{"count":221415,"next":"https://panelapp-aus.org/api/v1/activities/?format=json&page=371","previous":"https://panelapp-aus.org/api/v1/activities/?format=json&page=369","results":[{"created":"2024-10-09T13:44:31.680039+11:00","panel_name":"Endometrial Cancer","panel_id":4373,"panel_version":"0.20","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: msh2 has been classified as Green List (High Evidence).","entity_name":"MSH2","entity_type":"gene"},{"created":"2024-10-09T13:44:21.473833+11:00","panel_name":"Endometrial Cancer","panel_id":4373,"panel_version":"0.20","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: MLH1 as ready","entity_name":"MLH1","entity_type":"gene"},{"created":"2024-10-09T13:44:21.450063+11:00","panel_name":"Endometrial Cancer","panel_id":4373,"panel_version":"0.20","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: mlh1 has been classified as Green List (High Evidence).","entity_name":"MLH1","entity_type":"gene"},{"created":"2024-10-09T13:44:11.303796+11:00","panel_name":"Endometrial Cancer","panel_id":4373,"panel_version":"0.20","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: EPCAM as ready","entity_name":"EPCAM","entity_type":"gene"},{"created":"2024-10-09T13:44:11.293239+11:00","panel_name":"Endometrial Cancer","panel_id":4373,"panel_version":"0.20","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: epcam has been classified as Green List (High Evidence).","entity_name":"EPCAM","entity_type":"gene"},{"created":"2024-10-09T13:44:02.418532+11:00","panel_name":"Endometrial Cancer","panel_id":4373,"panel_version":"0.20","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: BRCA1 as ready","entity_name":"BRCA1","entity_type":"gene"},{"created":"2024-10-09T13:44:02.389152+11:00","panel_name":"Endometrial Cancer","panel_id":4373,"panel_version":"0.20","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: brca1 has been classified as Green List (High Evidence).","entity_name":"BRCA1","entity_type":"gene"},{"created":"2024-10-09T13:43:34.852801+11:00","panel_name":"Diffuse Gastric Cancer","panel_id":4368,"panel_version":"1.0","user_name":"Zornitza Stark","item_type":"panel","text":"promoted panel to version 1.0","entity_name":null,"entity_type":null},{"created":"2024-10-09T13:43:27.685604+11:00","panel_name":"Diffuse Gastric Cancer","panel_id":4368,"panel_version":"0.5","user_name":"Zornitza Stark","item_type":"panel","text":"Panel status changed from internal to public","entity_name":null,"entity_type":null},{"created":"2024-10-09T13:43:16.476452+11:00","panel_name":"Diffuse Gastric Cancer","panel_id":4368,"panel_version":"0.4","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: CTNNA1 as ready","entity_name":"CTNNA1","entity_type":"gene"},{"created":"2024-10-09T13:43:16.446049+11:00","panel_name":"Diffuse Gastric Cancer","panel_id":4368,"panel_version":"0.4","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: ctnna1 has been classified as Green List (High Evidence).","entity_name":"CTNNA1","entity_type":"gene"},{"created":"2024-10-09T13:43:07.146695+11:00","panel_name":"Diffuse Gastric Cancer","panel_id":4368,"panel_version":"0.4","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: CDH1 as ready","entity_name":"CDH1","entity_type":"gene"},{"created":"2024-10-09T13:43:07.124111+11:00","panel_name":"Diffuse Gastric Cancer","panel_id":4368,"panel_version":"0.4","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cdh1 has been classified as Green List (High Evidence).","entity_name":"CDH1","entity_type":"gene"},{"created":"2024-10-09T12:55:32.501921+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"1.0","user_name":"Zornitza Stark","item_type":"panel","text":"promoted panel to version 1.0","entity_name":null,"entity_type":null},{"created":"2024-10-09T12:55:21.524808+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.41","user_name":"Zornitza Stark","item_type":"panel","text":"Panel status changed from internal to public","entity_name":null,"entity_type":null},{"created":"2024-10-09T12:55:04.211726+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: TP53 as ready","entity_name":"TP53","entity_type":"gene"},{"created":"2024-10-09T12:55:04.193803+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: tp53 has been classified as Green List (High Evidence).","entity_name":"TP53","entity_type":"gene"},{"created":"2024-10-09T12:54:56.942408+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: STK11 as ready","entity_name":"STK11","entity_type":"gene"},{"created":"2024-10-09T12:54:56.931951+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: stk11 has been classified as Green List (High Evidence).","entity_name":"STK11","entity_type":"gene"},{"created":"2024-10-09T12:54:49.605539+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: SMAD4 as ready","entity_name":"SMAD4","entity_type":"gene"},{"created":"2024-10-09T12:54:49.582774+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: smad4 has been classified as Green List (High Evidence).","entity_name":"SMAD4","entity_type":"gene"},{"created":"2024-10-09T12:54:42.693529+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: RNF43 as ready","entity_name":"RNF43","entity_type":"gene"},{"created":"2024-10-09T12:54:42.669228+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: rnf43 has been classified as Green List (High Evidence).","entity_name":"RNF43","entity_type":"gene"},{"created":"2024-10-09T12:54:35.234775+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: PTEN as ready","entity_name":"PTEN","entity_type":"gene"},{"created":"2024-10-09T12:54:35.216337+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: pten has been classified as Green List (High Evidence).","entity_name":"PTEN","entity_type":"gene"},{"created":"2024-10-09T12:54:26.187362+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: POLE as ready","entity_name":"POLE","entity_type":"gene"},{"created":"2024-10-09T12:54:26.165113+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: pole has been classified as Green List (High Evidence).","entity_name":"POLE","entity_type":"gene"},{"created":"2024-10-09T12:54:19.044979+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: POLD1 as ready","entity_name":"POLD1","entity_type":"gene"},{"created":"2024-10-09T12:54:19.026850+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: pold1 has been classified as Green List (High Evidence).","entity_name":"POLD1","entity_type":"gene"},{"created":"2024-10-09T12:54:08.312423+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: PMS2 as ready","entity_name":"PMS2","entity_type":"gene"},{"created":"2024-10-09T12:54:08.298481+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: pms2 has been classified as Green List (High Evidence).","entity_name":"PMS2","entity_type":"gene"},{"created":"2024-10-09T12:54:00.890897+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: NTHL1 as ready","entity_name":"NTHL1","entity_type":"gene"},{"created":"2024-10-09T12:54:00.880975+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: nthl1 has been classified as Green List (High Evidence).","entity_name":"NTHL1","entity_type":"gene"},{"created":"2024-10-09T12:53:53.627756+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: MUTYH as ready","entity_name":"MUTYH","entity_type":"gene"},{"created":"2024-10-09T12:53:53.611980+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: mutyh has been classified as Green List (High Evidence).","entity_name":"MUTYH","entity_type":"gene"},{"created":"2024-10-09T12:53:46.724623+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: MSH6 as ready","entity_name":"MSH6","entity_type":"gene"},{"created":"2024-10-09T12:53:46.706005+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: msh6 has been classified as Green List (High Evidence).","entity_name":"MSH6","entity_type":"gene"},{"created":"2024-10-09T12:52:43.719554+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: MSH3 as ready","entity_name":"MSH3","entity_type":"gene"},{"created":"2024-10-09T12:52:43.699675+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: msh3 has been classified as Green List (High Evidence).","entity_name":"MSH3","entity_type":"gene"},{"created":"2024-10-09T12:52:32.005234+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: MSH2 as ready","entity_name":"MSH2","entity_type":"gene"},{"created":"2024-10-09T12:52:31.991531+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: msh2 has been classified as Green List (High Evidence).","entity_name":"MSH2","entity_type":"gene"},{"created":"2024-10-09T12:52:19.167822+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: MLH1 as ready","entity_name":"MLH1","entity_type":"gene"},{"created":"2024-10-09T12:52:19.151448+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: mlh1 has been classified as Green List (High Evidence).","entity_name":"MLH1","entity_type":"gene"},{"created":"2024-10-09T12:52:10.151845+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: GREM1 as ready","entity_name":"GREM1","entity_type":"gene"},{"created":"2024-10-09T12:52:10.139947+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: grem1 has been classified as Green List (High Evidence).","entity_name":"GREM1","entity_type":"gene"},{"created":"2024-10-09T12:52:07.731420+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.40","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: GREM1 were changed from  to Colorectal cancer, MONDO:0005575; Polyposis, MONDO:0000147; Hereditary mixed polyposis syndrome, MONDO:0011023; GREM1-associated polyposis, no MIM#","entity_name":"GREM1","entity_type":"gene"},{"created":"2024-10-09T12:50:30.125480+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.39","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: EPCAM as ready","entity_name":"EPCAM","entity_type":"gene"},{"created":"2024-10-09T12:50:30.105928+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.39","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: epcam has been classified as Green List (High Evidence).","entity_name":"EPCAM","entity_type":"gene"},{"created":"2024-10-09T12:50:22.539216+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.39","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: BMPR1A as ready","entity_name":"BMPR1A","entity_type":"gene"},{"created":"2024-10-09T12:50:22.527366+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.39","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: bmpr1a has been classified as Green List (High Evidence).","entity_name":"BMPR1A","entity_type":"gene"},{"created":"2024-10-09T12:48:28.869324+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.39","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: AXIN2 as ready","entity_name":"AXIN2","entity_type":"gene"},{"created":"2024-10-09T12:48:28.846742+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.39","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: axin2 has been classified as Green List (High Evidence).","entity_name":"AXIN2","entity_type":"gene"},{"created":"2024-10-09T12:48:18.993486+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.39","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: APC as ready","entity_name":"APC","entity_type":"gene"},{"created":"2024-10-09T12:48:18.978492+11:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.39","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: apc has been classified as Green List (High Evidence).","entity_name":"APC","entity_type":"gene"},{"created":"2024-10-09T12:46:46.832060+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"1.0","user_name":"Zornitza Stark","item_type":"panel","text":"promoted panel to version 1.0","entity_name":null,"entity_type":null},{"created":"2024-10-09T12:45:21.300110+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.27","user_name":"Zornitza Stark","item_type":"panel","text":"Panel status changed from internal to public","entity_name":null,"entity_type":null},{"created":"2024-10-09T12:45:09.625925+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: TP53 as ready","entity_name":"TP53","entity_type":"gene"},{"created":"2024-10-09T12:45:09.601790+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: tp53 has been classified as Green List (High Evidence).","entity_name":"TP53","entity_type":"gene"},{"created":"2024-10-09T12:45:01.611325+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: STK11 as ready","entity_name":"STK11","entity_type":"gene"},{"created":"2024-10-09T12:45:01.593937+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: stk11 has been classified as Green List (High Evidence).","entity_name":"STK11","entity_type":"gene"},{"created":"2024-10-09T12:44:54.479223+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: RAD51D as ready","entity_name":"RAD51D","entity_type":"gene"},{"created":"2024-10-09T12:44:54.461985+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: rad51d has been classified as Green List (High Evidence).","entity_name":"RAD51D","entity_type":"gene"},{"created":"2024-10-09T12:44:04.033244+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: RAD51C as ready","entity_name":"RAD51C","entity_type":"gene"},{"created":"2024-10-09T12:44:04.012887+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: rad51c has been classified as Green List (High Evidence).","entity_name":"RAD51C","entity_type":"gene"},{"created":"2024-10-09T12:43:56.197271+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: PTEN as ready","entity_name":"PTEN","entity_type":"gene"},{"created":"2024-10-09T12:43:56.179406+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: pten has been classified as Green List (High Evidence).","entity_name":"PTEN","entity_type":"gene"},{"created":"2024-10-09T12:43:47.860426+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: PALB2 as ready","entity_name":"PALB2","entity_type":"gene"},{"created":"2024-10-09T12:43:47.846770+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: palb2 has been classified as Green List (High Evidence).","entity_name":"PALB2","entity_type":"gene"},{"created":"2024-10-09T12:43:40.055203+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: NF1 as ready","entity_name":"NF1","entity_type":"gene"},{"created":"2024-10-09T12:43:40.042031+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: nf1 has been classified as Green List (High Evidence).","entity_name":"NF1","entity_type":"gene"},{"created":"2024-10-09T12:43:33.040201+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: CHEK2 as ready","entity_name":"CHEK2","entity_type":"gene"},{"created":"2024-10-09T12:43:33.021918+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: chek2 has been classified as Green List (High Evidence).","entity_name":"CHEK2","entity_type":"gene"},{"created":"2024-10-09T12:43:23.738450+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: CDH1 as ready","entity_name":"CDH1","entity_type":"gene"},{"created":"2024-10-09T12:43:23.717942+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: cdh1 has been classified as Green List (High Evidence).","entity_name":"CDH1","entity_type":"gene"},{"created":"2024-10-09T12:43:14.329015+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: BRCA2 as ready","entity_name":"BRCA2","entity_type":"gene"},{"created":"2024-10-09T12:43:14.312510+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: brca2 has been classified as Green List (High Evidence).","entity_name":"BRCA2","entity_type":"gene"},{"created":"2024-10-09T12:40:52.118827+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: BRCA1 as ready","entity_name":"BRCA1","entity_type":"gene"},{"created":"2024-10-09T12:40:52.102850+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: brca1 has been classified as Green List (High Evidence).","entity_name":"BRCA1","entity_type":"gene"},{"created":"2024-10-09T12:40:44.182480+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: BARD1 as ready","entity_name":"BARD1","entity_type":"gene"},{"created":"2024-10-09T12:40:44.167802+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: bard1 has been classified as Green List (High Evidence).","entity_name":"BARD1","entity_type":"gene"},{"created":"2024-10-09T12:40:33.452495+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: ATM as ready","entity_name":"ATM","entity_type":"gene"},{"created":"2024-10-09T12:40:33.428533+11:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: atm has been classified as Green List (High Evidence).","entity_name":"ATM","entity_type":"gene"},{"created":"2024-10-09T12:40:11.508249+11:00","panel_name":"Basal Cell Cancer","panel_id":4360,"panel_version":"1.0","user_name":"Zornitza Stark","item_type":"panel","text":"promoted panel to version 1.0","entity_name":null,"entity_type":null},{"created":"2024-10-09T12:39:46.562000+11:00","panel_name":"Basal Cell Cancer","panel_id":4360,"panel_version":"0.7","user_name":"Zornitza Stark","item_type":"panel","text":"Panel status changed from internal to public","entity_name":null,"entity_type":null},{"created":"2024-10-09T12:39:31.851871+11:00","panel_name":"Basal Cell Cancer","panel_id":4360,"panel_version":"0.6","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: PTCH2 as ready","entity_name":"PTCH2","entity_type":"gene"},{"created":"2024-10-09T12:39:31.832757+11:00","panel_name":"Basal Cell Cancer","panel_id":4360,"panel_version":"0.6","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: ptch2 has been classified as Red List (Low Evidence).","entity_name":"PTCH2","entity_type":"gene"},{"created":"2024-10-09T12:39:22.809315+11:00","panel_name":"Basal Cell Cancer","panel_id":4360,"panel_version":"0.6","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: SUFU as ready","entity_name":"SUFU","entity_type":"gene"},{"created":"2024-10-09T12:39:22.798441+11:00","panel_name":"Basal Cell Cancer","panel_id":4360,"panel_version":"0.6","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: sufu has been classified as Green List (High Evidence).","entity_name":"SUFU","entity_type":"gene"},{"created":"2024-10-09T12:39:14.971102+11:00","panel_name":"Basal Cell Cancer","panel_id":4360,"panel_version":"0.6","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: PTCH1 as ready","entity_name":"PTCH1","entity_type":"gene"},{"created":"2024-10-09T12:39:14.940574+11:00","panel_name":"Basal Cell Cancer","panel_id":4360,"panel_version":"0.6","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: ptch1 has been classified as Green List (High Evidence).","entity_name":"PTCH1","entity_type":"gene"},{"created":"2024-10-08T18:26:56.641602+11:00","panel_name":"Macrocephaly_Megalencephaly","panel_id":135,"panel_version":"0.148","user_name":"Boris Keren","item_type":"entity","text":"changed review comment from: Two of the 5 patients in the Pilarowski paper have macrocephaly associated with their neurodevelopmental disorder. \r\nAll the variants in the Pilarowski paper are missenses, and the assumed mechanism is a dominant negative effect, although there are now a few pathogenic/likely pathogenic LoFs in ClinVar. \nSources: Literature; to: Two of the 5 patients in the Pilarowski paper have macrocephaly associated with their neurodevelopmental disorder. \r\nAll the variants in the Pilarowski paper are missenses, and the assumed mechanism is a dominant negative effect, although there are now a few pathogenic/likely pathogenic LoFs in ClinVar. \r\nSources: Literature","entity_name":"CHD1","entity_type":"gene"},{"created":"2024-10-08T18:26:41.469415+11:00","panel_name":"Macrocephaly_Megalencephaly","panel_id":135,"panel_version":"0.148","user_name":"Boris Keren","item_type":"entity","text":"gene: CHD1 was added\ngene: CHD1 was added to Macrocephaly_Megalencephaly. Sources: Literature\nMode of inheritance for gene: CHD1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: CHD1 were set to 28866611\nPhenotypes for gene: CHD1 were set to intellectual disability; macrocephaly\nPenetrance for gene: CHD1 were set to Incomplete\nMode of pathogenicity for gene: CHD1 was set to Other\nReview for gene: CHD1 was set to AMBER\ngene: CHD1 was marked as current diagnostic\nAdded comment: Two of the 5 patients in the Pilarowski paper have macrocephaly associated with their neurodevelopmental disorder. \r\nAll the variants in the Pilarowski paper are missenses, and the assumed mechanism is a dominant negative effect, although there are now a few pathogenic/likely pathogenic LoFs in ClinVar. \nSources: Literature","entity_name":"CHD1","entity_type":"gene"},{"created":"2024-10-08T16:56:55.798247+11:00","panel_name":"Prepair 1000+","panel_id":3861,"panel_version":"1.390","user_name":"Andrew Coventry","item_type":"entity","text":"reviewed gene: TPM3: Rating: GREEN; Mode of pathogenicity: None; Publications: 26418456 7704029 17376686 18382475 19487656 12196661 10619715; Phenotypes: Congenital myopathy 4B, autosomal recessive MIM#609284; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"TPM3","entity_type":"gene"},{"created":"2024-10-08T16:49:59.666825+11:00","panel_name":"Prepair 1000+","panel_id":3861,"panel_version":"1.390","user_name":"Andrew Coventry","item_type":"entity","text":"reviewed gene: TPI1: Rating: GREEN; Mode of pathogenicity: None; Publications: 9338582 32873690 8503454; Phenotypes: Hemolytic anemia due to triosephosphate isomerase deficiency MIM#615512; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"TPI1","entity_type":"gene"},{"created":"2024-10-08T16:47:43.118686+11:00","panel_name":"Prepair 1000+","panel_id":3861,"panel_version":"1.390","user_name":"Andrew Coventry","item_type":"entity","text":"reviewed gene: TNFRSF11B: Rating: GREEN; Mode of pathogenicity: None; Publications: 25108083 34166796 29080812 14672344; Phenotypes: Paget disease of bone 5, juvenile-onset MIM#239000; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal","entity_name":"TNFRSF11B","entity_type":"gene"},{"created":"2024-10-08T16:43:01.395736+11:00","panel_name":"Prepair 1000+","panel_id":3861,"panel_version":"1.390","user_name":"Andrew Coventry","item_type":"entity","text":"reviewed gene: THOC2: Rating: GREEN; Mode of pathogenicity: None; Publications: 26166480 32116545 29851191 32960281 34976470 37945483; Phenotypes: Intellectual developmental disorder, X-linked 12 MIM#300957; Mode of inheritance: X-LINKED: hemizygous mutation in males, biallelic mutations in females","entity_name":"THOC2","entity_type":"gene"},{"created":"2024-10-08T12:51:09.605969+11:00","panel_name":"Kidneyome_SuperPanel","panel_id":275,"panel_version":"8.79","user_name":"Zornitza Stark","item_type":"panel","text":"Changed child panels to: Renal Ciliopathies and Nephronophthisis; Renal Tubulopathies and related disorders; Hypertension and Aldosterone disorders; Renal Tubulointerstitial Disease; Haematuria_Alport; Proteinuria; Congenital anomalies of the kidney and urinary tract (CAKUT) Syndromic; Congenital anomalies of the kidney and urinary tract (CAKUT) Nonsyndromic; Renal Macrocystic Disease; Atypical Haemolytic Uraemic Syndrome_MPGN; Amyloidosis","entity_name":null,"entity_type":null},{"created":"2024-10-07T19:11:02.524853+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.6465","user_name":"Zornitza Stark","item_type":"entity","text":"Marked gene: IPO8 as ready","entity_name":"IPO8","entity_type":"gene"},{"created":"2024-10-07T19:11:02.505283+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.6465","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: ipo8 has been classified as Green List (High Evidence).","entity_name":"IPO8","entity_type":"gene"},{"created":"2024-10-07T19:10:57.202714+11:00","panel_name":"Intellectual disability syndromic and non-syndromic","panel_id":250,"panel_version":"0.6465","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: IPO8 as Green List (high evidence)","entity_name":"IPO8","entity_type":"gene"}]}