This panel contains genes associated with basal cell cancer. Only ‘Green’ genes should be tested and analysed for clinical testing, as they have sufficient peer-reviewed published evidence of association with basal cell cancer and are clinically actionable for diagnostic and/or predictive genetic testing. Ensure testing includes copy number variant (CNV) analysis, as CNVs contribute to a clinically significant proportion of pathogenic variants associated with familial risk of cancer. This panel has been compared against the Genomics England PanelApp and aligned with any assessments by ClinGen. This panel has been developed under the guidance of experts in cancer genetics (Dr Helen Mar Fan and Dr Nicola Poplawski).
Chirag Patel (Genetic Health Queensland)
Sarah Milton (Victorian Clinical Genetics Services)
| List | Entity | Reviews | Mode of inheritance | Details | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Green List (high evidence) |
ARHGAP36 downstream regulatory regionARHGAP36 downstream regulatory regionRegion |
1 review1 green |
X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males) |
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| Green List (high evidence) |
PTCH1 |
1 review1 green |
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted |
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| Green List (high evidence) |
SUFU |
1 review1 green |
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted |
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| Red List (low evidence) |
PTCH2 |
1 review1 red |
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted |
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Phenotypes
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