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It therefore excludes genes listed in the Incidentalome, such as those associated with some cardiac disorders, cancer predisposition syndromes, and neurodegenerative diseases. If analysis of these genes is required, the relevant disease-specific panel (e.g. Adult Additional Findings, Neurodegenerative Disease_Adult Onset, Regression, Breast Cancer) should be requested.\r\n\r\nPlease note that mitochondrially-encoded genes may only be analysed as part of some genomic tests, e.g. WGS with appropriate accreditation in place. If uncertain, please contact your test provider.\r\n\r\nSTRs are currently on this panel as 'grey' due to lack of clinical accreditation for STR analysis in Australian laboratories.\r\n\r\nThis panel was originally developed by VCGS and is a consensus panel used by RMH.","status":"public","version":"1.4756","version_created":"2026-04-21T17:26:37.026127+10:00","relevant_disorders":[],"stats":{"number_of_genes":6014,"number_of_strs":43,"number_of_regions":7},"types":[{"name":"Victorian Clinical Genetics Services","slug":"victorian-clinical-genetics-services","description":"Panel used by VCGS."},{"name":"Royal Melbourne Hospital","slug":"royal-melbourne-hospital","description":"Royal Melbourne Hospital"},{"name":"Rare Disease","slug":"rare-disease","description":"Rare disease panels"}],"child_panel_ids":[]},"transcript":null},{"gene_data":{"alias":["MTPOLB","HP55"],"biotype":"protein_coding","hgnc_id":"HGNC:9180","gene_name":"DNA polymerase gamma 2, accessory subunit","omim_gene":["604983"],"alias_name":null,"gene_symbol":"POLG2","hgnc_symbol":"POLG2","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"17:62473902-62493154","ensembl_id":"ENSG00000256525"}},"GRch38":{"90":{"location":"17:64477785-64497036","ensembl_id":"ENSG00000256525"}}},"hgnc_date_symbol_changed":"1999-09-16"},"entity_type":"gene","entity_name":"POLG2","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["16685652","21555342","27592148","31778857"],"evidence":["Expert Review Green","Victorian Clinical Genetics Services"],"phenotypes":["Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 4, MIM# 610131","Mitochondrial DNA depletion syndrome 16 , MIM# 618528"],"mode_of_inheritance":"BOTH monoallelic and biallelic, autosomal or pseudoautosomal","tags":[],"panel":{"id":137,"hash_id":null,"name":"Mendeliome","disease_group":"","disease_sub_group":"","description":"The Mendeliome contains genes currently associated with Mendelian gene disorders.\r\n\r\nThe Mendeliome is intended to be used to facilitate panel-agnostic analysis, particularly in complex paediatric patients with multi-system features, while still limiting analysis to genes with published evidence for gene-disease association and minimising the chance of incidental findings. 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If uncertain, please contact your test provider.\r\n\r\nSTRs are currently on this panel as 'grey' due to lack of clinical accreditation for STR analysis in Australian laboratories.\r\n\r\nThis panel was originally developed by VCGS and is a consensus panel used by RMH.","status":"public","version":"1.4756","version_created":"2026-04-21T17:26:37.026127+10:00","relevant_disorders":[],"stats":{"number_of_genes":6014,"number_of_strs":43,"number_of_regions":7},"types":[{"name":"Victorian Clinical Genetics Services","slug":"victorian-clinical-genetics-services","description":"Panel used by VCGS."},{"name":"Royal Melbourne Hospital","slug":"royal-melbourne-hospital","description":"Royal Melbourne Hospital"},{"name":"Rare Disease","slug":"rare-disease","description":"Rare disease panels"}],"child_panel_ids":[]},"transcript":null},{"gene_data":{"alias":["RAD30A","XP-V"],"biotype":"protein_coding","hgnc_id":"HGNC:9181","gene_name":"DNA polymerase eta","omim_gene":["603968"],"alias_name":null,"gene_symbol":"POLH","hgnc_symbol":"POLH","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"6:43543887-43586701","ensembl_id":"ENSG00000170734"}},"GRch38":{"90":{"location":"6:43576150-43615660","ensembl_id":"ENSG00000170734"}}},"hgnc_date_symbol_changed":"1997-09-12"},"entity_type":"gene","entity_name":"POLH","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["10385124","10398605"],"evidence":["Expert Review Green","Victorian Clinical Genetics Services"],"phenotypes":["Xeroderma pigmentosum, variant type, MIM# 278750","MONDO:0010214"],"mode_of_inheritance":"BIALLELIC, autosomal or pseudoautosomal","tags":[],"panel":{"id":137,"hash_id":null,"name":"Mendeliome","disease_group":"","disease_sub_group":"","description":"The Mendeliome contains genes currently associated with Mendelian gene disorders.\r\n\r\nThe Mendeliome is intended to be used to facilitate panel-agnostic analysis, particularly in complex paediatric patients with multi-system features, while still limiting analysis to genes with published evidence for gene-disease association and minimising the chance of incidental findings. 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If uncertain, please contact your test provider.\r\n\r\nSTRs are currently on this panel as 'grey' due to lack of clinical accreditation for STR analysis in Australian laboratories.\r\n\r\nThis panel was originally developed by VCGS and is a consensus panel used by RMH.","status":"public","version":"1.4756","version_created":"2026-04-21T17:26:37.026127+10:00","relevant_disorders":[],"stats":{"number_of_genes":6014,"number_of_strs":43,"number_of_regions":7},"types":[{"name":"Victorian Clinical Genetics Services","slug":"victorian-clinical-genetics-services","description":"Panel used by VCGS."},{"name":"Royal Melbourne Hospital","slug":"royal-melbourne-hospital","description":"Royal Melbourne Hospital"},{"name":"Rare Disease","slug":"rare-disease","description":"Rare disease panels"}],"child_panel_ids":[]},"transcript":null},{"gene_data":{"alias":["Wip1","PP2C-DELTA"],"biotype":"protein_coding","hgnc_id":"HGNC:9277","gene_name":"protein phosphatase, Mg2+/Mn2+ dependent 1D","omim_gene":["605100"],"alias_name":["wild-type p53-induced phosphatase 1","protein phosphatase 2C, delta isoform"],"gene_symbol":"PPM1D","hgnc_symbol":"PPM1D","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"17:58677544-58741849","ensembl_id":"ENSG00000170836"}},"GRch38":{"90":{"location":"17:60600183-60666280","ensembl_id":"ENSG00000170836"}}},"hgnc_date_symbol_changed":"1998-10-14"},"entity_type":"gene","entity_name":"PPM1D","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["28343630","31916397","30795918","29758292"],"evidence":["Expert Review Green","Victorian Clinical Genetics Services"],"phenotypes":["Jansen de Vries syndrome, MIM #617450"],"mode_of_inheritance":"MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted","tags":[],"panel":{"id":137,"hash_id":null,"name":"Mendeliome","disease_group":"","disease_sub_group":"","description":"The Mendeliome contains genes currently associated with Mendelian gene disorders.\r\n\r\nThe Mendeliome is intended to be used to facilitate panel-agnostic analysis, particularly in complex paediatric patients with multi-system features, while still limiting analysis to genes with published evidence for gene-disease association and minimising the chance of incidental findings. 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If uncertain, please contact your test provider.\r\n\r\nSTRs are currently on this panel as 'grey' due to lack of clinical accreditation for STR analysis in Australian laboratories.\r\n\r\nThis panel was originally developed by VCGS and is a consensus panel used by RMH.","status":"public","version":"1.4756","version_created":"2026-04-21T17:26:37.026127+10:00","relevant_disorders":[],"stats":{"number_of_genes":6014,"number_of_strs":43,"number_of_regions":7},"types":[{"name":"Victorian Clinical Genetics Services","slug":"victorian-clinical-genetics-services","description":"Panel used by VCGS."},{"name":"Royal Melbourne Hospital","slug":"royal-melbourne-hospital","description":"Royal Melbourne Hospital"},{"name":"Rare Disease","slug":"rare-disease","description":"Rare disease panels"}],"child_panel_ids":[]},"transcript":null},{"gene_data":{"alias":["PK2","BV8","MIT1","KAL4"],"biotype":"protein_coding","hgnc_id":"HGNC:18455","gene_name":"prokineticin 2","omim_gene":["607002"],"alias_name":["protein Bv8 homolog"],"gene_symbol":"PROK2","hgnc_symbol":"PROK2","hgnc_release":"2017-11-03","ensembl_genes":{"GRch37":{"82":{"location":"3:71820807-71834357","ensembl_id":"ENSG00000163421"}},"GRch38":{"90":{"location":"3:71771656-71785206","ensembl_id":"ENSG00000163421"}}},"hgnc_date_symbol_changed":"2002-07-22"},"entity_type":"gene","entity_name":"PROK2","confidence_level":"3","penetrance":null,"mode_of_pathogenicity":"","publications":["18559922","17054399","17959774","18285834"],"evidence":["Expert Review Green","Victorian Clinical Genetics Services"],"phenotypes":["Hypogonadotropic hypogonadism 4 with or without anosmia, MIM# 610628"],"mode_of_inheritance":"BOTH monoallelic and biallelic, autosomal or pseudoautosomal","tags":[],"panel":{"id":137,"hash_id":null,"name":"Mendeliome","disease_group":"","disease_sub_group":"","description":"The Mendeliome contains genes currently associated with Mendelian gene disorders.\r\n\r\nThe Mendeliome is intended to be used to facilitate panel-agnostic analysis, particularly in complex paediatric patients with multi-system features, while still limiting analysis to genes with published evidence for gene-disease association and minimising the chance of incidental findings. 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