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| Infertility and Recurrent Pregnancy Loss v1.159 | MLH3 | Zornitza Stark Marked gene: MLH3 as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Infertility and Recurrent Pregnancy Loss v1.159 | MLH3 | Zornitza Stark Gene: mlh3 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Infertility and Recurrent Pregnancy Loss v1.159 | MLH3 | Zornitza Stark Classified gene: MLH3 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Infertility and Recurrent Pregnancy Loss v1.159 | MLH3 | Zornitza Stark Gene: mlh3 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Infertility and Recurrent Pregnancy Loss v1.158 | MLH3 |
Zornitza Stark gene: MLH3 was added gene: MLH3 was added to Infertility and Recurrent Pregnancy Loss. Sources: Literature Mode of inheritance for gene: MLH3 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: MLH3 were set to 2000973; 41102564; 33517345; 32469048 Phenotypes for gene: MLH3 were set to Infertility disorder, MONDO:0005047, MLH3-related Review for gene: MLH3 was set to GREEN Added comment: PMIDs 42000973, 41102564, 33517345 and 32469048 collectively report 12 individuals from 11 unrelated families with biallelic loss‑of‑function MLH3 variants causing early embryonic arrest (4 families), unexplained recurrent pregnancy loss (5 families), severe oligozoospermia (1 family) and non‑obstructive azoospermia (1 family). Functional studies in mouse or cell models show impaired gametogenesis. Sources: Literature |
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