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Date	Panel	Item	Activity
Filter activities 5 actions
30 Dec 2025	Mendeliome v1.3872	TDRD6	Zornitza Stark Marked gene: TDRD6 as ready
30 Dec 2025	Mendeliome v1.3872	TDRD6	Zornitza Stark Gene: tdrd6 has been classified as Amber List (Moderate Evidence).
30 Dec 2025	Mendeliome v1.3872	TDRD6	Zornitza Stark Classified gene: TDRD6 as Amber List (moderate evidence)
30 Dec 2025	Mendeliome v1.3872	TDRD6	Zornitza Stark Gene: tdrd6 has been classified as Amber List (Moderate Evidence).
30 Dec 2025	Mendeliome v1.3871	TDRD6	Zornitza Stark gene: TDRD6 was added gene: TDRD6 was added to Mendeliome. Sources: Literature Mode of inheritance for gene: TDRD6 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: TDRD6 were set to 39764564; 39331689 Phenotypes for gene: TDRD6 were set to Infertility disorder, MONDO:0005047, TDRD6-related Review for gene: TDRD6 was set to AMBER Added comment: PMID 39331689 reports one family and PMID 39764564 reports two families, together three unrelated families with biallelic variants in TDRD6 causing severe oligo‑astheno‑teratozoospermia (OAT) and early embryonic arrest after ICSI. Supportive animal model. Note missense variant is relatively common on gnomAD. Sources: Literature