{"count":221415,"next":"https://panelapp-aus.org/api/v1/activities/?format=json&page=383","previous":"https://panelapp-aus.org/api/v1/activities/?format=json&page=381","results":[{"created":"2024-09-26T10:50:33.471918+10:00","panel_name":"Wilms Tumour","panel_id":4366,"panel_version":"0.8","user_name":"Chirag Patel","item_type":"entity","text":"gene: PALB2 was added\ngene: PALB2 was added to Wilms Tumour. Sources: Expert list,Expert Review\nMode of inheritance for gene: PALB2 was set to BIALLELIC, autosomal or pseudoautosomal\nPhenotypes for gene: PALB2 were set to Wilms tumor, MONDO:0006058; Fanconi anemia complementation group N, MONDO:0012565; Fanconi anemia, complementation group N, MIM#610832\nReview for gene: PALB2 was set to GREEN\nAdded comment: ClinGen definitive. Wilms tumour reported in condition. \nSources: Expert list, Expert Review","entity_name":"PALB2","entity_type":"gene"},{"created":"2024-09-26T10:50:10.342475+10:00","panel_name":"Systemic Autoinflammatory Disease_Periodic Fever","panel_id":238,"panel_version":"1.51","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: PSTPIP1: Changed phenotypes: Autoinflammatory syndrome with cytopenia, hyperzincemia, and hypercalprotectinemia, MIMM# 601979, Pyogenic sterile arthritis, pyoderma gangrenosum, and acne, MIM# 604416, PSTPIP1-associated myeloid-related proteinemia inflammatory (PAMI) syndrome","entity_name":"PSTPIP1","entity_type":"gene"},{"created":"2024-09-26T10:50:06.523164+10:00","panel_name":"Wilms Tumour","panel_id":4366,"panel_version":"0.7","user_name":"Chirag Patel","item_type":"entity","text":"gene: GPC3 was added\ngene: GPC3 was added to Wilms Tumour. Sources: Expert list,Expert Review\nMode of inheritance for gene: GPC3 was set to X-LINKED: hemizygous mutation in males, biallelic mutations in females\nPhenotypes for gene: GPC3 were set to Wilms tumor, MONDO:0006058; Simpson-Golabi-Behmel syndrome type 1, MONDO:0020602; Simpson-Golabi-Behmel syndrome, type 1, MIM#312870\nReview for gene: GPC3 was set to GREEN\nAdded comment: ClinGen definitive. Wilms tumour reported in condition. \nSources: Expert list, Expert Review","entity_name":"GPC3","entity_type":"gene"},{"created":"2024-09-26T10:49:49.269484+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"1.2017","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: PSTPIP1 were changed from Pyogenic sterile arthritis, pyoderma gangrenosum, and acne, MIM# 604416; PSTPIP1-associated myeloid-related proteinemia inflammatory (PAMI) syndrome to Autoinflammatory syndrome with cytopenia, hyperzincemia, and hypercalprotectinemia, MIMM# 601979; Pyogenic sterile arthritis, pyoderma gangrenosum, and acne, MIM# 604416; PSTPIP1-associated myeloid-related proteinemia inflammatory (PAMI) syndrome","entity_name":"PSTPIP1","entity_type":"gene"},{"created":"2024-09-26T10:49:48.950578+10:00","panel_name":"Wilms Tumour","panel_id":4366,"panel_version":"0.6","user_name":"Chirag Patel","item_type":"entity","text":"gene: DIS3L2 was added\ngene: DIS3L2 was added to Wilms Tumour. Sources: Expert list,Expert Review\nMode of inheritance for gene: DIS3L2 was set to BIALLELIC, autosomal or pseudoautosomal\nPhenotypes for gene: DIS3L2 were set to Wilms tumor, MONDO:0006058; Perlman syndrome, MONDO:0009965; Perlman syndrome, MIM#267000\nReview for gene: DIS3L2 was set to GREEN\nAdded comment: ClinGen definitive. Wilms tumour reported in condition. \nSources: Expert list, Expert Review","entity_name":"DIS3L2","entity_type":"gene"},{"created":"2024-09-26T10:49:24.397688+10:00","panel_name":"Wilms Tumour","panel_id":4366,"panel_version":"0.5","user_name":"Chirag Patel","item_type":"entity","text":"gene: CDKN1C was added\ngene: CDKN1C was added to Wilms Tumour. Sources: Expert list,Expert Review\nMode of inheritance for gene: CDKN1C was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: CDKN1C were set to Wilms tumor, MONDO:0006058; Beckwith-Wiedemann syndrome due to CDKN1C mutation, MONDO:0016476; Beckwith-Wiedemann syndrome, MIM#130650\nReview for gene: CDKN1C was set to GREEN\nAdded comment: Established gene-disease association. Wilms tumour reported in condition. \nSources: Expert list, Expert Review","entity_name":"CDKN1C","entity_type":"gene"},{"created":"2024-09-26T10:49:24.280062+10:00","panel_name":"Mendeliome","panel_id":137,"panel_version":"1.2016","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: PSTPIP1: Changed phenotypes: Autoinflammatory syndrome with cytopenia, hyperzincemia, and hypercalprotectinemia, MIMM# 601979, Pyogenic sterile arthritis, pyoderma gangrenosum, and acne, MIM# 604416, PSTPIP1-associated myeloid-related proteinemia inflammatory (PAMI) syndrome","entity_name":"PSTPIP1","entity_type":"gene"},{"created":"2024-09-26T10:49:02.159323+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"1.96","user_name":"Zornitza Stark","item_type":"entity","text":"Phenotypes for gene: PSTPIP1 were changed from Pyogenic sterile arthritis, pyoderma gangrenosum, and acne, MIM# 604416 to Pyogenic sterile arthritis, pyoderma gangrenosum, and acne, MIM# 604416; Autoinflammatory syndrome with cytopenia, hyperzincemia, and hypercalprotectinemia, MIMM# 601979","entity_name":"PSTPIP1","entity_type":"gene"},{"created":"2024-09-26T10:48:56.909819+10:00","panel_name":"Wilms Tumour","panel_id":4366,"panel_version":"0.4","user_name":"Chirag Patel","item_type":"entity","text":"gene: BUB1B was added\ngene: BUB1B was added to Wilms Tumour. Sources: Expert list,Expert Review\nMode of inheritance for gene: BUB1B was set to BIALLELIC, autosomal or pseudoautosomal\nPhenotypes for gene: BUB1B were set to Wilms tumor, MONDO:0006058; Mosaic variegated aneuploidy syndrome 1, MONDO:0009759; Mosaic variegated aneuploidy syndrome 1, MIM#257300\nReview for gene: BUB1B was set to GREEN\nAdded comment: ClinGen definitive. Wilms tumour reported in condition. \nSources: Expert list, Expert Review","entity_name":"BUB1B","entity_type":"gene"},{"created":"2024-09-26T10:48:42.269048+10:00","panel_name":"Wilms Tumour","panel_id":4366,"panel_version":"0.3","user_name":"Chirag Patel","item_type":"entity","text":"gene: BRCA2 was added\ngene: BRCA2 was added to Wilms Tumour. Sources: Expert list,Expert Review\nMode of inheritance for gene: BRCA2 was set to BIALLELIC, autosomal or pseudoautosomal\nPhenotypes for gene: BRCA2 were set to Wilms tumor, MONDO:0006058; Fanconi anemia complementation group D1,MONDO:0011584; Fanconi anemia, complementation group D1, MIM#605724\nReview for gene: BRCA2 was set to GREEN\nAdded comment: ClinGen definitive. Wilms tumour reported in condition. \nSources: Expert list, Expert Review","entity_name":"BRCA2","entity_type":"gene"},{"created":"2024-09-26T10:48:31.253567+10:00","panel_name":"Wilms Tumour","panel_id":4366,"panel_version":"0.2","user_name":"Chirag Patel","item_type":"entity","text":"gene: BLM was added\ngene: BLM was added to Wilms Tumour. Sources: Expert list,Expert Review\nMode of inheritance for gene: BLM was set to BIALLELIC, autosomal or pseudoautosomal\nPhenotypes for gene: BLM were set to Wilms tumor, MONDO:0006058; Bloom syndrome, MONDO:0008876; Bloom syndrome, MIM#210900\nReview for gene: BLM was set to GREEN\nAdded comment: ClinGen definitive. Wilms tumour reported in condition. \nSources: Expert list, Expert Review","entity_name":"BLM","entity_type":"gene"},{"created":"2024-09-26T10:48:21.112604+10:00","panel_name":"Bone Marrow Failure","panel_id":56,"panel_version":"1.95","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: PSTPIP1: Changed phenotypes: Pyogenic sterile arthritis, pyoderma gangrenosum, and acne, MIM# 604416, Autoinflammatory syndrome with cytopenia, hyperzincemia, and hypercalprotectinemia, MIMM# 601979","entity_name":"PSTPIP1","entity_type":"gene"},{"created":"2024-09-26T10:27:25.467320+10:00","panel_name":"Severe Combined Immunodeficiency (absent T present B cells)","panel_id":235,"panel_version":"1.6","user_name":"Peter McNaughton","item_type":"entity","text":"gene: TP63 was added\ngene: TP63 was added to Severe Combined Immunodeficiency (absent T present B cells). Sources: Literature\nMode of inheritance for gene: TP63 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: TP63 were set to doi: 10.3389/fimmu.2024.1438383\nPhenotypes for gene: TP63 were set to lymphopaenia\nReview for gene: TP63 was set to GREEN\nAdded comment: Multiple patients presenting with T cell lymphopaenia, potentially identified on SCID new born screening.  T cell lymphopaenia due to thymic defect rather than intrinsic T cell defect so treatment is with thymic transplant rather than HSCT.  Should be included in SCID panel as identification of this gene defect in lymphopaenic patients identified on SCID NBS will change treatment pathway dramatically. \nSources: Literature","entity_name":"TP63","entity_type":"gene"},{"created":"2024-09-26T09:49:12.136233+10:00","panel_name":"Sarcoma soft tissue","panel_id":4358,"panel_version":"0.34","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: POT1 as Amber List (moderate evidence)","entity_name":"POT1","entity_type":"gene"},{"created":"2024-09-26T09:49:12.122975+10:00","panel_name":"Sarcoma soft tissue","panel_id":4358,"panel_version":"0.34","user_name":"Chirag Patel","item_type":"entity","text":"Gene: pot1 has been classified as Amber List (Moderate Evidence).","entity_name":"POT1","entity_type":"gene"},{"created":"2024-09-26T09:49:06.362242+10:00","panel_name":"Sarcoma soft tissue","panel_id":4358,"panel_version":"0.33","user_name":"Chirag Patel","item_type":"entity","text":"gene: POT1 was added\ngene: POT1 was added to Sarcoma soft tissue. Sources: Expert Review,Literature\nMode of inheritance for gene: POT1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: POT1 were set to PMID: 36656928, 37466057\nPhenotypes for gene: POT1 were set to Soft tissue sarcoma, MONDO:0018078; Sarcoma, MONDO:0005089; Tumor predisposition syndrome 3, MONDO:0014368; Melanoma, cutaneous malignant, MIM#606478\nReview for gene: POT1 was set to AMBER\nAdded comment: Tumor predisposition syndrome-3 (TPDS3) is characterised by an increased risk for the development of various types of benign and malignant neoplasms throughout life, with age-dependent penetrance (e.g. neoplasms involving epithelial, mesenchymal, and neuronal tissues, as well as clonal hematopoietic syndromes, including lymphoid and myeloid cancers). \nSources: Expert Review, Literature","entity_name":"POT1","entity_type":"gene"},{"created":"2024-09-26T09:19:15.377546+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: CHEK2 as Green List (high evidence)","entity_name":"CHEK2","entity_type":"gene"},{"created":"2024-09-26T09:19:15.360651+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.26","user_name":"Chirag Patel","item_type":"entity","text":"Gene: chek2 has been classified as Green List (High Evidence).","entity_name":"CHEK2","entity_type":"gene"},{"created":"2024-09-26T09:19:10.818808+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.25","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: ATM as Green List (high evidence)","entity_name":"ATM","entity_type":"gene"},{"created":"2024-09-26T09:19:10.808465+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.25","user_name":"Chirag Patel","item_type":"entity","text":"Gene: atm has been classified as Green List (High Evidence).","entity_name":"ATM","entity_type":"gene"},{"created":"2024-09-26T09:19:05.416234+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.24","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: BARD1 as Green List (high evidence)","entity_name":"BARD1","entity_type":"gene"},{"created":"2024-09-26T09:19:05.400718+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.24","user_name":"Chirag Patel","item_type":"entity","text":"Gene: bard1 has been classified as Green List (High Evidence).","entity_name":"BARD1","entity_type":"gene"},{"created":"2024-09-26T09:19:00.593735+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.23","user_name":"Chirag Patel","item_type":"entity","text":"gene: BARD1 was added\ngene: BARD1 was added to Breast Cancer. Sources: Expert list,Expert Review\nMode of inheritance for gene: BARD1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: BARD1 were set to Breast cancer, MONDO:0007254; BARD1-related cancer predisposition, MONDO:0700267; Breast cancer, susceptibility to, MIM#114480\nReview for gene: BARD1 was set to GREEN\nAdded comment: ClinGen definitive. Breast cancers reported in condition. \nSources: Expert list, Expert Review","entity_name":"BARD1","entity_type":"gene"},{"created":"2024-09-26T09:18:52.680565+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.22","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: BRCA1 as Green List (high evidence)","entity_name":"BRCA1","entity_type":"gene"},{"created":"2024-09-26T09:18:52.663832+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.22","user_name":"Chirag Patel","item_type":"entity","text":"Gene: brca1 has been classified as Green List (High Evidence).","entity_name":"BRCA1","entity_type":"gene"},{"created":"2024-09-26T09:18:47.602038+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.21","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: BRCA2 as Green List (high evidence)","entity_name":"BRCA2","entity_type":"gene"},{"created":"2024-09-26T09:18:47.586158+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.21","user_name":"Chirag Patel","item_type":"entity","text":"Gene: brca2 has been classified as Green List (High Evidence).","entity_name":"BRCA2","entity_type":"gene"},{"created":"2024-09-26T09:18:42.837999+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.20","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: CDH1 as Green List (high evidence)","entity_name":"CDH1","entity_type":"gene"},{"created":"2024-09-26T09:18:42.817162+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.20","user_name":"Chirag Patel","item_type":"entity","text":"Gene: cdh1 has been classified as Green List (High Evidence).","entity_name":"CDH1","entity_type":"gene"},{"created":"2024-09-26T09:18:38.198294+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.19","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: NF1 as Green List (high evidence)","entity_name":"NF1","entity_type":"gene"},{"created":"2024-09-26T09:18:38.185924+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.19","user_name":"Chirag Patel","item_type":"entity","text":"Gene: nf1 has been classified as Green List (High Evidence).","entity_name":"NF1","entity_type":"gene"},{"created":"2024-09-26T09:18:32.869890+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.18","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: PALB2 as Green List (high evidence)","entity_name":"PALB2","entity_type":"gene"},{"created":"2024-09-26T09:18:32.854280+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.18","user_name":"Chirag Patel","item_type":"entity","text":"Gene: palb2 has been classified as Green List (High Evidence).","entity_name":"PALB2","entity_type":"gene"},{"created":"2024-09-26T09:18:28.415887+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.17","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: PTEN as Green List (high evidence)","entity_name":"PTEN","entity_type":"gene"},{"created":"2024-09-26T09:18:28.401329+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.17","user_name":"Chirag Patel","item_type":"entity","text":"Gene: pten has been classified as Green List (High Evidence).","entity_name":"PTEN","entity_type":"gene"},{"created":"2024-09-26T09:18:23.392462+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.16","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: RAD51C as Green List (high evidence)","entity_name":"RAD51C","entity_type":"gene"},{"created":"2024-09-26T09:18:23.377348+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.16","user_name":"Chirag Patel","item_type":"entity","text":"Gene: rad51c has been classified as Green List (High Evidence).","entity_name":"RAD51C","entity_type":"gene"},{"created":"2024-09-26T09:18:19.169782+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.15","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: RAD51D as Green List (high evidence)","entity_name":"RAD51D","entity_type":"gene"},{"created":"2024-09-26T09:18:19.153777+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.15","user_name":"Chirag Patel","item_type":"entity","text":"Gene: rad51d has been classified as Green List (High Evidence).","entity_name":"RAD51D","entity_type":"gene"},{"created":"2024-09-26T09:18:14.895310+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.14","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: STK11 as Green List (high evidence)","entity_name":"STK11","entity_type":"gene"},{"created":"2024-09-26T09:18:14.864615+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.14","user_name":"Chirag Patel","item_type":"entity","text":"Gene: stk11 has been classified as Green List (High Evidence).","entity_name":"STK11","entity_type":"gene"},{"created":"2024-09-26T09:18:09.351274+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.13","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: TP53 as Green List (high evidence)","entity_name":"TP53","entity_type":"gene"},{"created":"2024-09-26T09:18:09.335897+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.13","user_name":"Chirag Patel","item_type":"entity","text":"Gene: tp53 has been classified as Green List (High Evidence).","entity_name":"TP53","entity_type":"gene"},{"created":"2024-09-26T09:18:03.365734+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.12","user_name":"Chirag Patel","item_type":"entity","text":"gene: TP53 was added\ngene: TP53 was added to Breast Cancer. Sources: Expert list,Expert Review\nMode of inheritance for gene: TP53 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: TP53 were set to Breast cancer, MONDO:0007254; Li-Fraumeni syndrome, MONDO:0018875; Li-Fraumeni syndrome, MIM#151623\nReview for gene: TP53 was set to GREEN\nAdded comment: ClinGen definitive. Breast cancers reported in condition.\r\n\r\nConsider possibility that an identified variant could represent ACE (aberrant clonal expansion), which can be due to clonal haematopoiesis of indeterminate potential (CHIP) or an occult hematologic malignancy, especially in older patients who have undergone prior chemotherapy (PMID: 36040522). \nSources: Expert list, Expert Review","entity_name":"TP53","entity_type":"gene"},{"created":"2024-09-26T09:17:49.234227+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.11","user_name":"Chirag Patel","item_type":"entity","text":"gene: STK11 was added\ngene: STK11 was added to Breast Cancer. Sources: Expert list,Expert Review\nMode of inheritance for gene: STK11 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: STK11 were set to Breast cancer, MONDO:0007254; Peutz-Jeghers syndrome, MONDO:0008280; Peutz-Jeghers syndrome, MIM#175200\nReview for gene: STK11 was set to GREEN\nAdded comment: ClinGen definitive. Breast cancers reported in condition.\r\n\r\nSingle gene testing may be more appropriate if clinical features of JPS. \nSources: Expert list, Expert Review","entity_name":"STK11","entity_type":"gene"},{"created":"2024-09-26T09:17:35.086082+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.10","user_name":"Chirag Patel","item_type":"entity","text":"gene: RAD51D was added\ngene: RAD51D was added to Breast Cancer. Sources: Expert list,Expert Review\nMode of inheritance for gene: RAD51D was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: RAD51D were set to Breast cancer, MONDO:0007254; RAD51D-related cancer predisposition, MONDO:0700274; Breast-ovarian cancer, familial, susceptibility to, 4, MONDO:0013669; Breast-ovarian cancer, familial, susceptibility to, 4, MIM#614291\nReview for gene: RAD51D was set to GREEN\nAdded comment: ClinGen definitive. Breast cancers reported in condition. \nSources: Expert list, Expert Review","entity_name":"RAD51D","entity_type":"gene"},{"created":"2024-09-26T09:17:25.626173+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.9","user_name":"Chirag Patel","item_type":"entity","text":"gene: RAD51C was added\ngene: RAD51C was added to Breast Cancer. Sources: Expert list,Expert Review\nMode of inheritance for gene: RAD51C was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: RAD51C were set to Breast cancer, MONDO:0007254; RAD51C-related cancer predisposition, MONDO:0700273; Breast-ovarian cancer, familial, susceptibility to, 3, MONDO:0013253; Breast-ovarian cancer, familial, susceptibility to, 3, MIM#613399\nReview for gene: RAD51C was set to GREEN\nAdded comment: ClinGen definitive. Breast cancers reported in condition. \nSources: Expert list, Expert Review","entity_name":"RAD51C","entity_type":"gene"},{"created":"2024-09-26T09:17:14.958788+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.8","user_name":"Chirag Patel","item_type":"entity","text":"gene: PTEN was added\ngene: PTEN was added to Breast Cancer. Sources: Expert list,Expert Review\nMode of inheritance for gene: PTEN was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: PTEN were set to Breast cancer, MONDO:0007254; PTEN hamartoma tumor syndrome, MONDO:0017623; PTEN hamartoma tumour syndromes, MIM#158350\nReview for gene: PTEN was set to GREEN\nAdded comment: ClinGen definitive. Breast cancers reported in condition. \nSources: Expert list, Expert Review","entity_name":"PTEN","entity_type":"gene"},{"created":"2024-09-26T09:17:03.663279+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.7","user_name":"Chirag Patel","item_type":"entity","text":"gene: PALB2 was added\ngene: PALB2 was added to Breast Cancer. Sources: Expert list,Expert Review\nMode of inheritance for gene: PALB2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: PALB2 were set to Breast cancer, MONDO:0007254; PALB2-related cancer predisposition, MONDO:0700272; Breast-ovarian cancer, familial, susceptibility to, 5, MIM#620442; Pancreatic cancer, susceptibility to, 3, MIM#613348\nReview for gene: PALB2 was set to GREEN\nAdded comment: ClinGen definitive. Breast cancers reported in condition. \nSources: Expert list, Expert Review","entity_name":"PALB2","entity_type":"gene"},{"created":"2024-09-26T09:16:53.860816+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.6","user_name":"Chirag Patel","item_type":"entity","text":"gene: NF1 was added\ngene: NF1 was added to Breast Cancer. Sources: Expert list,Expert Review\nMode of inheritance for gene: NF1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: NF1 were set to Breast cancer, MONDO:0007254; Neurofibromatosis type 1, MONDO:0018975; Neurofibromatosis, type 1, MIM#162200\nReview for gene: NF1 was set to GREEN\nAdded comment: ClinGen definitive. Breast cancers reported in condition.\r\n\r\nSingle gene testing may be more appropriate if clinical features of NF1. \nSources: Expert list, Expert Review","entity_name":"NF1","entity_type":"gene"},{"created":"2024-09-26T09:16:38.931272+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.5","user_name":"Chirag Patel","item_type":"entity","text":"gene: CDH1 was added\ngene: CDH1 was added to Breast Cancer. Sources: Expert list,Expert Review\nMode of inheritance for gene: CDH1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: CDH1 were set to Breast cancer, MONDO:0007254; CDH1-related diffuse gastric and lobular breast cancer syndrome, MONDO:0100488; Diffuse gastric and lobular breast cancer syndrome with or without cleft lip and/or palate, MIM#137215\nReview for gene: CDH1 was set to GREEN\nAdded comment: ClinGen definitive. Breast cancers reported in condition. \nSources: Expert list, Expert Review","entity_name":"CDH1","entity_type":"gene"},{"created":"2024-09-26T09:16:17.894035+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.4","user_name":"Chirag Patel","item_type":"entity","text":"gene: BRCA2 was added\ngene: BRCA2 was added to Breast Cancer. Sources: Expert list,Expert Review\nMode of inheritance for gene: BRCA2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: BRCA2 were set to Breast cancer, MONDO:0007254; BRCA2-related cancer predisposition, MONDO:0700269; Breast-ovarian cancer, familial, 2, MIM#612555\nReview for gene: BRCA2 was set to GREEN\nAdded comment: ClinGen definitive. Breast cancers reported in condition. \nSources: Expert list, Expert Review","entity_name":"BRCA2","entity_type":"gene"},{"created":"2024-09-26T09:16:07.958269+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.3","user_name":"Chirag Patel","item_type":"entity","text":"gene: BRCA1 was added\ngene: BRCA1 was added to Breast Cancer. Sources: Expert list,Expert Review\nMode of inheritance for gene: BRCA1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: BRCA1 were set to Breast cancer, MONDO:0007254; BRCA1-related cancer predisposition, MONDO:0700268; Breast-ovarian cancer, familial, 1, MIM#604370\nReview for gene: BRCA1 was set to GREEN\nAdded comment: ClinGen definitive. Breast cancers reported in condition. \nSources: Expert list, Expert Review","entity_name":"BRCA1","entity_type":"gene"},{"created":"2024-09-26T09:15:35.397921+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.2","user_name":"Chirag Patel","item_type":"entity","text":"gene: ATM was added\ngene: ATM was added to Breast Cancer. Sources: Expert list,Expert Review\nMode of inheritance for gene: ATM was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: ATM were set to Breast cancer, MONDO:0007254; ATM-related cancer predisposition, MONDO:0700270; Breast cancer, susceptibility to, MIM#114480\nReview for gene: ATM was set to GREEN\nAdded comment: ClinGen definitive. Breast cancers reported in condition.\r\n\r\nConsider possibility that an identified variant could represent ACE (aberrant clonal expansion), which can be due to clonal haematopoiesis of indeterminate potential (CHIP) or an occult hematologic malignancy, especially in older patients who have undergone prior chemotherapy (PMID: 36040522). \nSources: Expert list, Expert Review","entity_name":"ATM","entity_type":"gene"},{"created":"2024-09-26T09:14:05.478429+10:00","panel_name":"Breast Cancer","panel_id":4375,"panel_version":"0.1","user_name":"Chirag Patel","item_type":"entity","text":"gene: CHEK2 was added\ngene: CHEK2 was added to Breast Cancer. Sources: Expert list,Expert Review,Literature\nMode of inheritance for gene: CHEK2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: CHEK2 were set to PMID: 33322746, 36529447\nPhenotypes for gene: CHEK2 were set to Breast cancer, MONDO:0007254; CHEK2-related cancer predisposition, MONDO:0700271; Breast/prostate cancer, susceptibility to, MIM#609265\nReview for gene: CHEK2 was set to GREEN\nAdded comment: Established gene-disease association. Breast cancers reported in condition.\r\n\r\nConsider possibility that an identified variant could represent ACE (aberrant clonal expansion), which can be due to clonal haematopoiesis of indeterminate potential (CHIP) or an occult hematologic malignancy, especially in older patients who have undergone prior chemotherapy (PMID: 36040522). \nSources: Expert list, Expert Review, Literature","entity_name":"CHEK2","entity_type":"gene"},{"created":"2024-09-26T08:30:26.829524+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.39","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: MLH1 as Green List (high evidence)","entity_name":"MLH1","entity_type":"gene"},{"created":"2024-09-26T08:30:26.813178+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.39","user_name":"Chirag Patel","item_type":"entity","text":"Gene: mlh1 has been classified as Green List (High Evidence).","entity_name":"MLH1","entity_type":"gene"},{"created":"2024-09-26T08:30:22.313877+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.38","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: MSH2 as Green List (high evidence)","entity_name":"MSH2","entity_type":"gene"},{"created":"2024-09-26T08:30:22.297249+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.38","user_name":"Chirag Patel","item_type":"entity","text":"Gene: msh2 has been classified as Green List (High Evidence).","entity_name":"MSH2","entity_type":"gene"},{"created":"2024-09-26T08:30:17.180762+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.37","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: MSH6 as Green List (high evidence)","entity_name":"MSH6","entity_type":"gene"},{"created":"2024-09-26T08:30:17.164189+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.37","user_name":"Chirag Patel","item_type":"entity","text":"Gene: msh6 has been classified as Green List (High Evidence).","entity_name":"MSH6","entity_type":"gene"},{"created":"2024-09-26T08:30:12.851066+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.36","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: PMS2 as Green List (high evidence)","entity_name":"PMS2","entity_type":"gene"},{"created":"2024-09-26T08:30:12.819891+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.36","user_name":"Chirag Patel","item_type":"entity","text":"Gene: pms2 has been classified as Green List (High Evidence).","entity_name":"PMS2","entity_type":"gene"},{"created":"2024-09-26T08:30:08.162111+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.35","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: MUTYH as Green List (high evidence)","entity_name":"MUTYH","entity_type":"gene"},{"created":"2024-09-26T08:30:08.128686+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.35","user_name":"Chirag Patel","item_type":"entity","text":"Gene: mutyh has been classified as Green List (High Evidence).","entity_name":"MUTYH","entity_type":"gene"},{"created":"2024-09-26T08:30:03.980159+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.34","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: NTHL1 as Green List (high evidence)","entity_name":"NTHL1","entity_type":"gene"},{"created":"2024-09-26T08:30:03.960905+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.34","user_name":"Chirag Patel","item_type":"entity","text":"Gene: nthl1 has been classified as Green List (High Evidence).","entity_name":"NTHL1","entity_type":"gene"},{"created":"2024-09-26T08:29:58.806758+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.33","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: MSH3 as Green List (high evidence)","entity_name":"MSH3","entity_type":"gene"},{"created":"2024-09-26T08:29:58.782262+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.33","user_name":"Chirag Patel","item_type":"entity","text":"Gene: msh3 has been classified as Green List (High Evidence).","entity_name":"MSH3","entity_type":"gene"},{"created":"2024-09-26T08:29:54.186178+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.32","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: GREM1 as Green List (high evidence)","entity_name":"GREM1","entity_type":"gene"},{"created":"2024-09-26T08:29:54.161348+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.32","user_name":"Chirag Patel","item_type":"entity","text":"Gene: grem1 has been classified as Green List (High Evidence).","entity_name":"GREM1","entity_type":"gene"},{"created":"2024-09-26T08:29:46.269635+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.31","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: RNF43 as Green List (high evidence)","entity_name":"RNF43","entity_type":"gene"},{"created":"2024-09-26T08:29:46.252312+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.31","user_name":"Chirag Patel","item_type":"entity","text":"Gene: rnf43 has been classified as Green List (High Evidence).","entity_name":"RNF43","entity_type":"gene"},{"created":"2024-09-26T08:29:39.883980+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.30","user_name":"Chirag Patel","item_type":"entity","text":"gene: RNF43 was added\ngene: RNF43 was added to Colorectal Cancer and Polyposis. Sources: Expert list,Expert Review,Literature\nMode of inheritance for gene: RNF43 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: RNF43 were set to PMID: 24512911, 34541672, 27329244, 27081527, 29330307\nPhenotypes for gene: RNF43 were set to Colorectal cancer, MONDO:0005575; Polyposis, MONDO:0000147; Sessile serrated polyposis cancer syndrome, MONDO:0014919; Sessile serrated polyposis cancer syndrome, MIM#617108\nReview for gene: RNF43 was set to GREEN\nAdded comment: ClinGen definitive. Colorectal cancers and/or polyposis reported in condition. \nSources: Expert list, Expert Review, Literature","entity_name":"RNF43","entity_type":"gene"},{"created":"2024-09-26T08:28:40.510784+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.29","user_name":"Chirag Patel","item_type":"entity","text":"edited their review of gene: GREM1: Changed phenotypes: Colorectal cancer, MONDO:0005575, Polyposis, MONDO:0000147, Hereditary mixed polyposis syndrome, MONDO:0011023, GREM1-associated polyposis, no MIM#","entity_name":"GREM1","entity_type":"gene"},{"created":"2024-09-26T08:28:07.084807+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.29","user_name":"Chirag Patel","item_type":"entity","text":"gene: GREM1 was added\ngene: GREM1 was added to Colorectal Cancer and Polyposis. Sources: Expert list,Expert Review,Literature\nMode of inheritance for gene: GREM1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: GREM1 were set to PMID: 22561515, 25419707\nMode of pathogenicity for gene: GREM1 was set to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments\nReview for gene: GREM1 was set to GREEN\nAdded comment: ClinGen definitive. Colorectal cancers and/or polyposis reported in condition. GOF variants.\r\n\r\nFour variants leading to partial or complete duplication of GREM1 regulatory regions or coding sequences have been reported, resulting in increased allele-specific GREM1 expression. Most are carriers of the Ashkenazi founder variant, a 40kb duplication upstream of GREM1 (SCG5-GREM1 dup). \nSources: Expert list, Expert Review, Literature","entity_name":"GREM1","entity_type":"gene"},{"created":"2024-09-26T08:27:19.938621+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.28","user_name":"Chirag Patel","item_type":"entity","text":"gene: MSH3 was added\ngene: MSH3 was added to Colorectal Cancer and Polyposis. Sources: Expert list,Expert Review\nMode of inheritance for gene: MSH3 was set to BIALLELIC, autosomal or pseudoautosomal\nPhenotypes for gene: MSH3 were set to Colorectal cancer, MONDO:0005575; Polyposis, MONDO:0000147; Familial adenomatous polyposis 4, MONDO:0044300; Familial adenomatous polyposis 4, MIM#617100\nReview for gene: MSH3 was set to GREEN\nAdded comment: ClinGen definitive. Colorectal cancers and/or polyposis reported in condition. \nSources: Expert list, Expert Review","entity_name":"MSH3","entity_type":"gene"},{"created":"2024-09-26T08:26:58.559399+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.27","user_name":"Chirag Patel","item_type":"entity","text":"gene: NTHL1 was added\ngene: NTHL1 was added to Colorectal Cancer and Polyposis. Sources: Expert list,Expert Review\nMode of inheritance for gene: NTHL1 was set to BIALLELIC, autosomal or pseudoautosomal\nPhenotypes for gene: NTHL1 were set to Colorectal cancer, MONDO:0005575; Polyposis, MONDO:0000147; NTHL1-deficiency tumor predisposition syndrome, MONDO:0100502; Familial adenomatous polyposis 3, MIM#616415\nReview for gene: NTHL1 was set to GREEN\nAdded comment: ClinGen definitive. Colorectal cancers and/or polyposis reported in condition. \nSources: Expert list, Expert Review","entity_name":"NTHL1","entity_type":"gene"},{"created":"2024-09-26T08:26:40.034075+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.26","user_name":"Chirag Patel","item_type":"entity","text":"gene: MUTYH was added\ngene: MUTYH was added to Colorectal Cancer and Polyposis. Sources: Expert list,Expert Review\nMode of inheritance for gene: MUTYH was set to BIALLELIC, autosomal or pseudoautosomal\nPhenotypes for gene: MUTYH were set to Colorectal cancer, MONDO:0005575; Polyposis, MONDO:0000147; Familial adenomatous polyposis 2, MONDO:0012041; Adenomas, multiple colorectal, MIM#608456\nReview for gene: MUTYH was set to GREEN\nAdded comment: ClinGen definitive. Colorectal cancers and/or polyposis reported in condition. \nSources: Expert list, Expert Review","entity_name":"MUTYH","entity_type":"gene"},{"created":"2024-09-26T08:26:16.035129+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.25","user_name":"Chirag Patel","item_type":"entity","text":"gene: PMS2 was added\ngene: PMS2 was added to Colorectal Cancer and Polyposis. Sources: Expert list,Expert Review\nMode of inheritance for gene: PMS2 was set to BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal\nPhenotypes for gene: PMS2 were set to Colorectal cancer, MONDO:0005575; Polyposis, MONDO:0000147; Lynch syndrome 4, MONDO:0013699; Mismatch repair cancer syndrome 4, MONDO:0030843; Lynch syndrome 4, MIM#614337; Mismatch repair cancer syndrome 4, MIM#619101\nReview for gene: PMS2 was set to GREEN\nAdded comment: ClinGen definitive. Colorectal cancers and/or polyposis reported in condition.\r\n\r\nNote: there is a high level of homology between PMS2 and pseudogenes \nSources: Expert list, Expert Review","entity_name":"PMS2","entity_type":"gene"},{"created":"2024-09-26T08:26:02.448510+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.24","user_name":"Chirag Patel","item_type":"entity","text":"gene: MSH6 was added\ngene: MSH6 was added to Colorectal Cancer and Polyposis. Sources: Expert list,Expert Review\nMode of inheritance for gene: MSH6 was set to BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal\nPhenotypes for gene: MSH6 were set to Colorectal cancer, MONDO:0005575; Polyposis, MONDO:0000147; Lynch syndrome 5, MONDO:0013710; Mismatch repair cancer syndrome 3, MONDO:0030841; Lynch syndrome 5, MIM#614350; Mismatch repair cancer syndrome 3, MIM#619097\nReview for gene: MSH6 was set to GREEN\nAdded comment: ClinGen definitive. Colorectal cancers and/or polyposis reported in condition. \nSources: Expert list, Expert Review","entity_name":"MSH6","entity_type":"gene"},{"created":"2024-09-26T08:25:51.016049+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.23","user_name":"Chirag Patel","item_type":"entity","text":"gene: MSH2 was added\ngene: MSH2 was added to Colorectal Cancer and Polyposis. Sources: Expert list,Expert Review\nMode of inheritance for gene: MSH2 was set to BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal\nPhenotypes for gene: MSH2 were set to Colorectal cancer, MONDO:0005575; Polyposis, MONDO:0000147; Lynch syndrome 1, MONDO:0007356; Mismatch repair cancer syndrome 2, MONDO:0030840; Lynch syndrome 1, MIM#120435; Mismatch repair cancer syndrome 2, MIM#619096\nReview for gene: MSH2 was set to GREEN\nAdded comment: ClinGen definitive. Colorectal cancers and/or polyposis reported in condition. \nSources: Expert list, Expert Review","entity_name":"MSH2","entity_type":"gene"},{"created":"2024-09-26T08:25:42.284591+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.22","user_name":"Chirag Patel","item_type":"entity","text":"gene: MLH1 was added\ngene: MLH1 was added to Colorectal Cancer and Polyposis. Sources: Expert list,Expert Review\nMode of inheritance for gene: MLH1 was set to BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal\nPhenotypes for gene: MLH1 were set to Colorectal cancer, MONDO:0005575; Polyposis, MONDO:0000147; Lynch syndrome 2, MONDO:0012249; Mismatch repair cancer syndrome 1, MONDO:0010159; Lynch syndrome 2, MIM#609310; Mismatch repair cancer syndrome 1, MIM#276300\nReview for gene: MLH1 was set to GREEN\nAdded comment: ClinGen definitive. Colorectal cancers and/or polyposis reported in condition. \nSources: Expert list, Expert Review","entity_name":"MLH1","entity_type":"gene"},{"created":"2024-09-26T08:22:28.118565+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.21","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: TP53 as Green List (high evidence)","entity_name":"TP53","entity_type":"gene"},{"created":"2024-09-26T08:22:28.104059+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.21","user_name":"Chirag Patel","item_type":"entity","text":"Gene: tp53 has been classified as Green List (High Evidence).","entity_name":"TP53","entity_type":"gene"},{"created":"2024-09-26T08:22:23.061206+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.20","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: STK11 as Green List (high evidence)","entity_name":"STK11","entity_type":"gene"},{"created":"2024-09-26T08:22:23.048278+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.20","user_name":"Chirag Patel","item_type":"entity","text":"Gene: stk11 has been classified as Green List (High Evidence).","entity_name":"STK11","entity_type":"gene"},{"created":"2024-09-26T08:22:18.115889+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.19","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: APC as Green List (high evidence)","entity_name":"APC","entity_type":"gene"},{"created":"2024-09-26T08:22:18.106552+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.19","user_name":"Chirag Patel","item_type":"entity","text":"Gene: apc has been classified as Green List (High Evidence).","entity_name":"APC","entity_type":"gene"},{"created":"2024-09-26T08:22:17.661793+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.18","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: APC as Green List (high evidence)","entity_name":"APC","entity_type":"gene"},{"created":"2024-09-26T08:22:17.618881+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.18","user_name":"Chirag Patel","item_type":"entity","text":"Gene: apc has been classified as Green List (High Evidence).","entity_name":"APC","entity_type":"gene"},{"created":"2024-09-26T08:22:13.061644+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.17","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: AXIN2 as Green List (high evidence)","entity_name":"AXIN2","entity_type":"gene"},{"created":"2024-09-26T08:22:13.046815+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.17","user_name":"Chirag Patel","item_type":"entity","text":"Gene: axin2 has been classified as Green List (High Evidence).","entity_name":"AXIN2","entity_type":"gene"},{"created":"2024-09-26T08:22:08.065811+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.16","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: BMPR1A as Green List (high evidence)","entity_name":"BMPR1A","entity_type":"gene"},{"created":"2024-09-26T08:22:08.046201+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.16","user_name":"Chirag Patel","item_type":"entity","text":"Gene: bmpr1a has been classified as Green List (High Evidence).","entity_name":"BMPR1A","entity_type":"gene"},{"created":"2024-09-26T08:22:02.845522+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.15","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: EPCAM as Green List (high evidence)","entity_name":"EPCAM","entity_type":"gene"},{"created":"2024-09-26T08:22:02.831188+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.15","user_name":"Chirag Patel","item_type":"entity","text":"Gene: epcam has been classified as Green List (High Evidence).","entity_name":"EPCAM","entity_type":"gene"},{"created":"2024-09-26T08:21:56.986585+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.14","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: POLD1 as Green List (high evidence)","entity_name":"POLD1","entity_type":"gene"},{"created":"2024-09-26T08:21:56.974039+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.14","user_name":"Chirag Patel","item_type":"entity","text":"Gene: pold1 has been classified as Green List (High Evidence).","entity_name":"POLD1","entity_type":"gene"},{"created":"2024-09-26T08:21:49.344858+10:00","panel_name":"Colorectal Cancer and Polyposis","panel_id":4371,"panel_version":"0.13","user_name":"Chirag Patel","item_type":"entity","text":"Classified gene: POLE as Green List (high evidence)","entity_name":"POLE","entity_type":"gene"}]}