| Date | Panel | Item | Activity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Pancreatic Cancer v0.24 | TP53 | Zornitza Stark Marked gene: TP53 as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | TP53 | Zornitza Stark Gene: tp53 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.24 | TP53 |
Chirag Patel changed review comment from: ClinGen definitive. Pancreatic cancer reported in condition. Consider possibility that an identified variant could represent ACE (aberrant clonal expansion), which can be due to clonal haematopoiesis of indeterminate potential (CHIP) or an occult hematologic malignancy, especially in older patients who have undergone prior chemotherapy. Genes most commonly associated with ACE include ATM, CHEK2, and TP53 (PMID: 36040522). Sources: Expert list, Expert Review; to: ClinGen definitive. Pancreatic cancer reported in condition. Consider possibility that an identified variant could represent ACE (aberrant clonal expansion), which can be due to clonal haematopoiesis of indeterminate potential (CHIP) or an occult hematologic malignancy, especially in older patients who have undergone prior chemotherapy (PMID: 36040522). Sources: Expert list, Expert Review |
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| Pancreatic Cancer v0.24 | TP53 |
Chirag Patel changed review comment from: ClinGen definitive. Pancreatic cancer reported in condition. Sources: Expert list, Expert Review; to: ClinGen definitive. Pancreatic cancer reported in condition. Consider possibility that an identified variant could represent ACE (aberrant clonal expansion), which can be due to clonal haematopoiesis of indeterminate potential (CHIP) or an occult hematologic malignancy, especially in older patients who have undergone prior chemotherapy. Genes most commonly associated with ACE include ATM, CHEK2, and TP53 (PMID: 36040522). Sources: Expert list, Expert Review |
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| Pancreatic Cancer v0.22 | TP53 | Chirag Patel Classified gene: TP53 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.22 | TP53 | Chirag Patel Gene: tp53 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancreatic Cancer v0.13 | TP53 |
Chirag Patel gene: TP53 was added gene: TP53 was added to Pancreatic Cancer. Sources: Expert list,Expert Review Mode of inheritance for gene: TP53 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: TP53 were set to Malignant pancreatic neoplasm, MONDO:0009831; Li-Fraumeni syndrome, MONDO:0018875; Li-Fraumeni syndrome, MIM#151623 Review for gene: TP53 was set to GREEN Added comment: ClinGen definitive. Pancreatic cancer reported in condition. Sources: Expert list, Expert Review |
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