{"count":221272,"next":"https://panelapp-aus.org/api/v1/activities/?format=json&page=1944","previous":"https://panelapp-aus.org/api/v1/activities/?format=json&page=1942","results":[{"created":"2020-02-03T19:17:58.400506+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.61","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: mrpl12 has been classified as Red List (Low Evidence).","entity_name":"MRPL12","entity_type":"gene"},{"created":"2020-02-03T19:17:11.603820+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.60","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: MRPL12: Rating: RED; Mode of pathogenicity: None; Publications: 23603806; Phenotypes: Growth retardation, neurological deterioration, mitochondrial translation deficiency; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"MRPL12","entity_type":"gene"},{"created":"2020-02-03T19:14:08.474762+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.60","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: LYRM4 as ready","entity_name":"LYRM4","entity_type":"gene"},{"created":"2020-02-03T19:14:08.463966+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.60","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: lyrm4 has been classified as Amber List (Moderate Evidence).","entity_name":"LYRM4","entity_type":"gene"},{"created":"2020-02-03T19:13:42.124664+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1204","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: LYRM4 as ready","entity_name":"LYRM4","entity_type":"gene"},{"created":"2020-02-03T19:13:42.114154+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1204","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: lyrm4 has been classified as Amber List (Moderate Evidence).","entity_name":"LYRM4","entity_type":"gene"},{"created":"2020-02-03T19:13:29.310816+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1204","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: LYRM4 were changed from  to Combined oxidative phosphorylation deficiency 19, MIM# 615595","entity_name":"LYRM4","entity_type":"gene"},{"created":"2020-02-03T19:13:04.819568+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1203","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: LYRM4 were set to ","entity_name":"LYRM4","entity_type":"gene"},{"created":"2020-02-03T19:12:42.676861+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1202","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: LYRM4 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"LYRM4","entity_type":"gene"},{"created":"2020-02-03T19:12:26.411019+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.60","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: LYRM4 were changed from  to Combined oxidative phosphorylation deficiency 19, MIM# 615595","entity_name":"LYRM4","entity_type":"gene"},{"created":"2020-02-03T19:12:16.694888+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1201","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: LYRM4 as Amber List (moderate evidence)","entity_name":"LYRM4","entity_type":"gene"},{"created":"2020-02-03T19:12:16.683184+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1201","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: lyrm4 has been classified as Amber List (Moderate Evidence).","entity_name":"LYRM4","entity_type":"gene"},{"created":"2020-02-03T19:11:51.968978+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.59","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: LYRM4 were set to ","entity_name":"LYRM4","entity_type":"gene"},{"created":"2020-02-03T19:11:49.005228+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1200","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: LYRM4: Rating: AMBER; Mode of pathogenicity: None; Publications: 23814038, 31497476; Phenotypes: Combined oxidative phosphorylation deficiency 19, MIM# 615595; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"LYRM4","entity_type":"gene"},{"created":"2020-02-03T19:11:23.462904+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.59","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: LYRM4 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"LYRM4","entity_type":"gene"},{"created":"2020-02-03T19:10:11.768714+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.58","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: LYRM4 as Amber List (moderate evidence)","entity_name":"LYRM4","entity_type":"gene"},{"created":"2020-02-03T19:10:11.758230+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.58","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: lyrm4 has been classified as Amber List (Moderate Evidence).","entity_name":"LYRM4","entity_type":"gene"},{"created":"2020-02-03T19:09:28.264391+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.57","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: LYRM4: Rating: AMBER; Mode of pathogenicity: None; Publications: 23814038, 31497476; Phenotypes: Combined oxidative phosphorylation deficiency 19, MIM# 615595; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"LYRM4","entity_type":"gene"},{"created":"2020-02-03T19:05:15.597414+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.57","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: COX8A as ready","entity_name":"COX8A","entity_type":"gene"},{"created":"2020-02-03T19:05:15.586577+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.57","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cox8a has been classified as Red List (Low Evidence).","entity_name":"COX8A","entity_type":"gene"},{"created":"2020-02-03T19:04:56.501866+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1200","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: COX8A as ready","entity_name":"COX8A","entity_type":"gene"},{"created":"2020-02-03T19:04:56.491209+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1200","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cox8a has been classified as Red List (Low Evidence).","entity_name":"COX8A","entity_type":"gene"},{"created":"2020-02-03T19:04:44.382039+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1200","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: COX8A were changed from  to Mitochondrial complex IV deficiency, MIM# 220110","entity_name":"COX8A","entity_type":"gene"},{"created":"2020-02-03T19:04:20.533425+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1199","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: COX8A were set to ","entity_name":"COX8A","entity_type":"gene"},{"created":"2020-02-03T19:03:59.724845+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1198","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: COX8A was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"COX8A","entity_type":"gene"},{"created":"2020-02-03T19:03:40.709895+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1197","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: COX8A as Red List (low evidence)","entity_name":"COX8A","entity_type":"gene"},{"created":"2020-02-03T19:03:40.698914+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1197","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cox8a has been classified as Red List (Low Evidence).","entity_name":"COX8A","entity_type":"gene"},{"created":"2020-02-03T19:03:21.513016+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.57","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: COX8A were changed from  to Mitochondrial complex IV deficiency, MIM# 220110","entity_name":"COX8A","entity_type":"gene"},{"created":"2020-02-03T19:03:21.486147+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1196","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: COX8A: Rating: RED; Mode of pathogenicity: None; Publications: 26685157; Phenotypes: Mitochondrial complex IV deficiency, MIM# 220110; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"COX8A","entity_type":"gene"},{"created":"2020-02-03T19:02:08.653982+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.56","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: COX8A was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"COX8A","entity_type":"gene"},{"created":"2020-02-03T19:01:32.374232+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.56","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: COX8A were set to ","entity_name":"COX8A","entity_type":"gene"},{"created":"2020-02-03T19:00:53.682899+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.55","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: COX8A as Red List (low evidence)","entity_name":"COX8A","entity_type":"gene"},{"created":"2020-02-03T19:00:53.672358+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.55","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cox8a has been classified as Red List (Low Evidence).","entity_name":"COX8A","entity_type":"gene"},{"created":"2020-02-03T19:00:09.410766+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.54","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: COX8A: Rating: RED; Mode of pathogenicity: None; Publications: 26685157; Phenotypes: Mitochondrial complex IV deficiency, MIM# 220110; Mode of inheritance: None","entity_name":"COX8A","entity_type":"gene"},{"created":"2020-02-03T18:58:00.696227+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1196","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: COA5 as ready","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:58:00.685476+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1196","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: coa5 has been classified as Red List (Low Evidence).","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:57:46.901886+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1196","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: COA5 were changed from  to Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 3, MIM# 616500","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:57:29.799985+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1195","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: COA5 were set to ","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:57:10.038379+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1194","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: COA5 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:56:52.094912+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1193","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: COA5 as Red List (low evidence)","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:56:52.084576+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1193","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: coa5 has been classified as Red List (Low Evidence).","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:54:41.198865+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1192","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: COA5: Rating: RED; Mode of pathogenicity: None; Publications: 21457908; Phenotypes: Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 3, MIM# 616500; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:54:07.113495+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.64","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: COA5 were changed from Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 3, MIM# 616500 to Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 3, MIM# 616500","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:53:24.221391+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.63","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: COA5 were changed from  to Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 3, MIM# 616500","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:52:33.794979+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.62","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: COA5 were set to ","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:51:57.921446+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.61","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: COA5 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:51:27.931095+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.61","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: COA5 as Red List (low evidence)","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:51:27.920450+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.61","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: coa5 has been classified as Red List (Low Evidence).","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:50:46.713564+11:00","panel_name":"Regression","panel_id":206,"panel_version":"0.60","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: COA5: Rating: RED; Mode of pathogenicity: None; Publications: 21457908; Phenotypes: Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 3, MIM# 616500; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:47:52.592684+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.54","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: COA5 as ready","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:47:52.582653+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.54","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: coa5 has been classified as Red List (Low Evidence).","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:47:46.254602+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.54","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: COA5 were changed from  to Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 3 616500","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:47:14.408791+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.53","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: COA5 were set to ","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:46:39.396671+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.52","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: COA5 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:46:07.999178+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.51","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: COA5 as Red List (low evidence)","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:46:07.988327+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.51","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: coa5 has been classified as Red List (Low Evidence).","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:45:27.074861+11:00","panel_name":"Mitochondrial disease","panel_id":203,"panel_version":"0.50","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: COA5: Rating: RED; Mode of pathogenicity: None; Publications: 21457908; Phenotypes: Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 3 616500; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"COA5","entity_type":"gene"},{"created":"2020-02-03T18:40:04.546271+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1192","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: CLCN5 as ready","entity_name":"CLCN5","entity_type":"gene"},{"created":"2020-02-03T18:40:04.535088+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1192","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: clcn5 has been classified as Green List (High Evidence).","entity_name":"CLCN5","entity_type":"gene"},{"created":"2020-02-03T18:39:51.368504+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1192","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: CLCN5 were changed from  to Dent disease, MIM#300009; Hypophosphatemic rickets, MIM#300554; Nephrolithiasis, type I, MIM#310468; Proteinuria, low molecular weight, with hypercalciuric nephrocalcinosis, MIM#308990","entity_name":"CLCN5","entity_type":"gene"},{"created":"2020-02-03T18:38:40.592314+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1191","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: CLCN5 was changed from Unknown to X-LINKED: hemizygous mutation in males, biallelic mutations in females","entity_name":"CLCN5","entity_type":"gene"},{"created":"2020-02-03T18:38:20.074319+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1190","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: CLCN5: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Dent disease, MIM#300009, Hypophosphatemic rickets, MIM#300554, Nephrolithiasis, type I, MIM#310468, Proteinuria, low molecular weight, with hypercalciuric nephrocalcinosis, MIM#308990; Mode of inheritance: X-LINKED: hemizygous mutation in males, biallelic mutations in females","entity_name":"CLCN5","entity_type":"gene"},{"created":"2020-02-03T18:29:20.964453+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1190","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: PHEX as ready","entity_name":"PHEX","entity_type":"gene"},{"created":"2020-02-03T18:29:20.953601+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1190","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: phex has been classified as Green List (High Evidence).","entity_name":"PHEX","entity_type":"gene"},{"created":"2020-02-03T18:29:04.212649+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1190","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: PHEX were changed from  to Hypophosphatemic rickets, MIM#307800","entity_name":"PHEX","entity_type":"gene"},{"created":"2020-02-03T18:28:38.974298+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1189","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: PHEX was changed from Unknown to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)","entity_name":"PHEX","entity_type":"gene"},{"created":"2020-02-03T18:28:16.795213+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1188","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: PHEX: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Hypophosphatemic rickets, MIM#307800; Mode of inheritance: X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)","entity_name":"PHEX","entity_type":"gene"},{"created":"2020-02-03T18:25:18.969483+11:00","panel_name":"Hypophosphataemic Rickets","panel_id":122,"panel_version":"0.4","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: PHEX as ready","entity_name":"PHEX","entity_type":"gene"},{"created":"2020-02-03T18:25:18.959049+11:00","panel_name":"Hypophosphataemic Rickets","panel_id":122,"panel_version":"0.4","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: phex has been classified as Green List (High Evidence).","entity_name":"PHEX","entity_type":"gene"},{"created":"2020-02-03T18:25:11.481256+11:00","panel_name":"Hypophosphataemic Rickets","panel_id":122,"panel_version":"0.4","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: PHEX were changed from  to Hypophosphatemic rickets, MIM#307800","entity_name":"PHEX","entity_type":"gene"},{"created":"2020-02-03T18:19:26.614189+11:00","panel_name":"Hypophosphataemic Rickets","panel_id":122,"panel_version":"0.3","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: PHEX were set to ","entity_name":"PHEX","entity_type":"gene"},{"created":"2020-02-03T18:18:54.649771+11:00","panel_name":"Hypophosphataemic Rickets","panel_id":122,"panel_version":"0.2","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: PHEX was changed from Unknown to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)","entity_name":"PHEX","entity_type":"gene"},{"created":"2020-02-03T16:48:42.269535+11:00","panel_name":"Congenital Disorders of Glycosylation","panel_id":68,"panel_version":"0.36","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: PMM2 as ready","entity_name":"PMM2","entity_type":"gene"},{"created":"2020-02-03T16:48:42.258622+11:00","panel_name":"Congenital Disorders of Glycosylation","panel_id":68,"panel_version":"0.36","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: pmm2 has been classified as Green List (High Evidence).","entity_name":"PMM2","entity_type":"gene"},{"created":"2020-02-03T16:48:37.182912+11:00","panel_name":"Congenital Disorders of Glycosylation","panel_id":68,"panel_version":"0.36","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: PMM2 were changed from  to Congenital disorder of glycosylation, type Ia 212065","entity_name":"PMM2","entity_type":"gene"},{"created":"2020-02-03T16:48:06.072016+11:00","panel_name":"Congenital Disorders of Glycosylation","panel_id":68,"panel_version":"0.35","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: PMM2 were set to ","entity_name":"PMM2","entity_type":"gene"},{"created":"2020-02-03T16:47:32.697045+11:00","panel_name":"Congenital Disorders of Glycosylation","panel_id":68,"panel_version":"0.34","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: PMM2 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"PMM2","entity_type":"gene"},{"created":"2020-02-03T16:46:20.247502+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1188","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: EHMT1 as ready","entity_name":"EHMT1","entity_type":"gene"},{"created":"2020-02-03T16:46:20.234933+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1188","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: ehmt1 has been classified as Green List (High Evidence).","entity_name":"EHMT1","entity_type":"gene"},{"created":"2020-02-03T16:46:11.788391+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1188","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: EHMT1 were changed from  to Kleefstra syndrome 1 (MIM#610253)","entity_name":"EHMT1","entity_type":"gene"},{"created":"2020-02-03T16:45:37.280425+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.1958","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: EHMT1 as ready","entity_name":"EHMT1","entity_type":"gene"},{"created":"2020-02-03T16:45:37.269833+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.1958","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: ehmt1 has been classified as Green List (High Evidence).","entity_name":"EHMT1","entity_type":"gene"},{"created":"2020-02-03T16:45:31.032316+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.1958","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: EHMT1 were changed from Kleefstra syndrome 1 (MIM#610253) to Kleefstra syndrome 1 (MIM#610253)","entity_name":"EHMT1","entity_type":"gene"},{"created":"2020-02-03T16:44:54.438501+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.1957","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: EHMT1 were changed from  to Kleefstra syndrome 1 (MIM#610253)","entity_name":"EHMT1","entity_type":"gene"},{"created":"2020-02-03T16:43:41.009232+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.1956","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: EHMT1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"EHMT1","entity_type":"gene"},{"created":"2020-02-03T16:43:01.295434+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.1955","user_name":"Zornitza Stark","item_type":"entity","text":"reviewed gene: EHMT1: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Kleefstra syndrome 1 (MIM#610253); Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"EHMT1","entity_type":"gene"},{"created":"2020-02-03T16:42:57.716643+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1187","user_name":"Zornitza Stark","item_type":"entity","text":"Publications for gene: EHMT1 were set to ","entity_name":"EHMT1","entity_type":"gene"},{"created":"2020-02-03T16:42:05.535106+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1186","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: EHMT1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"EHMT1","entity_type":"gene"},{"created":"2020-02-03T16:37:55.348299+11:00","panel_name":"Hypertrophic cardiomyopathy_HCM","panel_id":111,"panel_version":"0.11","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: FLNC as ready","entity_name":"FLNC","entity_type":"gene"},{"created":"2020-02-03T16:37:55.337807+11:00","panel_name":"Hypertrophic cardiomyopathy_HCM","panel_id":111,"panel_version":"0.11","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: flnc has been classified as Green List (High Evidence).","entity_name":"FLNC","entity_type":"gene"},{"created":"2020-02-03T16:37:50.887544+11:00","panel_name":"Hypertrophic cardiomyopathy_HCM","panel_id":111,"panel_version":"0.11","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: FLNC as Green List (high evidence)","entity_name":"FLNC","entity_type":"gene"},{"created":"2020-02-03T16:37:50.876966+11:00","panel_name":"Hypertrophic cardiomyopathy_HCM","panel_id":111,"panel_version":"0.11","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: flnc has been classified as Green List (High Evidence).","entity_name":"FLNC","entity_type":"gene"},{"created":"2020-02-03T16:36:45.446457+11:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"0.1185","user_name":"Crystle Lee","item_type":"entity","text":"reviewed gene: EHMT1: Rating: GREEN; Mode of pathogenicity: None; Publications: PMID: 19264732; Phenotypes: Kleefstra syndrome 1 (MIM#610253); Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown","entity_name":"EHMT1","entity_type":"gene"},{"created":"2020-02-03T16:30:12.799782+11:00","panel_name":"Hypertrophic cardiomyopathy_HCM","panel_id":111,"panel_version":"0.10","user_name":"Zornitza Stark","item_type":"entity","text":"gene: FLNC was added\ngene: FLNC was added to Hypertrophic cardiomyopathy_HCM. Sources: Expert Review\nMode of inheritance for gene: FLNC was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: FLNC were set to 31924696; 28356264\nPhenotypes for gene: FLNC were set to Cardiomyopathy, familial hypertrophic, 26\nReview for gene: FLNC was set to GREEN\nAdded comment: Multiple affected individuals with cardiomyopathy, including HOCM reported. \nSources: Expert Review","entity_name":"FLNC","entity_type":"gene"},{"created":"2020-02-03T16:27:07.350127+11:00","panel_name":"Congenital Disorders of Glycosylation","panel_id":68,"panel_version":"0.33","user_name":"Melanie Marty","item_type":"entity","text":"reviewed gene: PMM2: Rating: GREEN; Mode of pathogenicity: None; Publications: 21541725; Phenotypes: Congenital disorder of glycosylation, type Ia 212065; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes","entity_name":"PMM2","entity_type":"gene"},{"created":"2020-02-03T16:20:04.859682+11:00","panel_name":"Hypophosphataemic Rickets","panel_id":122,"panel_version":"0.1","user_name":"Teresa Zhao","item_type":"entity","text":"reviewed gene: PHEX: Rating: GREEN; Mode of pathogenicity: None; Publications: PMID: 12727977, 30682568; Phenotypes: Hypophosphatemic rickets; Mode of inheritance: X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males); Current diagnostic: yes","entity_name":"PHEX","entity_type":"gene"},{"created":"2020-02-03T15:54:29.854028+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.1955","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: FTO as ready","entity_name":"FTO","entity_type":"gene"},{"created":"2020-02-03T15:54:29.843545+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.1955","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: fto has been classified as Amber List (Moderate Evidence).","entity_name":"FTO","entity_type":"gene"},{"created":"2020-02-03T15:54:13.435716+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.1955","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: FTO were changed from Growth retardation, developmental delay, facial dysmorphism, MIM# 612938 to Growth retardation, developmental delay, facial dysmorphism, MIM# 612938","entity_name":"FTO","entity_type":"gene"},{"created":"2020-02-03T15:53:31.365792+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.1954","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: FTO was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal","entity_name":"FTO","entity_type":"gene"}]}