| Date | Panel | Item | Activity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Atrial Fibrillation v1.6 | MYL4 | Bryony Thompson Classified gene: MYL4 as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Atrial Fibrillation v1.6 | MYL4 | Bryony Thompson Gene: myl4 has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Atrial Fibrillation v1.5 | MYL4 |
Bryony Thompson gene: MYL4 was added gene: MYL4 was added to Atrial Fibrillation. Sources: Literature Mode of inheritance for gene: MYL4 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal Publications for gene: MYL4 were set to 27742809; 27066836; 29080865 Phenotypes for gene: MYL4 were set to atrial fibrillation, familial, 18 MONDO:0015001 Review for gene: MYL4 was set to AMBER Added comment: PMID: 27742809 - MYL4 c.234delC identified homozygous in 8 cases from 5 families with early-onset atrial fibrillation in the Icelandic population. Heterozygous individuals were apparently unaffected. PMID: 27066836 - heterozygous MYL4 p.Glu11Lys segregates with early-onset atrial fibrillation in a single family. Zebrafish model of the variant (E17K) recapitulated atrial fibrillation. PMID: 29080865 - rat knock-in model MYL4p.E11K induced fibrotic atrial cardiomyopathy Sources: Literature |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||