{"count":220212,"next":"https://panelapp-aus.org/api/v1/activities/?format=json&page=1389","previous":"https://panelapp-aus.org/api/v1/activities/?format=json&page=1387","results":[{"created":"2021-03-10T21:05:55.391692+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.6658","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: CST3 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"CST3","entity_type":"gene"},{"created":"2021-03-10T21:05:36.467467+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.6657","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: CST3 as Amber List (moderate evidence)","entity_name":"CST3","entity_type":"gene"},{"created":"2021-03-10T21:05:36.456942+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.6657","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cst3 has been classified as Amber List (Moderate Evidence).","entity_name":"CST3","entity_type":"gene"},{"created":"2021-03-10T21:05:20.555341+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.6656","user_name":"Zornitza Stark","item_type":"entity","text":"Tag founder tag was added to gene: CST3.","entity_name":"CST3","entity_type":"gene"},{"created":"2021-03-10T21:05:07.956981+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.6656","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: CST3: Rating: AMBER; Mode of pathogenicity: None; Publications: 3495457; Phenotypes: Cerebral amyloid angiopathy, MIM# 105150; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"CST3","entity_type":"gene"},{"created":"2021-03-10T21:04:20.546634+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.244","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: CST3 as ready","entity_name":"CST3","entity_type":"gene"},{"created":"2021-03-10T21:04:20.537873+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.244","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cst3 has been classified as Red List (Low Evidence).","entity_name":"CST3","entity_type":"gene"},{"created":"2021-03-10T21:04:15.469535+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.244","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: CST3 as Red List (low evidence)","entity_name":"CST3","entity_type":"gene"},{"created":"2021-03-10T21:04:15.458906+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.244","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cst3 has been classified as Red List (Low Evidence).","entity_name":"CST3","entity_type":"gene"},{"created":"2021-03-10T21:03:45.668175+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.243","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: CST3: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None","entity_name":"CST3","entity_type":"gene"},{"created":"2021-03-10T21:03:10.761822+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.80","user_name":"Zornitza Stark","item_type":"entity","text":"Tag founder tag was added to gene: CST3.","entity_name":"CST3","entity_type":"gene"},{"created":"2021-03-10T21:02:59.223927+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.80","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: CST3 as ready","entity_name":"CST3","entity_type":"gene"},{"created":"2021-03-10T21:02:59.212978+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.80","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cst3 has been classified as Amber List (Moderate Evidence).","entity_name":"CST3","entity_type":"gene"},{"created":"2021-03-10T21:02:48.250728+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.80","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: CST3 were changed from Hereditary cerebral amyloid angiopathy, Icelandic type, MIM#105150 to Cerebral amyloid angiopathy, MIM# 105150","entity_name":"CST3","entity_type":"gene"},{"created":"2021-03-10T21:02:36.889971+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.79","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: CST3 were changed from Hereditary cerebral amyloid angiopathy, Icelandic type to Hereditary cerebral amyloid angiopathy, Icelandic type, MIM#105150","entity_name":"CST3","entity_type":"gene"},{"created":"2021-03-10T21:02:06.646964+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.78","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: CST3 were set to ","entity_name":"CST3","entity_type":"gene"},{"created":"2021-03-10T21:01:49.142985+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.77","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: CST3 as Amber List (moderate evidence)","entity_name":"CST3","entity_type":"gene"},{"created":"2021-03-10T21:01:49.132431+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.77","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cst3 has been classified as Amber List (Moderate Evidence).","entity_name":"CST3","entity_type":"gene"},{"created":"2021-03-10T21:01:34.493070+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.76","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: CST3: Rating: AMBER; Mode of pathogenicity: None; Publications: 3495457; Phenotypes: Cerebral amyloid angiopathy, MIM# 105150; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"CST3","entity_type":"gene"},{"created":"2021-03-10T20:57:26.790734+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.6656","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: NR3C1 as ready","entity_name":"NR3C1","entity_type":"gene"},{"created":"2021-03-10T20:57:26.781093+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.6656","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: nr3c1 has been classified as Green List (High Evidence).","entity_name":"NR3C1","entity_type":"gene"},{"created":"2021-03-10T20:57:15.509634+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.6656","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: NR3C1 were changed from  to Glucocorticoid resistance, OMIM # 615962","entity_name":"NR3C1","entity_type":"gene"},{"created":"2021-03-10T20:56:54.510123+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.6655","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: NR3C1 were set to ","entity_name":"NR3C1","entity_type":"gene"},{"created":"2021-03-10T20:56:27.754284+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.6654","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: NR3C1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"NR3C1","entity_type":"gene"},{"created":"2021-03-10T20:56:01.259052+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.6653","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: NR3C1: Rating: GREEN; Mode of pathogenicity: None; Publications: 12754700, 1704018, 8445027, 31995340, 30158362; Phenotypes: Glucocorticoid resistance, OMIM # 615962; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"NR3C1","entity_type":"gene"},{"created":"2021-03-10T20:53:37.743768+11:00","panel_name":"Renal Hypertension and Disorders of Aldosterone Metabolism","panel_id":190,"panel_version":"0.20","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: NR3C1 as ready","entity_name":"NR3C1","entity_type":"gene"},{"created":"2021-03-10T20:53:37.730226+11:00","panel_name":"Renal Hypertension and Disorders of Aldosterone Metabolism","panel_id":190,"panel_version":"0.20","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: nr3c1 has been classified as Green List (High Evidence).","entity_name":"NR3C1","entity_type":"gene"},{"created":"2021-03-10T15:13:20.496408+11:00","panel_name":"Renal Hypertension and Disorders of Aldosterone Metabolism","panel_id":190,"panel_version":"0.20","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: NR3C1 as Green List (high evidence)","entity_name":"NR3C1","entity_type":"gene"},{"created":"2021-03-10T15:13:20.488822+11:00","panel_name":"Renal Hypertension and Disorders of Aldosterone Metabolism","panel_id":190,"panel_version":"0.20","user_name":"Chirag Patel","item_type":"entity","text":"Gene: nr3c1 has been classified as Green List (High Evidence).","entity_name":"NR3C1","entity_type":"gene"},{"created":"2021-03-10T15:12:47.768429+11:00","panel_name":"Renal Hypertension and Disorders of Aldosterone Metabolism","panel_id":190,"panel_version":"0.19","user_name":"Chirag Patel","item_type":"entity","text":"gene: NR3C1 was added\ngene: NR3C1 was added to Renal Hypertension and Disorders of Aldosterone Metabolism. Sources: Literature\nMode of inheritance for gene: NR3C1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: NR3C1 were set to PubMed: 12754700, 1704018, 8445027, 31995340\nPhenotypes for gene: NR3C1 were set to Glucocorticoid resistance, OMIM # 615962\nReview for gene: NR3C1 was set to GREEN\nAdded comment: Hurley et al. (1991) identified a heterozygous missense mutation in the GCR gene (D641V) in affected members of the kindred originally reported by Vingerhoeds et al. (1976) with generalized glucocorticoid deficiency.\r\n\r\nKarl et al. (1993) identified heterozygosity for a 4-bp deletion in the GCR gene in all 3 affected members of a Dutch kindred with glucocorticoid resistance. \r\n\r\nBray and Cotton (2003) stated that a total of 15 missense, 3 nonsense, 3 frameshift, 1 splice site, and 2 alternatively spliced mutations had been reported in the NR3C1 gene to be associated with glucocorticoid resistance. Sixteen polymorphisms in the gene had also been reported. \nSources: Literature","entity_name":"NR3C1","entity_type":"gene"},{"created":"2021-03-10T13:22:13.432957+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.76","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: TTR as ready","entity_name":"TTR","entity_type":"gene"},{"created":"2021-03-10T13:22:13.424085+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.76","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: ttr has been classified as Green List (High Evidence).","entity_name":"TTR","entity_type":"gene"},{"created":"2021-03-10T13:22:11.108897+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.76","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: TTR were changed from Amyloidogenic transthyretin amyloidosis to Amyloidosis, hereditary, transthyretin-related, MIM# 105210","entity_name":"TTR","entity_type":"gene"},{"created":"2021-03-10T13:22:02.281530+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.75","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: TTR were set to ","entity_name":"TTR","entity_type":"gene"},{"created":"2021-03-10T13:21:48.473546+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.74","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: TTR: Rating: GREEN; Mode of pathogenicity: None; Publications: 32789836, 12771253; Phenotypes: Amyloidosis, hereditary, transthyretin-related, MIM# 105210; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"TTR","entity_type":"gene"},{"created":"2021-03-10T13:20:40.118001+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.74","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: WFS1 as ready","entity_name":"WFS1","entity_type":"gene"},{"created":"2021-03-10T13:20:40.109471+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.74","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: wfs1 has been classified as Red List (Low Evidence).","entity_name":"WFS1","entity_type":"gene"},{"created":"2021-03-10T13:20:29.234818+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.74","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: WFS1 as Red List (low evidence)","entity_name":"WFS1","entity_type":"gene"},{"created":"2021-03-10T13:20:29.217983+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.74","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: wfs1 has been classified as Red List (Low Evidence).","entity_name":"WFS1","entity_type":"gene"},{"created":"2021-03-10T13:17:55.283702+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.6653","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: YY1AP1 were set to ","entity_name":"YY1AP1","entity_type":"gene"},{"created":"2021-03-10T13:17:29.310638+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.6652","user_name":"Zornitza Stark","item_type":"entity","text":"commented on gene: YY1AP1: Grange syndrome: multiple arterial stenoses, severe early onset hypertension, fibromuscular dysplasia, variable penetrance of brachydactyly, syndactyly, bone fragility, and learning disabilities. Missense variant reported PMID: 31633303 with moyamoya like phenotype in adult case; fibroblasts suggest that the p.Pro360Leu variant decreases the stability of the YY1AP1 protein but most LOF. PMID: 30556293 non coding variants reported (intronic variants leading to aberrant splicing)","entity_name":"YY1AP1","entity_type":"gene"},{"created":"2021-03-10T13:16:42.353688+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.6652","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: YY1AP1: Changed publications: 31633303, 30356112, 31270375, 22987684, 16691574, 27939641, 30556293","entity_name":"YY1AP1","entity_type":"gene"},{"created":"2021-03-10T13:15:25.196642+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.73","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: YY1AP1 as ready","entity_name":"YY1AP1","entity_type":"gene"},{"created":"2021-03-10T13:15:25.188352+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.73","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: yy1ap1 has been classified as Green List (High Evidence).","entity_name":"YY1AP1","entity_type":"gene"},{"created":"2021-03-10T13:15:22.208831+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.73","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: YY1AP1 were set to 31633303; 30356112; 31270375; 22987684; 16691574","entity_name":"YY1AP1","entity_type":"gene"},{"created":"2021-03-10T13:13:20.869959+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.72","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: CTSA as ready","entity_name":"CTSA","entity_type":"gene"},{"created":"2021-03-10T13:13:20.858178+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.72","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: ctsa has been classified as Green List (High Evidence).","entity_name":"CTSA","entity_type":"gene"},{"created":"2021-03-10T13:13:16.789943+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.72","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: CTSA were set to 27664989; 31177426; 23175731","entity_name":"CTSA","entity_type":"gene"},{"created":"2021-03-10T13:13:04.005829+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.71","user_name":"Zornitza Stark","item_type":"entity","text":"Tag founder tag was added to gene: CTSA.","entity_name":"CTSA","entity_type":"gene"},{"created":"2021-03-10T13:12:58.527445+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.71","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: CTSA as Green List (high evidence)","entity_name":"CTSA","entity_type":"gene"},{"created":"2021-03-10T13:12:58.516212+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.71","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: ctsa has been classified as Green List (High Evidence).","entity_name":"CTSA","entity_type":"gene"},{"created":"2021-03-10T13:12:42.849211+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.70","user_name":"Zornitza Stark","item_type":"entity","text":"changed review comment from: 19 individuals reported, but single founder variant, c.973C>T; p.R325C.\r\n\r\nBi-allelic variants in this gene are associated with galactosialidosis.; to: Borderline Green/Amber. 19 individuals reported, but single founder variant, c.973C>T; p.R325C.\r\n\r\nBi-allelic variants in this gene are associated with galactosialidosis.","entity_name":"CTSA","entity_type":"gene"},{"created":"2021-03-10T13:12:26.010471+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.70","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: CTSA: Changed rating: GREEN","entity_name":"CTSA","entity_type":"gene"},{"created":"2021-03-10T13:05:25.321067+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.70","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: CTSA: Rating: AMBER; Mode of pathogenicity: None; Publications: 32842921, 31177426; Phenotypes: Cathepsin-A-related arteriopathy with strokes and leukoencephalopathy (CARASAL); Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"CTSA","entity_type":"gene"},{"created":"2021-03-10T12:27:57.211441+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.70","user_name":"Natasha Brown","item_type":"entity","text":"reviewed gene: TTR: Rating: ; Mode of pathogenicity: None; Publications: PMID: 32789836, 12771253; Phenotypes: ; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"TTR","entity_type":"gene"},{"created":"2021-03-10T12:05:29.699771+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.70","user_name":"Natasha Brown","item_type":"entity","text":"reviewed gene: WFS1: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None","entity_name":"WFS1","entity_type":"gene"},{"created":"2021-03-10T11:58:41.266879+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.70","user_name":"Natasha Brown","item_type":"entity","text":"reviewed gene: YY1AP1: Rating: GREEN; Mode of pathogenicity: None; Publications: PMID: 31270375, 31633303, 27939641, 30556293; Phenotypes: ; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"YY1AP1","entity_type":"gene"},{"created":"2021-03-10T11:49:03.625804+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.70","user_name":"Natasha Brown","item_type":"entity","text":"reviewed gene: CTSA: Rating: GREEN; Mode of pathogenicity: None; Publications: PMID: 32842921, 31177426; Phenotypes: cerebral microangiopathy; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"CTSA","entity_type":"gene"},{"created":"2021-03-10T11:41:55.802601+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.70","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: HBB as ready","entity_name":"HBB","entity_type":"gene"},{"created":"2021-03-10T11:41:55.791936+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.70","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: hbb has been classified as Green List (High Evidence).","entity_name":"HBB","entity_type":"gene"},{"created":"2021-03-10T11:41:51.137995+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.70","user_name":"Zornitza Stark","item_type":"entity","text":"Tag SV/CNV tag was added to gene: HBB.","entity_name":"HBB","entity_type":"gene"},{"created":"2021-03-10T11:40:18.063343+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.70","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: ABCA1 as ready","entity_name":"ABCA1","entity_type":"gene"},{"created":"2021-03-10T11:40:18.056250+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.70","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: abca1 has been classified as Green List (High Evidence).","entity_name":"ABCA1","entity_type":"gene"},{"created":"2021-03-10T11:39:41.243946+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.6652","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: NOS3 as ready","entity_name":"NOS3","entity_type":"gene"},{"created":"2021-03-10T11:39:41.234260+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.6652","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: nos3 has been classified as Red List (Low Evidence).","entity_name":"NOS3","entity_type":"gene"},{"created":"2021-03-10T11:39:33.695592+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.6652","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: NOS3 were changed from  to {Hypertension, susceptibility to}, MIM#145500; {Ischemic stroke, susceptibility to}, MIM# 601367; {Hypertension, pregnancy-induced}, MIM# 189800","entity_name":"NOS3","entity_type":"gene"},{"created":"2021-03-10T11:39:12.099319+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.6651","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: NOS3 were set to ","entity_name":"NOS3","entity_type":"gene"},{"created":"2021-03-10T11:38:48.378725+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.6650","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: NOS3 as Red List (low evidence)","entity_name":"NOS3","entity_type":"gene"},{"created":"2021-03-10T11:38:48.368369+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.6650","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: nos3 has been classified as Red List (Low Evidence).","entity_name":"NOS3","entity_type":"gene"},{"created":"2021-03-10T11:38:28.855832+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.6649","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: NOS3: Rating: RED; Mode of pathogenicity: None; Publications: 24986538, 28084234, 33652340; Phenotypes: {Hypertension, susceptibility to}, MIM#145500, {Ischemic stroke, susceptibility to}, MIM# 601367, {Hypertension, pregnancy-induced}, MIM# 189800; Mode of inheritance: Unknown","entity_name":"NOS3","entity_type":"gene"},{"created":"2021-03-10T11:34:47.889708+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.70","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: NOS3 as ready","entity_name":"NOS3","entity_type":"gene"},{"created":"2021-03-10T11:34:47.879277+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.70","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: nos3 has been classified as Red List (Low Evidence).","entity_name":"NOS3","entity_type":"gene"},{"created":"2021-03-10T11:34:46.023751+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.70","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: NOS3 were changed from  to {Ischemic stroke, susceptibility to} MIM#601367","entity_name":"NOS3","entity_type":"gene"},{"created":"2021-03-10T11:34:39.308248+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.69","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: NOS3 were set to ","entity_name":"NOS3","entity_type":"gene"},{"created":"2021-03-10T11:33:22.083264+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.68","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: ASS1 as ready","entity_name":"ASS1","entity_type":"gene"},{"created":"2021-03-10T11:33:22.068788+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.68","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: ass1 has been classified as Green List (High Evidence).","entity_name":"ASS1","entity_type":"gene"},{"created":"2021-03-10T11:33:19.638783+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.68","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: ASS1 were changed from Citrullinemia type to Citrullinemia, MIM# 215700","entity_name":"ASS1","entity_type":"gene"},{"created":"2021-03-10T11:33:05.307255+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.67","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: ASS1: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Citrullinemia, MIM# 215700; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"ASS1","entity_type":"gene"},{"created":"2021-03-10T11:30:09.605132+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.67","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: APP as ready","entity_name":"APP","entity_type":"gene"},{"created":"2021-03-10T11:30:09.594686+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.67","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: app has been classified as Green List (High Evidence).","entity_name":"APP","entity_type":"gene"},{"created":"2021-03-10T11:30:07.300157+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.67","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: APP were changed from Cerebral amyloid angiopathy, APP-related to Cerebral amyloid angiopathy, Dutch, Italian, Iowa, Flemish, Arctic variants, MIM# 605714; Cerebral amyloid angiopathy, APP-related","entity_name":"APP","entity_type":"gene"},{"created":"2021-03-10T11:29:56.370853+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.66","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: APP were set to ","entity_name":"APP","entity_type":"gene"},{"created":"2021-03-10T11:29:40.825623+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.65","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: APP: Rating: GREEN; Mode of pathogenicity: None; Publications: 16178030, 11409420, 16612981; Phenotypes: Cerebral amyloid angiopathy, Dutch, Italian, Iowa, Flemish, Arctic variants, MIM# 605714; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"APP","entity_type":"gene"},{"created":"2021-03-10T11:25:27.576408+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.65","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: ADA2 as ready","entity_name":"ADA2","entity_type":"gene"},{"created":"2021-03-10T11:25:27.569312+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.65","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: ada2 has been classified as Green List (High Evidence).","entity_name":"ADA2","entity_type":"gene"},{"created":"2021-03-10T11:25:24.454400+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.65","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: ADA2 were changed from Polyarteritis nodosa; Sneddon syndrome 182410 to Vasculitis, autoinflammation, immunodeficiency, and hematologic defects syndrome, MIM# 615688","entity_name":"ADA2","entity_type":"gene"},{"created":"2021-03-10T11:25:12.993573+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.64","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: ADA2 were set to ","entity_name":"ADA2","entity_type":"gene"},{"created":"2021-03-10T11:25:00.875485+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.63","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: ADA2: Rating: GREEN; Mode of pathogenicity: None; Publications: 32892503; Phenotypes: Vasculitis, autoinflammation, immunodeficiency, and hematologic defects syndrome, MIM# 615688; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"ADA2","entity_type":"gene"},{"created":"2021-03-10T11:23:05.453113+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.63","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: ACVRL1 as ready","entity_name":"ACVRL1","entity_type":"gene"},{"created":"2021-03-10T11:23:05.442684+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.63","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: acvrl1 has been classified as Green List (High Evidence).","entity_name":"ACVRL1","entity_type":"gene"},{"created":"2021-03-10T11:22:55.810782+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.63","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: ACVRL1 were changed from Telangiectasia, hereditary hemorrhagic, type 2 600376 to Telangiectasia, hereditary hemorrhagic, type 2, MIM# 600376","entity_name":"ACVRL1","entity_type":"gene"},{"created":"2021-03-10T11:22:41.140255+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.62","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: ACVRL1: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Telangiectasia, hereditary hemorrhagic, type 2, MIM# 600376; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"ACVRL1","entity_type":"gene"},{"created":"2021-03-10T11:21:43.819263+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.62","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: ACTA2 as ready","entity_name":"ACTA2","entity_type":"gene"},{"created":"2021-03-10T11:21:43.810991+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.62","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: acta2 has been classified as Green List (High Evidence).","entity_name":"ACTA2","entity_type":"gene"},{"created":"2021-03-10T11:21:17.656381+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.62","user_name":"Zornitza Stark","item_type":"entity","text":"changed review comment from: Well established gene-disease association, stroke, especially cerebellar stroke reported.; to: Well established gene-disease association, cerebellar stroke reported.","entity_name":"ACAD9","entity_type":"gene"},{"created":"2021-03-10T11:20:53.435164+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.62","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: ACAD9 as ready","entity_name":"ACAD9","entity_type":"gene"},{"created":"2021-03-10T11:20:53.426187+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.62","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: acad9 has been classified as Green List (High Evidence).","entity_name":"ACAD9","entity_type":"gene"},{"created":"2021-03-10T11:20:50.740702+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.62","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: ACAD9 were changed from Acyl-CoA dehydrogenase family, member 9, deficiency of to Mitochondrial complex I deficiency, nuclear type 20, MIM# 611126","entity_name":"ACAD9","entity_type":"gene"},{"created":"2021-03-10T11:20:15.635142+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.61","user_name":"Natasha Brown","item_type":"entity","text":"reviewed gene: NOS3: Rating: RED; Mode of pathogenicity: None; Publications: PMID: 24986538, 28084234; Phenotypes: ; Mode of inheritance: Unknown","entity_name":"NOS3","entity_type":"gene"},{"created":"2021-03-10T11:20:01.774087+11:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.61","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: ACAD9 were set to ","entity_name":"ACAD9","entity_type":"gene"}]}