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Arthrogryposis v1.4 KIF21A Rylee Peters Phenotypes for gene: KIF21A were changed from Severe fetal akinesia with arthrogryposis multiplex to Arthrogryposis multiplex congenita, MONDO:0015168, KIF21A-related
Arthrogryposis v1.3 KIF21A Rylee Peters Publications for gene: KIF21A were set to PMID: 34740919
Arthrogryposis v1.2 KIF21A Rylee Peters Classified gene: KIF21A as Green List (high evidence)
Arthrogryposis v1.2 KIF21A Rylee Peters Gene: kif21a has been classified as Green List (High Evidence).
Arthrogryposis v1.1 KIF21A Rylee Peters reviewed gene: KIF21A: Rating: GREEN; Mode of pathogenicity: None; Publications: 37921537, 34740919, 32686171; Phenotypes: Arthrogryposis multiplex congenita, MONDO:0015168, KIF21A-related; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Arthrogryposis v0.630 KIF21A Zornitza Stark Marked gene: KIF21A as ready
Arthrogryposis v0.630 KIF21A Zornitza Stark Gene: kif21a has been classified as Amber List (Moderate Evidence).
Arthrogryposis v0.397 KIF21A Chirag Patel Classified gene: KIF21A as Amber List (moderate evidence)
Arthrogryposis v0.397 KIF21A Chirag Patel Gene: kif21a has been classified as Amber List (Moderate Evidence).
Arthrogryposis v0.396 KIF21A Chirag Patel gene: KIF21A was added
gene: KIF21A was added to Arthrogryposis. Sources: Literature
Mode of inheritance for gene: KIF21A was set to BIALLELIC, autosomal or pseudoautosomal
Publications for gene: KIF21A were set to PMID: 34740919
Phenotypes for gene: KIF21A were set to Severe fetal akinesia with arthrogryposis multiplex
Review for gene: KIF21A was set to AMBER
Added comment: 2 unrelated consanguineous Turkish families with 5 affected fetuses with severe fetal akinesia with arthrogryposis multiplex. WES identified different homozygous LOF variants in KIF21A gene (p.Leu449* and p.Arg791Glufs*8). Parents and a healthy sibling were heterozygous carriers. No functional studies.
Sources: Literature