{"count":221304,"next":"https://panelapp-aus.org/api/v1/activities/?format=json&page=1877","previous":"https://panelapp-aus.org/api/v1/activities/?format=json&page=1875","results":[{"created":"2020-04-07T19:53:47.976804+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.101","user_name":"Bryony Thompson","item_type":"entity","text":"reviewed gene: ZAP70: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: Autoimmune disease, multisystem, infantile-onset, 2 MIM#617006, Immunodeficiency 48 MIM#269840; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"ZAP70","entity_type":"gene"},{"created":"2020-04-07T13:45:16.110798+10:00","panel_name":"Usher Syndrome","panel_id":3086,"panel_version":"0.6","user_name":"Chern Lim","item_type":"entity","text":"reviewed gene: USH2A: Rating: GREEN; Mode of pathogenicity: None; Publications: 26927203, 22135276; Phenotypes: Retinitis pigmentosa 39, MIM#613809, Usher syndrome, type 2A, MIM#276901; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"USH2A","entity_type":"gene"},{"created":"2020-04-07T12:24:56.077758+10:00","panel_name":"Renal Macrocystic Disease","panel_id":194,"panel_version":"0.25","user_name":"Bryony Thompson","item_type":"panel","text":"Panel types changed to Victorian Clinical Genetics Services; KidGen; Royal Melbourne Hospital; Rare Disease","entity_name":null,"entity_type":null},{"created":"2020-04-07T11:28:05.545617+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2033","user_name":"Kristin Rigbye","item_type":"entity","text":"reviewed gene: KCNT2: Rating: GREEN; Mode of pathogenicity: Other; Publications: 29069600, 29740868, 32038177; Phenotypes: Epileptic encephalopathy, early infantile, 57, 617771, Epilepsy of infancy with migrating focal seizures (EIMFS); Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"KCNT2","entity_type":"gene"},{"created":"2020-04-07T10:46:45.826554+10:00","panel_name":"Limb Girdle Muscular Dystrophy","panel_id":3071,"panel_version":"0.4","user_name":"Zornitza Stark","item_type":"panel","text":"Panel types changed to Victorian Clinical Genetics Services; Royal Melbourne Hospital; Rare Disease","entity_name":null,"entity_type":null},{"created":"2020-04-06T20:20:09.907412+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.101","user_name":"Zornitza Stark","item_type":"panel","text":"Panel types changed to Victorian Clinical Genetics Services; Rare Disease","entity_name":null,"entity_type":null},{"created":"2020-04-06T20:17:19.021579+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.100","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: BTK as ready","entity_name":"BTK","entity_type":"gene"},{"created":"2020-04-06T20:17:19.012631+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.100","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: btk has been classified as Red List (Low Evidence).","entity_name":"BTK","entity_type":"gene"},{"created":"2020-04-06T20:17:12.115617+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.100","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: BTK were changed from  to X-linked agammaglobulinemia; isolated growth hormone deficiency type III with agammaglobulinemia","entity_name":"BTK","entity_type":"gene"},{"created":"2020-04-06T20:16:48.288681+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.99","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: BTK was changed from Unknown to X-LINKED: hemizygous mutation in males, biallelic mutations in females","entity_name":"BTK","entity_type":"gene"},{"created":"2020-04-06T20:16:21.144406+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.98","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: BTK as Red List (low evidence)","entity_name":"BTK","entity_type":"gene"},{"created":"2020-04-06T20:16:21.119829+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.98","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: btk has been classified as Red List (Low Evidence).","entity_name":"BTK","entity_type":"gene"},{"created":"2020-04-06T20:15:36.790231+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.97","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: HPS1 as ready","entity_name":"HPS1","entity_type":"gene"},{"created":"2020-04-06T20:15:36.776655+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.97","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: hps1 has been classified as Amber List (Moderate Evidence).","entity_name":"HPS1","entity_type":"gene"},{"created":"2020-04-06T20:15:33.833458+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.97","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: HPS1 were changed from  to Hermansky-Pudlak syndrome 1 (203300)","entity_name":"HPS1","entity_type":"gene"},{"created":"2020-04-06T20:15:11.552294+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.96","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: HPS1 were set to ","entity_name":"HPS1","entity_type":"gene"},{"created":"2020-04-06T20:14:42.417459+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.95","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: HPS1 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"HPS1","entity_type":"gene"},{"created":"2020-04-06T20:14:14.705762+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.94","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: HPS1 as Amber List (moderate evidence)","entity_name":"HPS1","entity_type":"gene"},{"created":"2020-04-06T20:14:14.696657+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.94","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: hps1 has been classified as Amber List (Moderate Evidence).","entity_name":"HPS1","entity_type":"gene"},{"created":"2020-04-06T20:13:24.351586+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.93","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: HPS4 as ready","entity_name":"HPS4","entity_type":"gene"},{"created":"2020-04-06T20:13:24.338183+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.93","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: hps4 has been classified as Amber List (Moderate Evidence).","entity_name":"HPS4","entity_type":"gene"},{"created":"2020-04-06T20:13:21.012377+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.93","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: HPS4 were changed from  to Hermansky-Pudlak syndrome 4 (614073)","entity_name":"HPS4","entity_type":"gene"},{"created":"2020-04-06T20:12:57.482543+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.92","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: HPS4 were set to ","entity_name":"HPS4","entity_type":"gene"},{"created":"2020-04-06T20:12:33.624868+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.91","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: HPS4 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"HPS4","entity_type":"gene"},{"created":"2020-04-06T20:12:11.327672+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.90","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: HPS4 as Amber List (moderate evidence)","entity_name":"HPS4","entity_type":"gene"},{"created":"2020-04-06T20:12:11.314482+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.90","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: hps4 has been classified as Amber List (Moderate Evidence).","entity_name":"HPS4","entity_type":"gene"},{"created":"2020-04-06T20:11:21.595508+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.89","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: HPS6 as ready","entity_name":"HPS6","entity_type":"gene"},{"created":"2020-04-06T20:11:21.587108+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.89","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: hps6 has been classified as Amber List (Moderate Evidence).","entity_name":"HPS6","entity_type":"gene"},{"created":"2020-04-06T20:11:18.218876+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.89","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: HPS6 were changed from  to Hermansky-Pudlak syndrome 6 (614075)","entity_name":"HPS6","entity_type":"gene"},{"created":"2020-04-06T20:10:54.918240+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.88","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: HPS6 were set to ","entity_name":"HPS6","entity_type":"gene"},{"created":"2020-04-06T20:10:32.069785+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.87","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: HPS6 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"HPS6","entity_type":"gene"},{"created":"2020-04-06T20:10:10.239062+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.86","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: HPS6 as Amber List (moderate evidence)","entity_name":"HPS6","entity_type":"gene"},{"created":"2020-04-06T20:10:10.230921+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.86","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: hps6 has been classified as Amber List (Moderate Evidence).","entity_name":"HPS6","entity_type":"gene"},{"created":"2020-04-06T20:09:10.700969+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.85","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: HTRA2 as ready","entity_name":"HTRA2","entity_type":"gene"},{"created":"2020-04-06T20:09:10.691848+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.85","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: htra2 has been classified as Green List (High Evidence).","entity_name":"HTRA2","entity_type":"gene"},{"created":"2020-04-06T20:09:05.694209+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.85","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: HTRA2 as Green List (high evidence)","entity_name":"HTRA2","entity_type":"gene"},{"created":"2020-04-06T20:09:05.681096+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.85","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: htra2 has been classified as Green List (High Evidence).","entity_name":"HTRA2","entity_type":"gene"},{"created":"2020-04-06T20:08:08.134735+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.84","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: ICOS as ready","entity_name":"ICOS","entity_type":"gene"},{"created":"2020-04-06T20:08:08.121336+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.84","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: icos has been classified as Red List (Low Evidence).","entity_name":"ICOS","entity_type":"gene"},{"created":"2020-04-06T20:08:04.597514+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.84","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: ICOS were changed from  to Common variable immunodeficiency 1 (604558)","entity_name":"ICOS","entity_type":"gene"},{"created":"2020-04-06T20:07:41.488691+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.83","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: ICOS was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"ICOS","entity_type":"gene"},{"created":"2020-04-06T20:07:15.245875+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.82","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: ICOS as Red List (low evidence)","entity_name":"ICOS","entity_type":"gene"},{"created":"2020-04-06T20:07:15.233193+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.82","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: icos has been classified as Red List (Low Evidence).","entity_name":"ICOS","entity_type":"gene"},{"created":"2020-04-06T20:06:28.842682+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.81","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: IKBKG as ready","entity_name":"IKBKG","entity_type":"gene"},{"created":"2020-04-06T20:06:28.828673+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.81","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: ikbkg has been classified as Amber List (Moderate Evidence).","entity_name":"IKBKG","entity_type":"gene"},{"created":"2020-04-06T20:06:25.249849+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.81","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: IKBKG were changed from  to Incontinentia pigmenti (308300); / Ectodermal dysplasia and immunodeficiency 1 (300291); Ectodermal dysplasia, anhidrotic, lymphoedema and immunodeficiency (300301); Immunodeficiency 33 (300636); Immunodeficiency, isolated (300584); Invasive pneumococcal disease, recurrent isolated 2 (300640)","entity_name":"IKBKG","entity_type":"gene"},{"created":"2020-04-06T20:06:02.003366+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.80","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: IKBKG were set to ","entity_name":"IKBKG","entity_type":"gene"},{"created":"2020-04-06T20:05:24.328813+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.79","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: IKBKG was changed from Unknown to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)","entity_name":"IKBKG","entity_type":"gene"},{"created":"2020-04-06T20:04:54.660194+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.78","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: IKBKG as Amber List (moderate evidence)","entity_name":"IKBKG","entity_type":"gene"},{"created":"2020-04-06T20:04:54.646933+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.78","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: ikbkg has been classified as Amber List (Moderate Evidence).","entity_name":"IKBKG","entity_type":"gene"},{"created":"2020-04-06T20:03:58.704962+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.77","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: IL10 as ready","entity_name":"IL10","entity_type":"gene"},{"created":"2020-04-06T20:03:58.696072+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.77","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: il10 has been classified as Red List (Low Evidence).","entity_name":"IL10","entity_type":"gene"},{"created":"2020-04-06T20:03:54.064640+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.77","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: IL10 as Red List (low evidence)","entity_name":"IL10","entity_type":"gene"},{"created":"2020-04-06T20:03:54.050874+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.77","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: il10 has been classified as Red List (Low Evidence).","entity_name":"IL10","entity_type":"gene"},{"created":"2020-04-06T20:03:00.345092+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.76","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: IL10RA as ready","entity_name":"IL10RA","entity_type":"gene"},{"created":"2020-04-06T20:03:00.336844+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.76","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: il10ra has been classified as Red List (Low Evidence).","entity_name":"IL10RA","entity_type":"gene"},{"created":"2020-04-06T20:02:56.687454+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.76","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: IL10RA were changed from  to Inflammatory bowel disease 28, early onset (613148)","entity_name":"IL10RA","entity_type":"gene"},{"created":"2020-04-06T20:02:33.533799+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.75","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: IL10RA was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"IL10RA","entity_type":"gene"},{"created":"2020-04-06T20:02:10.786125+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.74","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: IL10RA as Red List (low evidence)","entity_name":"IL10RA","entity_type":"gene"},{"created":"2020-04-06T20:02:10.777204+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.74","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: il10ra has been classified as Red List (Low Evidence).","entity_name":"IL10RA","entity_type":"gene"},{"created":"2020-04-06T19:57:28.292251+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2033","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: PIEZO1 as ready","entity_name":"PIEZO1","entity_type":"gene"},{"created":"2020-04-06T19:57:28.283430+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2033","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: piezo1 has been classified as Green List (High Evidence).","entity_name":"PIEZO1","entity_type":"gene"},{"created":"2020-04-06T19:57:17.333128+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2033","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: PIEZO1 were set to ","entity_name":"PIEZO1","entity_type":"gene"},{"created":"2020-04-06T19:56:32.980537+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2032","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: PIEZO1 were changed from  to Lymphatic malformation 6, 616843; Dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema, 194380","entity_name":"PIEZO1","entity_type":"gene"},{"created":"2020-04-06T19:56:18.594086+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2031","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of pathogenicity for gene: PIEZO1 was changed from  to Other","entity_name":"PIEZO1","entity_type":"gene"},{"created":"2020-04-06T19:56:01.099364+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2030","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: PIEZO1 was changed from Unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal","entity_name":"PIEZO1","entity_type":"gene"},{"created":"2020-04-06T19:54:49.928119+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2029","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: TBX19 as ready","entity_name":"TBX19","entity_type":"gene"},{"created":"2020-04-06T19:54:49.919592+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2029","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: tbx19 has been classified as Green List (High Evidence).","entity_name":"TBX19","entity_type":"gene"},{"created":"2020-04-06T19:54:41.619456+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2029","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: TBX19 were changed from  to Adrenocorticotropic hormone deficiency, 201400","entity_name":"TBX19","entity_type":"gene"},{"created":"2020-04-06T19:54:24.186668+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2028","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: TBX19 were set to ","entity_name":"TBX19","entity_type":"gene"},{"created":"2020-04-06T19:54:01.760578+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.2027","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: TBX19 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"TBX19","entity_type":"gene"},{"created":"2020-04-06T19:52:42.472784+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.73","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: IL10RB as ready","entity_name":"IL10RB","entity_type":"gene"},{"created":"2020-04-06T19:52:42.456534+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.73","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: il10rb has been classified as Red List (Low Evidence).","entity_name":"IL10RB","entity_type":"gene"},{"created":"2020-04-06T19:52:39.465264+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.73","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: IL10RB were changed from  to Inflammatory bowel disease 25, early onset (612567)","entity_name":"IL10RB","entity_type":"gene"},{"created":"2020-04-06T19:51:55.350018+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.72","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: IL10RB was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"IL10RB","entity_type":"gene"},{"created":"2020-04-06T19:51:32.739160+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.71","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: IL10RB as Red List (low evidence)","entity_name":"IL10RB","entity_type":"gene"},{"created":"2020-04-06T19:51:32.726351+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.71","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: il10rb has been classified as Red List (Low Evidence).","entity_name":"IL10RB","entity_type":"gene"},{"created":"2020-04-06T19:50:38.415830+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.70","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: IL2RG as ready","entity_name":"IL2RG","entity_type":"gene"},{"created":"2020-04-06T19:50:38.402267+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.70","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: il2rg has been classified as Red List (Low Evidence).","entity_name":"IL2RG","entity_type":"gene"},{"created":"2020-04-06T19:50:35.645754+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.70","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: IL2RG were changed from  to Severe combined immunodeficiency, X-linked (300400); Moderate combined immunodeficiency, X-linked (312863)","entity_name":"IL2RG","entity_type":"gene"},{"created":"2020-04-06T19:50:11.649228+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.69","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: IL2RG was changed from Unknown to X-LINKED: hemizygous mutation in males, biallelic mutations in females","entity_name":"IL2RG","entity_type":"gene"},{"created":"2020-04-06T19:49:37.259287+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.68","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: IL2RG as Red List (low evidence)","entity_name":"IL2RG","entity_type":"gene"},{"created":"2020-04-06T19:49:37.250972+10:00","panel_name":"Cataract","panel_id":66,"panel_version":"0.68","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: il2rg has been classified as Red List (Low Evidence).","entity_name":"IL2RG","entity_type":"gene"},{"created":"2020-04-06T19:48:23.241460+10:00","panel_name":"Porphyria","panel_id":3077,"panel_version":"0.1","user_name":"Bryony Thompson","item_type":"panel","text":"Panel name changed from Porphyria_RMH to Porphyria\nPanel status changed from internal to public\nPanel types changed to Royal Melbourne Hospital; Rare Disease","entity_name":null,"entity_type":null},{"created":"2020-04-06T19:47:49.868258+10:00","panel_name":"Overgrowth","panel_id":151,"panel_version":"0.19","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: TCF20 as ready","entity_name":"TCF20","entity_type":"gene"},{"created":"2020-04-06T19:47:49.854882+10:00","panel_name":"Overgrowth","panel_id":151,"panel_version":"0.19","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: tcf20 has been classified as Amber List (Moderate Evidence).","entity_name":"TCF20","entity_type":"gene"},{"created":"2020-04-06T19:47:46.919879+10:00","panel_name":"Overgrowth","panel_id":151,"panel_version":"0.19","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: TCF20 were changed from  to Developmental delay with variable intellectual impairment and behavioral abnormalities, AD, MIM#618430","entity_name":"TCF20","entity_type":"gene"},{"created":"2020-04-06T19:47:17.372127+10:00","panel_name":"Overgrowth","panel_id":151,"panel_version":"0.18","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: TCF20 were set to ","entity_name":"TCF20","entity_type":"gene"},{"created":"2020-04-06T19:46:49.374058+10:00","panel_name":"Overgrowth","panel_id":151,"panel_version":"0.17","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: TCF20 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"TCF20","entity_type":"gene"},{"created":"2020-04-06T19:45:41.686307+10:00","panel_name":"Overgrowth","panel_id":151,"panel_version":"0.16","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: TCF20 as Amber List (moderate evidence)","entity_name":"TCF20","entity_type":"gene"},{"created":"2020-04-06T19:45:41.673118+10:00","panel_name":"Overgrowth","panel_id":151,"panel_version":"0.16","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: tcf20 has been classified as Amber List (Moderate Evidence).","entity_name":"TCF20","entity_type":"gene"},{"created":"2020-04-06T19:45:13.108660+10:00","panel_name":"Overgrowth","panel_id":151,"panel_version":"0.15","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: TCF20: Rating: AMBER; Mode of pathogenicity: None; Publications: 30739909, 30819258, 25228304; Phenotypes: Developmental delay with variable intellectual impairment and behavioral abnormalities, AD, MIM#618430; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"TCF20","entity_type":"gene"},{"created":"2020-04-06T19:43:24.090442+10:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.2515","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: TCF20 as ready","entity_name":"TCF20","entity_type":"gene"},{"created":"2020-04-06T19:43:24.077014+10:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.2515","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: tcf20 has been classified as Green List (High Evidence).","entity_name":"TCF20","entity_type":"gene"},{"created":"2020-04-06T19:41:03.818256+10:00","panel_name":"Dystonia - complex","panel_id":290,"panel_version":"0.57","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: XK as ready","entity_name":"XK","entity_type":"gene"},{"created":"2020-04-06T19:41:03.808847+10:00","panel_name":"Dystonia - complex","panel_id":290,"panel_version":"0.57","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: xk has been classified as Green List (High Evidence).","entity_name":"XK","entity_type":"gene"},{"created":"2020-04-06T19:40:57.054775+10:00","panel_name":"Dystonia - complex","panel_id":290,"panel_version":"0.57","user_name":"Bryony Thompson","item_type":"entity","text":"Classified gene: XK as Green List (high evidence)","entity_name":"XK","entity_type":"gene"},{"created":"2020-04-06T19:40:57.046193+10:00","panel_name":"Dystonia - complex","panel_id":290,"panel_version":"0.57","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: xk has been classified as Green List (High Evidence).","entity_name":"XK","entity_type":"gene"},{"created":"2020-04-06T19:40:44.045951+10:00","panel_name":"Dystonia - complex","panel_id":290,"panel_version":"0.56","user_name":"Bryony Thompson","item_type":"entity","text":"gene: XK was added\ngene: XK was added to Dystonia - complex. Sources: Expert list\nMode of inheritance for gene: XK was set to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)\nPublications for gene: XK were set to 11761473\nPhenotypes for gene: XK were set to McLeod syndrome with or without chronic granulomatous disease MIM#300842\nReview for gene: XK was set to GREEN\nAdded comment: 5 out of 13 cases had dystonia as a feature of the condition. \nSources: Expert list","entity_name":"XK","entity_type":"gene"},{"created":"2020-04-06T19:25:33.379937+10:00","panel_name":"Dystonia - complex","panel_id":290,"panel_version":"0.55","user_name":"Bryony Thompson","item_type":"entity","text":"gene: VPS37A was added\ngene: VPS37A was added to Dystonia - complex. Sources: Expert list\nMode of inheritance for gene: VPS37A was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: VPS37A were set to 22717650\nPhenotypes for gene: VPS37A were set to Spastic paraplegia 53, autosomal recessive MIM#614898\nReview for gene: VPS37A was set to RED\nAdded comment: Single consanguineous Arab Moslem kindred with dystonia as a feature of the condition. \nSources: Expert list","entity_name":"VPS37A","entity_type":"gene"}]}