{"count":220363,"next":"https://panelapp-aus.org/api/v1/activities/?format=json&page=1479","previous":"https://panelapp-aus.org/api/v1/activities/?format=json&page=1477","results":[{"created":"2020-12-11T15:27:36.809753+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5619","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: WEE2 as ready","entity_name":"WEE2","entity_type":"gene"},{"created":"2020-12-11T15:27:36.799132+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5619","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: wee2 has been classified as Green List (High Evidence).","entity_name":"WEE2","entity_type":"gene"},{"created":"2020-12-11T15:27:18.162932+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.116","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: TUBB8 as ready","entity_name":"TUBB8","entity_type":"gene"},{"created":"2020-12-11T15:27:18.152723+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.116","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: tubb8 has been classified as Red List (Low Evidence).","entity_name":"TUBB8","entity_type":"gene"},{"created":"2020-12-11T15:27:15.917184+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.116","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: TUBB8 were changed from  to Oocyte maturation defect 2, MIM# 616780","entity_name":"TUBB8","entity_type":"gene"},{"created":"2020-12-11T15:27:06.607092+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.115","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: TUBB8 were set to ","entity_name":"TUBB8","entity_type":"gene"},{"created":"2020-12-11T15:26:57.767104+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.114","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: TUBB8 was changed from Unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal","entity_name":"TUBB8","entity_type":"gene"},{"created":"2020-12-11T15:26:47.541919+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.113","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: TUBB8: Rating: RED; Mode of pathogenicity: None; Publications: 26789871, 27273344; Phenotypes: Oocyte maturation defect 2, MIM# 616780; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal","entity_name":"TUBB8","entity_type":"gene"},{"created":"2020-12-11T15:24:48.824232+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5619","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: WEE2 were changed from  to Oocyte maturation defect 5, MIM# 617996","entity_name":"WEE2","entity_type":"gene"},{"created":"2020-12-11T15:23:23.838238+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.113","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: MRPS22 as ready","entity_name":"MRPS22","entity_type":"gene"},{"created":"2020-12-11T15:23:23.827852+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.113","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: mrps22 has been classified as Green List (High Evidence).","entity_name":"MRPS22","entity_type":"gene"},{"created":"2020-12-11T15:23:20.072245+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.113","user_name":"Bryony Thompson","item_type":"entity","text":"Classified gene: MRPS22 as Green List (high evidence)","entity_name":"MRPS22","entity_type":"gene"},{"created":"2020-12-11T15:23:20.063404+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.113","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: mrps22 has been classified as Green List (High Evidence).","entity_name":"MRPS22","entity_type":"gene"},{"created":"2020-12-11T15:23:11.167884+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.112","user_name":"Bryony Thompson","item_type":"entity","text":"reviewed gene: MRPS22: Rating: GREEN; Mode of pathogenicity: None; Publications: 29566152, 31042289; Phenotypes: Ovarian dysgenesis 7 MIM#618117; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"MRPS22","entity_type":"gene"},{"created":"2020-12-11T15:20:10.319228+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5618","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: WEE2 were set to ","entity_name":"WEE2","entity_type":"gene"},{"created":"2020-12-11T15:19:37.324013+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5617","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: WEE2 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"WEE2","entity_type":"gene"},{"created":"2020-12-11T15:19:19.537675+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5616","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: WEE2: Rating: GREEN; Mode of pathogenicity: None; Publications: 29606300, 30628060; Phenotypes: Oocyte maturation defect 5, MIM# 617996; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"WEE2","entity_type":"gene"},{"created":"2020-12-11T15:19:17.526185+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.112","user_name":"Bryony Thompson","item_type":"entity","text":"Deleted their review","entity_name":"MRPS22","entity_type":"gene"},{"created":"2020-12-11T15:18:28.304082+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.112","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: WEE2 as ready","entity_name":"WEE2","entity_type":"gene"},{"created":"2020-12-11T15:18:28.292896+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.112","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: wee2 has been classified as Red List (Low Evidence).","entity_name":"WEE2","entity_type":"gene"},{"created":"2020-12-11T15:18:25.912022+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.112","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: WEE2 were changed from  to Oocyte maturation defect 5, MIM# 617996","entity_name":"WEE2","entity_type":"gene"},{"created":"2020-12-11T15:18:18.411000+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.111","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: WEE2 were set to ","entity_name":"WEE2","entity_type":"gene"},{"created":"2020-12-11T15:18:10.895108+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.110","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: WEE2 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"WEE2","entity_type":"gene"},{"created":"2020-12-11T15:18:01.616094+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.109","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: WEE2: Rating: RED; Mode of pathogenicity: None; Publications: 29606300, 30628060; Phenotypes: Oocyte maturation defect 5, MIM# 617996; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"WEE2","entity_type":"gene"},{"created":"2020-12-11T15:02:58.923701+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.109","user_name":"Bryony Thompson","item_type":"entity","text":"reviewed gene: MRPS22: Rating: ; Mode of pathogenicity: None; Publications: ; Phenotypes: Ovarian dysgenesis 7 618117; Mode of inheritance: None","entity_name":"MRPS22","entity_type":"gene"},{"created":"2020-12-11T15:00:43.344462+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.109","user_name":"Bryony Thompson","item_type":"entity","text":"Phenotypes for gene: EIF4ENIF1 were changed from  to Primary ovarian insufficiency","entity_name":"EIF4ENIF1","entity_type":"gene"},{"created":"2020-12-11T15:00:35.037284+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.108","user_name":"Bryony Thompson","item_type":"entity","text":"Publications for gene: EIF4ENIF1 were set to ","entity_name":"EIF4ENIF1","entity_type":"gene"},{"created":"2020-12-11T15:00:27.911593+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.107","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of inheritance for gene: EIF4ENIF1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"EIF4ENIF1","entity_type":"gene"},{"created":"2020-12-11T15:00:18.505015+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.106","user_name":"Bryony Thompson","item_type":"entity","text":"Classified gene: EIF4ENIF1 as Amber List (moderate evidence)","entity_name":"EIF4ENIF1","entity_type":"gene"},{"created":"2020-12-11T15:00:18.494238+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.106","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: eif4enif1 has been classified as Amber List (Moderate Evidence).","entity_name":"EIF4ENIF1","entity_type":"gene"},{"created":"2020-12-11T15:00:08.167827+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.105","user_name":"Bryony Thompson","item_type":"entity","text":"reviewed gene: EIF4ENIF1: Rating: AMBER; Mode of pathogenicity: None; Publications: 31810472, 23902945, 33095795; Phenotypes: Primary ovarian insufficiency; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"EIF4ENIF1","entity_type":"gene"},{"created":"2020-12-11T14:21:50.523852+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.105","user_name":"Bryony Thompson","item_type":"entity","text":"Phenotypes for gene: DACH2 were changed from  to Primary ovarian insufficiency","entity_name":"DACH2","entity_type":"gene"},{"created":"2020-12-11T14:21:43.059760+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.104","user_name":"Bryony Thompson","item_type":"entity","text":"Publications for gene: DACH2 were set to ","entity_name":"DACH2","entity_type":"gene"},{"created":"2020-12-11T14:21:34.398264+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.103","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of inheritance for gene: DACH2 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"DACH2","entity_type":"gene"},{"created":"2020-12-11T14:21:15.058315+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.102","user_name":"Bryony Thompson","item_type":"entity","text":"reviewed gene: DACH2: Rating: RED; Mode of pathogenicity: None; Publications: 15459172; Phenotypes: Primary ovarian insufficiency; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"DACH2","entity_type":"gene"},{"created":"2020-12-11T14:00:25.093600+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.102","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: HNF1B as ready","entity_name":"HNF1B","entity_type":"gene"},{"created":"2020-12-11T14:00:25.080980+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.102","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: hnf1b has been classified as Red List (Low Evidence).","entity_name":"HNF1B","entity_type":"gene"},{"created":"2020-12-11T13:55:36.862477+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.102","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: GDF9 as ready","entity_name":"GDF9","entity_type":"gene"},{"created":"2020-12-11T13:55:36.851484+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.102","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: gdf9 has been classified as Green List (High Evidence).","entity_name":"GDF9","entity_type":"gene"},{"created":"2020-12-11T13:55:32.678972+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.102","user_name":"Bryony Thompson","item_type":"entity","text":"Publications for gene: GDF9 were set to 29044499; 8849725","entity_name":"GDF9","entity_type":"gene"},{"created":"2020-12-11T13:55:23.689921+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.101","user_name":"Bryony Thompson","item_type":"entity","text":"Classified gene: GDF9 as Green List (high evidence)","entity_name":"GDF9","entity_type":"gene"},{"created":"2020-12-11T13:55:23.677417+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.101","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: gdf9 has been classified as Green List (High Evidence).","entity_name":"GDF9","entity_type":"gene"},{"created":"2020-12-11T13:55:05.024999+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.100","user_name":"Bryony Thompson","item_type":"entity","text":"edited their review of gene: GDF9: Added comment: PMID: 33036707 - Additional compound het case with primary amenorrhea and was diagnosed with non-syndromic POI and supporting functional assays.; Changed rating: GREEN; Changed publications: 29044499, 8849725, 33036707","entity_name":"GDF9","entity_type":"gene"},{"created":"2020-12-11T13:49:11.085974+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.100","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: FANCM as ready","entity_name":"FANCM","entity_type":"gene"},{"created":"2020-12-11T13:49:11.052602+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.100","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: fancm has been classified as Green List (High Evidence).","entity_name":"FANCM","entity_type":"gene"},{"created":"2020-12-11T13:49:07.785833+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.100","user_name":"Bryony Thompson","item_type":"entity","text":"Phenotypes for gene: FANCM were changed from  to Premature ovarian failure 15 MIM#618096","entity_name":"FANCM","entity_type":"gene"},{"created":"2020-12-11T13:47:59.155280+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.99","user_name":"Bryony Thompson","item_type":"entity","text":"Publications for gene: FANCM were set to ","entity_name":"FANCM","entity_type":"gene"},{"created":"2020-12-11T13:47:28.541080+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.98","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of inheritance for gene: FANCM was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"FANCM","entity_type":"gene"},{"created":"2020-12-11T13:47:17.011628+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.97","user_name":"Bryony Thompson","item_type":"entity","text":"Classified gene: FANCM as Green List (high evidence)","entity_name":"FANCM","entity_type":"gene"},{"created":"2020-12-11T13:47:16.999447+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.97","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: fancm has been classified as Green List (High Evidence).","entity_name":"FANCM","entity_type":"gene"},{"created":"2020-12-11T13:46:42.655160+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.96","user_name":"Bryony Thompson","item_type":"entity","text":"reviewed gene: FANCM: Rating: GREEN; Mode of pathogenicity: None; Publications: 29231814, 28837162, 33036707, 25010009; Phenotypes: Premature ovarian failure 15 MIM#618096; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"FANCM","entity_type":"gene"},{"created":"2020-12-11T13:02:42.165603+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5616","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: ZP1 as ready","entity_name":"ZP1","entity_type":"gene"},{"created":"2020-12-11T13:02:42.154185+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5616","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: zp1 has been classified as Green List (High Evidence).","entity_name":"ZP1","entity_type":"gene"},{"created":"2020-12-11T13:02:32.642032+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5616","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: ZP1 as Green List (high evidence)","entity_name":"ZP1","entity_type":"gene"},{"created":"2020-12-11T13:02:32.634378+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5616","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: zp1 has been classified as Green List (High Evidence).","entity_name":"ZP1","entity_type":"gene"},{"created":"2020-12-11T13:02:01.209410+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5615","user_name":"Zornitza Stark","item_type":"entity","text":"gene: ZP1 was added\ngene: ZP1 was added to Mendeliome. Sources: Expert list\nMode of inheritance for gene: ZP1 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal\nPublications for gene: ZP1 were set to 24670168; 30810869; 32573113; 33272616\nPhenotypes for gene: ZP1 were set to Oocyte maturation defect 1, MIM# 615774\nReview for gene: ZP1 was set to GREEN\nAdded comment: Multiple unrelated individuals reported, presents as primary infertility. \nSources: Expert list","entity_name":"ZP1","entity_type":"gene"},{"created":"2020-12-11T13:00:06.195298+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.96","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: ZP1 as ready","entity_name":"ZP1","entity_type":"gene"},{"created":"2020-12-11T13:00:06.183718+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.96","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: zp1 has been classified as Red List (Low Evidence).","entity_name":"ZP1","entity_type":"gene"},{"created":"2020-12-11T13:00:03.706922+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.96","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: ZP1 were changed from  to Oocyte maturation defect 1, MIM# 615774","entity_name":"ZP1","entity_type":"gene"},{"created":"2020-12-11T12:59:55.100918+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.95","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: ZP1 were set to ","entity_name":"ZP1","entity_type":"gene"},{"created":"2020-12-11T12:59:45.580017+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.94","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: ZP1 was changed from Unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal","entity_name":"ZP1","entity_type":"gene"},{"created":"2020-12-11T12:59:34.924880+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.93","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: ZP1: Rating: RED; Mode of pathogenicity: None; Publications: 24670168, 30810869, 32573113, 33272616; Phenotypes: Oocyte maturation defect 1, MIM# 615774; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal","entity_name":"ZP1","entity_type":"gene"},{"created":"2020-12-11T12:56:15.824873+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5614","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: ZP2 were changed from Female infertility to Oocyte maturation defect 6, MIM# 618353; Female infertility","entity_name":"ZP2","entity_type":"gene"},{"created":"2020-12-11T12:55:56.372321+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5613","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: ZP2: Changed phenotypes: Oocyte maturation defect 6, MIM# 618353, Female infertility","entity_name":"ZP2","entity_type":"gene"},{"created":"2020-12-11T12:55:17.643932+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.93","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: ZP2 as ready","entity_name":"ZP2","entity_type":"gene"},{"created":"2020-12-11T12:55:17.634342+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.93","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: zp2 has been classified as Red List (Low Evidence).","entity_name":"ZP2","entity_type":"gene"},{"created":"2020-12-11T12:55:14.267478+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.93","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: ZP2 were changed from  to Oocyte maturation defect 6, MIM#\t618353; Female infertility","entity_name":"ZP2","entity_type":"gene"},{"created":"2020-12-11T12:54:51.368947+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.92","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: ZP2 were set to ","entity_name":"ZP2","entity_type":"gene"},{"created":"2020-12-11T12:54:42.535779+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.91","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: ZP2 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"ZP2","entity_type":"gene"},{"created":"2020-12-11T12:54:32.558707+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.90","user_name":"Zornitza Stark","item_type":"entity","text":"changed review comment from: Three unrelated individuals reported with bi-allelic variants in this gene and thin zona pellucida. \nSources: Literature; to: Three unrelated individuals reported with bi-allelic variants in this gene and thin zona pellucida. Presents with primary infertility rather than POI/POF.\r\nSources: Literature","entity_name":"ZP2","entity_type":"gene"},{"created":"2020-12-11T12:54:13.832863+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.90","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: ZP2: Changed rating: RED","entity_name":"ZP2","entity_type":"gene"},{"created":"2020-12-11T12:53:31.680332+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5613","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: ZP3 as ready","entity_name":"ZP3","entity_type":"gene"},{"created":"2020-12-11T12:53:31.668057+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5613","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: zp3 has been classified as Green List (High Evidence).","entity_name":"ZP3","entity_type":"gene"},{"created":"2020-12-11T12:53:21.704861+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5613","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: ZP3 as Green List (high evidence)","entity_name":"ZP3","entity_type":"gene"},{"created":"2020-12-11T12:53:21.696118+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5613","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: zp3 has been classified as Green List (High Evidence).","entity_name":"ZP3","entity_type":"gene"},{"created":"2020-12-11T12:53:04.091293+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5612","user_name":"Zornitza Stark","item_type":"entity","text":"gene: ZP3 was added\ngene: ZP3 was added to Mendeliome. Sources: Expert list\nMode of inheritance for gene: ZP3 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: ZP3 were set to 28886344; 30810869; 33272616; 32573113\nPhenotypes for gene: ZP3 were set to Oocyte maturation defect 3, MIM# 617712\nReview for gene: ZP3 was set to GREEN\nAdded comment: Oocyte maturation defect with normal ovarian reserves and menstrual cycles, presents as infertility. \nSources: Expert list","entity_name":"ZP3","entity_type":"gene"},{"created":"2020-12-11T12:43:31.070138+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.90","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: ZP3 as ready","entity_name":"ZP3","entity_type":"gene"},{"created":"2020-12-11T12:43:31.045757+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.90","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: zp3 has been classified as Red List (Low Evidence).","entity_name":"ZP3","entity_type":"gene"},{"created":"2020-12-11T12:43:28.501412+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.90","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: ZP3 were changed from  to Oocyte maturation defect 3, MIM# 617712","entity_name":"ZP3","entity_type":"gene"},{"created":"2020-12-11T12:43:19.806711+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.89","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: ZP3 were set to ","entity_name":"ZP3","entity_type":"gene"},{"created":"2020-12-11T12:43:07.059002+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.88","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: ZP3 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"ZP3","entity_type":"gene"},{"created":"2020-12-11T12:42:55.613810+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.87","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: ZP3: Rating: RED; Mode of pathogenicity: None; Publications: 28886344, 30810869; Phenotypes: Oocyte maturation defect 3, MIM# 617712; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"ZP3","entity_type":"gene"},{"created":"2020-12-11T12:34:45.915115+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.87","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: ERAL1 as ready","entity_name":"ERAL1","entity_type":"gene"},{"created":"2020-12-11T12:34:45.904519+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.87","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: eral1 has been classified as Amber List (Moderate Evidence).","entity_name":"ERAL1","entity_type":"gene"},{"created":"2020-12-11T12:34:40.665964+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.87","user_name":"Bryony Thompson","item_type":"entity","text":"Phenotypes for gene: ERAL1 were changed from  to Perrault syndrome 6, MIM# 617565","entity_name":"ERAL1","entity_type":"gene"},{"created":"2020-12-11T12:34:33.187305+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.86","user_name":"Bryony Thompson","item_type":"entity","text":"Publications for gene: ERAL1 were set to ","entity_name":"ERAL1","entity_type":"gene"},{"created":"2020-12-11T12:34:24.090791+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.85","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of inheritance for gene: ERAL1 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"ERAL1","entity_type":"gene"},{"created":"2020-12-11T12:34:17.816376+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.84","user_name":"Bryony Thompson","item_type":"entity","text":"Classified gene: ERAL1 as Amber List (moderate evidence)","entity_name":"ERAL1","entity_type":"gene"},{"created":"2020-12-11T12:34:17.805462+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.84","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: eral1 has been classified as Amber List (Moderate Evidence).","entity_name":"ERAL1","entity_type":"gene"},{"created":"2020-12-11T12:33:10.611042+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.83","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: BTG4 as ready","entity_name":"BTG4","entity_type":"gene"},{"created":"2020-12-11T12:33:10.603417+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.83","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: btg4 has been classified as Green List (High Evidence).","entity_name":"BTG4","entity_type":"gene"},{"created":"2020-12-11T12:33:07.648691+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.83","user_name":"Bryony Thompson","item_type":"entity","text":"Publications for gene: BTG4 were set to ","entity_name":"BTG4","entity_type":"gene"},{"created":"2020-12-11T12:33:01.534127+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.82","user_name":"Bryony Thompson","item_type":"entity","text":"Phenotypes for gene: BTG4 were changed from  to Oocyte maturation defect, MIM#619009","entity_name":"BTG4","entity_type":"gene"},{"created":"2020-12-11T12:32:51.435839+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.81","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of inheritance for gene: BTG4 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"BTG4","entity_type":"gene"},{"created":"2020-12-11T12:32:44.181771+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.80","user_name":"Bryony Thompson","item_type":"entity","text":"Classified gene: BTG4 as Green List (high evidence)","entity_name":"BTG4","entity_type":"gene"},{"created":"2020-12-11T12:32:44.170261+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.80","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: btg4 has been classified as Green List (High Evidence).","entity_name":"BTG4","entity_type":"gene"},{"created":"2020-12-11T12:31:54.846660+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.79","user_name":"Bryony Thompson","item_type":"entity","text":"Phenotypes for gene: GDF9 were changed from  to Premature ovarian failure 14 MIM#618014","entity_name":"GDF9","entity_type":"gene"},{"created":"2020-12-11T12:31:46.101876+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.78","user_name":"Bryony Thompson","item_type":"entity","text":"Publications for gene: GDF9 were set to ","entity_name":"GDF9","entity_type":"gene"},{"created":"2020-12-11T12:31:36.603913+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.77","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of inheritance for gene: GDF9 was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to BIALLELIC, autosomal or pseudoautosomal","entity_name":"GDF9","entity_type":"gene"},{"created":"2020-12-11T12:31:10.906098+11:00","panel_name":"Primary Ovarian Insufficiency_Premature Ovarian Failure","panel_id":3166,"panel_version":"0.76","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: FEZF1 as ready","entity_name":"FEZF1","entity_type":"gene"}]}