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Cataract v0.624 VCAN Zornitza Stark Marked gene: VCAN as ready
Cataract v0.624 VCAN Zornitza Stark Gene: vcan has been classified as Amber List (Moderate Evidence).
Cataract v0.624 VCAN Zornitza Stark Classified gene: VCAN as Amber List (moderate evidence)
Cataract v0.624 VCAN Zornitza Stark Gene: vcan has been classified as Amber List (Moderate Evidence).
Cataract v0.623 VCAN Zornitza Stark gene: VCAN was added
gene: VCAN was added to Cataract. Sources: Literature
Mode of inheritance for gene: VCAN was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Publications for gene: VCAN were set to 36333947; 29071374
Phenotypes for gene: VCAN were set to Wagner syndrome 1, MIM# 143200
Review for gene: VCAN was set to AMBER
Added comment: PMID 29071374 reports 28 individuals from 1 family with heterozygous splice‑acceptor c.4004-1G>A variant presenting with Wagner syndrome (vitreoretinopathy, cataract, retinal detachment). PMID 36333947 reports 4 individuals from 1 family with heterozygous splice‑site indel c.4004-4_c.4004-3delinsCA variant presenting with Wagner vitreoretinopathy (cataract, vitreous syneresis, retinal detachment).
Sources: Literature