{"count":220771,"next":"https://panelapp-aus.org/api/v1/activities/?format=json&page=1590","previous":"https://panelapp-aus.org/api/v1/activities/?format=json&page=1588","results":[{"created":"2020-09-15T13:54:20.923730+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.148","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: SMARCAL1 were changed from  to Schimke immunoosseous dysplasia, MIM# 242900","entity_name":"SMARCAL1","entity_type":"gene"},{"created":"2020-09-15T13:53:52.766718+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.147","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: SMARCAL1 were set to ","entity_name":"SMARCAL1","entity_type":"gene"},{"created":"2020-09-15T13:53:30.941787+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.146","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: SMARCAL1 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"SMARCAL1","entity_type":"gene"},{"created":"2020-09-15T13:53:03.200940+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.145","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: SMARCAL1: Rating: GREEN; Mode of pathogenicity: None; Publications: 11799392, 17089404; Phenotypes: Schimke immunoosseous dysplasia, MIM# 242900; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"SMARCAL1","entity_type":"gene"},{"created":"2020-09-15T13:49:31.475982+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.145","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: SLX4 as ready","entity_name":"SLX4","entity_type":"gene"},{"created":"2020-09-15T13:49:31.463180+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.145","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: slx4 has been classified as Green List (High Evidence).","entity_name":"SLX4","entity_type":"gene"},{"created":"2020-09-15T13:49:28.775923+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.145","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: SLX4 were changed from  to Fanconi anemia, complementation group P, MIM# 613951","entity_name":"SLX4","entity_type":"gene"},{"created":"2020-09-15T13:49:05.233928+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.144","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: SLX4 were set to ","entity_name":"SLX4","entity_type":"gene"},{"created":"2020-09-15T13:47:44.809190+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.143","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: SLX4 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"SLX4","entity_type":"gene"},{"created":"2020-09-15T13:47:12.942306+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.142","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: SLX4: Rating: GREEN; Mode of pathogenicity: None; Publications: 21240275, 21240277; Phenotypes: Fanconi anemia, complementation group P, MIM# 613951; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"SLX4","entity_type":"gene"},{"created":"2020-09-15T13:45:29.475695+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.142","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: SLC37A4 as ready","entity_name":"SLC37A4","entity_type":"gene"},{"created":"2020-09-15T13:45:29.464955+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.142","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: slc37a4 has been classified as Green List (High Evidence).","entity_name":"SLC37A4","entity_type":"gene"},{"created":"2020-09-15T13:45:26.970375+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.142","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: SLC37A4 were changed from  to Glycogen storage disease Ib, MIM# 232220","entity_name":"SLC37A4","entity_type":"gene"},{"created":"2020-09-15T13:44:59.279327+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.141","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: SLC37A4 were set to ","entity_name":"SLC37A4","entity_type":"gene"},{"created":"2020-09-15T13:44:35.214199+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.140","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: SLC37A4 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"SLC37A4","entity_type":"gene"},{"created":"2020-09-15T13:44:11.319633+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.139","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: SLC37A4: Rating: GREEN; Mode of pathogenicity: None; Publications: 31788408, 31536830; Phenotypes: Glycogen storage disease Ib, MIM# 232220; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"SLC37A4","entity_type":"gene"},{"created":"2020-09-15T13:39:56.942120+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4437","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: SLC25A38 as ready","entity_name":"SLC25A38","entity_type":"gene"},{"created":"2020-09-15T13:39:56.930960+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4437","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: slc25a38 has been classified as Green List (High Evidence).","entity_name":"SLC25A38","entity_type":"gene"},{"created":"2020-09-15T13:39:44.860008+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4437","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: SLC25A38 were changed from  to Anemia, sideroblastic, 2, pyridoxine-refractory, MIM# 205950","entity_name":"SLC25A38","entity_type":"gene"},{"created":"2020-09-15T13:39:23.951305+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4436","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: SLC25A38 were set to ","entity_name":"SLC25A38","entity_type":"gene"},{"created":"2020-09-15T13:39:06.315827+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4435","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: SLC25A38 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"SLC25A38","entity_type":"gene"},{"created":"2020-09-15T13:38:50.329006+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4434","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: SLC25A38: Rating: GREEN; Mode of pathogenicity: None; Publications: 19412178; Phenotypes: Anemia, sideroblastic, 2, pyridoxine-refractory, MIM# 205950; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"SLC25A38","entity_type":"gene"},{"created":"2020-09-15T13:38:27.400860+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.139","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: SLC25A38 as ready","entity_name":"SLC25A38","entity_type":"gene"},{"created":"2020-09-15T13:38:27.389972+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.139","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: slc25a38 has been classified as Green List (High Evidence).","entity_name":"SLC25A38","entity_type":"gene"},{"created":"2020-09-15T13:37:58.217124+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.139","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: SLC25A38 were changed from  to Anemia, sideroblastic, 2, pyridoxine-refractory, MIM# 205950","entity_name":"SLC25A38","entity_type":"gene"},{"created":"2020-09-15T13:37:31.173357+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.138","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: SLC25A38 were set to ","entity_name":"SLC25A38","entity_type":"gene"},{"created":"2020-09-15T13:37:06.784777+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.137","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: SLC25A38 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"SLC25A38","entity_type":"gene"},{"created":"2020-09-15T13:36:35.896198+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.136","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: SLC25A38: Rating: GREEN; Mode of pathogenicity: None; Publications: 19412178; Phenotypes: Anemia, sideroblastic, 2, pyridoxine-refractory, MIM# 205950; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"SLC25A38","entity_type":"gene"},{"created":"2020-09-15T13:35:14.538421+10:00","panel_name":"Deafness_IsolatedAndComplex","panel_id":209,"panel_version":"0.389","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: SLC19A2 as ready","entity_name":"SLC19A2","entity_type":"gene"},{"created":"2020-09-15T13:35:14.527347+10:00","panel_name":"Deafness_IsolatedAndComplex","panel_id":209,"panel_version":"0.389","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: slc19a2 has been classified as Green List (High Evidence).","entity_name":"SLC19A2","entity_type":"gene"},{"created":"2020-09-15T13:35:10.018544+10:00","panel_name":"Deafness_IsolatedAndComplex","panel_id":209,"panel_version":"0.389","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: SLC19A2 as Green List (high evidence)","entity_name":"SLC19A2","entity_type":"gene"},{"created":"2020-09-15T13:35:10.007897+10:00","panel_name":"Deafness_IsolatedAndComplex","panel_id":209,"panel_version":"0.389","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: slc19a2 has been classified as Green List (High Evidence).","entity_name":"SLC19A2","entity_type":"gene"},{"created":"2020-09-15T13:34:45.503575+10:00","panel_name":"Deafness_IsolatedAndComplex","panel_id":209,"panel_version":"0.388","user_name":"Zornitza Stark","item_type":"entity","text":"gene: SLC19A2 was added\ngene: SLC19A2 was added to Deafness_IsolatedAndComplex. Sources: Expert Review\nMode of inheritance for gene: SLC19A2 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: SLC19A2 were set to 10391221; 10978358\nPhenotypes for gene: SLC19A2 were set to Thiamine-responsive megaloblastic anemia syndrome, MIM# 249270\nReview for gene: SLC19A2 was set to GREEN\nAdded comment: Over 5 unrelated families reported, sensorineural deafness is part of the phenotype. \nSources: Expert Review","entity_name":"SLC19A2","entity_type":"gene"},{"created":"2020-09-15T13:33:21.249484+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4434","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: SLC19A2 as ready","entity_name":"SLC19A2","entity_type":"gene"},{"created":"2020-09-15T13:33:21.236774+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4434","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: slc19a2 has been classified as Green List (High Evidence).","entity_name":"SLC19A2","entity_type":"gene"},{"created":"2020-09-15T13:33:14.615661+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4434","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: SLC19A2 were changed from  to Thiamine-responsive megaloblastic anemia syndrome, MIM# 249270","entity_name":"SLC19A2","entity_type":"gene"},{"created":"2020-09-15T13:32:58.874590+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4433","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: SLC19A2 were set to ","entity_name":"SLC19A2","entity_type":"gene"},{"created":"2020-09-15T13:32:42.515526+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4432","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: SLC19A2 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"SLC19A2","entity_type":"gene"},{"created":"2020-09-15T13:32:24.104801+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4431","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: SLC19A2: Rating: GREEN; Mode of pathogenicity: None; Publications: 10391221, 10978358; Phenotypes: Thiamine-responsive megaloblastic anemia syndrome, MIM# 249270; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"SLC19A2","entity_type":"gene"},{"created":"2020-09-15T13:31:10.167568+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.136","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: SLC19A2 as ready","entity_name":"SLC19A2","entity_type":"gene"},{"created":"2020-09-15T13:31:10.158876+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.136","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: slc19a2 has been classified as Green List (High Evidence).","entity_name":"SLC19A2","entity_type":"gene"},{"created":"2020-09-15T13:31:07.980969+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.136","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: SLC19A2 were changed from  to Thiamine-responsive megaloblastic anemia syndrome, MIM# 249270","entity_name":"SLC19A2","entity_type":"gene"},{"created":"2020-09-15T13:30:40.812844+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.135","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: SLC19A2 were set to ","entity_name":"SLC19A2","entity_type":"gene"},{"created":"2020-09-15T13:30:17.692428+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.134","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: SLC19A2 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"SLC19A2","entity_type":"gene"},{"created":"2020-09-15T13:29:52.468081+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.133","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: SLC19A2: Rating: GREEN; Mode of pathogenicity: None; Publications: 10391221, 10978358; Phenotypes: Thiamine-responsive megaloblastic anemia syndrome, MIM# 249270; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"SLC19A2","entity_type":"gene"},{"created":"2020-09-15T11:04:33.926893+10:00","panel_name":"Paroxysmal Dyskinesia","panel_id":259,"panel_version":"0.80","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: ATP7B as Amber List (moderate evidence)","entity_name":"ATP7B","entity_type":"gene"},{"created":"2020-09-15T11:04:33.918618+10:00","panel_name":"Paroxysmal Dyskinesia","panel_id":259,"panel_version":"0.80","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: atp7b has been classified as Amber List (Moderate Evidence).","entity_name":"ATP7B","entity_type":"gene"},{"created":"2020-09-15T11:04:09.619816+10:00","panel_name":"Paroxysmal Dyskinesia","panel_id":259,"panel_version":"0.79","user_name":"Zornitza Stark","item_type":"entity","text":"changed review comment from: In a recent cohort of 82 affected individuals, movement disorders were noted in 78/82 (95.1%) patients and included dystonia in 69 (84.1%), chorea in 31 (37.8%), tremor in 24 (29.3%), parkinsonism in 19 (23.2%), athetosis in 13 (15.9%), and myoclonus in 9 (11.0%) patients. Dystonia was more frequently observed in the patients with thalamic (76.8 vs 23.2%), globus pallidus (72.0 vs 28.0%), putamen (69.5 vs 30.5%), caudate (68.3 vs 31.7%) and brainstem (61.0 vs 39.0%) involvement, and tremor with cerebellar involvement (37.5 vs 5.2%).\r\n\r\nParoxysmal dyskinesia does not appear to be a common feature, and the gene is already included in the Dystonia_Complex panel.; to: In a recent cohort of 82 affected individuals, movement disorders were noted in 78/82 (95.1%) patients and included dystonia in 69 (84.1%), chorea in 31 (37.8%), tremor in 24 (29.3%), parkinsonism in 19 (23.2%), athetosis in 13 (15.9%), and myoclonus in 9 (11.0%) patients. Dystonia was more frequently observed in the patients with thalamic (76.8 vs 23.2%), globus pallidus (72.0 vs 28.0%), putamen (69.5 vs 30.5%), caudate (68.3 vs 31.7%) and brainstem (61.0 vs 39.0%) involvement, and tremor with cerebellar involvement (37.5 vs 5.2%).\r\n\r\nParoxysmal dyskinesia does not appear to be a common feature, and the gene is already included in the Dystonia_Complex panel. However, there are rare reports and this is a treatable disorder.","entity_name":"ATP7B","entity_type":"gene"},{"created":"2020-09-15T11:03:37.110979+10:00","panel_name":"Paroxysmal Dyskinesia","panel_id":259,"panel_version":"0.79","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: ATP7B: Changed rating: AMBER","entity_name":"ATP7B","entity_type":"gene"},{"created":"2020-09-15T06:45:42.218394+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4431","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: SEC23B as ready","entity_name":"SEC23B","entity_type":"gene"},{"created":"2020-09-15T06:45:42.206931+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4431","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: sec23b has been classified as Green List (High Evidence).","entity_name":"SEC23B","entity_type":"gene"},{"created":"2020-09-15T06:45:33.563080+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4431","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: SEC23B were changed from  to Dyserythropoietic anemia, congenital, type II , MIM#224100","entity_name":"SEC23B","entity_type":"gene"},{"created":"2020-09-14T21:40:33.388626+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4430","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: SEC23B were set to ","entity_name":"SEC23B","entity_type":"gene"},{"created":"2020-09-14T21:40:15.472638+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4429","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: SEC23B was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"SEC23B","entity_type":"gene"},{"created":"2020-09-14T21:39:54.025380+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4428","user_name":"Zornitza Stark","item_type":"entity","text":"commented on gene: SEC23B: Over 20 families reported.","entity_name":"SEC23B","entity_type":"gene"},{"created":"2020-09-14T21:39:37.880668+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4428","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: SEC23B: Rating: GREEN; Mode of pathogenicity: None; Publications: 19561605, 19621418; Phenotypes: Dyserythropoietic anemia, congenital, type II , MIM#224100; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"SEC23B","entity_type":"gene"},{"created":"2020-09-14T21:38:48.862171+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.133","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: SEC23B as ready","entity_name":"SEC23B","entity_type":"gene"},{"created":"2020-09-14T21:38:48.853164+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.133","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: sec23b has been classified as Green List (High Evidence).","entity_name":"SEC23B","entity_type":"gene"},{"created":"2020-09-14T21:38:43.115568+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.133","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: SEC23B were changed from  to Dyserythropoietic anemia, congenital, type II , MIM#224100","entity_name":"SEC23B","entity_type":"gene"},{"created":"2020-09-14T21:38:14.057970+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.132","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: SEC23B were set to ","entity_name":"SEC23B","entity_type":"gene"},{"created":"2020-09-14T21:37:50.726210+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.131","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: SEC23B was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"SEC23B","entity_type":"gene"},{"created":"2020-09-14T21:37:22.323170+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.130","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: SEC23B: Rating: GREEN; Mode of pathogenicity: None; Publications: 19561605, 19621418; Phenotypes: Dyserythropoietic anemia, congenital, type II , MIM#224100; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"SEC23B","entity_type":"gene"},{"created":"2020-09-14T21:35:17.024382+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.130","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: RUNX1 as ready","entity_name":"RUNX1","entity_type":"gene"},{"created":"2020-09-14T21:35:17.013424+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.130","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: runx1 has been classified as Green List (High Evidence).","entity_name":"RUNX1","entity_type":"gene"},{"created":"2020-09-14T21:35:14.192471+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.130","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: RUNX1 were changed from  to Platelet disorder, familial, with associated myeloid malignancy, MIM# 601399","entity_name":"RUNX1","entity_type":"gene"},{"created":"2020-09-14T21:34:55.375174+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.129","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: RUNX1 were set to ","entity_name":"RUNX1","entity_type":"gene"},{"created":"2020-09-14T21:34:26.150006+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.128","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: RUNX1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"RUNX1","entity_type":"gene"},{"created":"2020-09-14T21:34:00.485523+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.127","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: RUNX1: Rating: GREEN; Mode of pathogenicity: None; Publications: 10508512, 11830488; Phenotypes: Platelet disorder, familial, with associated myeloid malignancy, MIM# 601399; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"RUNX1","entity_type":"gene"},{"created":"2020-09-14T20:28:47.713822+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4428","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: RPS27 as ready","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:28:47.700234+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4428","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: rps27 has been classified as Red List (Low Evidence).","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:28:40.076932+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4428","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: RPS27 were changed from  to Diamond-Blackfan anemia 17, MIM# 617409","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:28:15.868836+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4427","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: RPS27 were set to ","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:27:57.635773+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4426","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: RPS27 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:27:40.985323+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4425","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: RPS27 as Red List (low evidence)","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:27:40.976813+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4425","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: rps27 has been classified as Red List (Low Evidence).","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:27:24.976029+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4424","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: RPS27: Rating: RED; Mode of pathogenicity: None; Publications: 25424902; Phenotypes: Diamond-Blackfan anemia 17, MIM# 617409; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:26:43.731698+10:00","panel_name":"Diamond Blackfan anaemia","panel_id":98,"panel_version":"0.28","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: RPS27 as ready","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:26:43.723931+10:00","panel_name":"Diamond Blackfan anaemia","panel_id":98,"panel_version":"0.28","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: rps27 has been classified as Red List (Low Evidence).","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:26:41.405088+10:00","panel_name":"Diamond Blackfan anaemia","panel_id":98,"panel_version":"0.28","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: RPS27 were changed from  to Diamond-Blackfan anemia 17, MIM# 617409","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:26:16.083114+10:00","panel_name":"Diamond Blackfan anaemia","panel_id":98,"panel_version":"0.27","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: RPS27 were set to ","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:25:59.172585+10:00","panel_name":"Diamond Blackfan anaemia","panel_id":98,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: RPS27 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:25:38.574878+10:00","panel_name":"Diamond Blackfan anaemia","panel_id":98,"panel_version":"0.25","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: RPS27 as Red List (low evidence)","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:25:38.552318+10:00","panel_name":"Diamond Blackfan anaemia","panel_id":98,"panel_version":"0.25","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: rps27 has been classified as Red List (Low Evidence).","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:25:08.626314+10:00","panel_name":"Diamond Blackfan anaemia","panel_id":98,"panel_version":"0.24","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: RPS27: Rating: RED; Mode of pathogenicity: None; Publications: 25424902; Phenotypes: Diamond-Blackfan anemia 17, MIM# 617409; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:24:24.665111+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.127","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: RPS27 as ready","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:24:24.656345+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.127","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: rps27 has been classified as Red List (Low Evidence).","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:24:20.869987+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.127","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: RPS27 were changed from  to Diamond-Blackfan anemia 17, MIM# 617409","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:23:54.821369+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.126","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: RPS27 were set to ","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:23:33.660975+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.125","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: RPS27 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:23:09.575221+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.124","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: RPS27 as Red List (low evidence)","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:23:09.566812+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.124","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: rps27 has been classified as Red List (Low Evidence).","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:22:47.025725+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"0.123","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: RPS27: Rating: RED; Mode of pathogenicity: None; Publications: 25424902; Phenotypes: Diamond-Blackfan anemia 17, MIM# 617409; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"RPS27","entity_type":"gene"},{"created":"2020-09-14T20:19:08.955910+10:00","panel_name":"Radial Ray Abnormalities","panel_id":163,"panel_version":"0.73","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: RPS17 as ready","entity_name":"RPS17","entity_type":"gene"},{"created":"2020-09-14T20:19:08.945632+10:00","panel_name":"Radial Ray Abnormalities","panel_id":163,"panel_version":"0.73","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: rps17 has been classified as Green List (High Evidence).","entity_name":"RPS17","entity_type":"gene"},{"created":"2020-09-14T20:19:06.412538+10:00","panel_name":"Radial Ray Abnormalities","panel_id":163,"panel_version":"0.73","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: RPS17 were changed from  to Diamond-Blackfan anemia 4, MIM# 612527","entity_name":"RPS17","entity_type":"gene"},{"created":"2020-09-14T20:18:41.964389+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4424","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: RPS17 as ready","entity_name":"RPS17","entity_type":"gene"},{"created":"2020-09-14T20:18:41.955858+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4424","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: rps17 has been classified as Green List (High Evidence).","entity_name":"RPS17","entity_type":"gene"},{"created":"2020-09-14T20:18:16.270000+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.4424","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: RPS17 were changed from  to Diamond-Blackfan anemia 4, MIM# 612527","entity_name":"RPS17","entity_type":"gene"},{"created":"2020-09-14T20:18:16.240937+10:00","panel_name":"Radial Ray Abnormalities","panel_id":163,"panel_version":"0.72","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: RPS17 were set to ","entity_name":"RPS17","entity_type":"gene"},{"created":"2020-09-14T20:17:55.669656+10:00","panel_name":"Radial Ray Abnormalities","panel_id":163,"panel_version":"0.71","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: RPS17 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"RPS17","entity_type":"gene"}]}