{"count":220459,"next":"https://panelapp-aus.org/api/v1/activities/?format=json&page=1525","previous":"https://panelapp-aus.org/api/v1/activities/?format=json&page=1523","results":[{"created":"2020-10-25T20:38:16.752697+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.3117","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: APOPT1 were changed from  to Mitochondrial complex IV deficiency, nuclear type 17, MIM#619061","entity_name":"APOPT1","entity_type":"gene"},{"created":"2020-10-25T20:37:30.387244+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.197","user_name":"Zornitza Stark","item_type":"entity","text":"gene: APOPT1 was added\ngene: APOPT1 was added to Regression. Sources: Expert list\nMode of inheritance for gene: APOPT1 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: APOPT1 were set to 25175347\nPhenotypes for gene: APOPT1 were set to Mitochondrial complex IV deficiency, nuclear type 17, MIM#619061\nReview for gene: APOPT1 was set to GREEN\nAdded comment: 6 individuals from 5 unrelated families reported, presenting in late infancy or early childhood with evidence of complex IV deficiency. Phenotype varied widely. Five individuals had episodes of neurologic regression manifest as gait difficulties and spastic tetraparesis, sensorimotor polyneuropathy, and dysarthria that in some cases improved over time. The sixth individual never developed neurologic signs. Three had normal cognition and 3 had impaired cognition. Brain imaging showed a cavitating leukodystrophy, predominantly affecting the posterior cerebral white matter and corpus callosum, that stabilized or even improved over time. \nSources: Expert list","entity_name":"APOPT1","entity_type":"gene"},{"created":"2020-10-25T20:37:02.720355+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.3116","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: APOPT1 were set to ","entity_name":"APOPT1","entity_type":"gene"},{"created":"2020-10-25T20:36:17.101337+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.3115","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: APOPT1 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"APOPT1","entity_type":"gene"},{"created":"2020-10-25T20:35:41.525213+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.3114","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: APOPT1: Rating: GREEN; Mode of pathogenicity: None; Publications: 25175347; Phenotypes: Mitochondrial complex IV deficiency, nuclear type 17, MIM#619061; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"APOPT1","entity_type":"gene"},{"created":"2020-10-25T20:34:55.269707+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.544","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: APOPT1 as ready","entity_name":"APOPT1","entity_type":"gene"},{"created":"2020-10-25T20:34:55.261854+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.544","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: apopt1 has been classified as Green List (High Evidence).","entity_name":"APOPT1","entity_type":"gene"},{"created":"2020-10-25T20:34:52.584943+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5125","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: APOPT1 as ready","entity_name":"APOPT1","entity_type":"gene"},{"created":"2020-10-25T20:34:52.573542+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5125","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: apopt1 has been classified as Green List (High Evidence).","entity_name":"APOPT1","entity_type":"gene"},{"created":"2020-10-25T20:34:49.093723+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.544","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: APOPT1 were changed from  to Mitochondrial complex IV deficiency, nuclear type 17, MIM#619061","entity_name":"APOPT1","entity_type":"gene"},{"created":"2020-10-25T20:34:45.248773+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5125","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: APOPT1 were changed from  to Mitochondrial complex IV deficiency, nuclear type 17, MIM#619061","entity_name":"APOPT1","entity_type":"gene"},{"created":"2020-10-25T20:34:25.732852+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5124","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: APOPT1 were set to ","entity_name":"APOPT1","entity_type":"gene"},{"created":"2020-10-25T20:34:20.635259+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.543","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: APOPT1 were set to 25175347","entity_name":"APOPT1","entity_type":"gene"},{"created":"2020-10-25T20:34:00.096547+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.542","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: APOPT1 were set to 25175347]","entity_name":"APOPT1","entity_type":"gene"},{"created":"2020-10-25T20:33:43.637456+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5123","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: APOPT1 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"APOPT1","entity_type":"gene"},{"created":"2020-10-25T20:33:40.588738+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.542","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: APOPT1 were set to 25175347]","entity_name":"APOPT1","entity_type":"gene"},{"created":"2020-10-25T20:33:13.605214+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5122","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: APOPT1: Rating: GREEN; Mode of pathogenicity: None; Publications: 25175347]; Phenotypes: Mitochondrial complex IV deficiency, nuclear type 17, MIM#619061; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"APOPT1","entity_type":"gene"},{"created":"2020-10-25T20:33:05.043567+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.541","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: APOPT1 were set to ","entity_name":"APOPT1","entity_type":"gene"},{"created":"2020-10-25T20:32:46.035846+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.540","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: APOPT1 was changed from BIALLELIC, autosomal or pseudoautosomal to BIALLELIC, autosomal or pseudoautosomal","entity_name":"APOPT1","entity_type":"gene"},{"created":"2020-10-25T20:32:27.431282+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.540","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: APOPT1 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"APOPT1","entity_type":"gene"},{"created":"2020-10-25T20:31:59.348752+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.539","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: APOPT1: Rating: GREEN; Mode of pathogenicity: None; Publications: 25175347]; Phenotypes: Mitochondrial complex IV deficiency, nuclear type 17, MIM#619061; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"APOPT1","entity_type":"gene"},{"created":"2020-10-25T20:29:33.200593+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.196","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: COX4I1 as ready","entity_name":"COX4I1","entity_type":"gene"},{"created":"2020-10-25T20:29:33.185117+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.196","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cox4i1 has been classified as Amber List (Moderate Evidence).","entity_name":"COX4I1","entity_type":"gene"},{"created":"2020-10-25T20:29:27.982296+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.196","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: COX4I1 as Amber List (moderate evidence)","entity_name":"COX4I1","entity_type":"gene"},{"created":"2020-10-25T20:29:27.972122+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.196","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cox4i1 has been classified as Amber List (Moderate Evidence).","entity_name":"COX4I1","entity_type":"gene"},{"created":"2020-10-25T20:28:59.809385+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.195","user_name":"Zornitza Stark","item_type":"entity","text":"gene: COX4I1 was added\ngene: COX4I1 was added to Regression. Sources: Expert list\nMode of inheritance for gene: COX4I1 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: COX4I1 were set to 28766551; 22592081; 31290619\nPhenotypes for gene: COX4I1 were set to Mitochondrial complex IV deficiency, nuclear type 16, MIM#619060\nReview for gene: COX4I1 was set to AMBER\nAdded comment: Two unrelated families reported, regression was a feature in both. \nSources: Expert list","entity_name":"COX4I1","entity_type":"gene"},{"created":"2020-10-25T20:28:22.456065+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5122","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: COX4I1 as ready","entity_name":"COX4I1","entity_type":"gene"},{"created":"2020-10-25T20:28:22.445632+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5122","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cox4i1 has been classified as Amber List (Moderate Evidence).","entity_name":"COX4I1","entity_type":"gene"},{"created":"2020-10-25T20:28:05.784746+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5122","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: COX4I1 as Amber List (moderate evidence)","entity_name":"COX4I1","entity_type":"gene"},{"created":"2020-10-25T20:28:05.776155+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5122","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cox4i1 has been classified as Amber List (Moderate Evidence).","entity_name":"COX4I1","entity_type":"gene"},{"created":"2020-10-25T20:27:11.768166+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5121","user_name":"Zornitza Stark","item_type":"entity","text":"gene: COX4I1 was added\ngene: COX4I1 was added to Mendeliome. Sources: Expert list\nMode of inheritance for gene: COX4I1 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: COX4I1 were set to 28766551; 22592081; 31290619\nPhenotypes for gene: COX4I1 were set to Mitochondrial complex IV deficiency, nuclear type 16, MIM#619060\nReview for gene: COX4I1 was set to AMBER\nAdded comment: Two unrelated families reported.\r\n\r\nTwo more variants reported in PMID: 22592081: one is non-coding and the other rare missense, appear to have been identified in separate individuals, i.e. heterozygous in each individual. \nSources: Expert list","entity_name":"COX4I1","entity_type":"gene"},{"created":"2020-10-25T20:26:42.569712+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.539","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: COX4I1 were changed from short stature; mild dysmorphic features; Fanconi anemia to Mitochondrial complex IV deficiency, nuclear type 16, MIM#619060; regression; seizures; short stature; mild dysmorphic features; Fanconi anemia","entity_name":"COX4I1","entity_type":"gene"},{"created":"2020-10-25T20:26:17.581928+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.538","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: COX4I1 were set to 28766551; 22592081","entity_name":"COX4I1","entity_type":"gene"},{"created":"2020-10-25T20:25:04.995487+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.537","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: COX4I1 as Amber List (moderate evidence)","entity_name":"COX4I1","entity_type":"gene"},{"created":"2020-10-25T20:25:04.987716+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.537","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cox4i1 has been classified as Amber List (Moderate Evidence).","entity_name":"COX4I1","entity_type":"gene"},{"created":"2020-10-25T20:24:35.295372+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.536","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: COX4I1: Added comment: Further family with two affected sibs reported in PMID 31290619, upgrade to Amber.; Changed rating: AMBER; Changed publications: 28766551, 22592081, 31290619; Changed phenotypes: Mitochondrial complex IV deficiency, nuclear type 16, MIM#619060","entity_name":"COX4I1","entity_type":"gene"},{"created":"2020-10-25T20:22:43.148250+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5120","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: COX8A were changed from Mitochondrial complex IV deficiency, MIM# 220110 to Mitochondrial complex IV deficiency, nuclear type 15, MIM#619059","entity_name":"COX8A","entity_type":"gene"},{"created":"2020-10-25T20:22:24.599213+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5119","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: COX8A: Changed phenotypes: Mitochondrial complex IV deficiency, nuclear type 15, MIM#619059","entity_name":"COX8A","entity_type":"gene"},{"created":"2020-10-25T20:22:05.562300+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.536","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: COX8A were changed from Mitochondrial complex IV deficiency, MIM# 220110 to Mitochondrial complex IV deficiency, nuclear type 15, MIM#619059","entity_name":"COX8A","entity_type":"gene"},{"created":"2020-10-25T20:21:33.924780+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.535","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: COX8A: Changed phenotypes: Mitochondrial complex IV deficiency, nuclear type 15, MIM#619059","entity_name":"COX8A","entity_type":"gene"},{"created":"2020-10-25T20:20:55.329309+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.3114","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: COA3 were changed from Mitochondrial complex IV deficiency to Mitochondrial complex IV deficiency, nuclear type 14, MIM# 619058","entity_name":"COA3","entity_type":"gene"},{"created":"2020-10-25T20:20:24.076129+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.3113","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: COA3: Changed phenotypes: Mitochondrial complex IV deficiency, nuclear type 14, MIM# 619058","entity_name":"COA3","entity_type":"gene"},{"created":"2020-10-25T20:20:07.237391+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5119","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: COA3 were changed from Mitochondrial complex IV deficiency to Mitochondrial complex IV deficiency, nuclear type 14, MIM# 619058","entity_name":"COA3","entity_type":"gene"},{"created":"2020-10-25T20:19:49.113488+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5118","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: COA3: Changed phenotypes: Mitochondrial complex IV deficiency, nuclear type 14, MIM# 619058","entity_name":"COA3","entity_type":"gene"},{"created":"2020-10-25T20:19:40.321598+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.535","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: COA3 were changed from Mitochondrial complex IV deficiency to Mitochondrial complex IV deficiency, nuclear type 14, MIM#619058","entity_name":"COA3","entity_type":"gene"},{"created":"2020-10-25T20:19:03.384066+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.534","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: COA3: Changed phenotypes: Mitochondrial complex IV deficiency, nuclear type 14, MIM# 619058","entity_name":"COA3","entity_type":"gene"},{"created":"2020-10-25T20:18:06.671143+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.194","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: PET100 as ready","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:18:06.660365+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.194","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: pet100 has been classified as Red List (Low Evidence).","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:18:00.477158+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.194","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: PET100 were changed from  to Mitochondrial complex IV deficiency, nuclear type 12, MIM# 619055","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:17:41.531803+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.193","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: PET100 were set to 24462369; 25293719; 31406627","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:17:22.178441+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.193","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: PET100 were set to ","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:17:00.231804+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.192","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: PET100 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:15:57.535602+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.191","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: PET100 as Red List (low evidence)","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:15:57.528279+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.191","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: pet100 has been classified as Red List (Low Evidence).","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:15:29.744148+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.190","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: PET100: Rating: RED; Mode of pathogenicity: None; Publications: 24462369, 25293719, 31406627; Phenotypes: Mitochondrial complex IV deficiency, nuclear type 12, MIM# 619055; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:14:14.693269+11:00","panel_name":"Genetic Epilepsy","panel_id":202,"panel_version":"0.893","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: PET100 as ready","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:14:14.681298+11:00","panel_name":"Genetic Epilepsy","panel_id":202,"panel_version":"0.893","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: pet100 has been classified as Green List (High Evidence).","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:14:11.870367+11:00","panel_name":"Genetic Epilepsy","panel_id":202,"panel_version":"0.893","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: PET100 were changed from  to Mitochondrial complex IV deficiency, nuclear type 12, MIM# 619055","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:13:42.902163+11:00","panel_name":"Genetic Epilepsy","panel_id":202,"panel_version":"0.892","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: PET100 were set to ","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:13:15.223980+11:00","panel_name":"Genetic Epilepsy","panel_id":202,"panel_version":"0.891","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: PET100 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:12:46.661673+11:00","panel_name":"Genetic Epilepsy","panel_id":202,"panel_version":"0.890","user_name":"Zornitza Stark","item_type":"entity","text":"Tag founder tag was added to gene: PET100.","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:12:37.420943+11:00","panel_name":"Genetic Epilepsy","panel_id":202,"panel_version":"0.890","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: PET100: Rating: GREEN; Mode of pathogenicity: None; Publications: 24462369, 25293719, 31406627; Phenotypes: Mitochondrial complex IV deficiency, nuclear type 12, MIM# 619055; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:11:31.661290+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.3113","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: PET100 were changed from Mitochondrial complex IV deficiency, MIM# 220110 to Mitochondrial complex IV deficiency, nuclear type 12, MIM# 619055","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:11:01.919940+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.3112","user_name":"Zornitza Stark","item_type":"entity","text":"Tag founder tag was added to gene: PET100.","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:10:46.225041+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.3112","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: PET100: Changed phenotypes: Mitochondrial complex IV deficiency, nuclear type 12, MIM# 619055","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:10:26.207226+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5118","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: PET100 as ready","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:10:26.189700+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5118","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: pet100 has been classified as Green List (High Evidence).","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:10:13.900275+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5118","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: PET100 were changed from  to Mitochondrial complex IV deficiency, nuclear type 12, MIM# 619055","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:09:53.685126+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5117","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: PET100 were set to ","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:09:35.667149+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5116","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: PET100 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:09:19.170073+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5115","user_name":"Zornitza Stark","item_type":"entity","text":"Tag founder tag was added to gene: PET100.","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:09:07.830317+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5115","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: PET100: Rating: GREEN; Mode of pathogenicity: None; Publications: 24462369, 25293719, 31406627; Phenotypes: Mitochondrial complex IV deficiency, nuclear type 12, MIM# 619055; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:08:45.687553+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.534","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: PET100 as ready","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:08:45.675085+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.534","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: pet100 has been classified as Green List (High Evidence).","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:08:23.194760+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.534","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: PET100 were changed from  to Mitochondrial complex IV deficiency, nuclear type 12, MIM# 619055","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:07:31.900460+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.533","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: PET100 were set to ","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:07:03.488911+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.532","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: PET100 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:06:36.787567+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.531","user_name":"Zornitza Stark","item_type":"entity","text":"Tag founder tag was added to gene: PET100.","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:06:28.273344+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.531","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: PET100: Rating: GREEN; Mode of pathogenicity: None; Publications: 24462369, 25293719, 31406627; Phenotypes: Mitochondrial complex IV deficiency, nuclear type 12, MIM# 619055; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"PET100","entity_type":"gene"},{"created":"2020-10-25T20:02:01.369304+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5115","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: COX20 as ready","entity_name":"COX20","entity_type":"gene"},{"created":"2020-10-25T20:02:01.347171+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5115","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cox20 has been classified as Green List (High Evidence).","entity_name":"COX20","entity_type":"gene"},{"created":"2020-10-25T20:01:54.470493+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5115","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: COX20 were changed from  to Mitochondrial complex IV deficiency, nuclear type 11, MIM#619054","entity_name":"COX20","entity_type":"gene"},{"created":"2020-10-25T20:01:32.290832+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5114","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: COX20 were set to ","entity_name":"COX20","entity_type":"gene"},{"created":"2020-10-25T20:01:14.428295+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5113","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: COX20 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"COX20","entity_type":"gene"},{"created":"2020-10-25T20:00:56.404956+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.5112","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: COX20: Rating: GREEN; Mode of pathogenicity: None; Publications: 24202787, 31079202, 30656193, 23125284, 32606554; Phenotypes: Mitochondrial complex IV deficiency, nuclear type 11, MIM#619054; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"COX20","entity_type":"gene"},{"created":"2020-10-25T20:00:30.319715+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.531","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: COX20 as ready","entity_name":"COX20","entity_type":"gene"},{"created":"2020-10-25T20:00:30.307532+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.531","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cox20 has been classified as Green List (High Evidence).","entity_name":"COX20","entity_type":"gene"},{"created":"2020-10-25T20:00:23.396507+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.531","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: COX20 were changed from  to Mitochondrial complex IV deficiency, nuclear type 11, MIM#619054","entity_name":"COX20","entity_type":"gene"},{"created":"2020-10-25T19:59:50.367388+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.530","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: COX20 were set to ","entity_name":"COX20","entity_type":"gene"},{"created":"2020-10-25T19:59:21.121861+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.529","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: COX20 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"COX20","entity_type":"gene"},{"created":"2020-10-25T19:58:51.925748+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.528","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: COX20: Rating: GREEN; Mode of pathogenicity: None; Publications: 24202787, 31079202, 30656193, 23125284, 32606554; Phenotypes: Mitochondrial complex IV deficiency, nuclear type 11, MIM#619054; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"COX20","entity_type":"gene"},{"created":"2020-10-25T19:49:12.621238+11:00","panel_name":"Cardiomyopathy_Paediatric","panel_id":3270,"panel_version":"0.35","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: COX14 as ready","entity_name":"COX14","entity_type":"gene"},{"created":"2020-10-25T19:49:12.611075+11:00","panel_name":"Cardiomyopathy_Paediatric","panel_id":3270,"panel_version":"0.35","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cox14 has been classified as Amber List (Moderate Evidence).","entity_name":"COX14","entity_type":"gene"},{"created":"2020-10-25T19:49:07.751466+11:00","panel_name":"Cardiomyopathy_Paediatric","panel_id":3270,"panel_version":"0.35","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: COX14 were changed from ?Mitochondrial complex IV deficiency, 220110 to Mitochondrial complex IV deficiency, nuclear type 10, MIM# 619053","entity_name":"COX14","entity_type":"gene"},{"created":"2020-10-25T19:48:48.853857+11:00","panel_name":"Cardiomyopathy_Paediatric","panel_id":3270,"panel_version":"0.34","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: COX14 were set to ","entity_name":"COX14","entity_type":"gene"},{"created":"2020-10-25T19:48:34.602253+11:00","panel_name":"Cardiomyopathy_Paediatric","panel_id":3270,"panel_version":"0.33","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: COX14 as Amber List (moderate evidence)","entity_name":"COX14","entity_type":"gene"},{"created":"2020-10-25T19:48:34.594387+11:00","panel_name":"Cardiomyopathy_Paediatric","panel_id":3270,"panel_version":"0.33","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cox14 has been classified as Amber List (Moderate Evidence).","entity_name":"COX14","entity_type":"gene"},{"created":"2020-10-25T19:48:24.881689+11:00","panel_name":"Cardiomyopathy_Paediatric","panel_id":3270,"panel_version":"0.32","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: COX14: Rating: AMBER; Mode of pathogenicity: None; Publications: 22243966; Phenotypes: Mitochondrial complex IV deficiency, nuclear type 10, MIM# 619053; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"COX14","entity_type":"gene"},{"created":"2020-10-25T19:47:36.076248+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.3112","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: COX14 were changed from Mitochondrial complex IV deficiency, MIM#220110 to Mitochondrial complex IV deficiency, nuclear type 10, MIM#619053","entity_name":"COX14","entity_type":"gene"},{"created":"2020-10-25T19:47:02.566774+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.3111","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: COX14: Changed phenotypes: Mitochondrial complex IV deficiency, nuclear type 10, MIM#619053","entity_name":"COX14","entity_type":"gene"}]}