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Date	Panel	Item	Activity
Filter activities 27 actions
16 Jul 2026	Mendeliome v2.234	HDAC4	chirag patel Mode of pathogenicity for gene: HDAC4 was changed from Other to None
16 Jul 2026	Mendeliome v2.233	HDAC4	chirag patel Publications for gene: HDAC4 were set to 24715439; 20691407; 31209962; 33537682; 30968599
16 Jul 2026	Mendeliome v2.233	HDAC4	chirag patel Publications for gene: HDAC4 were set to 24715439; 20691407; 31209962; 33537682
16 Jul 2026	Mendeliome v2.232	HDAC4	chirag patel Phenotypes for gene: HDAC4 were changed from Neurodevelopmental disorder with central hypotonia and dysmorphic facies MIM#619797; Brachydactyly mental retardation syndrome; Brachydactyly without intellectual disability; Intellectual disability syndrome; Monogenic diabetes, MONDO:0015967 to Neurodevelopmental disorder with central hypotonia and dysmorphic facies MIM#619797; Brachydactyly mental retardation syndrome; Brachydactyly without intellectual disability; Intellectual disability syndrome; Monogenic diabetes, MONDO:0015967
16 Jul 2026	Mendeliome v2.231	HDAC4	chirag patel Phenotypes for gene: HDAC4 were changed from Neurodevelopmental disorder with central hypotonia and dysmorphic facies MIM#619797; Brachydactyly mental retardation syndrome; Brachydactyly without intellectual disability; Intellectual disability syndrome to Neurodevelopmental disorder with central hypotonia and dysmorphic facies MIM#619797; Brachydactyly mental retardation syndrome; Brachydactyly without intellectual disability; Intellectual disability syndrome; Monogenic diabetes, MONDO:0015967
16 Jul 2026	Mendeliome v2.230		chirag patel Added reviews for gene HDAC4 from panel Monogenic Diabetes
07 Jun 2026	Mendeliome v2.0	HDAC4	Gene migrated from ENSG00000068024 to ENSG00000068024 (gene set migration)
28 Nov 2025	Mendeliome v1.3718	HDAC4	Lucy Spencer Phenotypes for gene: HDAC4 were changed from Brachydactyly mental retardation syndrome; Brachydactyly without intellectual disability; Intellectual disability syndrome to Neurodevelopmental disorder with central hypotonia and dysmorphic facies MIM#619797; Brachydactyly mental retardation syndrome; Brachydactyly without intellectual disability; Intellectual disability syndrome
15 Apr 2021	Mendeliome v0.7196	HDAC4	Bryony Thompson Publications for gene: HDAC4 were set to 24715439; 20691407; 31209962; https://doi.org/10.1016/j.xhgg.2020.100015
15 Apr 2021	Mendeliome v0.7195	HDAC4	Bryony Thompson edited their review of gene: HDAC4: Changed publications: 33537682
27 Nov 2020	Mendeliome v0.5477	HDAC4	Bryony Thompson Publications for gene: HDAC4 were set to 24715439; 20691407; 31209962
27 Nov 2020	Mendeliome v0.5476	HDAC4	Bryony Thompson Classified gene: HDAC4 as Green List (high evidence)
27 Nov 2020	Mendeliome v0.5476	HDAC4	Bryony Thompson Gene: hdac4 has been classified as Green List (High Evidence).
27 Nov 2020	Mendeliome v0.5475	HDAC4	Bryony Thompson Phenotypes for gene: HDAC4 were changed from Brachydactyly mental retardation syndrome; Brachydactyly without intellectual disability to Brachydactyly mental retardation syndrome; Brachydactyly without intellectual disability; Intellectual disability syndrome
27 Nov 2020	Mendeliome v0.5474	HDAC4	Bryony Thompson reviewed gene: HDAC4: Rating: GREEN; Mode of pathogenicity: None; Publications: https://doi.org/10.1016/j.xhgg.2020.100015; Phenotypes: Intellectual disability, hypotonia, dysmorphism; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
06 Feb 2020	Mendeliome v0.1271	HDAC4	Zornitza Stark changed review comment from: Comment when marking as ready: Contradictory evidence: deletions linked to brachydactyly-MR but note some individuals reported without MR. Only reports of intragenic variants (still structural rather than SNVs).; to: Comment when marking as ready: Contradictory evidence: deletions linked to brachydactyly-MR but note some individuals reported without MR. Only two reports of intragenic variants (still structural rather than SNVs).
06 Feb 2020	Mendeliome v0.1271	HDAC4	Zornitza Stark Marked gene: HDAC4 as ready
06 Feb 2020	Mendeliome v0.1271	HDAC4	Zornitza Stark Added comment: Comment when marking as ready: Contradictory evidence: deletions linked to brachydactyly-MR but note some individuals reported without MR. Only reports of intragenic variants (still structural rather than SNVs).
06 Feb 2020	Mendeliome v0.1271	HDAC4	Zornitza Stark Gene: hdac4 has been classified as Amber List (Moderate Evidence).
06 Feb 2020	Mendeliome v0.1271	HDAC4	Zornitza Stark Phenotypes for gene: HDAC4 were changed from to Brachydactyly mental retardation syndrome; Brachydactyly without intellectual disability
06 Feb 2020	Mendeliome v0.1270	HDAC4	Zornitza Stark Mode of pathogenicity for gene: HDAC4 was changed from to Other
06 Feb 2020	Mendeliome v0.1269	HDAC4	Zornitza Stark Publications for gene: HDAC4 were set to
06 Feb 2020	Mendeliome v0.1268	HDAC4	Zornitza Stark Mode of inheritance for gene: HDAC4 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
06 Feb 2020	Mendeliome v0.1267	HDAC4	Zornitza Stark Classified gene: HDAC4 as Amber List (moderate evidence)
06 Feb 2020	Mendeliome v0.1267	HDAC4	Zornitza Stark Gene: hdac4 has been classified as Amber List (Moderate Evidence).
06 Feb 2020	Mendeliome v0.1262	HDAC4	Elena Savva reviewed gene: HDAC4: Rating: AMBER; Mode of pathogenicity: Other; Publications: PMID: 24715439, 20691407, 31209962; Phenotypes: Brachydactyly mental retardation syndrome, Brachydactyly without intellectual disability; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown; Current diagnostic: yes
17 Nov 2019	Mendeliome v0.0	HDAC4	Zornitza Stark gene: HDAC4 was added gene: HDAC4 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: HDAC4 was set to Unknown