| Date | Panel | Item | Activity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Susceptibility to Viral Infections v0.126 | RNASEL | Zornitza Stark Marked gene: RNASEL as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Susceptibility to Viral Infections v0.126 | RNASEL | Zornitza Stark Gene: rnasel has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Susceptibility to Viral Infections v0.126 | RNASEL | Zornitza Stark Phenotypes for gene: RNASEL were changed from MIS-C to Multisystem inflammatory syndrome, MONDO:0035375, RNASEL-related | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Susceptibility to Viral Infections v0.125 | RNASEL | Zornitza Stark Classified gene: RNASEL as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Susceptibility to Viral Infections v0.125 | RNASEL | Zornitza Stark Gene: rnasel has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Susceptibility to Viral Infections v0.124 | RNASEL | Zornitza Stark reviewed gene: RNASEL: Rating: AMBER; Mode of pathogenicity: None; Publications: ; Phenotypes: Multisystem inflammatory syndrome, MONDO:0035375, RNASEL-related; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Susceptibility to Viral Infections v0.117 | RNASEL |
Peter McNaughton gene: RNASEL was added gene: RNASEL was added to Susceptibility to Viral Infections. Sources: Literature Mode of inheritance for gene: RNASEL was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: RNASEL were set to PMID: 36538032 Phenotypes for gene: RNASEL were set to MIS-C Review for gene: RNASEL was set to AMBER Added comment: Single patient presenting with similar presentation and functional findings to OAS1 and OAS2 Sources: Literature |
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| Susceptibility to Viral Infections v0.117 | OAS2 |
Peter McNaughton gene: OAS2 was added gene: OAS2 was added to Susceptibility to Viral Infections. Sources: Literature Mode of inheritance for gene: OAS2 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: OAS2 were set to PMID: 36538032 Phenotypes for gene: OAS2 were set to MIS-C Review for gene: OAS2 was set to GREEN Added comment: 3x unrelated patients with MIS-C after COVID infection. Patients displayed excessive inflammatory responses to intracellular dsRNA, SARS-CoV-2, SARS-CoV-2–infected cells, and their RNA, providing a plausible mechanism for MIS-C. Similar presentation to OAS1 and RNASEL. Sources: Literature |
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