{"count":221413,"next":"https://panelapp-aus.org/api/v1/activities/?format=json&page=1815","previous":"https://panelapp-aus.org/api/v1/activities/?format=json&page=1813","results":[{"created":"2020-04-30T17:19:36.832481+10:00","panel_name":"Systemic Autoinflammatory Disease_Periodic Fever","panel_id":238,"panel_version":"0.72","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: stat2 has been classified as Green List (High Evidence).","entity_name":"STAT2","entity_type":"gene"},{"created":"2020-04-30T17:19:32.059520+10:00","panel_name":"Systemic Autoinflammatory Disease_Periodic Fever","panel_id":238,"panel_version":"0.72","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: STAT2 were changed from  to Autoinflammatory disorder","entity_name":"STAT2","entity_type":"gene"},{"created":"2020-04-30T17:18:58.047261+10:00","panel_name":"Systemic Autoinflammatory Disease_Periodic Fever","panel_id":238,"panel_version":"0.71","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: STAT2 as Green List (high evidence)","entity_name":"STAT2","entity_type":"gene"},{"created":"2020-04-30T17:18:58.033243+10:00","panel_name":"Systemic Autoinflammatory Disease_Periodic Fever","panel_id":238,"panel_version":"0.71","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: stat2 has been classified as Green List (High Evidence).","entity_name":"STAT2","entity_type":"gene"},{"created":"2020-04-30T17:18:28.398594+10:00","panel_name":"Systemic Autoinflammatory Disease_Periodic Fever","panel_id":238,"panel_version":"0.70","user_name":"Zornitza Stark","item_type":"entity","text":"gene: STAT2 was added\ngene: STAT2 was added to Systemic Autoinflammatory Disease_Periodic Fever. Sources: Literature\nMode of inheritance for gene: STAT2 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: STAT2 were set to 31836668; 32092142\nReview for gene: STAT2 was set to GREEN\nAdded comment: Three individuals from two unrelated families reported with bi-allelic GoF variants and severe auto inflammatory disease. Functional data. Note gene is already associated with other immune phenotypes. \nSources: Literature","entity_name":"STAT2","entity_type":"gene"},{"created":"2020-04-30T13:01:25.022284+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2667","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: ABHD12 as ready","entity_name":"ABHD12","entity_type":"gene"},{"created":"2020-04-30T13:01:25.012867+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2667","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: abhd12 has been classified as Green List (High Evidence).","entity_name":"ABHD12","entity_type":"gene"},{"created":"2020-04-30T13:01:14.195365+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2667","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: ABHD12 were changed from  to Polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract MIM#612674","entity_name":"ABHD12","entity_type":"gene"},{"created":"2020-04-30T13:00:51.376483+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2666","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: ABHD12 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"ABHD12","entity_type":"gene"},{"created":"2020-04-30T13:00:13.732468+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2665","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: ABCC6 as ready","entity_name":"ABCC6","entity_type":"gene"},{"created":"2020-04-30T13:00:13.720162+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2665","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: abcc6 has been classified as Green List (High Evidence).","entity_name":"ABCC6","entity_type":"gene"},{"created":"2020-04-30T12:59:06.405086+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2665","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: AAAS as ready","entity_name":"AAAS","entity_type":"gene"},{"created":"2020-04-30T12:59:06.396214+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2665","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: aaas has been classified as Green List (High Evidence).","entity_name":"AAAS","entity_type":"gene"},{"created":"2020-04-30T12:58:50.998103+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2665","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: AAAS were changed from  to Achalasia-addisonianism-alacrimia syndrome, MIM#231550","entity_name":"AAAS","entity_type":"gene"},{"created":"2020-04-30T12:58:23.522623+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2664","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: AAAS was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"AAAS","entity_type":"gene"},{"created":"2020-04-30T09:29:30.454223+10:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.442","user_name":"Kristin Rigbye","item_type":"entity","text":"commented on gene: DNM2","entity_name":"DNM2","entity_type":"gene"},{"created":"2020-04-29T19:56:50.899550+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.52","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: POLR3C as ready","entity_name":"POLR3C","entity_type":"gene"},{"created":"2020-04-29T19:56:50.888165+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.52","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: polr3c has been classified as Amber List (Moderate Evidence).","entity_name":"POLR3C","entity_type":"gene"},{"created":"2020-04-29T19:56:29.006599+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.52","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: IL18BP as ready","entity_name":"IL18BP","entity_type":"gene"},{"created":"2020-04-29T19:56:28.993886+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.52","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: il18bp has been classified as Red List (Low Evidence).","entity_name":"IL18BP","entity_type":"gene"},{"created":"2020-04-29T19:55:08.374666+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2663","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: NOS2 as ready","entity_name":"NOS2","entity_type":"gene"},{"created":"2020-04-29T19:55:08.361653+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2663","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: nos2 has been classified as Red List (Low Evidence).","entity_name":"NOS2","entity_type":"gene"},{"created":"2020-04-29T19:54:58.780452+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2663","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: NOS2 were changed from  to {Malaria, resistance to} 611162; Disseminated CMV disease","entity_name":"NOS2","entity_type":"gene"},{"created":"2020-04-29T19:25:20.618996+10:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.4","user_name":"Bryony Thompson","item_type":"entity","text":"Classified gene: NOS3 as Red List (low evidence)","entity_name":"NOS3","entity_type":"gene"},{"created":"2020-04-29T19:25:20.608189+10:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.4","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: nos3 has been classified as Red List (Low Evidence).","entity_name":"NOS3","entity_type":"gene"},{"created":"2020-04-29T19:25:11.966035+10:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.3","user_name":"Bryony Thompson","item_type":"entity","text":"reviewed gene: NOS3: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: {Ischemic stroke, susceptibility to} MIM#601367; Mode of inheritance: Unknown","entity_name":"NOS3","entity_type":"gene"},{"created":"2020-04-29T19:01:29.713111+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2662","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: NOS2 were set to ","entity_name":"NOS2","entity_type":"gene"},{"created":"2020-04-29T19:01:08.855327+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2661","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: NOS2 as Red List (low evidence)","entity_name":"NOS2","entity_type":"gene"},{"created":"2020-04-29T19:01:08.845367+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2661","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: nos2 has been classified as Red List (Low Evidence).","entity_name":"NOS2","entity_type":"gene"},{"created":"2020-04-29T19:01:05.611087+10:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.3","user_name":"Bryony Thompson","item_type":"entity","text":"Classified gene: MMACHC as Green List (high evidence)","entity_name":"MMACHC","entity_type":"gene"},{"created":"2020-04-29T19:01:05.599937+10:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.3","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: mmachc has been classified as Green List (High Evidence).","entity_name":"MMACHC","entity_type":"gene"},{"created":"2020-04-29T19:00:49.690402+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2660","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: NOS2: Changed rating: RED","entity_name":"NOS2","entity_type":"gene"},{"created":"2020-04-29T19:00:35.121077+10:00","panel_name":"Stroke","panel_id":3141,"panel_version":"0.2","user_name":"Bryony Thompson","item_type":"entity","text":"gene: MMACHC was added\ngene: MMACHC was added to Stroke. Sources: Literature\nMode of inheritance for gene: MMACHC was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: MMACHC were set to 12552044; 11742888; 30356112\nPhenotypes for gene: MMACHC were set to Methylmalonic aciduria and homocystinuria, cblC type\tMIM#277400\nReview for gene: MMACHC was set to GREEN\nAdded comment: Large artery atherosclerosis, large artery non-atherosclerosis with dissections, coagulation pathology venous thrombosis, and coagulation pathology arterial thrombosis are stroke subtypes reported in this condition. \nSources: Literature","entity_name":"MMACHC","entity_type":"gene"},{"created":"2020-04-29T19:00:34.014094+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2660","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: NOS2: Rating: AMBER; Mode of pathogenicity: None; Publications: 12433515, 31995689; Phenotypes: {Malaria, resistance to} 611162, Disseminated CMV disease; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"NOS2","entity_type":"gene"},{"created":"2020-04-29T18:55:06.027535+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.52","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: NOS2 as ready","entity_name":"NOS2","entity_type":"gene"},{"created":"2020-04-29T18:55:06.012315+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.52","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: nos2 has been classified as Red List (Low Evidence).","entity_name":"NOS2","entity_type":"gene"},{"created":"2020-04-29T18:54:57.315154+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.52","user_name":"Zornitza Stark","item_type":"entity","text":"gene: NOS2 was added\ngene: NOS2 was added to Susceptibility to Viral Infections. Sources: Expert list\nMode of inheritance for gene: NOS2 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: NOS2 were set to 31995689\nPhenotypes for gene: NOS2 were set to Disseminated CMV disease\nReview for gene: NOS2 was set to RED\nAdded comment: Single individual reported with progressive, fatal CMV disease and homozygous LoF variant in NOS2. \nSources: Expert list","entity_name":"NOS2","entity_type":"gene"},{"created":"2020-04-29T18:42:19.415675+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.51","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: CD70 as ready","entity_name":"CD70","entity_type":"gene"},{"created":"2020-04-29T18:42:19.402640+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.51","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cd70 has been classified as Green List (High Evidence).","entity_name":"CD70","entity_type":"gene"},{"created":"2020-04-29T18:42:14.536660+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.51","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: CD70 as Green List (high evidence)","entity_name":"CD70","entity_type":"gene"},{"created":"2020-04-29T18:42:14.527924+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.51","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cd70 has been classified as Green List (High Evidence).","entity_name":"CD70","entity_type":"gene"},{"created":"2020-04-29T18:41:43.258096+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.50","user_name":"Zornitza Stark","item_type":"entity","text":"gene: CD70 was added\ngene: CD70 was added to Susceptibility to Viral Infections. Sources: Expert list\nMode of inheritance for gene: CD70 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: CD70 were set to 28011864; 28011863,\nPhenotypes for gene: CD70 were set to Lymphoproliferative syndrome 3, MIM#\t618261; Host response to EBV\nReview for gene: CD70 was set to GREEN\nAdded comment: Three unrelated families reported. \nSources: Expert list","entity_name":"CD70","entity_type":"gene"},{"created":"2020-04-29T18:39:31.538463+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.49","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: CD27 as ready","entity_name":"CD27","entity_type":"gene"},{"created":"2020-04-29T18:39:31.527790+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.49","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cd27 has been classified as Green List (High Evidence).","entity_name":"CD27","entity_type":"gene"},{"created":"2020-04-29T18:39:26.407988+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.49","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: CD27 as Green List (high evidence)","entity_name":"CD27","entity_type":"gene"},{"created":"2020-04-29T18:39:26.399528+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.49","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cd27 has been classified as Green List (High Evidence).","entity_name":"CD27","entity_type":"gene"},{"created":"2020-04-29T18:38:56.333804+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.48","user_name":"Zornitza Stark","item_type":"entity","text":"gene: CD27 was added\ngene: CD27 was added to Susceptibility to Viral Infections. Sources: Expert list\nMode of inheritance for gene: CD27 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: CD27 were set to 22801960; 22197273\nPhenotypes for gene: CD27 were set to Lymphoproliferative syndrome 2, MIM#\t615122; Host response to EBV\nReview for gene: CD27 was set to GREEN\nAdded comment: At least four families reported. \nSources: Expert list","entity_name":"CD27","entity_type":"gene"},{"created":"2020-04-29T18:36:50.551679+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.47","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: ITK as ready","entity_name":"ITK","entity_type":"gene"},{"created":"2020-04-29T18:36:50.542951+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.47","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: itk has been classified as Green List (High Evidence).","entity_name":"ITK","entity_type":"gene"},{"created":"2020-04-29T18:36:46.111017+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.47","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: ITK as Green List (high evidence)","entity_name":"ITK","entity_type":"gene"},{"created":"2020-04-29T18:36:46.098867+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.47","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: itk has been classified as Green List (High Evidence).","entity_name":"ITK","entity_type":"gene"},{"created":"2020-04-29T18:36:15.844279+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.46","user_name":"Zornitza Stark","item_type":"entity","text":"gene: ITK was added\ngene: ITK was added to Susceptibility to Viral Infections. Sources: Expert list\nMode of inheritance for gene: ITK was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: ITK were set to 19425169; 22289921; 21109689\nPhenotypes for gene: ITK were set to Lymphoproliferative syndrome 1, MIM#\t613011; EBV- associated B cell lymphoproliferation, lymphoma\nReview for gene: ITK was set to GREEN\nAdded comment: At least three families reported, abnormal host response to EBV. \nSources: Expert list","entity_name":"ITK","entity_type":"gene"},{"created":"2020-04-29T18:34:03.602838+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.45","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: XIAP as ready","entity_name":"XIAP","entity_type":"gene"},{"created":"2020-04-29T18:34:03.591835+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.45","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: xiap has been classified as Green List (High Evidence).","entity_name":"XIAP","entity_type":"gene"},{"created":"2020-04-29T18:33:58.580651+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.45","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: XIAP as Green List (high evidence)","entity_name":"XIAP","entity_type":"gene"},{"created":"2020-04-29T18:33:58.571623+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.45","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: xiap has been classified as Green List (High Evidence).","entity_name":"XIAP","entity_type":"gene"},{"created":"2020-04-29T18:33:27.785387+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.44","user_name":"Zornitza Stark","item_type":"entity","text":"gene: XIAP was added\ngene: XIAP was added to Susceptibility to Viral Infections. Sources: Expert list\nMode of inheritance for gene: XIAP was set to X-LINKED: hemizygous mutation in males, biallelic mutations in females\nPublications for gene: XIAP were set to 17080092\nPhenotypes for gene: XIAP were set to Lymphoproliferative syndrome, X-linked, 2\t300635; Host response to EBV\nReview for gene: XIAP was set to GREEN\nAdded comment: Sources: Expert list","entity_name":"XIAP","entity_type":"gene"},{"created":"2020-04-29T18:30:53.326228+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.43","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: SH2D1A as ready","entity_name":"SH2D1A","entity_type":"gene"},{"created":"2020-04-29T18:30:53.313909+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.43","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: sh2d1a has been classified as Green List (High Evidence).","entity_name":"SH2D1A","entity_type":"gene"},{"created":"2020-04-29T18:30:35.299712+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.43","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: SH2D1A as Green List (high evidence)","entity_name":"SH2D1A","entity_type":"gene"},{"created":"2020-04-29T18:30:35.291344+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.43","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: sh2d1a has been classified as Green List (High Evidence).","entity_name":"SH2D1A","entity_type":"gene"},{"created":"2020-04-29T18:30:04.385782+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.42","user_name":"Zornitza Stark","item_type":"entity","text":"gene: SH2D1A was added\ngene: SH2D1A was added to Susceptibility to Viral Infections. Sources: Expert list\nMode of inheritance for gene: SH2D1A was set to X-LINKED: hemizygous mutation in males, biallelic mutations in females\nPublications for gene: SH2D1A were set to 9771704\nPhenotypes for gene: SH2D1A were set to Host response to EBV infection; Lymphoproliferative syndrome, X-linked, 1\t308240\nReview for gene: SH2D1A was set to GREEN\nAdded comment: Sources: Expert list","entity_name":"SH2D1A","entity_type":"gene"},{"created":"2020-04-29T18:24:08.284478+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.41","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: NLRP1 as ready","entity_name":"NLRP1","entity_type":"gene"},{"created":"2020-04-29T18:24:08.275149+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.41","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: nlrp1 has been classified as Red List (Low Evidence).","entity_name":"NLRP1","entity_type":"gene"},{"created":"2020-04-29T18:24:01.094169+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.41","user_name":"Zornitza Stark","item_type":"entity","text":"gene: NLRP1 was added\ngene: NLRP1 was added to Susceptibility to Viral Infections. Sources: Expert list\nMode of inheritance for gene: NLRP1 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: NLRP1 were set to 31484767\nPhenotypes for gene: NLRP1 were set to Recurrent respiratory papillomatosis\nReview for gene: NLRP1 was set to RED\nAdded comment: Single family reported with homozygous GoF variants in siblings with recurrent respiratory papillomatosis. Note gene is associated with multiple, mono- and bi-allelic immunological phenotypes. \nSources: Expert list","entity_name":"NLRP1","entity_type":"gene"},{"created":"2020-04-29T18:19:55.237412+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: CIB1 as ready","entity_name":"CIB1","entity_type":"gene"},{"created":"2020-04-29T18:19:55.223618+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cib1 has been classified as Green List (High Evidence).","entity_name":"CIB1","entity_type":"gene"},{"created":"2020-04-29T18:19:51.397640+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: CIB1 as Green List (high evidence)","entity_name":"CIB1","entity_type":"gene"},{"created":"2020-04-29T18:19:51.388855+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cib1 has been classified as Green List (High Evidence).","entity_name":"CIB1","entity_type":"gene"},{"created":"2020-04-29T18:19:21.666442+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.39","user_name":"Zornitza Stark","item_type":"entity","text":"gene: CIB1 was added\ngene: CIB1 was added to Susceptibility to Viral Infections. Sources: Expert list\nMode of inheritance for gene: CIB1 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: CIB1 were set to 30068544\nPhenotypes for gene: CIB1 were set to Epidermodysplasia verruciformis 3, MIM#\t618267; HPV infections and cancer of the skin\nReview for gene: CIB1 was set to GREEN\nAdded comment: 24 individuals from six families reported. \nSources: Expert list","entity_name":"CIB1","entity_type":"gene"},{"created":"2020-04-29T18:13:13.949405+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2660","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: SNORA31 as ready","entity_name":"SNORA31","entity_type":"gene"},{"created":"2020-04-29T18:13:13.937471+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2660","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: snora31 has been classified as Green List (High Evidence).","entity_name":"SNORA31","entity_type":"gene"},{"created":"2020-04-29T18:13:04.598748+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2660","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: SNORA31 as Green List (high evidence)","entity_name":"SNORA31","entity_type":"gene"},{"created":"2020-04-29T18:13:04.589990+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2660","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: snora31 has been classified as Green List (High Evidence).","entity_name":"SNORA31","entity_type":"gene"},{"created":"2020-04-29T18:12:44.786178+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2659","user_name":"Zornitza Stark","item_type":"entity","text":"gene: SNORA31 was added\ngene: SNORA31 was added to Mendeliome. Sources: Expert list\nMode of inheritance for gene: SNORA31 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: SNORA31 were set to 31806906\nPhenotypes for gene: SNORA31 were set to Susceptibility to HSV1 encephalitis\nReview for gene: SNORA31 was set to GREEN\nAdded comment: Five unrelated individuals reported with rare missense variants in this gene, functional data to support susceptibility to herpes simplex encephalitis. \nSources: Expert list","entity_name":"SNORA31","entity_type":"gene"},{"created":"2020-04-29T18:12:26.420216+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.38","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: SNORA31 as ready","entity_name":"SNORA31","entity_type":"gene"},{"created":"2020-04-29T18:12:26.411522+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.38","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: snora31 has been classified as Green List (High Evidence).","entity_name":"SNORA31","entity_type":"gene"},{"created":"2020-04-29T18:11:27.491475+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.38","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: SNORA31 were changed from Susceptibility to herpes simplex encephalitis to Susceptibility to HSV1 encephalitis","entity_name":"SNORA31","entity_type":"gene"},{"created":"2020-04-29T18:10:57.904620+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.37","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: SNORA31 as Green List (high evidence)","entity_name":"SNORA31","entity_type":"gene"},{"created":"2020-04-29T18:10:57.891311+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.37","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: snora31 has been classified as Green List (High Evidence).","entity_name":"SNORA31","entity_type":"gene"},{"created":"2020-04-29T18:10:23.500031+10:00","panel_name":"Susceptibility to Viral Infections","panel_id":237,"panel_version":"0.36","user_name":"Zornitza Stark","item_type":"entity","text":"gene: SNORA31 was added\ngene: SNORA31 was added to Susceptibility to Viral Infections. Sources: Expert list\nMode of inheritance for gene: SNORA31 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: SNORA31 were set to 31806906\nPhenotypes for gene: SNORA31 were set to Susceptibility to herpes simplex encephalitis\nReview for gene: SNORA31 was set to GREEN\nAdded comment: Five unrelated individuals reported with rare missense variants in this gene, functional data to support susceptibility to herpes simplex encephalitis. \nSources: Expert list","entity_name":"SNORA31","entity_type":"gene"},{"created":"2020-04-29T16:43:37.999693+10:00","panel_name":"Macular Dystrophy/Stargardt Disease","panel_id":303,"panel_version":"0.10","user_name":"Bryony Thompson","item_type":"entity","text":"Classified gene: PRDM13 as Green List (high evidence)","entity_name":"PRDM13","entity_type":"gene"},{"created":"2020-04-29T16:43:37.995572+10:00","panel_name":"Macular Dystrophy/Stargardt Disease","panel_id":303,"panel_version":"0.10","user_name":"Bryony Thompson","item_type":"entity","text":"Added comment: Comment on list classification: Cause of condition cannot be detected by WES","entity_name":"PRDM13","entity_type":"gene"},{"created":"2020-04-29T16:43:37.971882+10:00","panel_name":"Macular Dystrophy/Stargardt Disease","panel_id":303,"panel_version":"0.10","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: prdm13 has been classified as Green List (High Evidence).","entity_name":"PRDM13","entity_type":"gene"},{"created":"2020-04-29T16:41:44.929454+10:00","panel_name":"Macular Dystrophy/Stargardt Disease","panel_id":303,"panel_version":"0.9","user_name":"Bryony Thompson","item_type":"entity","text":"edited their review of gene: PRDM13: Changed rating: GREEN","entity_name":"PRDM13","entity_type":"gene"},{"created":"2020-04-29T16:41:29.715893+10:00","panel_name":"Macular Dystrophy/Stargardt Disease","panel_id":303,"panel_version":"0.9","user_name":"Bryony Thompson","item_type":"entity","text":"Deleted their comment","entity_name":"PRDM13","entity_type":"gene"},{"created":"2020-04-29T16:27:22.937662+10:00","panel_name":"Cerebellar and Pontocerebellar Hypoplasia","panel_id":72,"panel_version":"0.139","user_name":"Bryony Thompson","item_type":"panel","text":"Panel types changed to Victorian Clinical Genetics Services; Royal Melbourne Hospital; Rare Disease","entity_name":null,"entity_type":null},{"created":"2020-04-29T15:58:13.673693+10:00","panel_name":"Cerebellar and Pontocerebellar Hypoplasia","panel_id":72,"panel_version":"0.137","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: FKRP as ready","entity_name":"FKRP","entity_type":"gene"},{"created":"2020-04-29T15:58:13.660759+10:00","panel_name":"Cerebellar and Pontocerebellar Hypoplasia","panel_id":72,"panel_version":"0.137","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: fkrp has been classified as Green List (High Evidence).","entity_name":"FKRP","entity_type":"gene"},{"created":"2020-04-29T15:58:01.569616+10:00","panel_name":"Cerebellar and Pontocerebellar Hypoplasia","panel_id":72,"panel_version":"0.137","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: FKRP as Green List (high evidence)","entity_name":"FKRP","entity_type":"gene"},{"created":"2020-04-29T15:58:01.558443+10:00","panel_name":"Cerebellar and Pontocerebellar Hypoplasia","panel_id":72,"panel_version":"0.137","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: fkrp has been classified as Green List (High Evidence).","entity_name":"FKRP","entity_type":"gene"},{"created":"2020-04-29T15:57:18.835413+10:00","panel_name":"Cerebellar and Pontocerebellar Hypoplasia","panel_id":72,"panel_version":"0.136","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: POMT2 as ready","entity_name":"POMT2","entity_type":"gene"},{"created":"2020-04-29T15:57:18.826445+10:00","panel_name":"Cerebellar and Pontocerebellar Hypoplasia","panel_id":72,"panel_version":"0.136","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: pomt2 has been classified as Green List (High Evidence).","entity_name":"POMT2","entity_type":"gene"},{"created":"2020-04-29T15:57:14.992043+10:00","panel_name":"Cerebellar and Pontocerebellar Hypoplasia","panel_id":72,"panel_version":"0.136","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: POMT2 as Green List (high evidence)","entity_name":"POMT2","entity_type":"gene"},{"created":"2020-04-29T15:57:14.983317+10:00","panel_name":"Cerebellar and Pontocerebellar Hypoplasia","panel_id":72,"panel_version":"0.136","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: pomt2 has been classified as Green List (High Evidence).","entity_name":"POMT2","entity_type":"gene"},{"created":"2020-04-29T15:56:30.124638+10:00","panel_name":"Cerebellar and Pontocerebellar Hypoplasia","panel_id":72,"panel_version":"0.135","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: ROBO3 as ready","entity_name":"ROBO3","entity_type":"gene"},{"created":"2020-04-29T15:56:30.113467+10:00","panel_name":"Cerebellar and Pontocerebellar Hypoplasia","panel_id":72,"panel_version":"0.135","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: robo3 has been classified as Green List (High Evidence).","entity_name":"ROBO3","entity_type":"gene"},{"created":"2020-04-29T15:56:25.262608+10:00","panel_name":"Cerebellar and Pontocerebellar Hypoplasia","panel_id":72,"panel_version":"0.135","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: ROBO3 as Green List (high evidence)","entity_name":"ROBO3","entity_type":"gene"},{"created":"2020-04-29T15:56:25.253444+10:00","panel_name":"Cerebellar and Pontocerebellar Hypoplasia","panel_id":72,"panel_version":"0.135","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: robo3 has been classified as Green List (High Evidence).","entity_name":"ROBO3","entity_type":"gene"},{"created":"2020-04-29T15:55:23.073125+10:00","panel_name":"Cerebellar and Pontocerebellar Hypoplasia","panel_id":72,"panel_version":"0.134","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: FKTN as ready","entity_name":"FKTN","entity_type":"gene"}]}