Entity Name	Entity type	Gene Symbol	Sources(; separated)	Level4	Level3	Level2	Model_Of_Inheritance	Phenotypes	Omim	Orphanet	HPO	Publications	Description	Flagged	GEL_Status	UserRatings_Green_amber_red	version	ready	Mode of pathogenicity	EnsemblId(GRch37)	EnsemblId(GRch38)	HGNC	Position Chromosome	Position GRCh37 Start	Position GRCh37 End	Position GRCh38 Start	Position GRCh38 End	STR Repeated Sequence	STR Normal Repeats	STR Pathogenic Repeats	Region Haploinsufficiency Score	Region Triplosensitivity Score	Region Required Overlap Percentage	Region Variant Type	Region Verbose Name
ACBD6	gene	ACBD6	Expert Review Amber;Literature	Severe early-onset obesity		Endocrine disorders	BIALLELIC, autosomal or pseudoautosomal	Neurodevelopmental disorder with progressive movement abnormalities, MIM# 620785			Obesity;HP:0001513	36457943;21937992;35446914		False	2	0;100;0	1.32	True		ENSG00000230124	ENSG00000230124	HGNC:23339													
BDNF	gene	BDNF	Expert Review Amber;Victorian Clinical Genetics Services	Severe early-onset obesity		Endocrine disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Obesity disorder, MONDO:0011122, BDNF-related			Obesity;HP:0001513	41680086;37329217;33442278;32493978;30926952;28397838		False	2	0;100;0	1.32	True		ENSG00000176697	ENSG00000176697	HGNC:1033													
C8orf37	gene	C8orf37	Expert list;Expert Review Amber	Severe early-onset obesity		Endocrine disorders	BIALLELIC, autosomal or pseudoautosomal	Bardet-Biedl syndrome 21, MIM#617406			Obesity;HP:0001513	27008867;26854863		False	2	0;100;0	1.32	True		ENSG00000156172	ENSG00000156172	HGNC:27232													
CEP19	gene	CEP19	Expert list;Expert Review Amber;Genomics England PanelApp	Severe early-onset obesity		Endocrine disorders	BIALLELIC, autosomal or pseudoautosomal	Morbid obesity and spermatogenic failure, OMIM:615703;Bardet Biedl syndrome			Obesity;HP:0001513	24268657;29127258		False	2	0;50;50	1.32	True		ENSG00000174007	ENSG00000174007	HGNC:28209													
INPP5E	gene	INPP5E	Expert Review Amber;Genomics England PanelApp	Severe early-onset obesity		Endocrine disorders	BIALLELIC, autosomal or pseudoautosomal	Mental retardation, truncal obesity, retinal dystrophy, and micropenis, OMIM:610156			Obesity;HP:0001513	31173343;19668215		False	2	50;50;0	1.32	True		ENSG00000148384	ENSG00000148384	HGNC:21474													
OTP	gene	OTP	Expert Review Amber;Literature	Severe early-onset obesity		Endocrine disorders	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Obesity disorder, MONDO:0011122, OTP-related			Obesity;HP:0001513	39813316;29107289		False	2	0;100;0	1.32	True		ENSG00000171540	ENSG00000171540	HGNC:8518													
SREK1	gene	SREK1	Expert Review Amber;Literature	Severe early-onset obesity		Endocrine disorders	BIALLELIC, autosomal or pseudoautosomal	Prader-Willi-like syndrome, SREK1-related MONDO:0008300			Obesity;HP:0001513	40549565		False	2	0;100;0	1.32	True		ENSG00000153914	ENSG00000153914	HGNC:17882													
TUB	gene	TUB	Expert Review Amber;Genomics England PanelApp	Severe early-onset obesity		Endocrine disorders	BIALLELIC, autosomal or pseudoautosomal	Retinal dystrophy and obesity, MIM# 616188			Obesity;HP:0001513	16443771;22618246;24375934;18619628;12076089;16643894;8612280;10629044;19885003;10196693;22492381;17955208 (candidate for late-onset obesity);18183286		False	2	0;50;50	1.32	True		ENSG00000166402	ENSG00000166402	HGNC:12406