Zornitza Stark edited their review of gene: CFAP119: Added comment: PMID 42290102 reports two families with homozygous CFAP119 variants (c.709_711del frameshift and c.898C>T missense) presenting with severe oligoasthenoteratozoospermia (low count, poor motility, abnormal head/tail morphology). PMID 40759592 reports an additional consanguineous family harbouring the same homozygous missense c.898C>T variant. Functional studies demonstrate markedly reduced CFAP119 mRNA and protein levels, loss of CABCOCO1 interaction and flagellar structural defects, but no rescue experiments or animal‑model validation. Amber rating as two of the families have the same homozygous missense variant.; Changed rating: AMBER; Changed publications: 40759592, 42290102; Changed phenotypes: Spermatogenic failure, MONDO:0004983, CFAP119-related