| Date | Panel | Item | Activity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Pancreatic Cancer v0.24 | ATM | Zornitza Stark Marked gene: ATM as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | ATM | Zornitza Stark Gene: atm has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | ATM |
Chirag Patel changed review comment from: ClinGen definitive. Pancreatic cancer reported in condition. Sources: Expert list, Expert Review; to: ClinGen definitive. Pancreatic cancer reported in condition. Consider possibility that an identified variant could represent ACE (aberrant clonal expansion), which can be due to clonal haematopoiesis of indeterminate potential (CHIP) or an occult hematologic malignancy, especially in older patients who have undergone prior chemotherapy (PMID: 36040522). Sources: Expert list, Expert Review |
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| Pancreatic Cancer v0.24 | TP53 |
Chirag Patel changed review comment from: ClinGen definitive. Pancreatic cancer reported in condition. Consider possibility that an identified variant could represent ACE (aberrant clonal expansion), which can be due to clonal haematopoiesis of indeterminate potential (CHIP) or an occult hematologic malignancy, especially in older patients who have undergone prior chemotherapy. Genes most commonly associated with ACE include ATM, CHEK2, and TP53 (PMID: 36040522). Sources: Expert list, Expert Review; to: ClinGen definitive. Pancreatic cancer reported in condition. Consider possibility that an identified variant could represent ACE (aberrant clonal expansion), which can be due to clonal haematopoiesis of indeterminate potential (CHIP) or an occult hematologic malignancy, especially in older patients who have undergone prior chemotherapy (PMID: 36040522). Sources: Expert list, Expert Review |
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| Pancreatic Cancer v0.24 | TP53 |
Chirag Patel changed review comment from: ClinGen definitive. Pancreatic cancer reported in condition. Sources: Expert list, Expert Review; to: ClinGen definitive. Pancreatic cancer reported in condition. Consider possibility that an identified variant could represent ACE (aberrant clonal expansion), which can be due to clonal haematopoiesis of indeterminate potential (CHIP) or an occult hematologic malignancy, especially in older patients who have undergone prior chemotherapy. Genes most commonly associated with ACE include ATM, CHEK2, and TP53 (PMID: 36040522). Sources: Expert list, Expert Review |
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| Pancreatic Cancer v0.24 | ATM | Chirag Patel Classified gene: ATM as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | ATM | Chirag Patel Gene: atm has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.11 | ATM |
Chirag Patel gene: ATM was added gene: ATM was added to Pancreatic Cancer. Sources: Expert list,Expert Review Mode of inheritance for gene: ATM was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: ATM were set to Malignant pancreatic neoplasm, MONDO:0009831; ATM-related cancer predisposition, MONDO:0700270; Breast cancer, susceptibility to, MIM#114480 Review for gene: ATM was set to GREEN Added comment: ClinGen definitive. Pancreatic cancer reported in condition. Sources: Expert list, Expert Review |
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