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Adrenal insufficiency v0.67 CPOX Chirag Patel Marked gene: CPOX as ready
Adrenal insufficiency v0.67 CPOX Chirag Patel Gene: cpox has been classified as Green List (High Evidence).
Adrenal insufficiency v0.67 CPOX Chirag Patel Classified gene: CPOX as Green List (high evidence)
Adrenal insufficiency v0.67 CPOX Chirag Patel Gene: cpox has been classified as Green List (High Evidence).
Adrenal insufficiency v0.66 CPOX Chirag Patel gene: CPOX was added
gene: CPOX was added to Adrenal insufficiency. Sources: Literature
Mode of inheritance for gene: CPOX was set to BIALLELIC, autosomal or pseudoautosomal
Publications for gene: CPOX were set to 40857591; 40481674; 40296768
Phenotypes for gene: CPOX were set to harderoporphyria, MONDO:0030048
Review for gene: CPOX was set to GREEN
Added comment: ClinGen DEFINITIVE association (Jan 2023).

Childhood‑onset primary adrenal insufficiency reported in 5 individuals from 4 unrelated families with biallelic loss‑of‑function CPOX variants, with 3 individuals also having 46,XY DSD (PMID 40296768 and 40481674).
Sources: Literature