Susceptibility to Viral Infections

Gene: OAS2

Green List (high evidence)

OAS2 (2'-5'-oligoadenylate synthetase 2)
EnsemblGeneIds (GRCh38): ENSG00000111335
EnsemblGeneIds (GRCh37): ENSG00000111335
OMIM: 603350, Gene2Phenotype
OAS2 is in 3 panels

2 reviews

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Functional data.
Created: 2 Aug 2024, 1:43 a.m. | Last Modified: 2 Aug 2024, 1:43 a.m.
Panel Version: 0.122

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Multisystem inflammatory syndrome, MONDO:0035375, OAS2-related

Publications

Peter McNaughton (Queensland Children's Hospital)

Green List (high evidence)

3x unrelated patients with MIS-C after COVID infection. Patients displayed excessive inflammatory responses to intracellular dsRNA, SARS-CoV-2, SARS-CoV-2–infected cells, and their RNA, providing a plausible mechanism for MIS-C. Similar presentation to OAS1 and RNASEL.
Sources: Literature
Created: 29 Jul 2024, 5:18 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
MIS-C

Publications

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
Phenotypes
  • Multisystem inflammatory syndrome, MONDO:0035375, OAS2-related
OMIM
603350
Clinvar variants
Variants in OAS2
Penetrance
None
Publications
Panels with this gene

History Filter Activity

2 Aug 2024, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: oas2 has been classified as Green List (High Evidence).

2 Aug 2024, Gel status: 3

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: OAS2 were changed from MIS-C to Multisystem inflammatory syndrome, MONDO:0035375, OAS2-related

2 Aug 2024, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: oas2 has been classified as Green List (High Evidence).

29 Jul 2024, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Peter McNaughton (Queensland Children's Hospital)

gene: OAS2 was added gene: OAS2 was added to Susceptibility to Viral Infections. Sources: Literature Mode of inheritance for gene: OAS2 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: OAS2 were set to PMID: 36538032 Phenotypes for gene: OAS2 were set to MIS-C Review for gene: OAS2 was set to GREEN