Susceptibility to Viral Infections
Gene: OAS2
Functional data.Created: 2 Aug 2024, 1:43 a.m. | Last Modified: 2 Aug 2024, 1:43 a.m.
Panel Version: 0.122
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Multisystem inflammatory syndrome, MONDO:0035375, OAS2-related
Publications
3x unrelated patients with MIS-C after COVID infection. Patients displayed excessive inflammatory responses to intracellular dsRNA, SARS-CoV-2, SARS-CoV-2–infected cells, and their RNA, providing a plausible mechanism for MIS-C. Similar presentation to OAS1 and RNASEL.
Sources: LiteratureCreated: 29 Jul 2024, 5:18 a.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
MIS-C
Publications
Gene: oas2 has been classified as Green List (High Evidence).
Phenotypes for gene: OAS2 were changed from MIS-C to Multisystem inflammatory syndrome, MONDO:0035375, OAS2-related
Gene: oas2 has been classified as Green List (High Evidence).
gene: OAS2 was added gene: OAS2 was added to Susceptibility to Viral Infections. Sources: Literature Mode of inheritance for gene: OAS2 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: OAS2 were set to PMID: 36538032 Phenotypes for gene: OAS2 were set to MIS-C Review for gene: OAS2 was set to GREEN