{"count":221415,"next":"https://panelapp-aus.org/api/v1/activities/?format=json&page=558","previous":"https://panelapp-aus.org/api/v1/activities/?format=json&page=556","results":[{"created":"2023-08-22T17:21:29.201845+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.291","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: MAPT as ready","entity_name":"MAPT","entity_type":"gene"},{"created":"2023-08-22T17:21:29.185439+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.291","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: mapt has been classified as Green List (High Evidence).","entity_name":"MAPT","entity_type":"gene"},{"created":"2023-08-22T17:21:07.808946+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.291","user_name":"Bryony Thompson","item_type":"entity","text":"Phenotypes for gene: MAPT were changed from  to Supranuclear palsy, progressive (MIM# 601104) AD; Supranuclear palsy, progressive atypical (MIM# 260540) AR","entity_name":"MAPT","entity_type":"gene"},{"created":"2023-08-22T17:20:28.634613+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.290","user_name":"Bryony Thompson","item_type":"entity","text":"Publications for gene: MAPT were set to ","entity_name":"MAPT","entity_type":"gene"},{"created":"2023-08-22T17:19:06.025048+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.289","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of inheritance for gene: MAPT was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"MAPT","entity_type":"gene"},{"created":"2023-08-22T17:18:41.494491+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.288","user_name":"Bryony Thompson","item_type":"entity","text":"Tag adult onset neurodegenerative tag was added to gene: MAPT.","entity_name":"MAPT","entity_type":"gene"},{"created":"2023-08-22T17:18:12.463302+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.288","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: LRRK2 as ready","entity_name":"LRRK2","entity_type":"gene"},{"created":"2023-08-22T17:18:12.450232+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.288","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: lrrk2 has been classified as Green List (High Evidence).","entity_name":"LRRK2","entity_type":"gene"},{"created":"2023-08-22T17:17:55.902414+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.288","user_name":"Bryony Thompson","item_type":"entity","text":"Phenotypes for gene: LRRK2 were changed from  to Parkinson Disease type 8 (MONDO:0005180, MIM#607060)","entity_name":"LRRK2","entity_type":"gene"},{"created":"2023-08-22T17:17:07.548533+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.287","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of pathogenicity for gene: LRRK2 was changed from  to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments","entity_name":"LRRK2","entity_type":"gene"},{"created":"2023-08-22T17:07:27.892475+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.286","user_name":"Bryony Thompson","item_type":"entity","text":"Publications for gene: LRRK2 were set to ","entity_name":"LRRK2","entity_type":"gene"},{"created":"2023-08-22T17:06:15.085160+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.285","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of inheritance for gene: LRRK2 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"LRRK2","entity_type":"gene"},{"created":"2023-08-22T17:05:38.079513+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.284","user_name":"Bryony Thompson","item_type":"entity","text":"Tag adult onset neurodegenerative tag was added to gene: LRRK2.","entity_name":"LRRK2","entity_type":"gene"},{"created":"2023-08-22T16:41:28.641929+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.284","user_name":"Bryony Thompson","item_type":"entity","text":"Publications for gene: LDLR were set to ","entity_name":"LDLR","entity_type":"gene"},{"created":"2023-08-22T16:40:58.202357+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.283","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: LDLR as ready","entity_name":"LDLR","entity_type":"gene"},{"created":"2023-08-22T16:40:58.187224+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.283","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: ldlr has been classified as Green List (High Evidence).","entity_name":"LDLR","entity_type":"gene"},{"created":"2023-08-22T16:19:56.017352+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.283","user_name":"Bryony Thompson","item_type":"entity","text":"Phenotypes for gene: LDLR were changed from  to Hypercholesterolemia, familial, 1, MIM# 143890","entity_name":"LDLR","entity_type":"gene"},{"created":"2023-08-22T16:19:42.513303+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.282","user_name":"Bryony Thompson","item_type":"entity","text":"Tag cardiac tag was added to gene: LDLR.","entity_name":"LDLR","entity_type":"gene"},{"created":"2023-08-22T16:07:37.739934+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.282","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of inheritance for gene: LDLR was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"LDLR","entity_type":"gene"},{"created":"2023-08-22T16:05:55.473423+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.281","user_name":"Bryony Thompson","item_type":"entity","text":"Tag adult onset neurodegenerative tag was added to gene: ITM2B.","entity_name":"ITM2B","entity_type":"gene"},{"created":"2023-08-22T16:05:44.860023+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.281","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: ITM2B as ready","entity_name":"ITM2B","entity_type":"gene"},{"created":"2023-08-22T16:05:44.848026+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.281","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: itm2b has been classified as Green List (High Evidence).","entity_name":"ITM2B","entity_type":"gene"},{"created":"2023-08-22T15:50:21.296219+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.281","user_name":"Bryony Thompson","item_type":"entity","text":"Publications for gene: ITM2B were set to ","entity_name":"ITM2B","entity_type":"gene"},{"created":"2023-08-22T15:45:53.191517+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.280","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of pathogenicity for gene: ITM2B was changed from None to Other","entity_name":"ITM2B","entity_type":"gene"},{"created":"2023-08-22T15:45:05.371159+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.279","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: GRN as ready","entity_name":"GRN","entity_type":"gene"},{"created":"2023-08-22T15:45:05.339602+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.279","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: grn has been classified as Green List (High Evidence).","entity_name":"GRN","entity_type":"gene"},{"created":"2023-08-22T15:44:40.713607+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.279","user_name":"Bryony Thompson","item_type":"entity","text":"Phenotypes for gene: GRN were changed from  to frontotemporal dementia and/or amyotrophic lateral sclerosis MONDO:0030923","entity_name":"GRN","entity_type":"gene"},{"created":"2023-08-22T15:36:28.690087+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.278","user_name":"Bryony Thompson","item_type":"entity","text":"Publications for gene: GRN were set to ","entity_name":"GRN","entity_type":"gene"},{"created":"2023-08-22T15:33:49.783886+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.277","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of inheritance for gene: GRN was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"GRN","entity_type":"gene"},{"created":"2023-08-22T15:33:19.521072+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.276","user_name":"Bryony Thompson","item_type":"entity","text":"Tag adult onset neurodegenerative tag was added to gene: GRN.","entity_name":"GRN","entity_type":"gene"},{"created":"2023-08-22T15:33:00.332353+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.276","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: GBA as ready","entity_name":"GBA","entity_type":"gene"},{"created":"2023-08-22T15:33:00.322930+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.276","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: gba has been classified as Green List (High Evidence).","entity_name":"GBA","entity_type":"gene"},{"created":"2023-08-22T14:01:21.212722+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.276","user_name":"Bryony Thompson","item_type":"entity","text":"Publications for gene: GBA were set to ","entity_name":"GBA","entity_type":"gene"},{"created":"2023-08-22T13:59:16.787229+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.275","user_name":"Bryony Thompson","item_type":"entity","text":"Phenotypes for gene: GBA were changed from  to Parkinson's disease, MONDO:0005180, GBA-related","entity_name":"GBA","entity_type":"gene"},{"created":"2023-08-22T13:58:06.159801+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.274","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of inheritance for gene: GBA was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"GBA","entity_type":"gene"},{"created":"2023-08-22T13:57:22.364216+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.273","user_name":"Bryony Thompson","item_type":"entity","text":"Tag adult onset neurodegenerative tag was added to gene: GBA.","entity_name":"GBA","entity_type":"gene"},{"created":"2023-08-22T13:11:25.729385+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.273","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: FUS as ready","entity_name":"FUS","entity_type":"gene"},{"created":"2023-08-22T13:11:25.720709+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.273","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: fus has been classified as Green List (High Evidence).","entity_name":"FUS","entity_type":"gene"},{"created":"2023-08-22T13:11:22.268137+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.273","user_name":"Bryony Thompson","item_type":"entity","text":"Tag adult onset neurodegenerative tag was added to gene: FUS.","entity_name":"FUS","entity_type":"gene"},{"created":"2023-08-22T13:10:17.721268+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.273","user_name":"Bryony Thompson","item_type":"entity","text":"Phenotypes for gene: FUS were changed from  to Amyotrophic lateral sclerosis 6, with or without frontotemporal dementia, MIM# 608030","entity_name":"FUS","entity_type":"gene"},{"created":"2023-08-22T13:09:42.756486+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.272","user_name":"Bryony Thompson","item_type":"entity","text":"Publications for gene: FUS were set to ","entity_name":"FUS","entity_type":"gene"},{"created":"2023-08-22T12:01:22.244968+10:00","panel_name":"Deafness_IsolatedAndComplex","panel_id":209,"panel_version":"1.160","user_name":"Zornitza Stark","item_type":"entity","text":"Mode of inheritance for gene: GJB6 was changed from Unknown to Other","entity_name":"GJB6","entity_type":"gene"},{"created":"2023-08-22T12:00:48.510226+10:00","panel_name":"Deafness_IsolatedAndComplex","panel_id":209,"panel_version":"1.159","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: GJB6: Changed mode of inheritance: Other","entity_name":"GJB6","entity_type":"gene"},{"created":"2023-08-22T12:00:33.771075+10:00","panel_name":"Deafness_IsolatedAndComplex","panel_id":209,"panel_version":"1.159","user_name":"Zornitza Stark","item_type":"entity","text":"Classified gene: GJB6 as Green List (high evidence)","entity_name":"GJB6","entity_type":"gene"},{"created":"2023-08-22T12:00:33.759191+10:00","panel_name":"Deafness_IsolatedAndComplex","panel_id":209,"panel_version":"1.159","user_name":"Zornitza Stark","item_type":"entity","text":"Gene: gjb6 has been classified as Green List (High Evidence).","entity_name":"GJB6","entity_type":"gene"},{"created":"2023-08-22T12:00:06.354015+10:00","panel_name":"Deafness_IsolatedAndComplex","panel_id":209,"panel_version":"1.158","user_name":"Zornitza Stark","item_type":"entity","text":"Tag SV/CNV tag was added to gene: GJB6.","entity_name":"GJB6","entity_type":"gene"},{"created":"2023-08-22T11:59:55.811261+10:00","panel_name":"Deafness_IsolatedAndComplex","panel_id":209,"panel_version":"1.158","user_name":"Zornitza Stark","item_type":"entity","text":"changed review comment from: Association with deafness classified as REFUTED by ClinGen.; to: Association os SNVs in this gene with isolated deafness classified as REFUTED by ClinGen.\r\n\r\nThe GJB6-D13S1830 deletion is a relatively common disease allele in many populations and is classified as pathogenic for hearing loss, frequently identified in homozygosity or in trans with a pathogenic GJB2 variant. This is a deletion of approximately 309kb of DNA including the 5' end of GJB6 and a region upstream of both GJB6 and the GJB2 gene. It has been proposed that GJB6 and GJB2 are co-regulated by a cis-acting element (Ahmad 2007 PMID 17227867). \r\n\r\nGREEN rating on the panel relates to the DELETION ONLY.","entity_name":"GJB6","entity_type":"gene"},{"created":"2023-08-22T11:58:48.514467+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.271","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of inheritance for gene: FUS was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"FUS","entity_type":"gene"},{"created":"2023-08-22T11:57:05.224368+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.270","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: FTL as ready","entity_name":"FTL","entity_type":"gene"},{"created":"2023-08-22T11:57:05.204539+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.270","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: ftl has been classified as Green List (High Evidence).","entity_name":"FTL","entity_type":"gene"},{"created":"2023-08-22T11:57:00.407175+10:00","panel_name":"Deafness_IsolatedAndComplex","panel_id":209,"panel_version":"1.158","user_name":"Zornitza Stark","item_type":"entity","text":"edited their review of gene: GJB6: Changed rating: GREEN","entity_name":"GJB6","entity_type":"gene"},{"created":"2023-08-22T11:56:24.038033+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.270","user_name":"Bryony Thompson","item_type":"entity","text":"Phenotypes for gene: FTL were changed from  to Neurodegeneration with brain iron accumulation 3, MIM# 606159","entity_name":"FTL","entity_type":"gene"},{"created":"2023-08-22T11:07:39.590693+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.269","user_name":"Bryony Thompson","item_type":"entity","text":"Publications for gene: FTL were set to ","entity_name":"FTL","entity_type":"gene"},{"created":"2023-08-22T10:12:11.138125+10:00","panel_name":"Motor Neurone Disease","panel_id":25,"panel_version":"1.4","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: CHMP2B as ready","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T10:12:11.123869+10:00","panel_name":"Motor Neurone Disease","panel_id":25,"panel_version":"1.4","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: chmp2b has been classified as Green List (High Evidence).","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T10:12:03.147281+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.268","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of inheritance for gene: FTL was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"FTL","entity_type":"gene"},{"created":"2023-08-22T10:11:54.864693+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.267","user_name":"Bryony Thompson","item_type":"entity","text":"Tag neurological tag was added to gene: FTL.","entity_name":"FTL","entity_type":"gene"},{"created":"2023-08-22T10:11:19.235619+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.267","user_name":"Bryony Thompson","item_type":"entity","text":"Tag review tag was added to gene: FIG4.","entity_name":"FIG4","entity_type":"gene"},{"created":"2023-08-22T10:09:35.235733+10:00","panel_name":"Motor Neurone Disease","panel_id":25,"panel_version":"1.4","user_name":"Bryony Thompson","item_type":"entity","text":"Phenotypes for gene: CHMP2B were changed from  to Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 (MIM#600795, MONDO:0010936)","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T10:07:29.400056+10:00","panel_name":"Motor Neurone Disease","panel_id":25,"panel_version":"1.3","user_name":"Bryony Thompson","item_type":"entity","text":"Publications for gene: CHMP2B were set to ","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T09:53:47.372172+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.267","user_name":"Bryony Thompson","item_type":"entity","text":"Tag cancer tag was added to gene: DICER1.","entity_name":"DICER1","entity_type":"gene"},{"created":"2023-08-22T09:53:21.044091+10:00","panel_name":"Motor Neurone Disease","panel_id":25,"panel_version":"1.2","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of pathogenicity for gene: CHMP2B was changed from  to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T09:52:34.205687+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.267","user_name":"Bryony Thompson","item_type":"entity","text":"Tag cancer tag was added to gene: DDX41.","entity_name":"DDX41","entity_type":"gene"},{"created":"2023-08-22T09:52:05.432411+10:00","panel_name":"Motor Neurone Disease","panel_id":25,"panel_version":"1.1","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of inheritance for gene: CHMP2B was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T09:51:44.492265+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.267","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: CLU as ready","entity_name":"CLU","entity_type":"gene"},{"created":"2023-08-22T09:51:44.477471+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.267","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: clu has been classified as Red List (Low Evidence).","entity_name":"CLU","entity_type":"gene"},{"created":"2023-08-22T09:51:03.701611+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.267","user_name":"Bryony Thompson","item_type":"entity","text":"Phenotypes for gene: CLU were changed from  to Alzheimer's Disease (MIM#104300)","entity_name":"CLU","entity_type":"gene"},{"created":"2023-08-22T09:50:50.809459+10:00","panel_name":"Early-onset Dementia","panel_id":24,"panel_version":"1.5","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: CHMP2B as ready","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T09:50:50.795603+10:00","panel_name":"Early-onset Dementia","panel_id":24,"panel_version":"1.5","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: chmp2b has been classified as Green List (High Evidence).","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T09:48:58.628133+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.266","user_name":"Bryony Thompson","item_type":"entity","text":"Classified gene: CLU as Red List (low evidence)","entity_name":"CLU","entity_type":"gene"},{"created":"2023-08-22T09:48:58.614071+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.266","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: clu has been classified as Red List (Low Evidence).","entity_name":"CLU","entity_type":"gene"},{"created":"2023-08-22T09:48:49.572479+10:00","panel_name":"Early-onset Dementia","panel_id":24,"panel_version":"1.5","user_name":"Bryony Thompson","item_type":"entity","text":"Phenotypes for gene: CHMP2B were changed from  to Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 (MIM#600795; MONDO:0010936)","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T09:47:31.042024+10:00","panel_name":"Early-onset Dementia","panel_id":24,"panel_version":"1.4","user_name":"Bryony Thompson","item_type":"entity","text":"Publications for gene: CHMP2B were set to ","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T09:46:53.893162+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.265","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: CHMP2B as ready","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T09:46:53.878475+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.265","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: chmp2b has been classified as Green List (High Evidence).","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T09:46:50.883022+10:00","panel_name":"Early-onset Dementia","panel_id":24,"panel_version":"1.3","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of pathogenicity for gene: CHMP2B was changed from Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T09:46:48.868695+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.265","user_name":"Bryony Thompson","item_type":"entity","text":"Tag adult onset neurodegenerative tag was added to gene: CHMP2B.","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T09:46:31.195928+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.265","user_name":"Bryony Thompson","item_type":"entity","text":"Phenotypes for gene: CHMP2B were changed from  to Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 (MIM#600795; MONDO:0010936)","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T09:46:20.300613+10:00","panel_name":"Early-onset Dementia","panel_id":24,"panel_version":"1.2","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of pathogenicity for gene: CHMP2B was changed from  to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T09:45:58.743837+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.264","user_name":"Bryony Thompson","item_type":"entity","text":"Publications for gene: CHMP2B were set to ","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T09:44:47.647941+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.263","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of pathogenicity for gene: CHMP2B was changed from  to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T09:44:33.843101+10:00","panel_name":"Early-onset Dementia","panel_id":24,"panel_version":"1.1","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of inheritance for gene: CHMP2B was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T09:44:25.699321+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.262","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of inheritance for gene: CHMP2B was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T09:43:18.210692+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.262","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of inheritance for gene: CHMP2B was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T09:43:18.163674+10:00","panel_name":"Early-onset Dementia","panel_id":24,"panel_version":"1.1","user_name":"Bryony Thompson","item_type":"entity","text":"Mode of inheritance for gene: CHMP2B was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","entity_name":"CHMP2B","entity_type":"gene"},{"created":"2023-08-22T09:41:02.623965+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.261","user_name":"Bryony Thompson","item_type":"entity","text":"Tag cancer tag was added to gene: CHEK2.","entity_name":"CHEK2","entity_type":"gene"},{"created":"2023-08-22T09:40:19.276815+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.261","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: CHCHD2 as ready","entity_name":"CHCHD2","entity_type":"gene"},{"created":"2023-08-22T09:40:19.267160+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.261","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: chchd2 has been classified as Green List (High Evidence).","entity_name":"CHCHD2","entity_type":"gene"},{"created":"2023-08-22T09:40:12.771756+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.261","user_name":"Bryony Thompson","item_type":"entity","text":"Tag adult onset neurodegenerative tag was added to gene: CHCHD2.","entity_name":"CHCHD2","entity_type":"gene"},{"created":"2023-08-22T09:26:33.195092+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.261","user_name":"Bryony Thompson","item_type":"entity","text":"Tag cancer tag was added to gene: CDH1.","entity_name":"CDH1","entity_type":"gene"},{"created":"2023-08-22T09:25:45.331835+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.261","user_name":"Bryony Thompson","item_type":"entity","text":"Classified gene: CCNF as Amber List (moderate evidence)","entity_name":"CCNF","entity_type":"gene"},{"created":"2023-08-22T09:25:45.327055+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.261","user_name":"Bryony Thompson","item_type":"entity","text":"Added comment: Comment on list classification: Limited gene-disease validity assessment by ClinGen ALS spectrum disorders GCEP - 05/04/2022","entity_name":"CCNF","entity_type":"gene"},{"created":"2023-08-22T09:25:45.299539+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.261","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: ccnf has been classified as Amber List (Moderate Evidence).","entity_name":"CCNF","entity_type":"gene"},{"created":"2023-08-22T09:25:18.486470+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.260","user_name":"Bryony Thompson","item_type":"entity","text":"Classified gene: CCNF as Amber List (moderate evidence)","entity_name":"CCNF","entity_type":"gene"},{"created":"2023-08-22T09:25:18.472541+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.260","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: ccnf has been classified as Amber List (Moderate Evidence).","entity_name":"CCNF","entity_type":"gene"},{"created":"2023-08-22T09:24:19.346319+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.259","user_name":"Bryony Thompson","item_type":"entity","text":"Tag cardiac tag was added to gene: CACNA1C.","entity_name":"CACNA1C","entity_type":"gene"},{"created":"2023-08-22T09:23:57.073633+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.259","user_name":"Bryony Thompson","item_type":"entity","text":"Marked gene: CALHM1 as ready","entity_name":"CALHM1","entity_type":"gene"},{"created":"2023-08-22T09:23:57.061129+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.259","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: calhm1 has been classified as Red List (Low Evidence).","entity_name":"CALHM1","entity_type":"gene"},{"created":"2023-08-22T09:23:24.966576+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.259","user_name":"Bryony Thompson","item_type":"entity","text":"Classified gene: CALHM1 as Red List (low evidence)","entity_name":"CALHM1","entity_type":"gene"},{"created":"2023-08-22T09:23:24.954659+10:00","panel_name":"Incidentalome","panel_id":126,"panel_version":"0.259","user_name":"Bryony Thompson","item_type":"entity","text":"Gene: calhm1 has been classified as Red List (Low Evidence).","entity_name":"CALHM1","entity_type":"gene"}]}