":"2021-04-07T17:17:42.260908+10:00","panel_name":"Ataxia - paediatric","panel_id":271,"panel_version":"0.275","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: ATCAY as Green List (high evidence)","entity_name":"ATCAY","entity_type":"gene"},{"created":"2021-04-07T17:17:42.249553+10:00","panel_name":"Ataxia - paediatric","panel_id":271,"panel_version":"0.275","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: atcay has been classified as Green List (High Evidence).","entity_name":"ATCAY","entity_type":"gene"},{"created":"2021-04-07T17:14:54.044672+10:00","panel_name":"Microcephaly","panel_id":138,"panel_version":"1.1","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: COPB1 were changed from Severe intellectual disability; variable microcephaly; cataracts to Baralle-Macken syndrome, MIM# 619255; Severe intellectual disability; variable microcephaly; cataracts","entity_name":"COPB1","entity_type":"gene"},{"created":"2021-04-07T17:14:11.137101+10:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.3597","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: COPB1 were changed from Severe intellectual disability; variable microcephaly; cataracts to Baralle-Macken syndrome, MIM# 619255; Severe intellectual disability; variable microcephaly; cataracts","entity_name":"COPB1","entity_type":"gene"},{"created":"2021-04-07T17:12:28.023638+10:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.3596","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: COPB1: Changed phenotypes: Baralle-Macken syndrome, MIM# 619255, Severe intellectual disability, variable microcephaly, cataracts","entity_name":"COPB1","entity_type":"gene"},{"created":"2021-04-07T17:12:06.895333+10:00","panel_name":"Microcephaly","panel_id":138,"panel_version":"1.0","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: COPB1: Changed phenotypes: Baralle-Macken syndrome, MIM# 619255, Severe intellectual disability, variable microcephaly, cataracts","entity_name":"COPB1","entity_type":"gene"},{"created":"2021-04-07T17:10:07.492999+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7029","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: COPB1 were changed from Severe intellectual disability; variable microcephaly; cataracts to Baralle-Macken syndrome, MIM#\t619255; Severe intellectual disability; variable microcephaly; cataracts","entity_name":"COPB1","entity_type":"gene"},{"created":"2021-04-07T17:09:39.767176+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7028","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: COPB1: Changed phenotypes: Baralle-Macken syndrome, MIM# 619255, Severe intellectual disability, variable microcephaly, cataracts","entity_name":"COPB1","entity_type":"gene"},{"created":"2021-04-07T17:09:18.277732+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.269","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: COPB1 were changed from Severe intellectual disability; variable microcephaly; cataracts to Baralle-Macken syndrome, MIM#\t619255; Severe intellectual disability; variable microcephaly; cataracts","entity_name":"COPB1","entity_type":"gene"},{"created":"2021-04-07T17:08:49.086531+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.268","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: COPB1: Changed phenotypes: Baralle-Macken syndrome, MIM# 619255, Severe intellectual disability, variable microcephaly, cataracts","entity_name":"COPB1","entity_type":"gene"},{"created":"2021-04-07T07:21:09.833973+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7028","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: ARAP3 as ready","entity_name":"ARAP3","entity_type":"gene"},{"created":"2021-04-07T07:21:09.823074+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7028","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: arap3 has been classified as Amber List (Moderate Evidence).","entity_name":"ARAP3","entity_type":"gene"},{"created":"2021-04-07T07:21:00.170992+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7028","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: ARAP3 as Amber List (moderate evidence)","entity_name":"ARAP3","entity_type":"gene"},{"created":"2021-04-07T07:21:00.160550+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7028","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: arap3 has been classified as Amber List (Moderate Evidence).","entity_name":"ARAP3","entity_type":"gene"},{"created":"2021-04-07T07:20:41.808557+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7027","user_name":"Zornitza Stark","item_type":"entity","text":"gene: ARAP3 was added\ngene: ARAP3 was added to Mendeliome. Sources: Literature\nMode of inheritance for gene: ARAP3 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: ARAP3 were set to 32908855\nPhenotypes for gene: ARAP3 were set to Lymphoedema\nReview for gene: ARAP3 was set to AMBER\nAdded comment: Three unrelated families reported with rare missense variants in this gene as part of a lymphoedema cohort. However, incomplete information regarding segregation and no supporting functional data. \nSources: Literature","entity_name":"ARAP3","entity_type":"gene"},{"created":"2021-04-07T07:14:40.967827+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7026","user_name":"Zornitza Stark","item_type":"entity","text":"changed review comment from: Association with lymphoedema: Two individuals reported with LoF variants as part of a large cohort. Note gene is depleted for LoF in gnomad, and bi-allelic variants have been associated with immunodeficiency.; to: Association with lymphoedema: Two individuals reported with LoF variants as part of a large cohort. Note gene is depleted for LoF in gnomad, and bi-allelic variants have been associated with immunodeficiency. Moderate evidence for gene-disease association.","entity_name":"RORC","entity_type":"gene"},{"created":"2021-04-07T07:14:14.909408+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7026","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: RORC: Added comment: Association with lymphoedema: Two individuals reported with LoF variants as part of a large cohort. Note gene is depleted for LoF in gnomad, and bi-allelic variants have been associated with immunodeficiency.; Changed publications: 26160376, 32960152; Changed phenotypes: Immunodeficiency 42, MIM# 616622, Autosomal recessive mendelian susceptibility to mycobacterial diseases due to complete RORgamma receptor deficiency, MONDO:0014710, Lymphoedema; Changed mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal","entity_name":"RORC","entity_type":"gene"},{"created":"2021-04-07T07:06:46.248091+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7026","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: RORC as ready","entity_name":"RORC","entity_type":"gene"},{"created":"2021-04-07T07:06:46.236523+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7026","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: rorc has been classified as Green List (High Evidence).","entity_name":"RORC","entity_type":"gene"},{"created":"2021-04-07T07:06:38.850171+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7026","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: RORC were changed from  to Immunodeficiency 42, MIM# 616622; Autosomal recessive mendelian susceptibility to mycobacterial diseases due to complete RORgamma receptor deficiency, MONDO:0014710","entity_name":"RORC","entity_type":"gene"},{"created":"2021-04-07T07:06:16.768137+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7025","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: RORC were set to ","entity_name":"RORC","entity_type":"gene"},{"created":"2021-04-07T07:05:59.114708+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7024","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: RORC was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"RORC","entity_type":"gene"},{"created":"2021-04-07T07:05:40.206294+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7023","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: RORC: Rating: GREEN; Mode of pathogenicity: None; Publications: 26160376; Phenotypes: Immunodeficiency 42, MIM# 616622, Autosomal recessive mendelian susceptibility to mycobacterial diseases due to complete RORgamma receptor deficiency, MONDO:0014710; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"RORC","entity_type":"gene"},{"created":"2021-04-07T02:37:54.847288+10:00","panel_name":"Ataxia - paediatric","panel_id":271,"panel_version":"0.274","user_name":"Sarah Leigh","item_type":"entity","text":"reviewed gene: ATCAY: Rating: GREEN; Mode of pathogenicity: None; Publications: 29449188, 23226316, 26343454; Phenotypes: ; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"ATCAY","entity_type":"gene"},{"created":"2021-04-06T21:58:45.172658+10:00","panel_name":"Defects of innate immunity","panel_id":231,"panel_version":"0.75","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: IL17RC as ready","entity_name":"IL17RC","entity_type":"gene"},{"created":"2021-04-06T21:58:45.162628+10:00","panel_name":"Defects of innate immunity","panel_id":231,"panel_version":"0.75","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: il17rc has been classified as Green List (High Evidence).","entity_name":"IL17RC","entity_type":"gene"},{"created":"2021-04-06T21:58:33.691377+10:00","panel_name":"Defects of innate immunity","panel_id":231,"panel_version":"0.75","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: IL17RC were changed from  to Candidiasis, familial, 9, MIM# 616445; MONDO:0014642","entity_name":"IL17RC","entity_type":"gene"},{"created":"2021-04-06T21:58:08.433957+10:00","panel_name":"Defects of innate immunity","panel_id":231,"panel_version":"0.74","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: IL17RC were set to ","entity_name":"IL17RC","entity_type":"gene"},{"created":"2021-04-06T21:57:30.005763+10:00","panel_name":"Defects of innate immunity","panel_id":231,"panel_version":"0.73","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: IL17RC was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"IL17RC","entity_type":"gene"},{"created":"2021-04-06T21:43:55.814983+10:00","panel_name":"Defects of innate immunity","panel_id":231,"panel_version":"0.72","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: IL17RC: Rating: GREEN; Mode of pathogenicity: None; Publications: 25918342; Phenotypes: Candidiasis, familial, 9, MIM# 616445, MONDO:0014642; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"IL17RC","entity_type":"gene"},{"created":"2021-04-06T21:42:29.404665+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7023","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: IL17RC as ready","entity_name":"IL17RC","entity_type":"gene"},{"created":"2021-04-06T21:42:29.394556+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7023","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: il17rc has been classified as Green List (High Evidence).","entity_name":"IL17RC","entity_type":"gene"},{"created":"2021-04-06T21:42:16.286766+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7023","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: IL17RC were changed from  to Candidiasis, familial, 9, MIM# 616445; MONDO:0014642","entity_name":"IL17RC","entity_type":"gene"},{"created":"2021-04-06T21:41:56.339845+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7022","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: IL17RC were set to ","entity_name":"IL17RC","entity_type":"gene"},{"created":"2021-04-06T21:41:36.691748+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7021","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: IL17RC was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"IL17RC","entity_type":"gene"},{"created":"2021-04-06T21:41:16.825195+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7020","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: IL17RC: Rating: GREEN; Mode of pathogenicity: None; Publications: 25918342; Phenotypes: Candidiasis, familial, 9, MIM# 616445, MONDO:0014642; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"IL17RC","entity_type":"gene"},{"created":"2021-04-06T20:53:24.944156+10:00","panel_name":"Defects of innate immunity","panel_id":231,"panel_version":"0.72","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: IL17RA as ready","entity_name":"IL17RA","entity_type":"gene"},{"created":"2021-04-06T20:53:24.927397+10:00","panel_name":"Defects of innate immunity","panel_id":231,"panel_version":"0.72","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: il17ra has been classified as Green List (High Evidence).","entity_name":"IL17RA","entity_type":"gene"},{"created":"2021-04-06T20:53:22.647568+10:00","panel_name":"Defects of innate immunity","panel_id":231,"panel_version":"0.72","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: IL17RA were changed from  to Immunodeficiency 51, MIM# 613953; MONDO:0013500","entity_name":"IL17RA","entity_type":"gene"},{"created":"2021-04-06T20:52:53.823439+10:00","panel_name":"Defects of innate immunity","panel_id":231,"panel_version":"0.71","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: IL17RA were set to ","entity_name":"IL17RA","entity_type":"gene"},{"created":"2021-04-06T20:52:30.358436+10:00","panel_name":"Defects of innate immunity","panel_id":231,"panel_version":"0.70","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: IL17RA was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"IL17RA","entity_type":"gene"},{"created":"2021-04-06T20:51:50.700591+10:00","panel_name":"Defects of innate immunity","panel_id":231,"panel_version":"0.69","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: IL17RA: Rating: GREEN; Mode of pathogenicity: None; Publications: 21350122, 27930337; Phenotypes: Immunodeficiency 51, MIM# 613953, MONDO:0013500; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"IL17RA","entity_type":"gene"},{"created":"2021-04-06T20:50:55.571795+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7020","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: IL17RA were set to ","entity_name":"IL17RA","entity_type":"gene"},{"created":"2021-04-06T20:50:37.817075+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7019","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: IL17RA was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"IL17RA","entity_type":"gene"},{"created":"2021-04-06T20:50:04.098282+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7018","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: IL17RA as ready","entity_name":"IL17RA","entity_type":"gene"},{"created":"2021-04-06T20:50:04.088087+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7018","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: il17ra has been classified as Green List (High Evidence).","entity_name":"IL17RA","entity_type":"gene"},{"created":"2021-04-06T20:49:46.608616+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7018","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: IL17RA were changed from  to Immunodeficiency 51, MIM# 613953; MONDO:0013500","entity_name":"IL17RA","entity_type":"gene"},{"created":"2021-04-06T20:49:09.460785+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7017","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: IL17RA: Rating: GREEN; Mode of pathogenicity: None; Publications: 21350122, 27930337; Phenotypes: Immunodeficiency 51, MIM# 613953; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"IL17RA","entity_type":"gene"},{"created":"2021-04-06T20:44:53.766836+10:00","panel_name":"Defects of innate immunity","panel_id":231,"panel_version":"0.69","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: CARD9 as ready","entity_name":"CARD9","entity_type":"gene"},{"created":"2021-04-06T20:44:53.754433+10:00","panel_name":"Defects of innate immunity","panel_id":231,"panel_version":"0.69","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: card9 has been classified as Green List (High Evidence).","entity_name":"CARD9","entity_type":"gene"},{"created":"2021-04-06T20:44:50.492045+10:00","panel_name":"Defects of innate immunity","panel_id":231,"panel_version":"0.69","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: CARD9 were changed from  to Candidiasis, familial, 2, autosomal recessive, MIM# 212050; Predisposition to invasive fungal disease, MONDO:0008905","entity_name":"CARD9","entity_type":"gene"},{"created":"2021-04-06T20:44:27.346393+10:00","panel_name":"Defects of innate immunity","panel_id":231,"panel_version":"0.68","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: CARD9 were set to ","entity_name":"CARD9","entity_type":"gene"},{"created":"2021-04-06T20:44:03.307329+10:00","panel_name":"Defects of innate immunity","panel_id":231,"panel_version":"0.67","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: CARD9 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"CARD9","entity_type":"gene"},{"created":"2021-04-06T20:43:30.998093+10:00","panel_name":"Defects of innate immunity","panel_id":231,"panel_version":"0.66","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: CARD9: Rating: GREEN; Mode of pathogenicity: None; Publications: 19864672, 23335372, 24131138, 33789983, 33558980, 33180249; Phenotypes: Candidiasis, familial, 2, autosomal recessive, MIM# 212050, Predisposition to invasive fungal disease, MONDO:0008905; Mode of inheritance: None","entity_name":"CARD9","entity_type":"gene"},{"created":"2021-04-06T20:42:23.687216+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7017","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: CARD9 as ready","entity_name":"CARD9","entity_type":"gene"},{"created":"2021-04-06T20:42:23.606556+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7017","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: card9 has been classified as Green List (High Evidence).","entity_name":"CARD9","entity_type":"gene"},{"created":"2021-04-06T20:42:16.199056+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7017","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: CARD9 were changed from  to Candidiasis, familial, 2, autosomal recessive, MIM# 212050; Predisposition to invasive fungal disease, MONDO:0008905","entity_name":"CARD9","entity_type":"gene"},{"created":"2021-04-06T20:41:54.597139+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7016","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: CARD9 were set to ","entity_name":"CARD9","entity_type":"gene"},{"created":"2021-04-06T20:41:35.562478+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7015","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: CARD9 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"CARD9","entity_type":"gene"},{"created":"2021-04-06T20:41:16.768961+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.7014","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: CARD9: Rating: GREEN; Mode of pathogenicity: None; Publications: 19864672, 23335372, 24131138, 33789983, 33558980, 33180249; Phenotypes: Candidiasis, familial, 2, autosomal recessive, MIM# 212050, Predisposition to invasive fungal disease, MONDO:0008905; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"CARD9","entity_type":"gene"},{"created":"2021-04-06T12:30:49.958338+10:00","panel_name":"Hypercalcaemia","panel_id":117,"panel_version":"1.0","user_name":"Zornitza Stark","item_type":"panel","text":"promoted panel to version 1.0","entity_name":null,"entity_type":null},{"created":"2021-04-06T12:27:13.185645+10:00","panel_name":"Hypercalcaemia","panel_id":117,"panel_version":"0.38","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: SLC34A1 as ready","entity_name":"SLC34A1","entity_type":"gene"},{"created":"2021-04-06T12:27:13.176504+10:00","panel_name":"Hypercalcaemia","panel_id":117,"panel_version":"0.38","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: slc34a1 has been classified as Green List (High Evidence).","entity_name":"SLC34A1","entity_type":"gene"},{"created":"2021-04-06T12:27:06.353401+10:00","panel_name":"Hypercalcaemia","panel_id":117,"panel_version":"0.38","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: SLC34A1 were changed from  to Hypercalcaemia, infantile, 2 MIM#616963","entity_name":"SLC34A1","entity_type":"gene"},{"created":"2021-04-06T12:26:35.415825+10:00","panel_name":"Hypercalcaemia","panel_id":117,"panel_version":"0.37","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: SLC34A1 were set to ","entity_name":"SLC34A1","entity_type":"gene"},{"created":"2021-04-06T12:26:09.954466+10:00","panel_name":"Hypercalcaemia","panel_id":117,"panel_version":"0.36","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: SLC34A1 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"SLC34A1","entity_type":"gene"},{"created":"2021-04-06T12:25:42.771823+10:00","panel_name":"Hypercalcaemia","panel_id":117,"panel_version":"0.35","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: SLC34A1: Rating: GREEN; Mode of pathogenicity: None; Publications: 26047794, 33516786, 33099630, 32866123, 31188746, 30943683; Phenotypes: Hypercalcaemia, infantile, 2 MIM#616963; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"SLC34A1","entity_type":"gene"},{"created":"2021-04-06T12:23:01.042093+10:00","panel_name":"Hypercalcaemia","panel_id":117,"panel_version":"0.35","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: PTH1R as ready","entity_name":"PTH1R","entity_type":"gene"},{"created":"2021-04-06T12:23:01.030939+10:00","panel_name":"Hypercalcaemia","panel_id":117,"panel_version":"0.35","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: pth1r has been classified as Green List (High Evidence).","entity_name":"PTH1R","entity_type":"gene"},{"created":"2021-04-06T12:22:58.782779+10:00","panel_name":"Hypercalcaemia","panel_id":117,"panel_version":"0.35","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: PTH1R were changed from  to Metaphyseal chondrodysplasia, Murk Jansen type, MIM# 156400; MONDO:0007982","entity_name":"PTH1R","entity_type":"gene"},{"created":"2021-04-06T12:22:03.335550+10:00","panel_name":"Hypercalcaemia","panel_id":117,"panel_version":"0.34","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: PTH1R were set to ","entity_name":"PTH1R","entity_type":"gene"},{"created":"2021-04-06T12:21:39.569265+10:00","panel_name":"Hypercalcaemia","panel_id":117,"panel_version":"0.33","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: PTH1R was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"PTH1R","entity_type":"gene"},{"created":"2021-04-06T12:21:07.736268+10:00","panel_name":"Hypercalcaemia","panel_id":117,"panel_version":"0.32","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: PTH1R: Rating: GREEN; Mode of pathogenicity: None; Publications: 7701349, 29788189; Phenotypes: Metaphyseal chondrodysplasia, Murk Jansen type, MIM# 156400, MONDO:0007982; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"PTH1R","entity_type":"gene"},{"created":"2021-04-06T12:14:49.314325+10:00","panel_name":"Hypercalcaemia","panel_id":117,"panel_version":"0.32","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: GNA11 as ready","entity_name":"GNA11","entity_type":"gene"},{"created":"2021-04-06T12:14:49.300848+10:00","panel_name":"Hypercalcaemia","panel_id":117,"panel_version":"0.32","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: gna11 has been classified as Green List (High Evidence).","entity_name":"GNA11","entity_type":"gene"},{"created":"2021-04-06T12:14:46.823814+10:00","panel_name":"Hypercalcaemia","panel_id":117,"panel_version":"0.32","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: GNA11 were changed from  to Hypocalciuric hypercalcaemia, type II, MIM# 145981; MONDO:0007792","entity_name":"GNA11","entity_type":"gene"},{"created":"2021-04-06T12:14:17.971918+10:00","panel_name":"Hypercalcaemia","panel_id":117,"panel_version":"0.31","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: GNA11 were set to ","entity_name":"GNA11","entity_type":"gene"},{"created":"2021-04-06T12:13:51.415070+10:00","panel_name":"Hypercalcaemia","panel_id":117,"panel_version":"0.30","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: GNA11 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"GNA11","entity_type":"gene"},{"created":"2021-04-06T12:13:17.212424+10:00","panel_name":"Hypercalcaemia","panel_id":117,"panel_version":"0.29","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: GNA11: Rating: GREEN; Mode of pathogenicity: None; Publications: 23802516, 28833550, 27913609; Phenotypes: Hypocalciuric hypercalcaemia, type II, MIM# 145981, MONDO:0007792; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"GNA11","entity_type":"gene"},{"created":"2021-04-05T21:29:38.739660+10:00","panel_name":"Hypercalcaemia","panel_id":117,"panel_version":"0.29","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: MEN1 as ready","entity_name":"MEN1","entity_type":"gene"}]}