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Mendeliome v2.204 EIF1AX Rylee Peters Marked gene: EIF1AX as ready
Mendeliome v2.204 EIF1AX Rylee Peters Gene: eif1ax has been classified as Green List (High Evidence).
Mendeliome v2.204 EIF1AX Rylee Peters Classified gene: EIF1AX as Green List (high evidence)
Mendeliome v2.204 EIF1AX Rylee Peters Gene: eif1ax has been classified as Green List (High Evidence).
Mendeliome v2.203 EIF1AX Rylee Peters gene: EIF1AX was added
gene: EIF1AX was added to Mendeliome. Sources: Literature
Mode of inheritance for gene: EIF1AX was set to X-LINKED: hemizygous mutation in males, biallelic mutations in females
Publications for gene: EIF1AX were set to 42337333
Phenotypes for gene: EIF1AX were set to Neurodevelopmental disorder, MONDO:0700092, EIF1AX-related
Review for gene: EIF1AX was set to GREEN
Added comment: PMID: 42337333 reports 4 hemizygous males from 4 families with de novo hemizygous EIF1AX missense variants presenting with an X-linked syndromic neurodevelopmental disorder characterised by global developmental delay, autistic behaviour, facial dysmorphism, short stature and brain imaging abnormalities (3/4). All variants are absent from gnomAD (v4).
Sources: Literature