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Mendeliome v2.105 NRXN1 Sarah Milton edited their review of gene: NRXN1: Changed publications: PMID: 31932357, 40205044, 40126490, 41094379, 41094176, 20468056
Mendeliome v2.105 NRXN1 Sarah Milton Source Victorian Clinical Genetics Services was removed from NRXN1.
Source Literature was added to NRXN1.
Mode of inheritance for gene NRXN1 was changed from BIALLELIC, autosomal or pseudoautosomal to BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Phenotypes for gene: NRXN1 were changed from Pitt-Hopkins-like syndrome 2 - MIM#614325 to Pitt-Hopkins-like syndrome 2 - MIM#614325; Complex neurodevelopmental disorder, MONDO:0100038, NRXN1-related
Mendeliome v2.104 NRXN1 Sarah Milton reviewed gene: NRXN1: Rating: GREEN; Mode of pathogenicity: None; Publications: PMID: 40205044, 40126490, 41094379, 41094176, 20468056; Phenotypes: Neurodevelopmental disorder, MONDO:0700092, NRXN1-related; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Mendeliome v2.23 NRXN1 Teresa Zhao reviewed gene: NRXN1: Rating: AMBER; Mode of pathogenicity: None; Publications: PMID: 30031152, 30873608; Phenotypes: ; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Mendeliome v2.0 NRXN1 Gene migrated from ENSG00000179915 to ENSG00000179915 (gene set migration)
Mendeliome v0.12132 NRXN1 Zornitza Stark Marked gene: NRXN1 as ready
Mendeliome v0.12132 NRXN1 Zornitza Stark Gene: nrxn1 has been classified as Green List (High Evidence).
Mendeliome v0.12132 NRXN1 Zornitza Stark Phenotypes for gene: NRXN1 were changed from to Pitt-Hopkins-like syndrome 2 - MIM#614325
Mendeliome v0.12131 NRXN1 Zornitza Stark Publications for gene: NRXN1 were set to
Mendeliome v0.12130 NRXN1 Zornitza Stark Mode of inheritance for gene: NRXN1 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal
Mendeliome v0.12059 NRXN1 Krithika Murali reviewed gene: NRXN1: Rating: GREEN; Mode of pathogenicity: None; Publications: 25486015, 19896112, 21964664, 30873608, 35101781, 22337556, 22670139; Phenotypes: Pitt-Hopkins-like syndrome 2 - MIM#614325; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Mendeliome v0.0 NRXN1 Zornitza Stark gene: NRXN1 was added
gene: NRXN1 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: NRXN1 was set to Unknown