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Mendeliome v0.239 SEMA5A Zornitza Stark gene: SEMA5A was added
gene: SEMA5A was added to Mendeliome_VCGS. Sources: Literature
Mode of inheritance for gene: SEMA5A was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for gene: SEMA5A were set to 26395558
Phenotypes for gene: SEMA5A were set to Intellectual disability; autism
Review for gene: SEMA5A was set to AMBER
Added comment: 1 patient with de novo translocation t(5;22)(p15.3;q11.21) and ASD and ID. At the translocation breakpoint on chromosome 5, they observed a 861-kb deletion encompassing the end of the SEMA5A gene. No functional studies.

2 patients with ASD and predicted deleterious heterozygous variants (maternally inherited). No functional studies
Sources: Literature
Mendeliome v0.220 ACTL6B Zornitza Stark gene: ACTL6B was added
gene: ACTL6B was added to Mendeliome_VCGS. Sources: Literature
Mode of inheritance for gene: ACTL6B was set to BIALLELIC, autosomal or pseudoautosomal
Publications for gene: ACTL6B were set to 31134736; 31031012; 30656450; 30237576
Phenotypes for gene: ACTL6B were set to Epileptic encephalopathy, early infantile, 76, MIM# 618468; Intellectual developmental disorder with severe speech and ambulation defects, MIM# 618470
Review for gene: ACTL6B was set to GREEN
Added comment: Over 10 unrelated individuals reported in the literature.
Sources: Literature
Mendeliome v0.219 SELENOI Zornitza Stark Gene: selenoi has been classified as Amber List (Moderate Evidence).
Mendeliome v0.217 SELENOI Zornitza Stark Classified gene: SELENOI as Amber List (moderate evidence)
Mendeliome v0.217 SELENOI Zornitza Stark Gene: selenoi has been classified as Amber List (Moderate Evidence).
Mendeliome v0.216 SELENOI Zornitza Stark reviewed gene: SELENOI: Rating: AMBER; Mode of pathogenicity: None; Publications: 28052917; Phenotypes: developmental delay, spasticity, periventricular white mater abnormalities, peripheral neuropathy, seizures, bifid uvula in some affected individuals, microcephaly; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Mendeliome v0.214 PHC1 Zornitza Stark Gene: phc1 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.211 PHC1 Zornitza Stark Classified gene: PHC1 as Amber List (moderate evidence)
Mendeliome v0.211 PHC1 Zornitza Stark Gene: phc1 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.210 PHC1 Zornitza Stark reviewed gene: PHC1: Rating: AMBER; Mode of pathogenicity: None; Publications: 23418308; Phenotypes: Microcephaly 11, primary, autosomal recessive, MIM#615414; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Mendeliome v0.193 NECAP1 Zornitza Stark Gene: necap1 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.190 NECAP1 Zornitza Stark Classified gene: NECAP1 as Amber List (moderate evidence)
Mendeliome v0.190 NECAP1 Zornitza Stark Gene: necap1 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.186 NDUFB9 Zornitza Stark Gene: ndufb9 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.183 NDUFB9 Zornitza Stark Classified gene: NDUFB9 as Amber List (moderate evidence)
Mendeliome v0.183 NDUFB9 Zornitza Stark Gene: ndufb9 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.182 NDUFB9 Zornitza Stark reviewed gene: NDUFB9: Rating: AMBER; Mode of pathogenicity: None; Publications: 22200994; Phenotypes: Mitochondrial complex I deficiency, nuclear type 24, MIM#618245; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Mendeliome v0.182 MRPS16 Zornitza Stark Gene: mrps16 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.182 MRPS16 Zornitza Stark Gene: mrps16 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.182 MRPS16 Zornitza Stark Phenotypes for gene: MRPS16 were changed from to Combined oxidative phosphorylation deficiency 2; OMIM #610498
Mendeliome v0.179 MRPS16 Zornitza Stark Classified gene: MRPS16 as Amber List (moderate evidence)
Mendeliome v0.179 MRPS16 Zornitza Stark Gene: mrps16 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.177 MRPL3 Zornitza Stark Gene: mrpl3 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.177 MRPL3 Zornitza Stark Phenotypes for gene: MRPL3 were changed from to Combined oxidative phosphorylation deficiency 9; OMIM #614582
Mendeliome v0.174 MRPL3 Zornitza Stark Classified gene: MRPL3 as Amber List (moderate evidence)
Mendeliome v0.174 MRPL3 Zornitza Stark Gene: mrpl3 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.170 CDK16 Zornitza Stark Gene: cdk16 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.170 CDK16 Zornitza Stark Classified gene: CDK16 as Amber List (moderate evidence)
Mendeliome v0.170 CDK16 Zornitza Stark Gene: cdk16 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.169 CDK16 Zornitza Stark gene: CDK16 was added
gene: CDK16 was added to Mendeliome_VCGS. Sources: Expert list
Mode of inheritance for gene: CDK16 was set to X-LINKED: hemizygous mutation in males, biallelic mutations in females
Publications for gene: CDK16 were set to 25644381
Phenotypes for gene: CDK16 were set to Intellectual disability
Review for gene: CDK16 was set to AMBER
Added comment: Single family described in this manuscript describing multiple candidate genes for XLID.
Sources: Expert list
Mendeliome v0.146 CFAP57 Sebastian Lunke Classified gene: CFAP57 as Amber List (moderate evidence)
Mendeliome v0.146 CFAP57 Sebastian Lunke Gene: cfap57 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.145 CFAP57 Sebastian Lunke reviewed gene: CFAP57: Rating: AMBER; Mode of pathogenicity: None; Publications: bioRxiv 773028, doi: https://doi.org/10.1101/773028; Phenotypes: ; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Mendeliome v0.145 EXOSC2 Zornitza Stark Gene: exosc2 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.142 EXOSC2 Zornitza Stark Classified gene: EXOSC2 as Amber List (moderate evidence)
Mendeliome v0.142 EXOSC2 Zornitza Stark Gene: exosc2 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.109 COX14 Zornitza Stark Gene: cox14 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.106 COX14 Zornitza Stark Classified gene: COX14 as Amber List (moderate evidence)
Mendeliome v0.106 COX14 Zornitza Stark Gene: cox14 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.102 CEP63 Zornitza Stark Gene: cep63 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.99 CEP63 Zornitza Stark Classified gene: CEP63 as Amber List (moderate evidence)
Mendeliome v0.99 CEP63 Zornitza Stark Gene: cep63 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.97 CDK6 Zornitza Stark Gene: cdk6 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.94 CDK6 Zornitza Stark Classified gene: CDK6 as Amber List (moderate evidence)
Mendeliome v0.94 CDK6 Zornitza Stark Gene: cdk6 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.92 CD96 Zornitza Stark Gene: cd96 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.89 CD96 Zornitza Stark Classified gene: CD96 as Amber List (moderate evidence)
Mendeliome v0.89 CD96 Zornitza Stark Gene: cd96 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.79 CCDC78 Zornitza Stark Gene: ccdc78 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.76 CCDC78 Zornitza Stark Classified gene: CCDC78 as Amber List (moderate evidence)
Mendeliome v0.76 CCDC78 Zornitza Stark Gene: ccdc78 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.64 BBIP1 Zornitza Stark Gene: bbip1 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.64 BBIP1 Zornitza Stark Classified gene: BBIP1 as Amber List (moderate evidence)
Mendeliome v0.64 BBIP1 Zornitza Stark Gene: bbip1 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.53 TTI1 Sebastian Lunke Gene: tti1 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.53 TTI1 Sebastian Lunke Classified gene: TTI1 as Amber List (moderate evidence)
Mendeliome v0.53 TTI1 Sebastian Lunke Gene: tti1 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.30 HCN2 Zornitza Stark Gene: hcn2 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.30 HCN2 Zornitza Stark Classified gene: HCN2 as Amber List (moderate evidence)
Mendeliome v0.30 HCN2 Zornitza Stark Gene: hcn2 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.24 MASTL Zornitza Stark Gene: mastl has been classified as Amber List (Moderate Evidence).
Mendeliome v0.24 MASTL Zornitza Stark Classified gene: MASTL as Amber List (moderate evidence)
Mendeliome v0.24 MASTL Zornitza Stark Gene: mastl has been classified as Amber List (Moderate Evidence).
Mendeliome v0.22 PCLO Zornitza Stark Gene: pclo has been classified as Amber List (Moderate Evidence).
Mendeliome v0.22 PCLO Zornitza Stark Classified gene: PCLO as Amber List (moderate evidence)
Mendeliome v0.22 PCLO Zornitza Stark Gene: pclo has been classified as Amber List (Moderate Evidence).
Mendeliome v0.11 PNPLA4 Zornitza Stark Classified gene: PNPLA4 as Amber List (moderate evidence)
Mendeliome v0.11 PNPLA4 Zornitza Stark Gene: pnpla4 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.6 ASTN2 Zornitza Stark Gene: astn2 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.6 ASTN2 Zornitza Stark Classified gene: ASTN2 as Amber List (moderate evidence)
Mendeliome v0.6 ASTN2 Zornitza Stark Gene: astn2 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.5 ASTN2 Zornitza Stark Classified gene: ASTN2 as Amber List (moderate evidence)
Mendeliome v0.5 ASTN2 Zornitza Stark Gene: astn2 has been classified as Amber List (Moderate Evidence).
Mendeliome v0.4 ASTN2 Zornitza Stark reviewed gene: ASTN2: Rating: AMBER; Mode of pathogenicity: None; Publications: 28940097; Phenotypes: ; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Mendeliome v0.0 STAMBP Zornitza Stark gene: STAMBP was added
gene: STAMBP was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: STAMBP was set to Unknown
Mendeliome v0.0 PSMB9 Zornitza Stark gene: PSMB9 was added
gene: PSMB9 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: PSMB9 was set to Unknown
Mendeliome v0.0 PSMB8 Zornitza Stark gene: PSMB8 was added
gene: PSMB8 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: PSMB8 was set to Unknown
Mendeliome v0.0 PSMB4 Zornitza Stark gene: PSMB4 was added
gene: PSMB4 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: PSMB4 was set to Unknown
Mendeliome v0.0 MSMB Zornitza Stark gene: MSMB was added
gene: MSMB was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: MSMB was set to Unknown
Mendeliome v0.0 MBTPS2 Zornitza Stark gene: MBTPS2 was added
gene: MBTPS2 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: MBTPS2 was set to Unknown
Mendeliome v0.0 MBOAT7 Zornitza Stark gene: MBOAT7 was added
gene: MBOAT7 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: MBOAT7 was set to Unknown
Mendeliome v0.0 MBNL1 Zornitza Stark gene: MBNL1 was added
gene: MBNL1 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: MBNL1 was set to Unknown
Mendeliome v0.0 MBL2 Zornitza Stark gene: MBL2 was added
gene: MBL2 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: MBL2 was set to Unknown
Mendeliome v0.0 MBD5 Zornitza Stark gene: MBD5 was added
gene: MBD5 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: MBD5 was set to Unknown
Mendeliome v0.0 LMBRD1 Zornitza Stark gene: LMBRD1 was added
gene: LMBRD1 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: LMBRD1 was set to Unknown
Mendeliome v0.0 LMBR1 Zornitza Stark gene: LMBR1 was added
gene: LMBR1 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: LMBR1 was set to Unknown
Mendeliome v0.0 LAMB3 Zornitza Stark gene: LAMB3 was added
gene: LAMB3 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: LAMB3 was set to Unknown
Mendeliome v0.0 LAMB2 Zornitza Stark gene: LAMB2 was added
gene: LAMB2 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: LAMB2 was set to Unknown
Mendeliome v0.0 LAMB1 Zornitza Stark gene: LAMB1 was added
gene: LAMB1 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: LAMB1 was set to Unknown
Mendeliome v0.0 KCNMB1 Zornitza Stark gene: KCNMB1 was added
gene: KCNMB1 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: KCNMB1 was set to Unknown
Mendeliome v0.0 IGHMBP2 Zornitza Stark gene: IGHMBP2 was added
gene: IGHMBP2 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: IGHMBP2 was set to Unknown
Mendeliome v0.0 HMBS Zornitza Stark gene: HMBS was added
gene: HMBS was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: HMBS was set to Unknown
Mendeliome v0.0 GPNMB Zornitza Stark gene: GPNMB was added
gene: GPNMB was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: GPNMB was set to Unknown
Mendeliome v0.0 AMBN Zornitza Stark gene: AMBN was added
gene: AMBN was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: AMBN was set to Unknown