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| Mendeliome v2.248 | MEIKIN | Zornitza Stark Marked gene: MEIKIN as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Mendeliome v2.248 | MEIKIN | Zornitza Stark Gene: meikin has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Mendeliome v2.248 | MEIKIN | Zornitza Stark Classified gene: MEIKIN as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Mendeliome v2.248 | MEIKIN | Zornitza Stark Gene: meikin has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Mendeliome v2.247 | MEIKIN |
Zornitza Stark gene: MEIKIN was added gene: MEIKIN was added to Mendeliome. Sources: Literature Mode of inheritance for gene: MEIKIN was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: MEIKIN were set to 42221552 Phenotypes for gene: MEIKIN were set to Infertility disorder, MONDO:0005047 Review for gene: MEIKIN was set to AMBER Added comment: PMID 42221552 reports 3 individuals from independent families with biallelic loss-of-function MEIKIN variants presenting with recurrent good-quality cleavage-stage blastulation failure (R‑GQBF) and severe oligoasthenoteratozoospermia. Sperm FISH and single‑sperm whole‑genome sequencing demonstrated complex aneuploidy, and embryo chromosomal profiling revealed uniform aneuploidy, implicating MEIKIN loss-of-function in male infertility. No experimental evidence presented. Sources: Literature |
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